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592 |
Pribadi R.R., Simadibrata M. |
57194732282;23499598400; |
Increased serum amylase and/or lipase in coronavirus disease 2019 (COVID-19) patients: Is it really pancreatic injury? |
2021 |
JGH Open |
5 |
2 |
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190 |
192 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098140408&doi=10.1002%2fjgh3.12436&partnerID=40&md5=14da866c743f8e6c2bdfff73d45cc7a5 |
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Pribadi, R.R., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Simadibrata, M., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Coronavirus disease 2019 (COVID-19) is a novel disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although it mainly affects the respiratory system, the pancreas could also become the virus' target. The issue regarding pancreatic involvement in COVID-19 has been raised by several researchers. They found increased serum amylase and/or lipase in COVID-19 patients, which suggested pancreatic injury. We aimed to critically review the evidence to provide insights and to answer the very question of the possibility of pancreatic injury. Current evidence shows that increased amylase and/or lipase is not necessarily a pancreatic injury in COVID-19 patients. Those increased enzymes might also be found in other clinical conditions. © 2020 The Authors. JGH Open: An open access journal of gastroenterology and hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. |
amylases; COVID-19; lipase; pancreas |
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John Wiley and Sons Inc |
23979070 |
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Review |
Q3 |
546 |
9258 |
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748 |
Karina K., Ekaputri K., Biben J.A., Purwoko R.H., Sibuea T.P., Astuti S.L., Loho A.M., Limengka Y., Nelfidayani, Agustini S., Krisandi G., Maryam A., Rosadi I., Rosliana I., Sobariah S., Subroto W.R., Afini I., Widyastuti T., Zakiyah A., Ernanda D., Aini N., Jusryanti, Sulaeha A.D., Prestiani S.I., Donna I.M., Habibi, Mutiara M.S. |
57212146678;57285088000;55947833300;57286031400;57286487800;57285797400;57223264641;37029815800;57286487900;57286488000;57225009844;57286260300;57204720098;57186671400;57203547382;57218940654;57211068324;57211074403;57226293808;57226273639;57226289464;57286944600;57226286645;57283770100;57284210300;57285797500;57284210400; |
Evaluating the Safety of Intravenous Delivery of Autologous Activated Platelet-rich Plasma |
2021 |
Journal of Health Sciences |
11 |
2 |
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61 |
65 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111033469&doi=10.17532%2fjhsci.2021.1276&partnerID=40&md5=b0a026ecaccc92d972564c5dfd1f4824 |
Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia; Pusat Kajian Stem Cell, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Mulawarman University, Indonesia |
Karina, K., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia, Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia, Pusat Kajian Stem Cell, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia; Ekaputri, K., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Biben, J.A., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Purwoko, R.H., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Sibuea, T.P., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Astuti, S.L., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Loho, A.M., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Limengka, Y., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Nelfidayani, Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Agustini, S., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Krisandi, G., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Maryam, A., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Rosadi, I., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia, Department of Biology, Faculty of Mathematics and Natural Sciences, Mulawarman University, Indonesia; Rosliana, I., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Sobariah, S., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Subroto, W.R., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Afini, I., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Widyastuti, T., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Zakiyah, A., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Ernanda, D., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Aini, N., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Jusryanti, Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Sulaeha, A.D., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Prestiani, S.I., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Donna, I.M., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Habibi, Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Mutiara, M.S., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia |
Introduction: Autologous platelet-rich plasma (PRP) has been a growing trend in the field of medicine due to its broad range of application and is considered safe from bloodborne diseases. Furthermore, various studies have tried to optimize the use of autologous PRP through various preparation protocols, including PRP activation. However, most of the studies available have not evaluated the safety for intravenous delivery of PRP, especially autologous activated PRP (aaPRP). Therefore, this study aimed to evaluate the safety of intravenous delivery of aaPRP. Methods: Blood was drawn from each patient and aaPRP was isolated through calcium activation and light irradiation. Each aaPRP was administered intravenously to all patients. Adverse events were documented and analyzed. Results: Six hundred eleven patients participated in this study with a total of 4244 aaPRP therapies. Quality control of autologous aaPRP showed no platelets present after both calcium activation and light irradiation. No adverse events such as allergic reaction, infection, and coagulation problems were observed on all patients over the course of the study. Conclusion: Our results showed that intravenous administration of autologous aaPRP is safe even in patients with various pathological conditions. © 2021. Karina Karina, et al.; licensee University of Sarajevo - Faculty of Health Studies. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Intravenous infusion; platelet-rich plasma; safety |
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University of Sarajevo - Faculty of Health Studies |
22327576 |
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Article |
Q4 |
112 |
28273 |
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777 |
Sanjay S., Leo S.W., Au Eong K.G., Adriono G.A., Fong K.C.S., Anand K., Kadarisman R.S., Granet D.B., Mahendradas P., Shetty R., Souza S.D., Iyer S.P. |
24315097100;7004356152;7003590870;57199540275;57224986711;57205395095;6508028541;6701767974;16481136500;23478872600;57224976208;55828761800; |
Global Ophthalmology Practice Patterns during COVID-19 Pandemic and Lockdown |
2021 |
Ophthalmic Epidemiology |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108832186&doi=10.1080%2f09286586.2021.1934037&partnerID=40&md5=ba28f0a2d64e8a2f774b4efdf3e9b346 |
Department of Uvea and Ocular Immunology, Narayana Nethralaya, Bengaluru, India; Dr Leo Adult Paediatric Eye Specialist Pte Ltd, Mount Elizabeth Medical Centre, Singapore; International Eye Cataract Retina Center, Mount Elizabeth Medical Center and Farrer Park Medical Center, Singapore; Department of Ophthalmology Visual Sciences, Khoo Teck Puat Hospital, Singapore; Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Mangunkusumo Hospital, Jakarta, Indonesia; OasisEye Specialists, Kuala Lumpur, Malaysia; Great Plains Health Callahan Cancer Center, University of Nebraska, North PlatteNE, United States; Aini Eye Clinic, Jakarta Hospital, Jakarta, Indonesia; Ratner Children’s Eye Center, Shiley Eye Institute, University of California, San Diego, United States; Department of Cornea and Refractive Services, Narayana Nethralaya, Bengaluru, India; Department of Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, United States |
Sanjay, S., Department of Uvea and Ocular Immunology, Narayana Nethralaya, Bengaluru, India; Leo, S.W., Dr Leo Adult Paediatric Eye Specialist Pte Ltd, Mount Elizabeth Medical Centre, Singapore; Au Eong, K.G., International Eye Cataract Retina Center, Mount Elizabeth Medical Center and Farrer Park Medical Center, Singapore, Department of Ophthalmology Visual Sciences, Khoo Teck Puat Hospital, Singapore; Adriono, G.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Mangunkusumo Hospital, Jakarta, Indonesia; Fong, K.C.S., OasisEye Specialists, Kuala Lumpur, Malaysia; Anand, K., Great Plains Health Callahan Cancer Center, University of Nebraska, North PlatteNE, United States; Kadarisman, R.S., Aini Eye Clinic, Jakarta Hospital, Jakarta, Indonesia; Granet, D.B., Ratner Children’s Eye Center, Shiley Eye Institute, University of California, San Diego, United States; Mahendradas, P., Department of Uvea and Ocular Immunology, Narayana Nethralaya, Bengaluru, India; Shetty, R., Department of Cornea and Refractive Services, Narayana Nethralaya, Bengaluru, India; Souza, S.D., Department of Cornea and Refractive Services, Narayana Nethralaya, Bengaluru, India; Iyer, S.P., Department of Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, United States |
Aim: To assess the impact of practice patterns amongst global ophthalmologists during severe acute respiratory syndrome Coronavirus 2 (SARS Cov2) causing Corona virus disease (COVID-19) and understand the various modifications made to address emergency surgeries and practice needs. Methods: An online survey was sent to practicing ophthalmologists around the world through email, Whatsapp™ ListServ17.0™ (for pediatric ophthalmologists), WeChat™ (China) and ophthalmology associations (Indonesia, Philippines, Ireland). All queries were collected and categorized. Responses to the queries were given according to the recommendations by the Ophthalmology association. Practices ability to deal with the COVID were also classified according to country and type of access to PPE. Statistical analyses of the association between these data and queries, where appropriate were carried out. Results: One thousand nine hundred sixteen ophthalmologists were invited to participate in a survey between April 10th and April 30th, 2020 of which 1207 responded, which is a response rate of approximately 63%. The majority of respondents were from India, Indonesia, China, Singapore and the USA. Our study indicates a precipitous drop in surgical procedures with 46% (n = 538) ophthalmologists ceased to operate on their patients and almost 40% (n = 486) were doing less than 25% of their original number of surgeries. The intent to resume elective surgeries was a consideration in 41% (n = 495) after an evaluation of the situation and in consultation with professional bodies. More than 2/3 of the respondents (n = 703) made it a priority to use and mandate their patients to practice physical distancing, wearing masks, and hand dis-infection for protection to limit the spread of infection. Conclusion: This global survey provides a real-world assessment of diverse practices that were in various forms of “shut down mode” and circumstances with varying capabilities to deal with COVID. It is unprecedented that the collective wisdom for a curtailment of practice has had an enormous immediate and far reaching implications on the livelihoods of ophthalmologists, their staff, and their families. Nevertheless, ophthalmologists and their staff remain resilient and have adapted to these changes pragmatically. © 2021 Taylor & Francis Group, LLC. |
COVID19; ophthalmic surgery; outpatient consultations; PPE; telehealth |
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Taylor and Francis Ltd. |
09286586 |
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Article |
Q2 |
728 |
6800 |
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795 |
Nadhif M.H., Irsyad M., Utomo M.S., Suhaeri M., Whulanza Y. |
57189057498;57220935587;56180933900;56183087500;36807053500; |
Computational Analysis of Soft Polymer Lattices for 3D Wound Dressing Materials |
2021 |
Journal of Mechanical Engineering |
18 |
2 |
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1 |
11 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107456696&partnerID=40&md5=fb3bc81a587f3564de3a190ebd6e1a72 |
Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Indonesia; Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia; Research Center for Metallurgy and Material, Indonesia Institute of Science (LIPI), Indonesia; Indonesia Unit of Education, Research and Training, Universitas Indonesia Hospital, Universitas Indonesia, Indonesia; Department of Mechanical Engineering, Faculty of Engineering Universitas, Indonesia; Research Center on Biomedical Engineering (RCBE), Faculty of Engineering Universitas, Indonesia |
Nadhif, M.H., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia; Irsyad, M., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia; Utomo, M.S., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia; Suhaeri, M., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia, Research Center for Metallurgy and Material, Indonesia Institute of Science (LIPI), Indonesia, Indonesia Unit of Education, Research and Training, Universitas Indonesia Hospital, Universitas Indonesia, Indonesia; Whulanza, Y., Department of Mechanical Engineering, Faculty of Engineering Universitas, Indonesia, Research Center on Biomedical Engineering (RCBE), Faculty of Engineering Universitas, Indonesia |
One of the wound treatments was negative pressure wound therapy (NPWT), which used wound dressings on the wound bed to ameliorate the wound healing. Unfortunately, most wound dressings were two dimensional (2D), lacking the ability to cover severe wounds with a straightforward procedure. The sheets needed to be stacked following the wound curvature, which might be problematic since improper stacking could hinder the wound healing. Regarding the mentioned problems, our group develop 3D wound dressings, which are made using 3D printers. The wound dressings are made of polycaprolactone (PCL), polyurethane (PU), and polyvinyl alcohol (PVA). As the initial stage, the mechanical integrity of the soft polymers was investigated under uniaxial tensile and uniaxial compressive stress using computational methods. The polymers were defined as 3D lattices following the dimension of existing wound dressings. Based on the simulation results of displacement and von Mises stress, the three polymers are mechanically safe to be used as wound dressing materials. © 2021 College of Engineering, Universiti Teknologi MARA (UiTM), Malaysia. All Rights Reserved. |
Computational analysis; Lattice; Soft polymer; Wound dressing |
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UiTM Press |
18235514 |
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Article |
Q3 |
216 |
18402 |
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816 |
Pratomo I.P., Ariane A., Tedjo A., Heryanto R., Paramita R.I. |
57192904477;57210643323;57189320451;23392757600;54882436900; |
Xanthine oxidase inhibition in sars-cov-2 infection: The mechanism and potency of allopurinol and febuxostat in covid-19 management |
2021 |
Medical Journal of Indonesia |
30 |
1 |
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75 |
80 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104949199&doi=10.13181%2fmji.rev.204641&partnerID=40&md5=689e842e1dfa9cde24da9c6f8f7bbee1 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia; Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunksumo Hospital, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas IPB, Bogor, Indonesia; Tropical Biopharmaca Research Center, Universitas IPB, Bogor, Indonesia |
Pratomo, I.P., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia, Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ariane, A., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunksumo Hospital, Jakarta, Indonesia; Tedjo, A., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Heryanto, R., Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas IPB, Bogor, Indonesia, Tropical Biopharmaca Research Center, Universitas IPB, Bogor, Indonesia; Paramita, R.I., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
The number of coronavirus disease 2019 (COVID-19) infection cases has been increasing globally, including in Indonesia. Definitive therapy for COVID-19 has not yet been found; hence, repurposed drugs for COVID-19 have been considered and have been practiced by several researchers in the world. This literature review investigates the action of xanthine oxidase as a component of the biomolecular pathway against severe acute respiratory syndrome-related coronavirus-2, the cause of COVID-19, and describes the mechanism and potential of uric acid drugs (allopurinol and febuxostat) as prophylaxis and curative therapy for COVID-19. © 2020 Authors. |
COVID-19; Free radicals; Uric acid; Xanthine oxidase |
allopurinol; C reactive protein; febuxostat; free radical; gamma interferon; interleukin 2; interleukin 6; reactive oxygen metabolite; uric acid; xanthine oxidase; animal model; coronavirus disease 2019; cytokine production; cytokine storm; drug potency; epithelium; influenza; mouse; neutrophil; nonhuman; oxidative stress; pathogenesis; poultry; respiratory virus; Review; Severe acute respiratory syndrome coronavirus 2; virus infection |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Review |
Q4 |
164 |
21905 |
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863 |
Sahlan M., Tejamaya M., Arbianti R., Baruji T., Adawiyah R., Hermansyah H. |
57189182661;55295863200;55897945700;57222240819;57208658742;15759436800; |
The effects of nano-casein encapsulation and productions of a controlled-release on eugenol containing bio-pesticide toxicity |
2021 |
Key Engineering Materials |
874 KEM |
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115 |
127 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101971950&doi=10.4028%2fwww.scientific.net%2fKEM.874.115&partnerID=40&md5=6f6b175ce47bb2305dfbaffecf2240a3 |
Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Research Center of Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Department of Occupational Health and Safety, Faculty of Public Health, Universitas Indonesia, Depok, 16424, Indonesia; Center of Bioindustry Technology, Agency for The Assessment and Application of Technology, Jakarta, 10340, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Sahlan, M., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia, Research Center of Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Tejamaya, M., Department of Occupational Health and Safety, Faculty of Public Health, Universitas Indonesia, Depok, 16424, Indonesia; Arbianti, R., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Baruji, T., Center of Bioindustry Technology, Agency for The Assessment and Application of Technology, Jakarta, 10340, Indonesia; Adawiyah, R., Research Center of Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Hermansyah, H., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia |
The concern against long-term health and environmental adverse effects of synthetic pesticides has encouraged the development of bio-pesticides. Eugenol, a major constituent of clove oil, has been proven as potential bio-pesticides. However, evaporation and photosensitive properties of Eugenol needs to be controlled. Nano-encapsulation is a promising method that can preserve eugenol from evaporating and photodegradation. This study aims to investigate the production of a controlled-release of eugenol in casein micelle as well as the effects of nano-encapsulation on Eugenol Containing Biopesticide (ECB) toxicity against Artemia salina sp. Brine Shrimp Lethality Test (BSLT) was implemented to investigate effect of nano-encapsulation on ECB and the Response Surface Methodology was used to optimize the formula to investigate the production of a controlled-release of eugenol. The optimum condition revealed loading capacity and encapsulation efficiency response for 64.67% and 79.64%, respectively. The average diameter of the obtained nanocapsule-eugenol (NCE) was 179.83 nm. Release study was performed at 40 °C that represent as pesticide applied in farm, revealed that casein micelle capsule could delayed the release of eugenol. A cytotoxicity assay showed that the NCE has 21 times more effective compared with eugenol only. It was found that nano encapsulated ECB was statistically more toxic than ECBsuspension (without nano encapsulation) with a confidence level of 95%. Lethal Concentration 50 (LC50) of nano-ECB was 0.264 μg/L while LC50 of ECB-suspension was 4.445 μg/L. The increase of toxic properties after nano-encapsulation by casein could be explained by the increase of eugenol stability. Thus nano-encapsulation can be proposed as a method for improving the bio-pesticide ability of eugenol. © 2021 Trans Tech Publications Ltd, Switzerland. |
Biopesticide; BSLT1; Casein; Controlled-release; Eugenol; Nano encapsulation; Optimizing |
Casein; Dairies; Micelles; Suspensions (fluids); Toxicity; Brine shrimp lethalities; Cytotoxicity assays; Encapsulation efficiency; Investigate effects; Lethal concentration; Photosensitive properties; Response surface methodology; Synthetic pesticides; Pesticide effects |
Trans Tech Publications Ltd |
10139826 |
9783035737639 |
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Conference Paper |
Q4 |
175 |
21056 |
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871 |
Turana Y., Widyantoro B., Situmorang T.D., Delliana J., Roesli R.M.A., Danny S.S., Suhardjono, Sofiatin Y., Hermiawaty E., Kuncoro A.S., Barack R., Beaney T., Ster A.C., Poulter N.R., Santoso A. |
56083326000;35286148600;57202120316;57208720930;26428909500;56221848700;57205723084;56815068100;57208721982;56008103000;57202111674;55614780900;57221978746;7006154423;36905206100; |
May measurement Month 2018: An analysis of blood pressure screening results from Indonesia |
2021 |
European Heart Journal, Supplement |
22 |
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H66 |
H69 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101322980&doi=10.1093%2fEURHEARTJ%2fSUAA031&partnerID=40&md5=16a05b90991c40fdd180dd4e051eaaad |
Department of Neurology, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta, 14440, Indonesia; Department of Cardiology - Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center, Harapan Kita Hospital, Jl. S. Parman Kav 87, Slipi, Jakarta, 11420, Indonesia; Division of Nephrology, Department of Internal Medicine, PGI Cikini Hospital, Jakarta, 10330, Indonesia; Department of Cardiology, Directorate of Non-Communicable Disease, Ministry of Health - Republic of Indonesia, Jalan Percetakan Negara 29, Jakarta, 10560, Indonesia; Department of Internal Medicine, Faculty of Medicine, Padjadjaran University, Hasan Sadikin General Hospital, Bandung, 40161, Indonesia; Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto, Mangunkusumo National General Hospital, Jalan Pangeran Diponegoro No: 71, Jakarta, 10430, Indonesia; Department of Public Health, Faculty of Medicine, Padjadjaran University, Jalan Prof. Eijkman 38, Bandung, 40161, Indonesia; Department of Neurology, National Cardiovascular Center, Harapan Kita Hospital, Jl. S. Parman Kav 87, Slipi, Jakarta, 11420, Indonesia; Department of Cardiology, MMC Hospital, Jakarta, Indonesia; Imperial Clinical Trials Unit, Imperial College London, Stadium House, 68 Wood Lane, Shepherd's Bush, London, W12 7RH, United Kingdom; Department of Primary Care and Public Health, Imperial College London, St Dunstan's Road, London, W6 8RP, United Kingdom |
Turana, Y., Department of Neurology, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta, 14440, Indonesia; Widyantoro, B., Department of Cardiology - Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center, Harapan Kita Hospital, Jl. S. Parman Kav 87, Slipi, Jakarta, 11420, Indonesia; Situmorang, T.D., Division of Nephrology, Department of Internal Medicine, PGI Cikini Hospital, Jakarta, 10330, Indonesia; Delliana, J., Department of Cardiology, Directorate of Non-Communicable Disease, Ministry of Health - Republic of Indonesia, Jalan Percetakan Negara 29, Jakarta, 10560, Indonesia; Roesli, R.M.A., Department of Internal Medicine, Faculty of Medicine, Padjadjaran University, Hasan Sadikin General Hospital, Bandung, 40161, Indonesia; Danny, S.S., Department of Cardiology - Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center, Harapan Kita Hospital, Jl. S. Parman Kav 87, Slipi, Jakarta, 11420, Indonesia; Suhardjono, Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto, Mangunkusumo National General Hospital, Jalan Pangeran Diponegoro No: 71, Jakarta, 10430, Indonesia; Sofiatin, Y., Department of Public Health, Faculty of Medicine, Padjadjaran University, Jalan Prof. Eijkman 38, Bandung, 40161, Indonesia; Hermiawaty, E., Department of Neurology, National Cardiovascular Center, Harapan Kita Hospital, Jl. S. Parman Kav 87, Slipi, Jakarta, 11420, Indonesia; Kuncoro, A.S., Department of Cardiology - Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center, Harapan Kita Hospital, Jl. S. Parman Kav 87, Slipi, Jakarta, 11420, Indonesia; Barack, R., Department of Cardiology, MMC Hospital, Jakarta, Indonesia; Beaney, T., Imperial Clinical Trials Unit, Imperial College London, Stadium House, 68 Wood Lane, Shepherd's Bush, London, W12 7RH, United Kingdom, Department of Primary Care and Public Health, Imperial College London, St Dunstan's Road, London, W6 8RP, United Kingdom; Ster, A.C., Imperial Clinical Trials Unit, Imperial College London, Stadium House, 68 Wood Lane, Shepherd's Bush, London, W12 7RH, United Kingdom; Poulter, N.R., Imperial Clinical Trials Unit, Imperial College London, Stadium House, 68 Wood Lane, Shepherd's Bush, London, W12 7RH, United Kingdom; Santoso, A., Department of Cardiology - Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center, Harapan Kita Hospital, Jl. S. Parman Kav 87, Slipi, Jakarta, 11420, Indonesia |
Elevated blood pressure (BP) is a significant burden worldwide, leading to high cardiocerebro-reno-vascular morbidity and mortality. For the second year of the May Measurement Month (MMM) campaign in Indonesia in 2018, we recruited 174 sites in 31 out of 34 provinces in Indonesia and screened through convenience sampling in public areas and rural primary health centres. Hypertension was defined as systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg, or both, or on the basis of receiving antihypertensive medication. Blood pressure was measured three times followed the standard global MMM protocol, multiple imputation was used to estimate the mean of the 2nd and 3rd BP readings if these were not recorded. A total of 91 222 individuals were screened, and after multiple imputations, 27 331 (30.0%) had hypertension. Of individuals not receiving antihypertensive medication, 14 367 (18.4%) were hypertensive. Among the 47.4% of hypertensive individuals on antihypertensive medication, 10 106 (78.0%) had uncontrolled BP. MMM17 and MMM18 were still the most extensive standardized screening campaigns for BP measurement in Indonesia. Compared to the previous study, the proportion with uncontrolled BP on medication was significantly higher and provided the substantial challenges in managing hypertension in the rural community. © The Author(s) 2020. |
Blood pressure; Community; Control; Hypertension; Screening |
antihypertensive agent; adult; antihypertensive therapy; Article; blood pressure measurement; controlled study; cross-sectional study; female; human; hypertension; hypertensive patient; Indonesia; major clinical study; male; primary health care; priority journal; rural population |
Oxford University Press |
1520765X |
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Article |
Q3 |
389 |
12388 |
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873 |
Rosdiana D.S., Setiabudy R., Andalusia R., Gatot D., Louisa M., Bardosono S., Instiaty I. |
56955579800;6602316235;57191278723;6508292159;41461551400;21933841000;55703138400; |
Tpmt genetic variability and its association with hematotoxicity in indonesian children with acute lymphoblastic leukemia in maintenance therapy |
2021 |
Pharmacogenomics and Personalized Medicine |
14 |
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199 |
210 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101168492&doi=10.2147%2fPGPM.S288988&partnerID=40&md5=45069dfc59e995d12723c15428e48bcd |
Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dharmais National Cancer Hospital, Jakarta, Indonesia; Drug Registration Directorate, National Agency for Drug and Food Control, Jakarta, Indonesia; Division of Hematology-Oncology, Department of Pediatrics, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Rosdiana, D.S., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiabudy, R., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Andalusia, R., Dharmais National Cancer Hospital, Jakarta, Indonesia, Drug Registration Directorate, National Agency for Drug and Food Control, Jakarta, Indonesia; Gatot, D., Division of Hematology-Oncology, Department of Pediatrics, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Instiaty, I., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: Hematotoxicity monitoring in children with acute lymphoblastic leukemia (ALL) is critical to preventing life-threatening infections and drug discontinuation. The primary drug that causes hematotoxicity in ALL children is 6-mercaptopurine (6-MP). Genetic variability of the drug-metabolizing enzymes of 6-MP, thiopurine S-methyltransferase (TPMT), is one factor that might increase the susceptibility of children to hematotoxicity. The present study aimed to determine the variability in TPMT genotypes and phenotypes and its association with the occurrence of hematotoxicity in ALL children in maintenance therapy. Patients and Methods: A cross-sectional study was conducted at Cipto Mangunkusumo and Dharmais National Cancer Hospital, Jakarta, Indonesia, from June 2017 to October 2018. We included ALL patients, 1–18 years, who were receiving at least one month of 6-MP during maintenance therapy according to the Indonesian protocol for ALL 2013. Direct sequencing was used to determine TPMT*3A, *3B, and *3C genotypes, and LCMS/MS analysis was performed to measure the plasma concentrations of 6-MP and its metabolites. Association analysis between the TPMT genotype and hematotoxicity was evaluated using the unpaired t-test or Mann–Whitney’s test. Results: The prevalence of neutropenia, anemia, and thrombocytopenia in ALL children during maintenance therapy was 51.9%, 44.3%, and 6.6%, respectively. We found a low frequency of TPMT*3C, which is 0.95%. No association was found between hematotoxicity and TPMT genotypes or age, nutritional status, serum albumin levels, risk stratification, the daily dose of 6-MP, and cotrimoxazole co-administration. However, hematotoxicity was associated with 6-methylmercaptopurine (6-MeMP) plasma concentrations and the ratio 6-MeMP/6-thioguanine (6-TGN). We also found no association between TPMT genotypes and TPMT phenotypes. Conclusion: The 6-MeMP/6-TGN ratio is associated with hematotoxicity in ALL children during maintenance therapy but is not strong enough to predict hematotoxicity. © 2021 Rosdiana et al. |
Mercaptopurine; Methylmercaptopurine; Neutropenia; Thioguanine; Thiopurine methyltransferase |
6 methylthioinosine; albumin; cotrimoxazole; dexamethasone; methotrexate; thiopurine methyltransferase; tioguanine; vincristine; acute lymphoblastic leukemia; adolescent; adult; albumin blood level; anemia; Article; blood toxicity; child; cross-sectional study; drug blood level; drug safety; female; gene sequence; genetic variability; groups by age; human; human cell; Indonesia; Indonesian; liquid chromatography-mass spectrometry; maintenance therapy; major clinical study; male; neutropenia; nutritional status; prevalence; risk factor; thrombocytopenia; TPMT gene |
Dove Medical Press Ltd |
11787066 |
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Article |
Q2 |
845 |
5609 |
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886 |
Susanto A.D., Yusril N., Zaini J., Nuwidya F. |
57190425587;57221834981;57221833355;57221834238; |
Comparison of serum benzo(a)pyrene diol epoxide - Protein adducts level between kretek cigarette smokers and nonsmokers and the related factors |
2021 |
Journal of Natural Science, Biology and Medicine |
12 |
1 |
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52 |
56 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100352390&doi=10.4103%2fjnsbm.JNSBM_100_20&partnerID=40&md5=b1c54ebf4ef8452d480f9da52582dabe |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Susanto, A.D., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Yusril, N., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Zaini, J., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Nuwidya, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia, Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Benzopyrene is a carcinogenic agent found in cigarette smoke. Benzo(a)pyrene diol epoxide (BPDE) is one of the benzopyrene metabolites. In this study, we investigated the level of serum BPDE in kretek cigarette smokers compared to non-smokers. Methods: A cross-sectional study which involved 32 "healthy" kretek cigarette smokers and 32 "healthy" nonsmokers were conducted. We collected the blood sample and the serum BPDE level was assayed using enzyme-linked immunosorbent assay kit. The BPDE serum level in kretek cigarette smokers was compared to the level in nonsmokers. Results: A total of 32 kretek smokers and 32 controls underwent an examination of the BPDE-protein adducts level. In the kretek smokers group, 59.4% were aged over 45 years and 56.3% have a high educational background, while in the control group, 87.5% were aged under 45 years and 75% have high educational backgrounds. The level of BPDE-protein adducts in the kretek smokers subject was 12.15 (8.87-33.55) ng/ml and the levels in the control group were 11.4 (3.87-13.27) ng/ml, P = 0.004. The factors which influence the levels BDPE-protein adducts in smokers cigarettes, as determined by multivariate analysis, were sucking pattern (P = 0.002) and the degree of addiction (P = 0.047). Conclusion: The serum BPDE-protein adducts level was higher in smokers compared to nonsmokers, and the sucking pattern and degree of addiction are the influencing factors. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Benzo(a)pyrene diol epoxide-protein adducts; nonsmokers; smokers |
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Wolters Kluwer Medknow Publications |
09769668 |
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Article |
Q3 |
236 |
17374 |
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900 |
Pulungan A.B., Fadiana G., Annisa D. |
57192905981;57221614963;57205770955; |
Type 1 diabetes mellitus in children: Experience in Indonesia |
2021 |
Clinical Pediatric Endocrinology |
30 |
1 |
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11 |
18 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099564628&doi=10.1297%2fcpe.30.11&partnerID=40&md5=aba5de1c98be7c8ac4cc9cdd9a7ff21b |
Child Health Department, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Pulungan, A.B., Child Health Department, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Fadiana, G., Child Health Department, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Annisa, D., Child Health Department, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
The prevalence of type 1 diabetes mellitus (T1DM) in children in Indonesia is increasing although the real number is unknown due to high rate of misdiagnosis. Public and healthcare awareness on T1DM in children is still low, reflected by the high number of children diagnosed with diabetic ketoacidosis (DKA). The Indonesian Pediatric Society (IPS) had published a guideline on T1DM management, which consists of insulin injection, daily monitoring of blood glucose, nutrition, physical activity, and education. Aside from low awareness, current challenges on T1DM management in Indonesia are funding by the national health insurance, fasting during Ramadan, and inequities on DM care. The involvement of society, healthcare workers, stakeholders, and the government is of importance to ensure optimal management for children with diabetes. © 2021 by The Japanese Society for Pediatric Endocrinology. |
Children; Diabetes; Indonesia; Type 1 diabetes mellitus (T1DM) |
hemoglobin A1c; immunologic factor; insulin; vitamin D; awareness; blood glucose monitoring; blurred vision; body mass; body weight loss; caloric intake; carbohydrate intake; clinical article; diabetic ketoacidosis; diabetic retinopathy; education; endocrinologist; epigenetics; food intake; glucose blood level; glycemic control; health care personnel; health insurance; health survey; human; hyperglycemia; hyperphagia; hypertension; hypocalcemia; hypoglycemia; insulin dependent diabetes mellitus; insulin resistance; insulin sensitivity; insulin treatment; insulinoma; ketoacidosis; ketonuria; metabolic regulation; microalbuminuria; national health insurance; nocturia; non insulin dependent diabetes mellitus; nutrition; obesity; oral glucose tolerance test; pediatrician; physical activity; po |
Jeff Corporation Co. Ltd |
09185739 |
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Review |
Q2 |
461 |
10790 |
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