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464 |
Cahyono A.T., Louisa M., Mayang Permata T.B., Handoko, Nuryadi E., Kodrat H., Wibowo H., Hariandy Hamid A.R.A., Sekarutami S.M., Gondhowiardjo S.A. |
57222900545;41461551400;57197808751;57209984822;57197806814;57210639849;57217690943;57202054669;56576294500;6508327402; |
The potential of gallic acid as a radiosensitizer on human prostate cancer: A systematic review of preclinical studies |
2021 |
Malaysian Journal of Medicine and Health Sciences |
17 |
2 |
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246 |
254 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104201486&partnerID=40&md5=aff7e4b57216dc4b88ee83f02823372e |
Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Cahyono, A.T., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mayang Permata, T.B., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Handoko, Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kodrat, H., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wibowo, H., Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hariandy Hamid, A.R.A., Department of Urology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sekarutami, S.M., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gondhowiardjo, S.A., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Prostate adenocarcinoma accounts for majority of prostate cancer cases, and it was found to be highly radioresistant. Gallic acid is a phenolic acid naturally occurring in many plants, reported to exhibit biological activities in eliminating cancer cell lines and xenografts. The purpose of this study is to review gallic acid as a potential radiosensitizer agent in prostate cancer treatment. Article search was conducted in PubMed, EBSCO, and Scopus. 11 studies using different cell lines including DU145, PC-3, LNCaP, and 22Rv1 xenograft of human prostate cancer were reviewed in this paper. Gallic acid acts as a radiosensitizer mainly by increasing caspase-3 and caspase-9 activation resulting in apoptosis, while also reducing intracellular CDKs, cyclins, and cdc25 phosphatases ultimately causing G2-M cell cycle arrest. Gallic acid has a potential to be a new radiosensitizer compound in prostate cancer treatment. Additional clinical studies using gallic acid derivatives with lower hydrophilicity are needed. © 2021 UPM Press. All rights reserved. |
Apoptosis; Gallic acid; Prostate cancer; Radiobiology; Radiotherapy |
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Universiti Putra Malaysia Press |
16758544 |
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Review |
Q4 |
144 |
23823 |
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465 |
Mochtar I., Adi N.P., Hardjono A.W., Mansyur M. |
57222902121;57023786200;57222902350;37085506800; |
Return to work assessment in a radiographer assistant suffering a hemianopsia due to an ischemic stroke |
2021 |
Malaysian Journal of Medicine and Health Sciences |
17 |
2 |
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301 |
304 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104187321&partnerID=40&md5=cad74495ef91661c388194494f7d4e58 |
Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Occupational and Environmental Health Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Indonesian Occupational Medicine Specialist Association, Jakarta, 10350, Indonesia |
Mochtar, I., Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Adi, N.P., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia, Occupational and Environmental Health Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Hardjono, A.W., Indonesian Occupational Medicine Specialist Association, Jakarta, 10350, Indonesia; Mansyur, M., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia, Occupational and Environmental Health Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia |
Return to work assessment (RTWA) has been performed to a radiographer assistant suffering a hemianopsia due to an ischemic stroke. Stroke occurred two months prior to the examination. The general condition of the patient was good. The systemic examination was unremarkable except the presence of a partial vision loss in the left eye and often feeling fatigue and down. Perimetry Full-field 120 Point Screening Test confirmed a left temporal hemianopsia while Patient Health Questionnaire’s score (PHQ-9) indicated a moderate depression. The two conditions were not fully compatible with the job demand of a radiographer assistant, which required a complete and clear visual field as well as a good mental status. Risk assessment indicated that the patient might encounter health and safety issues if he resumed duty without work adjustment. The clinic still wanted to employ the patient and agreed to provide support. The patient was declared ‘fit’ to resume his duty with some recommendations. © 2021 UPM Press. All rights reserved. |
Hemianopsia; Return to work; Stroke |
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Universiti Putra Malaysia Press |
16758544 |
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Article |
Q4 |
144 |
23823 |
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483 |
Sekarsari D., Amal M.Y., Napitupulu M.R., Wityaningsih Y.S. |
57193342279;57221702104;57221696697;57221685402; |
Annular pancreas mimicking hypertrophic pyloric stenosis in a female infant |
2021 |
Radiology Case Reports |
16 |
4 |
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772 |
776 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099811331&doi=10.1016%2fj.radcr.2021.01.019&partnerID=40&md5=8fd0ab9e02d41a267af411f3964c26f2 |
Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Sekarsari, D., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Amal, M.Y., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Napitupulu, M.R., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Wityaningsih, Y.S., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Annular pancreas is a rare congenital intestinal obstruction to be found in infants. It is characterized by nonbilious vomiting, abdominal distention, and feeding intolerance that share similar symptoms with other intestinal obstructions. We reported a case of 11-month-old female infant with a history of nonbilious vomiting after coughing as much as 6 times per day 1 day before admission. The patient had an incorrect provisional diagnosis of hypertrophic pyloric stenosis based on ultrasound. Later on, an upper gastrointestinal series showed dilatation of the second part of the duodenum which was successfully treated by a duodenostomy during laparotomy procedure. It is suggested that treating an intestinal obstruction needs a further investigation when the symptoms were continuously repeated. © 2021 |
Annular pancreas; Congenital abnormality; Duodenostomy; Intestinal obstruction; Upper gastrointestinal series |
hemoglobin; abdominal radiography; anemia; annular pancreas; Article; case report; chronic suppurative otitis media; clinical article; coughing; diagnostic error; diagnostic imaging; Down syndrome; duodenostomy; electrolyte disturbance; female; fever; hematocrit; human; human cell; hypertrophic pylorus stenosis; infant; intestine obstruction; laparotomy; laryngomalacia; nutritional status; obstructive airway disease; priority journal; ultrasound; vomiting |
Elsevier Inc. |
19300433 |
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Article |
Q4 |
221 |
18127 |
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490 |
Oswari H., Kresnawati W., Yani A., Handjari D.R., Alatas F.S. |
12777323800;57210461975;57215433374;56160657900;57217150164; |
Abdominal Injury-Induced Gastric Outlet Obstruction in Primary Hypertrophic Pyloric Stenosis in Adolescent |
2021 |
Indian Journal of Surgery |
83 |
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264 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080887785&doi=10.1007%2fs12262-020-02097-y&partnerID=40&md5=341dca515f2fe3bdfc0a38dee8ba2ddb |
Department of Child Health, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia; Department of Pediatric Surgery, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathology Anatomy, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Oswari, H., Department of Child Health, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia; Kresnawati, W., Department of Child Health, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia; Yani, A., Department of Pediatric Surgery, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Handjari, D.R., Department of Pathology Anatomy, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Alatas, F.S., Department of Child Health, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia |
[No abstract available] |
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Springer |
09722068 |
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Letter |
Q4 |
183 |
20483 |
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492 |
Maulidina F., Rustam Z., Hartini S., Wibowo V.V.P., Wirasati I., Sadewo W. |
57221906584;26422482100;57211529061;57221911837;57221806240;55014544900; |
Feature optimization using Backward Elimination and Support Vector Machines (SVM) algorithm for diabetes classification |
2021 |
Journal of Physics: Conference Series |
1821 |
1 |
012006 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103897338&doi=10.1088%2f1742-6596%2f1821%2f1%2f012006&partnerID=40&md5=26c4c2f598bd765549c0283978c63185 |
Departement of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Department of Neurosurgery, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Indonesia |
Maulidina, F., Departement of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Rustam, Z., Departement of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Hartini, S., Departement of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Wibowo, V.V.P., Departement of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Wirasati, I., Departement of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Sadewo, W., Department of Neurosurgery, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Indonesia |
Diabetes is a disease that occurs when the blood glucose level is higher than normal and also leads to health problems. Early and accurate diagnosis needs to be carried out on individuals affected by this disease. Furthermore, excellent treatment needs to be provided to prevent worse situations. Some studies have used several machine learning methods to diagnose diabetes. Furthermore, in this study, the Backward Elimination and Support Vector Machine (SVM) algorithm was used to classify the PIMA Indians diabetes dataset. It consisted of 268 diabetic and 500 non-diabetic patients with eight attributes. Backward Elimination is a feature selection method used to remove irrelevant features based on the linear regression model. Using this method, the right features for the model was expected. This method has some advantages which include increasing training time, decreasing complexity and improving performance and accuracy. Therefore, the performance of SVM improved. Based on the experiments, it was discovered that by combining feature selection algorithm (backward elimination) and SVM, the highest accuracy obtained was 85.71% using 90% data training. Therefore, it was concluded that Backward Elimination combined with SVM algorithm is an excellent method to classify diabetes by using the PIMA Indians diabetes dataset. © Published under licence by IOP Publishing Ltd. |
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Classification (of information); Diagnosis; Experimental mineralogy; Feature extraction; Learning systems; Regression analysis; Feature optimizations; Feature selection algorithm; Feature selection methods; Improving performance; Linear regression models; Machine learning methods; Support vector machine algorithm; Support vector machines algorithms; Support vector machines |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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493 |
Wibowo V.V.P., Rustam Z., Hartini S., Maulidina F., Wirasati I., Sadewo W. |
57221911837;26422482100;57211529061;57221906584;57221806240;55014544900; |
Ovarian cancer classification using K-Nearest Neighbor and Support Vector Machine |
2021 |
Journal of Physics: Conference Series |
1821 |
1 |
012007 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103891589&doi=10.1088%2f1742-6596%2f1821%2f1%2f012007&partnerID=40&md5=8b428e7f3e510029f71b6c464cefbd2d |
Department of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Department of Neurosurgery, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Indonesia |
Wibowo, V.V.P., Department of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Rustam, Z., Department of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Hartini, S., Department of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Maulidina, F., Department of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Wirasati, I., Department of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Sadewo, W., Department of Neurosurgery, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Indonesia |
Ovarian cancer is one of the common malignancies in women and a known cause of death. This condition occurs when a tumor appears from the growth of abnormal cells in the ovary. It causes about 140.000 deaths out of 225.000 cases annually. Most women with ovarian cancer do not have distinctive signs and symptoms even at the late stage. Therefore, diagnosis at an early stage is necessary because it has a significant impact on the survival rate. Machine learning with various methods can be used in the medical field to classify diseases. Among the many methods, K-Nearest Neighbor (KNN) and Support Vector Machine (SVM) were used and analyzed in this study to classify ovarian cancer. The data used were from Al Islam Bandung Hospital consisting of 203 instances with 130 labeled ovarian cancer and 73 as non-ovarian. The results showed that the KNN produced higher results than SVM with 90.47% of accuracy and 94.11% of F1-score, while SVM produced accuracy and F1-score values of 90.47% and 92.30% respectively. © Published under licence by IOP Publishing Ltd. |
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Diagnosis; Diseases; Motion compensation; Nearest neighbor search; F1 scores; K nearest neighbor (KNN); K-nearest neighbors; Late stage; Medical fields; Ovarian cancers; Survival rate; Support vector machines |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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518 |
Apriadi W., Gani H.S., Prayitno P., Ibrahim N., Wijaya S.K. |
57205292872;57202775842;57222538092;56609777400;6506884322; |
Development of multithread acquisition system for high quality EEG signal measurement |
2021 |
Journal of Physics: Conference Series |
1816 |
1 |
012072 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103129496&doi=10.1088%2f1742-6596%2f1816%2f1%2f012072&partnerID=40&md5=8df825ddfea9b100797241af3b95358e |
Department of Physics, FMIPA Universitas Indonesia, Depok, 16424, Indonesia; Department of Physiology, Medical Faculty, Universitas Indonesia, Jakarta, 10430, Indonesia |
Apriadi, W., Department of Physics, FMIPA Universitas Indonesia, Depok, 16424, Indonesia; Gani, H.S., Department of Physics, FMIPA Universitas Indonesia, Depok, 16424, Indonesia; Prayitno, P., Department of Physics, FMIPA Universitas Indonesia, Depok, 16424, Indonesia; Ibrahim, N., Department of Physiology, Medical Faculty, Universitas Indonesia, Jakarta, 10430, Indonesia; Wijaya, S.K., Department of Physics, FMIPA Universitas Indonesia, Depok, 16424, Indonesia |
This work was concerned on development of the EEG acquisition and EEG signal processing by adding active electrodes and implementing multithread techniques. By using active electrodes, mounting them on the scalp surface would be easier to capture low signals of less than 1µV. The active electrodes were used to reduce noise when transfer signals from the electrode to the acquisition systems which equipped 20 gain. The verification was performed by comparing the active and passive electrodes using NETECH MiniSIM EEG Simulator 330. The advantage of this research was to reduce time delay for EEG signal computation on 32 channels. The acquisition system was based on Raspberry Pi and ADS1299 with multithread signal treatment. Signal filtering was performed into different threads and put all the EEG features into the database. A PC was used to process signal calculation such as processing FFT, signal feature extractions, and signal analysis. These calculations were divided into several functionally independent computations. The signals of each channel were calculated into different threads. The results of this work showed the effectiveness of the multithreaded method for processing large amounts of data (32 channels of 24 bits EEG signal) with low noise levels on the active electrodes. © Published under licence by IOP Publishing Ltd. |
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Electrodes; Acquisition systems; Active electrodes; Eeg acquisitions; EEG signal processing; Large amounts of data; Multithread techniques; Signal treatments; Transfer signals; Biomedical signal processing |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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520 |
Jamtani I., Nugroho A., Rahadiani N., Manangka R.S.W. |
57220165203;57192888914;16426455700;57222276868; |
Challenging retrovesical mass in men: Report of a rare liposarcoma case with concurrent COVID-19 infection |
2021 |
BMJ Case Reports |
14 |
3 |
e241466 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102142953&doi=10.1136%2fbcr-2020-241466&partnerID=40&md5=d155998c0d1b2e9350e4a10623455925 |
Department of Surgery, Fatmawati Central General Hospital, Jakarta Selatan, DKI Jakarta, Indonesia; Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National Referral Hostpital, Jakarta, Indonesia; Radiology Department, Mayapada Hospital, DKI Jakarta, Indonesia |
Jamtani, I., Department of Surgery, Fatmawati Central General Hospital, Jakarta Selatan, DKI Jakarta, Indonesia; Nugroho, A., Department of Surgery, Fatmawati Central General Hospital, Jakarta Selatan, DKI Jakarta, Indonesia; Rahadiani, N., Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National Referral Hostpital, Jakarta, Indonesia; Manangka, R.S.W., Radiology Department, Mayapada Hospital, DKI Jakarta, Indonesia |
We describe a case of retrovesical liposarcoma in a male patient with concurrent COVID-19. A 50-year-old man had lower urinary tract symptoms and dull pain along his right gluteus. Due to COVID-19 infection, management was delayed. During self-isolation, the patient developed urinary retention and his pain level was an eight on the Visual Analogue Scale. A urinary catheter and an epidural catheter were inserted without any difficulty. Abdominal-pelvic MRI revealed a retrovesical mass suspected of liposarcoma with clear borders from surrounding organs. Following two consecutive negative SARS-CoV-2 PCR tests, we proceeded with surgery. Histopathology was dedifferentiated liposarcoma. Postoperatively, the patient suffered reactivation of COVID-19, and he was eventually discharged after two consecutive negative results on the PCR test on Post Operative Day (POD)-10. Retrovesical dedifferentiated liposarcoma is rare and considered as high-grade liposarcoma. Although surgery may exacerbate COVID-19 infection, surgical resection of symptomatic high-grade sarcoma is prioritised and performed as soon as no infection detected. © |
cancer intervention; COVID-19; pathology; radiology; surgery |
docetaxel; gemcitabine; adult; Article; bladder catheterization; case report; clinical article; common cold; comorbidity; coronavirus disease 2019; decreased appetite; differential diagnosis; echography; erythrocyte concentrate; fatigue; fever; follow up; histopathology; home quarantine; hospital discharge; human; human tissue; impaired bladder emptying; liposarcoma; lower urinary tract symptom; male; middle aged; multiple cycle treatment; myalgia; neurilemoma; nuclear magnetic resonance imaging; patient history of surgery; physical examination; polymerase chain reaction; positron emission tomography; recurrent disease; retrovesical liposarcoma; retrovesical liposarcoma; surgical approach; urine retention; virus reactivation; visual analog scale; adjuvant chemoradiotherapy; cancer grading; |
BMJ Publishing Group |
1757790X |
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33653868 |
Article |
Q4 |
231 |
17583 |
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521 |
Gunardi E.R., Putri R.A., Pasidri Y. |
57192910998;57226166006;57226151144; |
A prospective study of effectivity, expulsion, and acceptability of post-placental iud cu t380a insertion using clamp in a tertiary hospital |
2021 |
Journal of SAFOG |
13 |
2 |
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92 |
96 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110568167&doi=10.5005%2fjp-journals-10006-1884&partnerID=40&md5=fce9faf05542751a7f70c62d508122a7 |
Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Gunardi, E.R., Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Putri, R.A., Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pasidri, Y., Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Aim: Intrauterine device (IUD) has a high effectivity of long-term contraception method. Post-placental IUD increases the number of contraception use and decreases the unmet need for contraception. The purposes of this study were to evaluate the effectivity, expulsion, acceptability, and side effects of post-placental IUD insertion using a clamp at Dr. Cipto Mangunkusumo National General Hospital. Materials and methods: This prospective longitudinal observational study was conducted at a tertiary teaching hospital (Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia) from April 2018 to March 2019. Post-placental IUD was inserted using a clamp. We interviewed the patients at 3 months and 6 months after insertion to evaluate the outcome. A total of 94 women were included in this study. Results: The effectivity was 100%. The expulsion rate was 2.13, 3.45, and 0% at 6 weeks, 3 months, and 6 months, respectively. The total acceptability rate at 6 weeks, 3 months, and 6 months was 96.81, 93.3, and 90.8%, respectively. Most of the subjects were satisfied with the IUD contraception at 3 months and 6 months. Conclusion: Post-placental IUD insertion using a clamp had good safety, effectivity, acceptance, and satisfaction. This data could be used for family planning counseling in daily practice. Post-placentaI IUD insertion should be routinely offered to all eligible postpartum women undergoing institutional deliveries. © Jaypee Brothers Medical Publishers. |
Acceptability; Effectivity; Expulsion; Insertion using a clamp; Post-placental IUD |
abdominal pain; adult; Article; bleeding; cesarean section; clinical outcome; contraception; controlled study; counseling; dyspareunia; family planning; female; follow up; gestational age; health care facility; human; hysterectomy; intrauterine device expulsion; lactation; longitudinal study; major clinical study; menstrual cycle; menstruation disorder; observational study; patient satisfaction; percutaneous coronary intervention; postpartum hemorrhage; postpartum pain; pregnancy; pregnancy outcome; pulse rate; questionnaire; tablet disintegration time; tertiary care center; unwanted pregnancy; vagina bleeding; vagina discharge (disease); vaginal delivery |
Jaypee Brothers Medical Publishers (P) Ltd |
09748938 |
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Article |
Q4 |
108 |
29032 |
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524 |
Purwaningsih E.H., Oertl A., Freisleben S.K.U., Freisleben H.-J. |
57186723500;6508320409;57192904042;7003437337; |
How can immunosuppression after organ transplantation be made more effective and safer? - A review on liposomal formulations with consideration of archaeal tetraetherlipid |
2021 |
Biomedical and Pharmacology Journal |
14 |
1 |
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33 |
52 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104470529&doi=10.13005%2fbpj%2f2097&partnerID=40&md5=d0059a38fb0687012c274dcda3c60c0f |
Faculty of Medicine, University of Indonesia, Jakarta-Depok, Indonesia; Faculty of Medicine, Goethe-University Frankfurt/Main, Germany; Asklepios Clinical Hospital and MVZ, Wiesbaden, Germany; Faculty of Natural Sciences, University of Indonesia, Jakarta-Depok, Indonesia |
Purwaningsih, E.H., Faculty of Medicine, University of Indonesia, Jakarta-Depok, Indonesia; Oertl, A., Faculty of Medicine, Goethe-University Frankfurt/Main, Germany, Asklepios Clinical Hospital and MVZ, Wiesbaden, Germany; Freisleben, S.K.U., Asklepios Clinical Hospital and MVZ, Wiesbaden, Germany, Faculty of Natural Sciences, University of Indonesia, Jakarta-Depok, Indonesia; Freisleben, H.-J., Faculty of Medicine, University of Indonesia, Jakarta-Depok, Indonesia, Faculty of Medicine, Goethe-University Frankfurt/Main, Germany |
Immune-suppressive agents such as methylprednisolone and cyclosporine exert tremendous side effects, because of high dosage and long-term application required for immune suppression after organ transplantation. Major side effects of methylprednisolone include bleeding of the gastro-intestinal tract, hypertension, and osteoporosis, whereas cyclosporine is nephrotoxic. Liposomes are phospholipid particles that allow delivery of drugs preferentially to the reticuloendothelial system. They can be prepared from phospholipids, such as lecithin from soybean or egg yolk, other specific or modified lipids or from membrane-spanning tetraether lipid (TEL), which can be extracted and purified from archaeal cell membranes. One advantage in the use of liposomal application is reduced toxicity of many drugs. We report on various liposomal preparations of cyclosporine, methylprednisolone (L-MPL) and its palmitate derivative (L-MPLP). It has been documented that liposomal cyclosporine A (L-CsA), 1.75 mg/kg/ day for seven days has potential for use as an immune-suppressive agent in rats with increased efficacy and decreased nephrotoxicity compared to commercially available forms of intravenous CsA. Liposomal methylprednisolone (L-MPL) 2 mg/kg, intravenously (IV), twice a week shows significantly prolonged cardiac allograft survival in rats and tissue-selective sequestration of the drug in comparison with the same dosage regimen of methylprednisolone in solution, administered daily. We report on organ distribution of L-MPLP in rats after intraperitoneal (IP) administration. Conclusion: Liposomal preparations of immunosuppressants have significantly higher immune-suppressive potential and lower toxicity than non-liposomal preparations. Bipolar TEL can be extracted, fractionated and purified from archaea to form stable liposomes which are extremely resistant, even to gastric fluid. Hence, TEL liposomes allow (besides IV and IP) for oral administration of immunosuppressants after organ transplantation with pharmacological and toxicological advantages over common liposomal phospholipid bilayer preparations. © 2021 Oriental Scientific Publishing Company. All rights reserved. |
Absorption; Allograft; Cyclosporine; Gastrointestinal stability; Immunosuppressant; Liposomes; Methylprednisolone; Oral administration; Organ transplantation; Toxicity |
alamethicin; albumin; cholesterol; coumarin; cyclosporine; dexamethasone; globulin; glucocorticoid; interleukin 1; liposome; lymphokine; methylprednisolone; phosphatidylcholine; phosphatidylglycerol; phospholipid; tumor necrosis factor; affinity chromatography; allograft; archaeon; Article; bioavailability; cytotoxicity; drug release; drug therapy; egg yolk; electron microscopy; encapsulation; fluorescence; gastrointestinal tract; gel filtration chromatography; helper cell; histocompatibility; human; hypertension; immune response; immunological tolerance; immunosuppressive treatment; lipophilicity; liposomal delivery; macrophage; nephrotoxicity; organ transplantation; osteoporosis; phagocytosis; reticuloendothelial system; soybean; stomach juice; T lymphocyte; thin layer chromatography |
Oriental Scientific Publishing Company |
09746242 |
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