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399 |
Zein A.F.M.Z., Pribadi R.R., Khasanah U., Bestari M.B., Syam A.F. |
57213220528;57194732282;57003497900;36098747800;8443384400; |
Clinical gastroenterology and gastrointestinal endoscopy practices during the coronavirus disease 2019 pandemic in Indonesia: An online nationwide survey |
2021 |
Clinical Endoscopy |
54 |
3 |
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348 |
355 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107405434&doi=10.5946%2fce.2020.216&partnerID=40&md5=e370aa84b3897533db44d1a14f2b8918 |
Department of Internal Medicine, Faculty of Medicine, Universitas Swadaya Gunung Jati-Waled General Hospital, Jalan Taman Pemuda 2 Kompleks Stadion Bima, Kesambi, Kota Cirebon, West Java, 45132, Indonesia; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Biostatistics and Epidemiology, Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia; Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran-Hasan Sadikin Hospital, Bandung, Indonesia |
Zein, A.F.M.Z., Department of Internal Medicine, Faculty of Medicine, Universitas Swadaya Gunung Jati-Waled General Hospital, Jalan Taman Pemuda 2 Kompleks Stadion Bima, Kesambi, Kota Cirebon, West Java, 45132, Indonesia; Pribadi, R.R., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Khasanah, U., Department of Biostatistics and Epidemiology, Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia; Bestari, M.B., Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran-Hasan Sadikin Hospital, Bandung, Indonesia; Syam, A.F., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Background/Aims: The coronavirus disease 2019 (COVID-19) pandemic has necessitated modifications to allow the safe practice of clinical gastroenterology and gastrointestinal endoscopy. This study aimed to investigate the characteristics of clinical gastroenterology and gastrointestinal endoscopy practices during the COVID-19 pandemic in Indonesia. Methods: This cross-sectional study enrolled physician members of the Indonesian Society for Digestive Endoscopy. We used an online self-administered questionnaire disseminated via social media. The 32-item survey determined the baseline characteristics of the participants, characteristics of clinical gastroenterology and gastrointestinal endoscopy practices, involvement of the physicians in the management of COVID-19, and overall impact of the pandemic on practice. All collected data were analyzed using descriptive statistics. Results: The 200 participants in this study had a median age of 50 (34-76) years. Modifications in clinical gastroenterology practice were frequently reported in the outpatient (95.5%) and inpatient (100%) settings. All participants reported changes in the gastrointestinal endoscopy practice patterns. Of the participants, 86.0% were working in high-risk zones, and several of them reported inadequate protective personal equipment (34.0%). The median overall impact score of the pandemic on practice was 9 (2-10). Conclusions: Physicians practicing clinical gastroenterology and gastrointestinal endoscopy in Indonesia work in high-risk settings. Modifications in clinical gastroenterology and gastrointestinal endoscopy practices are prevalent during the COVID-19 pandemic. © 2021 Korean Society of Gastrointestinal Endoscopy. |
Clinical; COVID-19; Gastroenterology; Gastrointestinal endoscopy; Practice |
adult; aged; coronavirus disease 2019; cross-sectional study; female; gastroenterology; gastrointestinal endoscopy; health survey; hospital patient; human; Indonesia; male; medical society; outpatient; pandemic; physician; professional practice; protective equipment shortage; questionnaire; Review; social media |
Korean Society of Gastrointestinal Endoscopy |
22342400 |
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Review |
Q2 |
612 |
8256 |
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406 |
Kristianto H., Waluyo A., Gayatri D., Yunir E., Blow D. |
56121348500;57211433568;57197786176;36520254800;57192313241; |
Neuromuscular taping treatment of diabetic foot: A concept analysis |
2021 |
Clinica Terapeutica |
72 |
3 |
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231 |
235 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105531246&doi=10.7417%2fCT.2021.2320&partnerID=40&md5=c143037b6dd7fff4b19b4ba2e89b5b93 |
Department of Medical Surgical Nursing, School of Nursing, Faculty of Medicine, Universitas Brawijaya, Indonesia; Faculty of Nursing, Universitas Indonesia, Indonesia; Faculty of Medicine, Universitas Indonesia, Indonesia; NeuroMuscular Taping Institute, Rome, Italy; Universitas Brawijaya, Indonesia; Universitas, Indonesia |
Kristianto, H., Department of Medical Surgical Nursing, School of Nursing, Faculty of Medicine, Universitas Brawijaya, Indonesia, Faculty of Nursing, Universitas Indonesia, Indonesia, Universitas Brawijaya, Indonesia, Universitas, Indonesia; Waluyo, A., Faculty of Nursing, Universitas Indonesia, Indonesia; Gayatri, D., Faculty of Nursing, Universitas Indonesia, Indonesia; Yunir, E., Faculty of Medicine, Universitas Indonesia, Indonesia; Blow, D., NeuroMuscular Taping Institute, Rome, Italy |
Objective. The definition of neuromuscular taping (NMT) has yet to be clearly analysed as a possible treatment for diabetic foot. Case studies, theoretical analysis and results of existing research may lead to varying perceptions on the definition of NMT and its possible effects on diabetic foot. This article aims to analyse the definition of the NMT concept and furthermore as a basis for future research development on diabetic foot. Methods. The procedure for reference source search include the principal data bases using “neuromuscular taping” and “diabetic foot” keywords for the period of 2010-2019. The concept analysis uses an 8-step approach with the Walker and Avant's method. Results. Analysis of the NMT concept on diabetic foot obtained attributes of elastic tape, skin, pain, edema, injury, sensorimotor, circulation, drainage, relaxation, local, proprioceptive, motion function, strength, contraction, stabilisation, reflex, rehabilitation, care, musculoskeletal, nerve, muscles, tendons, fascia, joints, lymphatic, longitudinal, wrinkles. There were four groups of attributes, namely inflammatory response, vascularity, neuromusculoskeletal function and musculoskeletal system. NMT application benefits for diabetic foot can be attributed to improving walking function, leg position, decreasing pain response, improving body function index, improving leg muscle strength and motor function, increasing range of movement (ROM), maintaining stability of leg joint function, preventing injury, increasing strength and improving position of ankle joints, reducing stiffness, reducing edema and helping wound healing processes. Conclusions. NMT is a decompression application of an elastic tape on the skin on the diabetic foot that has the effect of reducing the inflammatory response, improving vascularity and neuromusculoskeletal function. It aims to improve neuromusculoskeletal and lymphatic system functioning due to the presence of wrinkles, indicating dilation, with local effects on the sensorimotor and proprioceptive senses in conditions of care, rehabilitation and injury. Copyright © Società Editrice Universo (SEU) |
Concept analysis; Diabetic foot; Neuromuscular taping; Operational definition |
cerebral palsy; concept analysis; diabetic foot; edema; fascia; hemiplegia; human; hypertension; inflammation; joint function; leg muscle; lymphatic drainage; motor performance; rehabilitation care; Review; systematic review; tendon; wound healing; wrinkle; athletic tape; diabetes mellitus; diabetic foot; edema; physiology; skeletal muscle; walking; Athletic Tape; Diabetes Mellitus; Diabetic Foot; Edema; Humans; Muscle, Skeletal; Walking |
Societa Editrice Universo |
00099074 |
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33956043 |
Review |
Q3 |
450 |
11019 |
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407 |
Atmoko W., Raharja P.A.R., Birowo P., Ardy A.R., Hamid H., Taher A., Rasyid N. |
57193125664;57201013616;6504153311;57223308079;57223278890;7005269743;56245069300; |
Genetic polymorphisms as prognostic factors for recurrent kidney stones: A systematic review and meta-analysis |
2021 |
PLoS ONE |
16 |
5 May |
e0251235 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105518414&doi=10.1371%2fjournal.pone.0251235&partnerID=40&md5=b6950d085d520fd3088636a18669e525 |
Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Atmoko, W., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Raharja, P.A.R., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Birowo, P., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ardy, A.R., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hamid, H., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Taher, A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rasyid, N., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Genetic polymorphisms have been suggested as risk factors affecting the occurrence and recurrence of kidney stones, although findings regarding the latter remain inconclusive. We performed this systematic review and meta-analysis to clarify the associations between genetic polymorphisms and recurrent kidney stones. PubMed, SCOPUS, EMBASE, and Cochrane Library databases were searched through May 28th, 2020 to identify eligible studies. The Quality in prognostic studies (QUIPS) tool was used to evaluate bias risk. Allelic frequencies and different inheritance models were assessed. All analyses were performed using Review manager 5.4. A total of 14 studies were included for meta-analysis, assessing urokinase (ApaL1) and vitamin D receptor (VDR) (ApaI, BsmI, FokI, and TaqI) gene polymorphisms. The ApaLI polymorphism demonstrated protective association in the recessive model [odds ratio (OR) 0.45, P < 0.01] albeit higher risk among Caucasians in the heterozygous model (OR 16.03, P < 0.01). The VDR-ApaI polymorphism showed protective association in the dominant model (OR 0.60, P < 0.01). Among Asians, the VDR-FokI polymorphism recessive model showed significant positive association (OR 1.70, P < 0.01) and the VDR-TaqI polymorphism heterozygous model exhibited protective association (OR 0.72, P < 0.01). The VDR-BsmI polymorphism was not significantly associated with recurrent kidney stones in any model. Urokinase-ApaLI (recessive model), VDR-ApaI (dominant model), and VDR-TaqI (heterozygous model) polymorphisms were associated with decreased recurrent kidney stone risk whereas urokinase-ApaLI (heterozygous model) and VDR-FokI polymorphisms were associated with increased risk among Caucasians and Asians, respectively. These findings will assist in identifying individuals at risk of kidney stone recurrence. © 2021 Atmoko et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author andsource are credited. |
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urokinase; vitamin D receptor; ApaL1 gene; Asian; Caucasian; dominant inheritance; gene frequency; genetic association; genetic polymorphism; genetic variability; heterozygosity; high risk patient; human; nephrolithiasis; prognosis; protection; recessive inheritance; recurrence risk; Review; risk reduction; systematic review; VDR gene; genetic polymorphism; genetics; meta analysis; nephrolithiasis; prognosis; recurrent disease; Humans; Kidney Calculi; Polymorphism, Genetic; Prognosis; Recurrence |
Public Library of Science |
19326203 |
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33956883 |
Review |
Q1 |
990 |
4434 |
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443 |
Shatri H., Putranto R., Faisal E., Fitrianti F., Adhiatma K., Zulmiyusrini P., Diba S.F., Lukman P.R. |
28767986500;56074051000;57218497073;57226626294;57226627483;57208105781;57226627082;55981460300; |
Psychotherapy for Healthcare Provider During COVID-19 Pandemic: An Evidence Based Clinical Review |
2021 |
Acta medica Indonesiana |
53 |
2 |
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225 |
232 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112125259&partnerID=40&md5=67ed7e7351b78d9ad3f635d4564bfa25 |
1. Division of Psychosomatic and Palliative, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital Jakarta, Indonesia. 2. Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Shatri, H., 1. Division of Psychosomatic and Palliative, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital Jakarta, Indonesia. 2. Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Putranto, R.; Faisal, E.; Fitrianti, F.; Adhiatma, K.; Zulmiyusrini, P.; Diba, S.F.; Lukman, P.R. |
BACKGROUND: health workers are one of the groups affected physically as well as psychologically from the pandemic. Recent studies showed many of the health workers reported experiencing anxiety, depression, and insomnia. This study aims to identify psychotherapy as a psychological health intervention, for healthcare workers during the COVID-19 pandemic. METHODS: an evidence based clinical review of psychotherapy as a psychological health intervention, reported in the literature, which is developed for healthcare workers during the COVID-19 pandemic. The review was conducted following set out for Evidence-based clinical review by searching the following digital libraries: PubMed, ProQuest, Cochrane, and Google Scholar. RESULTS: six publications were selected. The identified psychotherapy used as a mental or psychological intervention for healthcare workers during COVID-19 consists of supportive psychotherapy, psychoeducation, social support, and music therapy. Overall, it shows that psychotherapy, especially supportive psychotherapy, can reduce anxiety, depression, and insomnia. CONCLUSION: the physiological condition of health workers needs to get attention during the COVID-19 pandemic. Although there is no standard of therapy yet, psychotherapy could be an option as it is proven to be able to reduce anxiety, depression, and insomnia. |
COVID-19; healthcare workers; internal medicine; medical journal; psychosomatic; psychotherapy |
epidemiology; evidence based medicine; health care personnel; human; pandemic; psychology; psychotherapy; COVID-19; Evidence-Based Medicine; Health Personnel; Humans; Pandemics; Psychotherapy; SARS-CoV-2 |
NLM (Medline) |
01259326 |
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34251353 |
Review |
Q3 |
321 |
14162 |
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446 |
Damanik J., Yunir E. |
57211582841;36520254800; |
Type 2 Diabetes Mellitus and Cognitive Impairment |
2021 |
Acta medica Indonesiana |
53 |
2 |
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213 |
220 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111560209&partnerID=40&md5=8b6a3af63f3b7bd6c8c50f2cf6ec2509 |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Damanik, J., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Yunir, E. |
Type 2 diabetes mellitus (T2DM) is strongly associated with lower performance on multiple domains of cognitive function and with structural abnormalities of the brain. With the growing epidemic of diabetes and aging population, neural complications of diabetes are expected to rise and becoming a challenge for future health implications. Understanding pathophysiology, factors associated with this complication, manifestation of cognitive impairment and various metabolic and neuroradiologic markers suggestive of this pathologic condition is crucial for proper management of this potentially debilitating complication of T2DM. This review will discuss briefly important aspects of cognitive impairment in T2DM. |
cognitive impairment; type 2 diabetes mellitus |
biological marker; aged; brain; cognition; human; non insulin dependent diabetes mellitus; pathology; pathophysiology; Aged; Biomarkers; Brain; Cognition; Diabetes Mellitus, Type 2; Humans |
NLM (Medline) |
01259326 |
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34251351 |
Review |
Q3 |
321 |
14162 |
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464 |
Cahyono A.T., Louisa M., Mayang Permata T.B., Handoko, Nuryadi E., Kodrat H., Wibowo H., Hariandy Hamid A.R.A., Sekarutami S.M., Gondhowiardjo S.A. |
57222900545;41461551400;57197808751;57209984822;57197806814;57210639849;57217690943;57202054669;56576294500;6508327402; |
The potential of gallic acid as a radiosensitizer on human prostate cancer: A systematic review of preclinical studies |
2021 |
Malaysian Journal of Medicine and Health Sciences |
17 |
2 |
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246 |
254 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104201486&partnerID=40&md5=aff7e4b57216dc4b88ee83f02823372e |
Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Cahyono, A.T., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mayang Permata, T.B., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Handoko, Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kodrat, H., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wibowo, H., Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hariandy Hamid, A.R.A., Department of Urology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sekarutami, S.M., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gondhowiardjo, S.A., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Prostate adenocarcinoma accounts for majority of prostate cancer cases, and it was found to be highly radioresistant. Gallic acid is a phenolic acid naturally occurring in many plants, reported to exhibit biological activities in eliminating cancer cell lines and xenografts. The purpose of this study is to review gallic acid as a potential radiosensitizer agent in prostate cancer treatment. Article search was conducted in PubMed, EBSCO, and Scopus. 11 studies using different cell lines including DU145, PC-3, LNCaP, and 22Rv1 xenograft of human prostate cancer were reviewed in this paper. Gallic acid acts as a radiosensitizer mainly by increasing caspase-3 and caspase-9 activation resulting in apoptosis, while also reducing intracellular CDKs, cyclins, and cdc25 phosphatases ultimately causing G2-M cell cycle arrest. Gallic acid has a potential to be a new radiosensitizer compound in prostate cancer treatment. Additional clinical studies using gallic acid derivatives with lower hydrophilicity are needed. © 2021 UPM Press. All rights reserved. |
Apoptosis; Gallic acid; Prostate cancer; Radiobiology; Radiotherapy |
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Universiti Putra Malaysia Press |
16758544 |
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Review |
Q4 |
144 |
23823 |
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470 |
Takhwifa F., Aninditha T., Setiawan H., Sauriasari R. |
57222711645;57189611205;55292870100;16246507200; |
The potential of metformin as an antineoplastic in brain tumors: A systematic review |
2021 |
Heliyon |
7 |
4 |
e06558 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103788211&doi=10.1016%2fj.heliyon.2021.e06558&partnerID=40&md5=ec9287d374f7d13b7c0752898249a4ba |
Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Takhwifa, F., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia; Aninditha, T., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiawan, H., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia; Sauriasari, R., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia |
Brain tumors are challenging to handle and cause severe mortality and morbidity. The primary therapy for brain tumors, a combination of radiotherapy, chemotherapy (i.e temozolomide), and corticosteroids, is considered inadequate to improve patients' clinical conditions and associated with many adverse effects. There is an urgent need for new compounds or repurposing of existing therapies, which could improve brain tumor patients' prognosis. Metformin, commonly used for type 2 diabetes medication, has been examined for its protective action in cancer, reducing cancer risk and cancer-related mortality. However, its effect on cancer is still in rigorous debate. This study examines recent studies on the effects of metformin in primary brain tumor patients through systematic reviews. The literature search was performed on PubMed, ScienceDirect, and SpringerLink databases for articles published between 2013 and 2020. We selected clinical studies comparing the therapeutic outcomes of brain tumor therapy with and without metformin. The clinical benefits of the drug were assessed through the overall survival (OS) and progression-free survival (PFS) of brain tumor patients. Those studies demonstrated that the combination of metformin with temozolomide given post-radiotherapy resulted in better OS and PFS. Nonetheless, the efficacy and safety of metformin need further clinical testing in the wider population. © 2021 The Authors |
Antidiabetic; Antineoplastic; Metformin; Primary brain tumor; Survival |
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Elsevier Ltd |
24058440 |
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Review |
Q1 |
455 |
10919 |
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480 |
Sukmawan R., Hoetama E., Suridanda Danny S., Giantini A., Listiyaningsih E., Gilang Rejeki V., Aziz Alkatiri A., Firdaus I. |
8651025300;57214138849;57222312102;12776781400;57224237184;57222313503;57222311692;55796864700; |
Increase in the risk of clopidogrel resistance and consequent TIMI flow impairment by DNA hypomethylation of CYP2C19 gene in STEMI patients undergoing primary percutaneous coronary intervention (PPCI) |
2021 |
Pharmacology Research and Perspectives |
9 |
2 |
e00738 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102225470&doi=10.1002%2fprp2.738&partnerID=40&md5=444f8c3e75e75ed786eedbe412614a0b |
Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Clinical Pathology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Public Hospital, Jakarta, Indonesia; Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Sukmawan, R., Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Hoetama, E., Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Suridanda Danny, S., Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Giantini, A., Clinical Pathology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Public Hospital, Jakarta, Indonesia; Listiyaningsih, E., Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Gilang Rejeki, V., Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Aziz Alkatiri, A., Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Firdaus, I., Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Clopidogrel resistance is an important risk factor of ischemic event recurrence after optimal antiplatelet therapy. This study aims to investigate the role of CYP2C19 gene DNA methylation as one of the epigenetic factors for the risk of clopidogrel resistance in STEMI patients undergoing PPCI. ST-segment elevation myocardial infarction (STEMI) patients undergoing PPCI were pretreated with clopidogrel, and their platelet function was measured using VerifyNow™ assay. The criteria for high on-treatment platelet reactivity (HPR) were defined according to the expert consensus criteria (PRU >208). DNA methylation of the CYP2C19 gene was performed using bisulfite genomic sequencing technology. Furthermore, clinical, laboratory, and angiographic data including TIMI flow were collected. Among 122 patients, clopidogrel resistance was found in 22%. DNA methylation level percentage was lower in the clopidogrel resistance group (76.7 vs. 88.8, p-value.038). But, the <50% methylation group was associated with increased risk of clopidogrel resistance (OR =4.5, 95%CI =2.1–9.3, p-value =.018). This group was also found to have suboptimal post-PCI TIMI flow (OR =3.4 95%CI =1.3–8.7, p-value =.045). The lower DNA methylation level of the CYP2C19 gene increases the risk of clopidogrel resistance and subsequent poorer clinical outcome. © 2021 The Authors. Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd. |
acute coronary syndrome; clopidogrel resistance; CYP2C19; DNA methylation |
acetylsalicylic acid; clopidogrel; cytochrome P450 2C19; clopidogrel; CYP2C19 protein, human; cytochrome P450 2C19; aged; angiography; blood clotting parameters; Cytochrome P450 2C19 gene; diabetes mellitus; DNA methylation; echocardiography; female; human; loading drug dose; major clinical study; male; percutaneous coronary intervention; Review; ST segment elevation myocardial infarction; adult; complication; drug effect; drug resistance; fibrinolytic therapy; genetics; metabolism; middle aged; percutaneous coronary intervention; procedures; recurrent disease; secondary prevention; ST segment elevation myocardial infarction; thrombocyte aggregation; Adult; Clopidogrel; Cytochrome P-450 CYP2C19; DNA Methylation; Drug Resistance; Female; Humans; Male; Middle Aged; Percutaneous Coronary Inte |
John Wiley and Sons Inc |
20521707 |
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33641235 |
Review |
Q1 |
975 |
4541 |
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488 |
Djaja Y.P., Prasetia R., Santoso A., Rahyussalim A.J., Mustamsir E., Dilogo I.H. |
57191042059;57196246350;57194659467;55212166100;57196246488;56161962800; |
A decade of evolution in Indonesian orthopedic publication: A bibliographic report |
2021 |
Journal of Clinical Orthopaedics and Trauma |
15 |
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110 |
116 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092623352&doi=10.1016%2fj.jcot.2020.10.016&partnerID=40&md5=54bca8c1ea47f4019dfac052838cc471 |
Department of Orthopedic & Traumatology, Fatmawati General Hospital, Jakarta, Indonesia; Faculty of Medicine, Department of Orthopaedic Surgery, Universitas Padjadjaran, Bandung, Indonesia; Department of Orthopaedic and Traumatology, Sebelas Maret University, Prof Dr R Soeharso Orthopaedic Hospital, Solo, Indonesia; Department of Orthopaedic & Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Faculty of Medicine Brawijaya University, Saiful Anwar General Hospital, Malang, Indonesia |
Djaja, Y.P., Department of Orthopedic & Traumatology, Fatmawati General Hospital, Jakarta, Indonesia; Prasetia, R., Faculty of Medicine, Department of Orthopaedic Surgery, Universitas Padjadjaran, Bandung, Indonesia; Santoso, A., Department of Orthopaedic and Traumatology, Sebelas Maret University, Prof Dr R Soeharso Orthopaedic Hospital, Solo, Indonesia; Rahyussalim, A.J., Department of Orthopaedic & Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Mustamsir, E., Department of Orthopaedics and Traumatology, Faculty of Medicine Brawijaya University, Saiful Anwar General Hospital, Malang, Indonesia; Dilogo, I.H., Department of Orthopaedic & Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
During the past decade, there was an increasing interest in orthopedic research in Indonesia. Therefore we aimed to investigate the profile of Indonesian orthopedic trend publication from 2010 to 2019. Systematic research was conducted to identify all orthopedic articles authored by Indonesian orthopedic surgeons. Article details (number of authors, authors’ affiliation, publishing journal), type of author's affiliation, affiliate collaboration, study field, type, and level of evidence (LOE) were recorded and evaluated. Publishing journal metric and author h-index were also recorded. Descriptive statistics were used to summarize the data. Two hundred and twenty articles were included in our study. Clinical studies were the most common article type, followed by case reports and basic science. Among clinical articles, therapeutic studies were found significantly more frequent. On the other hand, economic studies were not found in this study period. The most popular field was oncology, followed by knee and spine. The average number of authors per article was 5.23 with a total of 205 individuals who had contributed during this decade. University hospital was the most common affiliation found and single-center study was the most common affiliate collaboration. The most common level of evidence was level V (case reports). Eighty-seven specific publishing journals were identified. More than 42% of the articles were published in journals with SJR between 0.25 and 0.50. The average author h-index was 3.56 (0–7). Although there was an increasing trend and quantity of publications among Indonesian authors, most articles had level 5 evidence (case reports) and the quality of publishing journals was mostly Q3 with a low-moderate SJR. Improvement of the article's quality and institutional collaboration will be needed for future contribution in global orthopedic society. © 2020 Delhi Orthopedic Association |
Bibliographic; Indonesia; Orthopedic article; Publication trend |
adult; female; human; human experiment; Indonesia; knee; major clinical study; male; orthopedic surgeon; publishing; review; spine; university hospital |
Elsevier B.V. |
09765662 |
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Review |
Q3 |
471 |
10597 |
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529 |
Kario K., Hoshide S., Chia Y.-C., Buranakitjaroen P., Siddique S., Shin J., Turana Y., Park S., Tsoi K., Chen C.-H., Cheng H.-M., Fujiwara T., Li Y., Huynh V.M., Nagai M., Nailes J., Sison J., Soenarta A.A., Sogunuru G.P., Sukonthasarn A., Tay J.C., Teo B.W., Verma N., Wang T.-D., Zhang Y., Wang J.-G. |
7102633390;6603859769;57204080905;6603376248;57210091066;54791393300;56083326000;8556278400;16065259000;7501963868;57026688600;57212076752;55931488300;57222327024;23498874000;57204676117;36764809200;6507634613;26428524900;12793132900;24330212600;23570166200;7102496979;7405566618;56183109800;57211730247; |
Guidance on ambulatory blood pressure monitoring: A statement from the HOPE Asia Network |
2021 |
Journal of Clinical Hypertension |
23 |
3 |
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411 |
421 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103146577&doi=10.1111%2fjch.14128&partnerID=40&md5=d75ac783dd0b799133a4ba32d9d8a571 |
Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan; Department of Medical Sciences, School of Healthcare and Medical Sciences, Sunway University, Bandar Sunway, Malaysia; Department of Primary Care Medicine, Faculty of Medicine, University of Malaya Kuala, Lumpur, Malaysia; Division of Hypertension, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Punjab Medical Center, Lahore, Pakistan; Faculty of Cardiology Service, Hanyang University Medical Center, Seoul, South Korea; School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Division of Cardiology, Cardiovascular Hospital, Yonsei Health System, Seoul, South Korea; JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong; Institute of Public Health and Community Medicine Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan; Center for Evidence-based Medicine, Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan; Centre for Epidemiological Studies and Clinical Trials and Center for Vascular Evaluations, Shanghai Key Lab of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Department of Internal Medicine, University of Medicine and Pharmacy, Hue University, Viet Nam; Department of Internal Medicine, General Medicine and Cardiology, Hiroshima City Asa Hospital, Hiroshima, Japan; Department of Preventive and Community Medicine and Research Institute for Health Sciences, University of the East Ramon Magsaysay Memorial Medical Center Inc, Quezon City, Philippines; Section of Cardiology, Department of Medicine, Medical Center Manila, Manila, Philippines; Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia-National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia; MIOT International Hospital, Chennai, India; College of Medical Sciences, Kathmandu University, Bharatpur, Nepal; Cardiology Division, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Thailand; Department of General Medicine, Tan Tock Seng Hospital, Singapore, Singapore; Division of Nephrology Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore; Department of Physiology, King George's Medical University, Lucknow, India; Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan; National Taiwan University Hospital, Taipei City, Taiwan; Division of Hospital Medicine, Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan; Divisions of Hypertension and Heart Failure, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Hypertension, Centre for Epidemiological Studies and Clinical Trials, the Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China |
Kario, K., Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan; Hoshide, S., Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan; Chia, Y.-C., Department of Medical Sciences, School of Healthcare and Medical Sciences, Sunway University, Bandar Sunway, Malaysia, Department of Primary Care Medicine, Faculty of Medicine, University of Malaya Kuala, Lumpur, Malaysia; Buranakitjaroen, P., Division of Hypertension, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Siddique, S., Punjab Medical Center, Lahore, Pakistan; Shin, J., Faculty of Cardiology Service, Hanyang University Medical Center, Seoul, South Korea; Turana, Y., School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Park, S., Division of Cardiology, Cardiovascular Hospital, Yonsei Health System, Seoul, South Korea; Tsoi, K., JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong; Chen, C.-H., Institute of Public Health and Community Medicine Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan; Cheng, H.-M., Institute of Public Health and Community Medicine Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, Center for Evidence-based Medicine, Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan; Fujiwara, T., Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan; Li, Y., Centre for Epidemiological Studies and Clinical Trials and Center for Vascular Evaluations, Shanghai Key Lab of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Huynh, V.M., Department of Internal Medicine, University of Medicine and Pharmacy, Hue University, Viet Nam; Nagai, M., Department of Internal Medicine, General Medicine and Cardiology, Hiroshima City Asa Hospital, Hiroshima, Japan; Nailes, J., Department of Preventive and Community Medicine and Research Institute for Health Sciences, University of the East Ramon Magsaysay Memorial Medical Center Inc, Quezon City, Philippines; Sison, J., Section of Cardiology, Department of Medicine, Medical Center Manila, Manila, Philippines; Soenarta, A.A., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia-National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia; Sogunuru, G.P., MIOT International Hospital, Chennai, India, College of Medical Sciences, Kathmandu University, Bharatpur, Nepal; Sukonthasarn, A., Cardiology Division, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Thailand; Tay, J.C., Department of General Medicine, Tan Tock Seng Hospital, Singapore, Singapore; Teo, B.W., Division of Nephrology Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore; Verma, N., Department of Physiology, King George's Medical University, Lucknow, India; Wang, T.-D., Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan, National Taiwan University Hospital, Taipei City, Taiwan, Division of Hospital Medicine, Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan; Zhang, Y., Divisions of Hypertension and Heart Failure, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Wang, J.-G., Department of Hypertension, Centre for Epidemiological Studies and Clinical Trials, the Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China |
Hypertension is an important public health issue due to its association with a number of serious diseases, including cardiovascular disease and stroke. The importance of evaluating hypertension taking into account different blood pressure (BP) profiles and BP variability (BPV) is increasingly being recognized, and is particularly relevant in Asian populations given the specific features of hypertension in the region (including greater salt sensitivity and a high rate of nocturnal hypertension). Ambulatory BP monitoring (ABPM) is the gold standard for diagnosing hypertension and assessing 24-hour BP and provides data on several important parameters that cannot be obtained using any other form of BP measurement. In addition, ABPM parameters provide better information on cardio- and cerebrovascular risk than office BP. ABPM should be used in all patients with elevated BP, particularly those with unstable office or home BP, or who are suspected to have white-coat or masked hypertension. ABPM is also an important part of hypertension diagnosis and monitoring in high-risk patients. ABPM needs to be performed using a validated device and good practice techniques, and has a role both in hypertension diagnosis and in monitoring the response to antihypertensive therapy to ensure strict BP control throughout the 24-hour period. Use of ABPM in clinical practice may be limited by cost and accessibility, and practical education of physicians and patients is essential. The ABPM evidence and practice points in this document are based on the Hypertension Cardiovascular Outcome Prevention and Evidence (HOPE) Asia Network expert panel consensus recommendations for ABPM in Asia. © 2020 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC |
ambulatory blood pressure monitoring; blood pressure control; clinical practice; guidelines; hypertension |
angiotensin receptor antagonist; antihypertensive agent; calcium channel blocking agent; dipeptidyl carboxypeptidase inhibitor; antihypertensive agent; atherosclerosis; blood pressure monitoring; blood pressure regulation; blood pressure variability; brain hemorrhage; cardiovascular risk; circadian rhythm; cognitive defect; comorbidity; coronary artery disease; cost control; diastolic blood pressure; diastolic dysfunction; disease association; drug efficacy; health care access; heart left ventricle hypertrophy; high risk patient; human; low risk patient; masked hypertension; microangiopathy; prevalence; prognosis; reimbursement; Review; sensitivity and specificity; sleep disordered breathing; systolic blood pressure; telemedicine; treatment response; white coat hypertension; Asia; blood pr |
John Wiley and Sons Inc |
15246175 |
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33319412 |
Review |
Q2 |
909 |
5078 |
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