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851 |
Yunir E., Kurniawan F., Rezaprasga E., Wijaya I.P., Suroyo I., Matondang S., Irawan C., Soewondo P. |
36520254800;57202309006;57222478699;57193731572;57204106272;57192085914;28767651600;23475336100; |
Autologous Bone-Marrow vs. Peripheral Blood Mononuclear Cells Therapy for Peripheral Artery Disease in Diabetic Patients |
2021 |
International Journal of Stem Cells |
14 |
1 |
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21 |
32 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102786540&doi=10.15283%2fijsc20088&partnerID=40&md5=91f35aa55f974c266100f150613cc086 |
Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Yunir, E., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kurniawan, F., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rezaprasga, E., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wijaya, I.P., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Suroyo, I., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Matondang, S., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Irawan, C., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soewondo, P., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Diabetes mellitus (DM) remains one of the most important risk factors for peripheral artery disease (PAD), with approximately 20% of DM patients older than 40 years old are affected with PAD. The current standard management for severe PAD is endovascular intervention with or without surgical bypass. Unfortunately, up to 40% of patients are unable to undergo these revascularization therapies due to excessive surgical risk or adverse vascular side effects. Stem cell therapy has emerged as a novel therapeutic strategy for these ‘no-option’ patients. Several types of stem cells are utilized for PAD therapy, including bone marrow mononuclear cells (BMMNC) and peripheral blood mononuclear cells (PBMNC). Many studies have reported the safety of BMMNC and PBMNC, as well as its efficacy in reducing ischemic pain, ulcer size, pain-free walking distance, ankle-brachial index (ABI), and transcutaneous oxygen pressure (TcPO2). However, the capacity to establish the efficacy of reducing major amputation rates, amputation free survival, and all-cause mortality is limited, as shown by several randomized placebo-controlled trials. The present literature review will focus on comparing safety and efficacy between BMMNC and PBMNC as cell-based management in diabetic patients with PAD who are not suitable for revascularization therapy. Copyright © 2021 by the Korean Society for Stem Cell Research |
Bone marrow mononuclear cells; Diabetes mellitus; Peripheral artery disease; Peripheral blood mononuclear cells; Stem cell therapy |
Article; autologous bone marrow transplantation; bone marrow derived mononuclear cell; clinical trial (topic); comparative effectiveness; diabetes mellitus; diabetic patient; human; patient safety; peripheral blood mononuclear cell; peripheral occlusive artery disease; stem cell transplantation |
Sungkyunkwan University |
20053606 |
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Article |
Q4 |
569 |
8885 |
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852 |
Birowo P., Raharja P.A.R., Atmoko W., Rasyid N. |
6504153311;57201013616;57193125664;56245069300; |
X-ray-free endoscopic combined intrarenal surgery for complex proximal ureteral stone: A case report |
2021 |
Research and Reports in Urology |
13 |
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121 |
125 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102769053&doi=10.2147%2fRRU.S299707&partnerID=40&md5=032063a30ddb79b23195d2c16a6aaa56 |
Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Birowo, P., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Raharja, P.A.R., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Atmoko, W., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Rasyid, N., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
X-ray-free endoscopic combined intra renal surgery (ECIRS) is a feasible alternative to avoid radiation exposure to both surgical teams and patients, but has not been reported prior. The aim of this report is to present our first-hand experience of performing X-ray-free ECIRS for complex ureteral stone. A 57-year-old female presented with right flank pain, fever, dysuria, and leukocytosis. The computed tomography scan showed right impacted proximal ureteral stone sized 33 ´17 mm and grade IV hydrone-phrosis. Percutaneous nephrostomy was performed immediately. With improvement of clinical symptoms two days after nephrostomy, X-ray-free ECIRS was performed. The patient was placed in a Galdakao-modified supine position. During ureteroscopy (URS), there was noted right ureteral stenosis in the distal part of the stone, which could be passed. However, the stone was impacted and the semi-rigid URS was not able to push it. Therefore, antegrade approach with percutaneous nephrolithotomy was performed. Previous nephrostomy tract was used as percutaneous access. Tract dilatation was performed under direct visualization from the URS. The 28 Fr rigid nephroscope was used during the ECIRS procedure. The stone was fragmented using shock-pulse litho-tripters. There was no residual stone or infundibular laceration after the procedure. A 6 Fr double J stent was inserted retrogradely due to ureteral stenosis. There was no complication during and after the procedure. The patient was discharged on post-operative day three. X-ray free ECIRS for complex proximal ureteral stone was possible and showed good results. © 2021 Birowo et al. |
ECIRS; Modified procedure; Supine position; Ureterolithiasis |
creatinine; esterase; hemoglobin; levofloxacin; adult; Article; case report; clinical article; computer assisted tomography; creatinine blood level; diagnostic test accuracy study; dysuria; endoscopic surgery; Escherichia coli; female; fever; flank pain; hemoglobin blood level; human; human tissue; hydronephrosis; hydroureter; injection site reaction; kidney calyx; kidney surgery; leukocytosis; middle aged; nausea and vomiting; neutrophil; operation duration; operative blood loss; percussion; percutaneous nephrolithotomy; percutaneous nephrostomy; radiation exposure; supine position; ureter obstruction; ureter stone; ureteroscopy; urinalysis; X ray; x-ray computed tomography |
Dove Medical Press Ltd |
22532447 |
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Q2 |
506 |
9983 |
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 |
2021 |
Autophagy |
17 |
1 |
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1 |
382 |
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312 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102619204&doi=10.1080%2f15548627.2020.1797280&partnerID=40&md5=32bc24d3ffd8e3f626d0d619cf3a8fc8 |
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In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field. © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
Autophagosome; cancer; flux; LC3; lysosome; macroautophagy; neurodegeneration; phagophore; stress; vacuole |
adenylate kinase; atg16l1 protein; autophagy related protein; autophagy related protein 14; autophagy related protein 18; autophagy related protein 5; autophagy related protein 8 family; beclin 1; biological marker; dfcp1 protein; DNA; gamma interferon; green fluorescent protein; mammalian target of rapamycin; nanoparticle; phosphatidylinositol 3 kinase; protein; RNA; sequestosome 1; serine threonine protein kinase ULK1; SNARE protein; sphingolipid; stx17 protein; tecpr1 protein; ubiquitin; unclassified drug; aggrephagy; apicoplast; assay; autophagosome; autophagy (cellular); bimolecular fluorescence complementation; Caenorhabditis elegans; cell death; cell nucleus; cell stress; cell vacuole; chlorophagy; chromatophagy; clockophagy; crinophagy; data base; doryphagy; Drosophila melanogaster |
Taylor and Francis Ltd. |
15548627 |
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33634751 |
Review |
Q1 |
3934 |
400 |
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854 |
Kirana A.N., Prafiantini E., Hardiany N.S. |
57222361321;57193088368;57192910605; |
Protein intake and loss of proteostasis in the eldery |
2021 |
Ukrainian Biochemical Journal |
93 |
1 |
|
30 |
39 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102434761&doi=10.15407%2fubj93.01.030&partnerID=40&md5=e09be01091937944ac8ad3197ad54b2c |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Indonesia; Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine, Universitas Indonesia, Indonesia |
Kirana, A.N., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Prafiantini, E., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hardiany, N.S., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine, Universitas Indonesia, Indonesia |
Ageing is a process of declining bodily function and a major risk factor of chronic diseases. The declining bodily function in ageing can cause loss of proteostasis (protein homeostasis), which is a balance between protein synthesis, folding, modification and degradation. For the elderly, adequate protein intake is necessary to prevent sarcopenia, frailty, fracture and osteoporosis as well as reduced resistance to infection. However, increasing the protein intake can enhance the risk of oxidized protein formation, loss of proteostasis and degenerative disorder occurrence. On the other hand, several studies show that protein restriction would increase longevity. The aim of this review was to explain the importance of determining the right amount and composition of protein intake for the elderly. Oxidative stress and molecular mechanism of proteostasis loss in ageing cells as well as its suppression pathway by protein restriction are discussed in this review. © 2021 Kirana A. N. et al. |
Ageing; Dietary proteins; MTOR; Oxidative stress; Proteostasis loss |
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Palladin Institute of Biochemistry of the NASU |
24094943 |
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Article |
Q4 |
173 |
21241 |
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855 |
Syahrul S., Maliga H.A., Ilmawan M., Fahriani M., Mamada S.S., Fajar J.K., Frediansyah A., Syahrul F.N., Imran I., Haris S., Rambe A.S., Emran T.B., Rabaan A.A., Tiwari R., Dhama K., Nainu F., Mutiawati E., Harapan H. |
57216064819;57222334227;57217182580;57219947648;57211891425;56156139600;56897210000;57222337525;56589826700;57222343545;57193757980;55325267100;56049830800;55314856100;6507396956;57120069200;56652288600;55844857500; |
Hemorrhagic and ischemic stroke in patients with coronavirus disease 2019: Incidence, risk factors, and pathogenesis - a systematic review and meta-analysis |
2021 |
F1000Research |
10 |
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34 |
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12 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102340647&doi=10.12688%2ff1000research.42308.1&partnerID=40&md5=8cfb8151ce9b8e51bb3ec5847e7a2ca5 |
Department of Neurology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Department of Neurology, Dr. Zainoel Abidin Hospital, Banda Aceh, Aceh, 23111, Indonesia; Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65117, Indonesia; Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Faculty of Pharmacy, Hasanuddin University, Makassar, South Sulawesi, 90245, Indonesia; Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Research Division for Natural Product Technology (BPTBA), Indonesian Institute of Sciences (LIPI), Wonosari, 55861, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatra, 20155, Indonesia; Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, 4381, Bangladesh; Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, 31311, Saudi Arabia; Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, UP Pandit Deen Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan (DUVASU), Mathura, Uttar Pradesh, 281 001, India; Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, 243122, India; Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia |
Syahrul, S., Department of Neurology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Department of Neurology, Dr. Zainoel Abidin Hospital, Banda Aceh, Aceh, 23111, Indonesia; Maliga, H.A., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65117, Indonesia; Ilmawan, M., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65117, Indonesia; Fahriani, M., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Mamada, S.S., Faculty of Pharmacy, Hasanuddin University, Makassar, South Sulawesi, 90245, Indonesia; Fajar, J.K., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65117, Indonesia, Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Frediansyah, A., Research Division for Natural Product Technology (BPTBA), Indonesian Institute of Sciences (LIPI), Wonosari, 55861, Indonesia; Syahrul, F.N., Department of Neurology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Imran, I., Department of Neurology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Department of Neurology, Dr. Zainoel Abidin Hospital, Banda Aceh, Aceh, 23111, Indonesia; Haris, S., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Rambe, A.S., Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatra, 20155, Indonesia; Emran, T.B., Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, 4381, Bangladesh; Rabaan, A.A., Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, 31311, Saudi Arabia; Tiwari, R., Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, UP Pandit Deen Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan (DUVASU), Mathura, Uttar Pradesh, 281 001, India; Dhama, K., Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, 243122, India; Nainu, F., Faculty of Pharmacy, Hasanuddin University, Makassar, South Sulawesi, 90245, Indonesia; Mutiawati, E., Department of Neurology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Department of Neurology, Dr. Zainoel Abidin Hospital, Banda Aceh, Aceh, 23111, Indonesia; Harapan, H., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia |
Background: In this study, we aimed to determine the global prevalence, chronological order of symptom appearance, and mortality rates with regard to hemorrhagic and ischemic stroke in patients with coronavirus disease 2019 (COVID-19) and to discuss possible pathogeneses of hemorrhagic and ischemic stroke in individuals with the disease. Methods: We searched the PubMed, Scopus, and Web of Science databases for relevant articles published up to November 8, 2020. Data regarding study characteristics, hemorrhagic stroke, ischemic stroke, and COVID-19 were retrieved in accordance with the PRISMA guidelines. The Newcastle-Ottawa scale was used to assess the quality of the eligible studies. The pooled prevalence and mortality rate of hemorrhagic and ischemic stroke were calculated. Results: The pooled estimate of prevalence of hemorrhagic stroke was 0.46% (95% CI 0.40%-0.53%; I 2 =89.81%) among 67,155 COVID-19 patients and that of ischemic stroke was 1.11% (95% CI 1.03%-1.22%; I 2 =94.07%) among 58,104 COVID-19 patients. Ischemic stroke was more predominant (incidence: 71.58%) than hemorrhagic stroke (incidence: 28.42%) in COVID-19 patients who experienced a stroke. In COVID-19 patients who experienced a stroke, hospital admission with respiratory symptoms was more commonly reported than that with neurological symptoms (20.83% for hemorrhagic stroke and 5.51% for ischemic stroke versus 6.94% for hemorrhagic stroke and 5.33% for ischemic stroke, respectively). The pooled mortality rate of COVID-19 patients who experienced a hemorrhagic and ischemic stroke was 44.72% (95% CI 36.73%-52.98%) and 36.23% (95% CI 30.63%-42.24%), respectively. Conclusions: Although the occurrence of hemorrhagic and ischemic stroke is low, the mortality rates of both stroke types in patients with COVID-19 are concerning, and therefore, despite several potential pathogeneses that have been proposed, studies aimed at definitively elucidating the mechanisms of hemorrhagic and ischemic stroke in individuals with COVID-19 are warranted. PROSPERO registration: CRD42020224470 (04/12/20) © 2021 Syahrul S et al. |
COVID-19; Haemorrhagic stroke; Ischemic stroke; Meta-analysis; Pathogenesis; SARS-CoV-2; Systematic review |
Article; brain hemorrhage; clinical feature; clinical outcome; coronavirus disease 2019; hospital admission; human; incidence; ischemic stroke; meta analysis (topic); mortality rate; neurologic disease; Newcastle-Ottawa scale; pathogenesis; pooled analysis; Preferred Reporting Items for Systematic Reviews and Meta-Analyses; publication bias; respiratory tract disease; risk factor; statistical analysis; symptom; systematic review; brain ischemia; complication; incidence; meta analysis; prospective study; retrospective study; risk factor; Brain Ischemia; COVID-19; Humans; Incidence; Ischemic Stroke; Prospective Studies; Retrospective Studies; Risk Factors |
F1000 Research Ltd |
20461402 |
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33708378 |
Article |
Q1 |
1099 |
3793 |
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856 |
Rinaldi I., Louisa M., Sari R.M., Arwanih E. |
23475122400;41461551400;57208474079;57222314110; |
Flt3-itd mutation and flt3 ligand plasma level were not associated with one-year survival of Indonesian acute myeloid leukemia patients |
2021 |
OncoTargets and Therapy |
14 |
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1479 |
1486 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102287355&doi=10.2147%2fOTT.S282842&partnerID=40&md5=67e8a263fb7385921e3a50606454ebd6 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Hematology and Medical Oncology, Department of Internal Medicine, Dharmais Cancer Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rinaldi, I., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sari, R.M., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dharmais Cancer Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Arwanih, E., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: To analyze the association of FLT3-ITD mutation and FLT3 ligand plasma level with one-year survival of Indonesian acute myeloid leukemia (AML) patients. Methods: A prospective cohort study was conducted to determine the association between FLT-3-ITD mutation and FLT3 ligand plasma level with one-year survival of Indonesian AML patients. In the study, a total of 51 AML patients were obtained from two tertiary hospitals in Indonesia from year 2018 to 2020. Inclusion criteria were de novo AML male and female patients aged ≥18 years old. Exclusion criteria were prior myelodysplastic syndrome and patients that refused to participate in the study. FLT3-ITD genotype of patients was then analyzed using PCR method while FLT3 ligand plasma level was measured using ELISA method. Patients were then followed-up for 1 year or until death occurred with survival as the measured outcome. Association between independent and dependent variable were analyzed by cox regression proportional hazard. Results: Eleven patients (21.5%) in this study had FLT3-ITD mutation. The median age of AML patients was 45 (18–71) years, and the median blast percentage was 50% (5–87%). After one-year follow-up, 33 (64.7%) patients had died. The median survival of AML patients was 6 months. Univariate analysis showed no association between FLT3-ITD mutation status (HR: 1.051; 95% CI: 0.483–2.286; P: 0.901) and FLT3 ligand plasma level (HR: 0.798; 95% CI: 0.347–1.837; p= 0.596), and age (HR: 1.283; 95% CI: 0.575–2.862; p= 0.542) with one-year survival of AML patients, but multivariate analysis showed association between GFR with one-year survival of AML patients in this cohort (HR: 4.053; 95% CI: 1.469–11.183; p= 0.007). Conclusion: One-year survival of AML patients in Indonesia is not affected by FLT3-ITD mutation and FLT3 ligand plasma level. However, GFR showed association with one-year survival of AML patient in this cohort study. © 2021 Rinaldi et al. |
Acute myeloid leukemia; FLT3 Ligand Plasma; FLT3-ITD; One-year survival |
Flt3 ligand; acute myeloid leukemia; adult; age; aged; Article; cancer survival; clinical feature; cohort analysis; comparative study; controlled study; enzyme linked immunosorbent assay; female; follow up; gene mutation; genetic association; genotype; human; Indonesian; kidney function; major clinical study; male; myelodysplastic syndrome; outcome assessment; overall survival; polymerase chain reaction; prevalence; prospective study; protein blood level; survival time |
Dove Medical Press Ltd |
11786930 |
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Article |
Q2 |
1054 |
4053 |
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857 |
Sahar N., Muharam R., Pradhita A.D., Thuffi R., Zulhulaifah W.O., Birowo P. |
57212464367;57191492732;57212471291;57212475033;57222324817;6504153311; |
Expression of E-Cadherin in Pig-Tailed Monkey (Macaca nemestrina) Endometrium after Controlled Ovarian Hyperstimulation |
2021 |
BioMed Research International |
2021 |
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8824614 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102282318&doi=10.1155%2f2021%2f8824614&partnerID=40&md5=174042679bf5a7630610257f7a24b9a7 |
Department of Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia; Master Program Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia |
Sahar, N., Department of Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muharam, R., Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia; Pradhita, A.D., Master Program Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Thuffi, R., Master Program Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Zulhulaifah, W.O., Master Program Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Birowo, P., Department of Urology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia |
An increase of steroid hormones in controlled ovarian hyperstimulation (COH) procedures is reducing the success rate in assisted reproductive technology (ART), and this includes the pregnancy rate and/or implantation rate. Research has found that the decrease in the success rate occurred due to the decreased expression of the protein that is needed to prepare the endometrium so that the embryo could attach. The aim of the study was to analyse the changes in E-chaderin expression due to COH and its relations with increased level of steroid hormones as one of the proteins in the endometrium. There were 13 samples of stored biological tissue from Macaca nemestrina endometrial tissue; came from one group of natural cycles as the control group (n=4) and three groups of stimulated cycles. The first stimulated cycle group was injected by a 30 IU dose of rFSH (n=2). The second stimulated cycle group was injected by a 50 IU dose of rFSH (n=4). The third stimulated cycle group was injected by a 70 IU dose of rFSH (n=3). The expression of E-cadherin was measured by the immunohistochemistry (IHC) technique. Estradiol (E2) and progesterone (P4) levels were assessed using ELISA and have already been done. The IHC staining expression of E-cadherin was found in the cytoplasm of glandular epithelium. Immunostaining measurement used the H_SCORE. We found that the expression of E-cadherin within the group was not significantly different (p value: 0.178). Similarly, both the correlation between the estradiol level with E-cadherin and the correlation between the progesterone level with E-cadherin were not significantly different (p value: 0.872 and p value: 0.836). The conclusion is that the level of E-Cadherin expression in the endometrium that were taken in themiddle secretion phase not affected by the dose regimen that given. In addition, the level of expression is not influenced by the increase of serum E2 and P4 levels. © 2021 Nurhuda Sahar et al. |
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buserelin; chorionic gonadotropin; estradiol; progesterone; recombinant follitropin; uvomorulin; cadherin; animal experiment; animal tissue; Article; comparative study; controlled study; cytoplasm; endometrium; enzyme linked immunosorbent assay; estradiol blood level; female; follicular phase; immunohistochemistry; Macaca nemestrina; mitosis; nonhuman; ovary hyperstimulation; progesterone blood level; protein expression; retrospective study; animal; biosynthesis; endometrium; metabolism; ovulation induction; Animals; Cadherins; Endometrium; Female; Macaca nemestrina; Ovulation Induction |
Hindawi Limited |
23146133 |
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33708995 |
Article |
Q2 |
772 |
6290 |
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858 |
Eldafira E., Prasasty V.D., Abinawanto A., Syahfirdi L., Pujianto D.A. |
57204963791;56019989700;55625129700;57222327356;8745734300; |
Polymorphisms of estrogen receptor-α and estrogen receptor-β genes and its expression in endometriosis [Östrojen reseptör-α ve östrojen reseptör-β genlerinin polimorfizmi ve endometriozisde ifadelenmeleri] |
2021 |
Turkish Journal of Pharmaceutical Sciences |
18 |
1 |
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91 |
95 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102272548&doi=10.4274%2ftjps.galenos.2019.94914&partnerID=40&md5=ca75ed564cc74a659022ab862e0096b8 |
Universitas Indonesia, Faculty of Medicine, Department of Medical Biology, Depok, Indonesia; Universitas Indonesia, Faculty of Mathematics and Natural Sciences, Department of Biology, Jakarta, Indonesia; Atma Jaya Catholic University of Indonesia, Faculty of Biotechnology, Jakarta, Indonesia |
Eldafira, E., Universitas Indonesia, Faculty of Medicine, Department of Medical Biology, Depok, Indonesia, Universitas Indonesia, Faculty of Mathematics and Natural Sciences, Department of Biology, Jakarta, Indonesia; Prasasty, V.D., Atma Jaya Catholic University of Indonesia, Faculty of Biotechnology, Jakarta, Indonesia; Abinawanto, A., Universitas Indonesia, Faculty of Mathematics and Natural Sciences, Department of Biology, Jakarta, Indonesia; Syahfirdi, L., Universitas Indonesia, Faculty of Mathematics and Natural Sciences, Department of Biology, Jakarta, Indonesia; Pujianto, D.A., Universitas Indonesia, Faculty of Medicine, Department of Medical Biology, Depok, Indonesia |
Objectives: Endometriosis is a common gynecological disorder, characterized by the presence of endometrial-like tissue in the extrauterine location. The increasing estradiol concentration can influence endometriosis risk and estrogen receptor (ER) activity. Polymorphism in ER causes gene expression alteration and influences hormone-receptor interaction. This research aims to determine ER genetic polymorphisms in endometriosis pathogenesis. Materials and Methods: This study was performed on case-control polymorphisms, which compared 83 women with endometriosis and 76 women without endometriosis. However, the samples used for ER gene expression analysis and estrogen level measurement were obtained from 18 women with endometriosis and 18 women without endometriosis. Polymerase chain reaction-restriction fragment length polymorphism was used to determine ER genetic polymorphisms. Chi-square, Mann-Whitney test, Spearman’s correlation (p), t-independent, and two-tailed tests were used to analyze the data. Results: Association between the allele ERα rs9340799 A/G and endometriosis was significantly different (p=0.012), whereas rs2234693 T/C polymorphism showed no association with endometriosis. The correlation between the genotype frequencies of allele ERβ rs4986938 G/A and endometriosis was found significantly different (p=0.015; p=0.034). Conclusion: Estradiol level and ERβ expression increases, polymorphism genotypes and alleles of ERβ rs4986938 G/A gene and allele frequency of ERα rs9340799 A/G gene have roles in endometriosis. © Turk J Pharm Sci, Published by Galenos Publishing House. |
Endometriosis; Estradiol (E2); Estrogen receptor (ERα and ERβ) |
ammonium acetate; dodecyl sulfate sodium; estradiol; estrogen; estrogen receptor alpha; estrogen receptor beta; genomic DNA; adult; agar gel electrophoresis; allele; Article; case control study; centrifugation; controlled study; DNA extraction; DNA polymorphism; endometriosis; female; gene; gene amplification; gene frequency; genotype; human; illumination; intron; major clinical study; polymerase chain reaction; receptor gene; restriction fragment length polymorphism; rs2234693 gene; rs4986938 gene; spectrophotometry |
Turkish Pharmacists Association |
1304530X |
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Article |
Q3 |
241 |
17155 |
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859 |
Gunardi W.D., Karuniawati A., Umbas R., Bardosono S., Lydia A., Soebandrio A., Safari D. |
57222314683;54886816200;6602634832;21933841000;8451287200;8602893200;23493586700; |
Biofilm-Producing Bacteria and Risk Factors (Gender and Duration of Catheterization) Characterized as Catheter-Associated Biofilm Formation |
2021 |
International Journal of Microbiology |
2021 |
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8869275 |
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5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102259916&doi=10.1155%2f2021%2f8869275&partnerID=40&md5=2173f2f0a162e1277f45979d11bf433c |
Department of Clinical Microbiology, Faculty of Medicine, Krida Wacana Christian University, Jakarta, 1151, Indonesia; Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Department of Urology, FMUI-CMH, Jakarta, 10430, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, 10430, Indonesia |
Gunardi, W.D., Department of Clinical Microbiology, Faculty of Medicine, Krida Wacana Christian University, Jakarta, 1151, Indonesia; Karuniawati, A., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Umbas, R., Department of Urology, FMUI-CMH, Jakarta, 10430, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Lydia, A., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Soebandrio, A., Eijkman Institute for Molecular Biology, Jakarta, 10430, Indonesia; Safari, D., Eijkman Institute for Molecular Biology, Jakarta, 10430, Indonesia |
Background. A catheter-associated urinary tract infection (CA-UTI) is preceded by biofilm formation, which is related to several risk factors such as gender, age, diabetic status, duration of catheterization, bacteriuria before catheterization, virulence gene factor, and antibiotic usage. Aims. This study aims to identify the microbial composition of catheter samples, including its corresponding comparison with urine samples, to determine the most important risk factors of biofilm formation and characterize the virulence gene factors that correlate with biofilm formation. Methods. A longitudinal cross-sectional study was conducted on 109 catheterized patients from September 2017 to January 2018. The risk factors were obtained from the patients' medical records. All catheter and urine samples were cultured after removal, followed by biomass quantification. Isolate identification and antimicrobial susceptibility testing were performed using the Vitex2 system. Biofilm-producing bacteria were identified by the Congo Red Agar (CRA) method. A PCR test characterized the virulence genes of dominant bacteria (E. coli). All data were collected and processed for statistical analysis. Results. Out of 109 catheterized patients, 78% of the catheters were culture positive, which was higher than those of the urine samples (37.62%). The most common species isolated from the catheter cultures were Escherichia coli (28.1%), Candida sp. (17.8%), Klebsiella pneumoniae (15.9%), and Enterococcus faecalis (13.1%). E. coli (83.3%) and E. faecalis (78.6%) were the main isolates with a positive CRA. A statistical analysis showed that gender and duration prior to catheterization were associated with an increased risk of biofilm formation p<0.05. Conclusion. E. coli and E. faecalis were the most common biofilm-producing bacteria isolated from the urinary catheter. Gender and duration are two risk factors associated with biofilm formation, therefore determining the risk of CAUTI. The presence of PapC as a virulence gene encoding pili correlates with the biofilm formation. Biofilm-producing bacteria, female gender, duration of catheterization (more than five days), and PapC gene presence have strong correlation with the biofilm formation. To prevent CAUTI, patients with risk factors should be monitored by urinalysis tests to detect earlier the risk of biofilm formation. © 2021 Wani Devita Gunardi et al. |
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Hindawi Limited |
1687918X |
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Article |
Q3 |
696 |
7161 |
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860 |
Wuyung P.E., Rahadiati F.B., Tjahjadi H., Salinah S., Kusmardi K., Kodariah R., Wiweko B. |
57192889605;57222312428;57210953454;57222311659;56966625300;14010667100;43061741400; |
Histopathology and Arid1a Expression in Endometriosis-Associated Ovarian Carcinoma (EAOC) Carcinogenesis Model with Endometrial Autoimplantation and DMBA Induction |
2021 |
Asian Pacific Journal of Cancer Prevention |
22 |
2 |
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553 |
558 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102225233&doi=10.31557%2fAPJCP.2021.22.2.553&partnerID=40&md5=0851ed3cc33bf297db42accf77d7988a |
Department of Anatomical Pathology, Medicine Universitas Indonesia; Animal Research Facilities, Indonesian Medical Education and Research Institute, Medicine Universitas Indonesia; Specialty Programme in Anatomical Pathology, Department of Anatomical Pathology, Medicine Universitas Indonesia; Department of Obstetrics and Gynecology, Medicine Universitas Indonesia; Indonesian Medical Education and Research Institute, Medicine Universitas Indonesia |
Wuyung, P.E., Department of Anatomical Pathology, Medicine Universitas Indonesia, Animal Research Facilities, Indonesian Medical Education and Research Institute, Medicine Universitas Indonesia; Rahadiati, F.B., Specialty Programme in Anatomical Pathology, Department of Anatomical Pathology, Medicine Universitas Indonesia; Tjahjadi, H., Department of Anatomical Pathology, Medicine Universitas Indonesia; Salinah, S., Department of Anatomical Pathology, Medicine Universitas Indonesia; Kusmardi, K., Department of Anatomical Pathology, Medicine Universitas Indonesia; Kodariah, R., Department of Anatomical Pathology, Medicine Universitas Indonesia; Wiweko, B., Department of Obstetrics and Gynecology, Medicine Universitas Indonesia, Indonesian Medical Education and Research Institute, Medicine Universitas Indonesia |
Background: Ovarian carcinoma is one of the most deadly malignancies in the gynecologic field. The cause is not yet known, and the clinical symptoms are not specific. Endometrioid carcinoma and ovarian clear cell carcinoma can originate from endometriosis and are known as endometriosis-related ovarian carcinoma (EAOC). Development of EAOC experimental animal models is needed for basic research and clinical preparation of human tissue tests. This study aimed to determine the role of the Arid1a gene mutation in the carcinogenetic process of EAOC in experimental animal models induced with DMBA. Methods: In this study, the EAOC experimental model was developed using the autoimplantation technique and DMBA induction. This study involved placebo surgery mice (sham), endometrial autoimplantation, and a combination of endometrial autoimplantation and DMBA induction, which were sacrificed at weeks 5, 10, and 20, respectively. Histopathological assessment and immunohistochemical Arid1a staining with an assessment of positive percentages were carried out on 200 cells. Results: This study produced 1 (20%) atypical endometriosis and 1 (20%) clear cell carcinoma at implantation and after 10 weeks of DMBA induction, and 100% endometrioid carcinoma in the DMBA-induced group. Arid1a staining did not show any significant difference (p = 0.313) in all groups. Conclusion: The combination of endometrial autoimplantation techniques and DMBA induction in the ovary produced atypical endometriosis, clear cell carcinoma, and endometrioid carcinoma, where time is an important factor. There was no significant difference in Arid1a expression between the treatment and control groups. © 2021. All Rights Reserved. |
Arid1a; DMBA; EAOC; Endometriosis; experimental animal model |
ARID1A protein, human; DNA binding protein; transcription factor; animal; autotransplantation; carcinoma; complication; disease model; endometriosis; endometrium; female; metabolism; ovary tumor; pathology; rat; transplantation; Animals; Carcinoma; Disease Models, Animal; DNA-Binding Proteins; Endometriosis; Endometrium; Female; Ovarian Neoplasms; Rats; Transcription Factors; Transplantation, Autologous |
Asian Pacific Organization for Cancer Prevention |
15137368 |
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33639673 |
Article |
Q2 |
512 |
9866 |
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