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324 |
Lazarus G., Suhardi I.P., Wiyarta E., Rasyidah R.A., Barliana J.D. |
57214599425;57222253831;57221521342;57222252100;57200964187; |
Is there a need to reconsider the use of metformin in COVID-19 patients with type 2 diabetes mellitus? |
2021 |
International Journal of Diabetes in Developing Countries |
41 |
3 |
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377 |
382 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102035672&doi=10.1007%2fs13410-021-00924-w&partnerID=40&md5=6553878fa250ce9823f68e0c2659a9ff |
Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, RW 5, Kenari, Kec. Senen, Kota Jakarta Pusat, Jakarta, 10430, Indonesia; Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Lazarus, G., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, RW 5, Kenari, Kec. Senen, Kota Jakarta Pusat, Jakarta, 10430, Indonesia; Suhardi, I.P., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, RW 5, Kenari, Kec. Senen, Kota Jakarta Pusat, Jakarta, 10430, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, RW 5, Kenari, Kec. Senen, Kota Jakarta Pusat, Jakarta, 10430, Indonesia; Rasyidah, R.A., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, RW 5, Kenari, Kec. Senen, Kota Jakarta Pusat, Jakarta, 10430, Indonesia; Barliana, J.D., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: Diabetes has been linked with poorer outcomes in coronavirus disease (COVID-19) patients. However, the question to whether continue or withdraw metformin therapy in COVID-19 patients with type 2 diabetes mellitus remains contentious. This study aims to investigate the association between metformin and poor COVID-19 outcomes. Methods: Eligible studies published up to 21 October 2020 were included and appraised for validity, importance, and applicability. The included studies were further ranked according to the level of evidence (LOE). Results: Nine studies were included for further assessments, of which seven studies stated that metformin was not associated with poor COVID-19 outcomes (LOE II-V), while the other two with poorer designs stated otherwise (LOE V). Although metformin may increase the risk of developing acidosis and lactic acidosis (LOE IV), the observed risks were more accentuated in patients with severe COVID-19 disease or kidney impairment and in patients with > 2 daily metformin doses. Interestingly, one study revealed that metformin may even yield therapeutic role in reducing the risk of COVID-19 mortality (LOE II), although further studies are required to confirm these findings. Conclusions: Our findings indicated that metformin may be safely continued in COVID-19 patients. The benefit of metformin therapy with simultaneous continuous monitoring of COVID-19 severity and kidney function may outweigh the risks of lactic acidosis, of which incidence is relatively rare. © 2021, Research Society for Study of Diabetes in India. |
COVID-19; Metformin; Prognosis; Type 2 diabetes mellitus |
hemoglobin A1c; metformin; acidosis; adult; Article; case report; clinical article; coronavirus disease 2019; diabetic patient; disease course; disease severity; drug safety; estimated glomerular filtration rate; glycemic control; human; kidney failure; kidney function; lactic acidosis; male; middle aged; mortality; mortality risk; non insulin dependent diabetes mellitus; prognosis; systematic review |
Springer |
09733930 |
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Article |
Q3 |
205 |
19024 |
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341 |
Rustamadji P., Wiyarta E., Bethania K.A., Kusmardi K. |
55321572200;57221521342;57226320454;56966625300; |
Potential of AKT2 expression as a predictor of lymph-node metastasis in invasive breast carcinoma of no special type |
2021 |
Journal of Pathology and Translational Medicine |
51 |
3 |
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271 |
278 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111106383&doi=10.4132%2fjptm.2021.04.26&partnerID=40&md5=25c257f935b27c34728f8cc05fdeca15 |
Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rustamadji, P., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bethania, K.A., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kusmardi, K., Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Invasive breast carcinoma of no special type (IBC-NST) is the most common type of breast cancer and mainly causes regional lymph-node metastasis (LNM). We investigated the potential for AKT2 expression as a predictive biomarker for LNM in IBC-NST. Methods: Forty-eight paraffin blocks containing IBC-NST primary tumors were divided into two groups based on presence or absence of LNM. Age, tumor grade, tumor size, lymphovascular invasion (LVI), and AKT expression were assessed. AKT2 expression was assessed based on immunohistochemical staining, while other data were collected from archives. Results: Multiple logistic regression results showed that AKT2 expression and LVI were significantly associated with LNM (odds ratio [OR], 5.32; 95% confidence interval [CI], 1.42 to 19.93 and OR, 4.46; 95% CI, 1.17 to 16.97, respectively). AKT2 expression was able to discriminate against LNM (area under the receiver operating characteristic, 0.799 ± 0.063; 95% CI, 0.676 to 0.921) at an H-score cutoff of 104.62 (83.3% sensitivity, 62.5% specificity). Conclusions: AKT2 expression has potential as a predictor of LNM in IBC-NST. The H-score cutoff for AKT2 expression can be used as a classification guide in future studies. © 2021 The Korean Society of Pathologists/The Korean Society for Cytopathology. |
AKT2; Breast neoplasms; Immunohistochemistry; Metastasis |
biological marker; protein kinase B beta; adult; aged; Article; breast carcinoma; cancer grading; clinical article; confidence interval; controlled study; female; human; human tissue; immunohistochemistry; lymph vessel metastasis; multivariate logistic regression analysis; odds ratio; predictive value; protein expression; receiver operating characteristic; sensitivity and specificity; tumor invasion; tumor volume |
Seoul National University |
23837837 |
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Article |
Q2 |
684 |
7312 |
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343 |
Agustina R., Meilianawati, Fenny, Atmarita, Suparmi, Susiloretni K.A., Lestari W., Pritasari K., Shankar A.H. |
57214141404;57224214324;57226280026;57191035215;57201388096;55920057100;57222081857;36490128600;7005442634; |
Psychosocial, Eating Behavior, and Lifestyle Factors Influencing Overweight and Obesity in Adolescents |
2021 |
Food and Nutrition Bulletin |
42 |
1_suppl |
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S72 |
S91 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111017301&doi=10.1177%2f0379572121992750&partnerID=40&md5=430a97f5027110c908b0a552342f5ec8 |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia —Dr. Cipto, Mangunkusumo General Hospital, Jakarta, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; National Institute of Health Research and Development (NIHRD), Ministry of Health, Jakarta, Indonesia; Semarang Health Polytechnic Ministry of Health—Poltekkes Kemenkes Semarang, Indonesia; Directorate of Public Health, Ministry of Health, Jakarta, Indonesia; Centre for Tropical Medicine and Global Health, Oxford University, Oxford, United Kingdom |
Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia —Dr. Cipto, Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Meilianawati, Department of Nutrition, Faculty of Medicine, Universitas Indonesia —Dr. Cipto, Mangunkusumo General Hospital, Jakarta, Indonesia; Fenny, Department of Nutrition, Faculty of Medicine, Universitas Indonesia —Dr. Cipto, Mangunkusumo General Hospital, Jakarta, Indonesia; Atmarita, National Institute of Health Research and Development (NIHRD), Ministry of Health, Jakarta, Indonesia; Suparmi, National Institute of Health Research and Development (NIHRD), Ministry of Health, Jakarta, Indonesia; Susiloretni, K.A., Semarang Health Polytechnic Ministry of Health—Poltekkes Kemenkes Semarang, Indonesia; Lestari, W., Department of Nutrition, Faculty of Medicine, Universitas Indonesia —Dr. Cipto, Mangunkusumo General Hospital, Jakarta, Indonesia; Pritasari, K., Directorate of Public Health, Ministry of Health, Jakarta, Indonesia; Shankar, A.H., Centre for Tropical Medicine and Global Health, Oxford University, Oxford, United Kingdom |
Background: Adolescent overweight and obesity (AOO) is a global public health problem and risk for noncommunicable diseases. Understanding context-specific risks is crucial for interventions. Objective: Determine the prevalence of AOO in the Indonesian National Health Survey (INHS) 2013, assess the 5-year trend from 2013 to 2018, and identify risks. Methods: We selected adolescents aged 10 to 19 years (n = 174 290) from the INHS 2013 and used hierarchical logistic regression to identify gender-specific risks for those aged 15 to 19 years (n = 77 534). Change in AOO was assessed by comparison to INHS 2018 reports. Results: The national AOO prevalence increased over 5 years by 48% in young adolescents (13-15 years) and 85% in older ones (16-18 years). High prevalence areas included the urban location of Jakarta (20.9%) and the remote rural region of Papua (19.4%). Overall, AOO risks were being sedentary, male, lower education, married, younger adolescent, and school enrollment, with urban residence and higher wealth being persistent risks for all analyses. Data for depressive symptoms were available for older adolescents whose additional risks were being sedentary, depressive symptoms, and high-fat diet. Male risks were being sedentary and lower education, and female risks were being married, depressive symptoms, high-fat intake, and lower education. Higher intake of fruits and vegetables and fewer sweets did not protect against AOO if a high-fat diet was consumed. Conclusions: Adolescent overweight and obesity in Indonesia is rapidly increasing, especially in older adolescents and males, and with gender-specific risks. Customized multisectoral interventions to identify strategies for lifestyle change are urgently needed. © The Author(s) 2021. |
adolescents; depressive symptoms; nutrition; obesity; overweight |
adolescence; behavioral ecology; disease prevalence; factor analysis; health risk; lifestyle; noncommunicable disease; obesity; psychology; public health; Indonesia; Jakarta; Papua [(PRV) Indonesia] |
SAGE Publications Inc. |
03795721 |
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34282658 |
Article |
Q1 |
649 |
7743 |
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363 |
Yo E.C., Witjaksono A.N., Fitriani D.Y., Werdhani R.A., Parikesit D. |
57213188908;57224351398;57224589606;57189088848;57163830300; |
Assessing webinar outcomes for health professionals: A perspective from Indonesia during coronavirus disease 2019 pandemic |
2021 |
Korean Journal of Medical Education |
33 |
2 |
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87 |
96 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107416703&doi=10.3946%2fKJME.2021.190&partnerID=40&md5=0cbaa0d20d5fdaa64a279a62d1943b06 |
Faculty of Medicine, Universitas Indonesia, Indonesia; Ophthalmology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Indonesia; Occupational Medicine Staff Group, Universitas Indonesia Hospital, Universita Indonesia, Depok, Indonesia; Department of Community Medicine, Faculty of Medicine, Jakarta, Indonesia; Urology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia; Universitas Indonesia Hospital, Pondok Cina, Beji, Depok City, West Java, 16424, Indonesia |
Yo, E.C., Faculty of Medicine, Universitas Indonesia, Indonesia; Witjaksono, A.N., Ophthalmology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Indonesia; Fitriani, D.Y., Occupational Medicine Staff Group, Universitas Indonesia Hospital, Universita Indonesia, Depok, Indonesia, Department of Community Medicine, Faculty of Medicine, Jakarta, Indonesia; Werdhani, R.A., Department of Community Medicine, Faculty of Medicine, Jakarta, Indonesia, Universitas Indonesia Hospital, Pondok Cina, Beji, Depok City, West Java, 16424, Indonesia; Parikesit, D., Urology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia |
Purpose: With the ongoing coronavirus disease 2019 (COVID-19) pandemic, health institutions and hospitals are increasingly relying on e-learning for continuing education. However, in many countries there is still limited data on the effectiveness of online learning particularly in the healthcare field. This study aims to evaluate whether webinar as a form of online educational intervention is satisfactory and effective for the continuing education of health professionals in Indonesia. Methods: We collected participants' demographic information including health profession, place of work, work unit, and year of graduation. There were six independent webinars included in this study. Webinar outcomes included satisfaction and learning scores. Regarding satisfaction, participants were told to complete a satisfaction survey and asked whether they would recommend the webinar to their colleagues. Regarding learning, information on their mean pre-test and post-test scores was collected. Results: A total of 3,607 health professionals were enrolled, with the highest participation in webinars about emergency cases and COVID-19 management. The response towards satisfaction was overwhelmingly positive. In all six webinars, post-test scores were statistically significantly higher than pre-test scores. Recently graduated physicians scored higher in learning than senior physicians, while place of work and work unit did not significantly affect the scores. Conclusion: The use of webinar for health professionals training in Indonesia was well-received amid the ongoing pandemic. In the future, health institutions and teaching hospitals should optimize the implementation of webinar training as it is associated with low cost, high flexibility, and less time commuting. © 2021 Korean Journal of Medical Education. All Rights Reserved. |
Continuing education; Covid-19; Health occupations; Online learning; Videoconferencing |
continuing education; cost benefit analysis; disease management; education; health care personnel; human; Indonesia; learning; pandemic; physician; procedures; satisfaction; teaching; teaching hospital; Cost-Benefit Analysis; COVID-19; Disease Management; Education, Continuing; Education, Distance; Educational Measurement; Health Personnel; Hospitals, Teaching; Humans; Indonesia; Learning; Pandemics; Personal Satisfaction; Physicians; SARS-CoV-2; Teaching |
Korean Society of Medical Education |
2005727X |
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34062640 |
Article |
Q4 |
175 |
21057 |
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383 |
Pranata R., Henrina J., Yonas E., Putra I.C.S., Cahyadi I., Lim M.A., Munawar D.A., Munawar M. |
57201973901;57218482646;57201987097;57222144236;57221688594;57216039756;56470745000;16747447600; |
BMI and atrial fibrillation recurrence post catheter ablation: A dose-response meta-analysis |
2021 |
European Journal of Clinical Investigation |
51 |
6 |
e13499 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101961208&doi=10.1111%2feci.13499&partnerID=40&md5=72dba8a2a9279126fd9e453324e6df70 |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Binawaluya Cardiac Center, Jakarta, Indonesia; Balaraja General Hospital, Tangerang, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Syamsudin SH General Hospital, Sukabumi, Indonesia; Pasar Rebo General Hospital, Jakarta, Indonesia; Department of Cardiology, Lyell McEwin Hospital, University of Adelaide, Elizabeth Vale, Australia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Binawaluya Cardiac Center, Jakarta, Indonesia; Henrina, J., Balaraja General Hospital, Tangerang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Putra, I.C.S., Syamsudin SH General Hospital, Sukabumi, Indonesia; Cahyadi, I., Pasar Rebo General Hospital, Jakarta, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Munawar, D.A., Department of Cardiology, Lyell McEwin Hospital, University of Adelaide, Elizabeth Vale, Australia, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Munawar, M., Binawaluya Cardiac Center, Jakarta, Indonesia, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: The evidence on the association between obesity and atrial fibrillation (AF) recurrence was equivocal. We aimed to evaluate the dose-response relationship between body mass index (BMI) and AF recurrence and adverse events. Methods: A systematic literature search was conducted using PubMed, Europe PMC, EBSCO, ProQuest and Cochrane Library. Obesity was defined as BMI ≥28 kg/m2. The primary outcome was AF recurrence, and the secondary outcome was adverse events. Adverse events were defined as procedure-related complications and cardio-cerebrovascular events. Results: There were a total of 52,771 patients from 20 studies. Obesity was associated with higher AF recurrence (Odds ratio [OR] 1.30 [95% confidence interval [CI] 1.16-1.47], P <.001; I2: 72.7%) and similar rate of adverse events (OR 1.21 [95% CI 0.87-1.67], P =.264; I2: 23.9%). Meta-regression showed that the association varies by age (coefficient: −0.03, P =.024). Meta-analysis of highest versus lowest BMI showed that the highest group had higher AF recurrence (OR 1.37 [95% CI 1.18-1.58], P <.001; I2: 64.9%) and adverse events (OR 2.02 [95% CI 1.08-3.76], P =.028; I2: 49.5%). The linear association analysis for AF recurrence was not significant (P =.544). The dose-response relationship for BMI and AF recurrence was nonlinear (pnonlinearity < 0.001), the curve became steeper at 30-35 kg/m2. For adverse events, an increase of 1% for every 1 kg/m2 increase in BMI (OR 1.01 [95% CI 1.00-1.02], P =.001), the relationship was nonlinear (pnonlinearity = 0.001). Conclusion: Obesity was associated with higher AF recurrence in patients undergoing catheter ablation. High BMI might be associated with a higher risk for adverse events. PROSPERO ID: CRD42020198787. © 2021 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd |
arrhythmia; Atrial Fibrillation; catheter ablation; obesity; pulmonary vein isolation |
anticoagulant agent; warfarin; adult; adverse event; age; aged; Article; atrial fibrillation; body mass; cardiovascular disease; catheter ablation; cerebrovascular disease; female; high risk patient; human; male; meta analysis; middle aged; obesity; outcome assessment; recurrence risk; systematic review; atrial fibrillation; body mass; obesity; recurrent disease; severity of illness index; Atrial Fibrillation; Body Mass Index; Catheter Ablation; Humans; Obesity; Overweight; Recurrence; Severity of Illness Index |
John Wiley and Sons Inc |
00142972 |
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33544873 |
Article |
Q1 |
1164 |
3461 |
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384 |
Octaviana F., Yugo H.P., Safri A.Y., Indrawati L.A., Wiratman W., Ayuningtyas T., Hakim M. |
26029958700;57222124227;57091699300;57205117182;57191920526;57222133312;57216861859; |
Case series: COVID-19 in patients with mild to moderate myasthenia gravis in a National Referral Hospital in Indonesia |
2021 |
eNeurologicalSci |
23 |
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100332 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101576141&doi=10.1016%2fj.ensci.2021.100332&partnerID=40&md5=ccc7fd67857e6642deba6a14cfa9ae62 |
Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia; Cipto Mangunkusomo National General Hospital, Jakarta, Indonesia |
Octaviana, F., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Cipto Mangunkusomo National General Hospital, Jakarta, Indonesia; Yugo, H.P., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Cipto Mangunkusomo National General Hospital, Jakarta, Indonesia; Safri, A.Y., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Cipto Mangunkusomo National General Hospital, Jakarta, Indonesia; Indrawati, L.A., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Cipto Mangunkusomo National General Hospital, Jakarta, Indonesia; Wiratman, W., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Cipto Mangunkusomo National General Hospital, Jakarta, Indonesia; Ayuningtyas, T., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Cipto Mangunkusomo National General Hospital, Jakarta, Indonesia; Hakim, M., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Cipto Mangunkusomo National General Hospital, Jakarta, Indonesia |
Background: During the COVID-19 pandemic, patients with myasthenia gravis (MG) are most likely to be affected by this situation. Corticosteroids and immunosuppressant agents increase the risk of severe infection. Furthermore, viral infection and some medications in COVID-19 may exacerbate MG symptoms. Case description: We presented three patients with MG who contracted COVID-19. All of the patients had a favourable outcome. Only one patient who was not treated with corticosteroids or immunosuppressant therapy experienced deterioration of MG symptoms, while the other patients who received immunosuppressant therapy did not develop MG exacerbation. Surprisingly, azithromycin did not provoke myasthenic crisis (MC) in patients with normal MGFA classification. Conclusion: Using immunosuppressant agents may not lead to MG deterioration and may not be related to unfavourable outcomes. © 2021 The Author(s) |
COVID-19; Immunosuppressant; Myasthenia gravis |
acetylcysteine; alanine aminotransferase; ascorbic acid; aspartate aminotransferase; azathioprine; azithromycin; C reactive protein; ceftriaxone; D dimer; hydroxychloroquine; methylprednisolone; mycophenolate mofetil; oxygen; paracetamol; procalcitonin; pyridostigmine; abduction; adult; anosmia; Article; blood analysis; body temperature; case report; clinical article; clinical classification; consultation; coronavirus disease 2019; coughing; deterioration; diarrhea; disease exacerbation; drug dose increase; dry cough; dysphagia; fatigue; female; fever; food intake; home quarantine; hospital admission; hospital discharge; hospitalization; human; human tissue; Indonesia; leukocytosis; lung auscultation; lung infiltrate; male; mastication; medical history; middle aged; mucus; muscle weakness; |
Elsevier B.V. |
24056502 |
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Article |
Q3 |
570 |
8868 |
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394 |
Abdullah M., Sudrajat D.G., Muzellina V.N., Kurniawan J., Rizka A., Utari A.P., Pribadi R.R., Idrus M.F., Yusra Y., Meilany S., Surandy A., Shatri H., Rinaldi I., Pitoyo C.W., Renaldi K. |
7103393434;54893136100;57223968527;57193251655;57203243658;57113585900;57194732282;57223976376;57220998367;57193709281;57223964417;28767986500;23475122400;26022606900;57190963547; |
The value of anal swab RT-PCR for COVID-19 diagnosis in adult Indonesian patients |
2021 |
BMJ Open Gastroenterology |
8 |
1 |
e000590 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106611204&doi=10.1136%2fbmjgast-2020-000590&partnerID=40&md5=cc17ce689ac73f1e46021151c9319871 |
Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Indonesia Medical Education and Research Institute - Human Cancer Research Center, University of Indonesia Faculty of Medicine, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Hepatobilliary Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Geriatric Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Department of Clinical Pathology, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region Jakarta, Indonesia; Research Center for Virology and Cancer Pathobiology, University of Indonesia Faculty of Medicine, Jakarta, Special Capital Region of Jakarta, Indonesia; Psychosomatic and Palliative Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Special Capital Region of Jakarta, Central Jakarta, Indonesia; Hematology and Medical Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Respirology and Critical Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia |
Abdullah, M., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia, Indonesia Medical Education and Research Institute - Human Cancer Research Center, University of Indonesia Faculty of Medicine, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Sudrajat, D.G., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Muzellina, V.N., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Kurniawan, J., Hepatobilliary Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Rizka, A., Geriatric Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Utari, A.P., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Pribadi, R.R., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Idrus, M.F., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Yusra, Y., Department of Clinical Pathology, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region Jakarta, Indonesia; Meilany, S., Research Center for Virology and Cancer Pathobiology, University of Indonesia Faculty of Medicine, Jakarta, Special Capital Region of Jakarta, Indonesia; Surandy, A., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Shatri, H., Psychosomatic and Palliative Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Special Capital Region of Jakarta, Central Jakarta, Indonesia; Rinaldi, I., Hematology and Medical Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Pitoyo, C.W., Respirology and Critical Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Renaldi, K., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia |
Objective This study will test the performance of the anal swab PCR test when compared with the nasopharyngeal swab PCR test as a diagnostic tool for COVID-19. Design An observational descriptive study which included hospitalised suspected, or probable cases of hopitalised COVID-19 patients, conducted in Dr. Cipto Mangunkusumo National Hospital, Ciputra Hospital, Mitra Keluarga Depok Hospital and Mitra Keluarga Kelapa Gading Hospital, Indonesia. Epidemiological, clinical, laboratory and radiology data were obtained. Nasopharyngeal and anal swabs specimens were collected for SARS-CoV-2 RNA detection. Results We analysed 136 subjects as part of this study. The clinical spectrum of COVID-19 manifesation in this study was typical of hospitalised patients, with 25% classified as mild cases, 14.7% in severe condition and 12.5% of subjects classified as having acute respiratory distress syndrome. When compared with nasopharyngeal swab as the standard specimen for reverse transcription polymerase chain reaction (RT-PCR) detection of SARS-CoV-2 antigen, the sensitivity and specificity of the anal swab was 36.7% and 93.8%, respectively. The positive and negative predictive value were 97.8% and 16.5 %, respectively. The performance of the anal swab remained similar when only the subgroup of patients with gastrointestinal symptoms (n=92, 67.6%) was analysed (sensitivity 40% and specificity 91.7%). Out of all the subjects included in analysis, 67.6% had gastrointestinal symptoms. Similarly, 73.3% of patients in the anal swab-positive group had gastrointestinal symptoms. The two most common gastrointestinal symptoms in the subjects' population were nausea and anorexia. Conclusion Anal swab specimen has low sensitivity (36.7%) but high specificity (93.8%) for detecting SARS-CoV-2 antigen by RT-PCR. Only one additional positive result was found by anal swab among the nasopharyngeal swab-negative group. Anal swab may not be needed as an additional test at the beginning of a patient's diagnostic investigation and nasopharyngeal swab RT-PCR remains as the standard diagnostic test for COVID-19. © 2020 American Society of Mechanical Engineers (ASME). All rights reserved. |
anal; COVID-19; diagnostic virology |
abdominal pain; adult; adult respiratory distress syndrome; anal swab; anorexia; Article; body mass; clinical laboratory; controlled study; coronavirus disease 2019; coughing; COVID-19 testing; current smoker; diagnostic test accuracy study; diarrhea; ex-smoker; female; fever; gastrointestinal symptom; headache; heart disease; hospital patient; human; hypertension; Indonesian; lung disease; major clinical study; malaise; male; mortality rate; nasopharyngeal swab; nausea; non insulin dependent diabetes mellitus; practice guideline; predictive value; priority journal; respiratory tract infection; reverse transcription polymerase chain reaction; sensitivity and specificity; sore throat |
BMJ Publishing Group |
20544774 |
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Article |
Q1 |
1240 |
3126 |
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432 |
Aitken R.J., Curry B.J., Shokri S., Pujianto D.A., Gavriliouk D., Gibb Z., Whiting S., Connaughton H.S., Nixon B., Salamonsen L.A., Baker M.A. |
7201959888;56908506100;8856710600;8745734300;56926729700;36650800200;55363694400;55488741500;34571659200;7005800278;57201355280; |
Evidence that extrapancreatic insulin production is involved in the mediation of sperm survival |
2021 |
Molecular and Cellular Endocrinology |
526 |
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111193 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101239641&doi=10.1016%2fj.mce.2021.111193&partnerID=40&md5=dd3268ec7434c8487b5f42a0d81d0e4a |
Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia; Department of Anatomical Sciences, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Family Fertility Centre, Ashford Specialist CentreSA 5035, Australia; Hudson Institute of Medical Research, Centre for Reproductive Health, Monash UniversityVIC 3168, Australia |
Aitken, R.J., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia, Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia; Curry, B.J., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Shokri, S., Department of Anatomical Sciences, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; Pujianto, D.A., Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Gavriliouk, D., Family Fertility Centre, Ashford Specialist CentreSA 5035, Australia; Gibb, Z., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Whiting, S., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Connaughton, H.S., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Nixon, B., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia, Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia; Salamonsen, L.A., Hudson Institute of Medical Research, Centre for Reproductive Health, Monash UniversityVIC 3168, Australia; Baker, M.A., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia, Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia |
Evidence is presented for expression of the insulin receptor on the surface of mammalian spermatozoa as well as transcripts for the receptor substrate adaptor proteins (IRS1-4) needed to mediate insulin action. Exposure to this hormone resulted in insulin receptor phosphorylation (pTyr972), activation of AKT (pSer473) and the stimulation of sperm motility. Intriguingly, the male germ line is also shown to be capable of generating insulin, possessing the relevant mRNA transcript and expressing strong immunocytochemical signals for both insulin and C-peptide. Insulin could be released from the spermatozoa by sonication in a concentration-dependent manner but was not secreted in response to glucose, fructose or stimulation with progesterone. However, insulin release could be induced by factors present in human uterine lavages. Furthermore, the endometrium was also shown to possess the machinery for insulin production and action (mRNA, insulin, C-peptide, proprotein convertase and insulin receptor), releasing insulin into the uterine lumen prior to ovulation. These studies emphasize the fundamental importance of extra-pancreatic insulin in regulating the reproductive process, particularly in the support of spermatozoa on their perilous voyage to the site of fertilization. © 2021 Elsevier B.V. |
AKT-1; Apoptosis; Insulin; Motility; Spermatozoa |
C peptide; fructose; glucose; insulin; insulin receptor; messenger RNA; progesterone; proprotein convertase 1; proprotein convertase 3; protein kinase B; serine proteinase; unclassified drug; C peptide; insulin; insulin receptor; insulin receptor substrate; isoprotein; adult; animal tissue; Article; controlled study; enzyme activation; female; fertilization; human; immunocytochemistry; insulin release; male; mouse; nested polymerase chain reaction; nonhuman; ovulation; protein function; protein phosphorylation; protein RNA binding; real time polymerase chain reaction; spermatozoon motility; animal; biosynthesis; cell survival; cytology; endometrium; epithelium; germ cell; mammal; metabolism; pancreas; rat; spermatozoon; uterus; Animals; C-Peptide; Cell Survival; Endometrium; Epithelium; Fe |
Elsevier Ireland Ltd |
03037207 |
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33610643 |
Article |
Q1 |
1296 |
2909 |
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470 |
Takhwifa F., Aninditha T., Setiawan H., Sauriasari R. |
57222711645;57189611205;55292870100;16246507200; |
The potential of metformin as an antineoplastic in brain tumors: A systematic review |
2021 |
Heliyon |
7 |
4 |
e06558 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103788211&doi=10.1016%2fj.heliyon.2021.e06558&partnerID=40&md5=ec9287d374f7d13b7c0752898249a4ba |
Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Takhwifa, F., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia; Aninditha, T., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiawan, H., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia; Sauriasari, R., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia |
Brain tumors are challenging to handle and cause severe mortality and morbidity. The primary therapy for brain tumors, a combination of radiotherapy, chemotherapy (i.e temozolomide), and corticosteroids, is considered inadequate to improve patients' clinical conditions and associated with many adverse effects. There is an urgent need for new compounds or repurposing of existing therapies, which could improve brain tumor patients' prognosis. Metformin, commonly used for type 2 diabetes medication, has been examined for its protective action in cancer, reducing cancer risk and cancer-related mortality. However, its effect on cancer is still in rigorous debate. This study examines recent studies on the effects of metformin in primary brain tumor patients through systematic reviews. The literature search was performed on PubMed, ScienceDirect, and SpringerLink databases for articles published between 2013 and 2020. We selected clinical studies comparing the therapeutic outcomes of brain tumor therapy with and without metformin. The clinical benefits of the drug were assessed through the overall survival (OS) and progression-free survival (PFS) of brain tumor patients. Those studies demonstrated that the combination of metformin with temozolomide given post-radiotherapy resulted in better OS and PFS. Nonetheless, the efficacy and safety of metformin need further clinical testing in the wider population. © 2021 The Authors |
Antidiabetic; Antineoplastic; Metformin; Primary brain tumor; Survival |
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Elsevier Ltd |
24058440 |
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Review |
Q1 |
455 |
10919 |
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491 |
Susanto A.D., Triyoga P.A., Isbaniah F., Fairuz A., Cendikiawan H., Zaron F., Aryanti I., Irbah S.N., Hidayat M. |
57190425587;57222896246;36489441300;57222895896;57222896833;57222896488;57222896415;57222896232;56435992700; |
Lung fibrosis sequelae after recovery from COVID-19 infection |
2021 |
Journal of Infection in Developing Countries |
15 |
3 |
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360 |
365 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104167707&doi=10.3855%2fjidc.13686&partnerID=40&md5=622edaeb2b1f79f472a58df7a7dfdca2 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia; Lung Clinic, Eka Hospital Cibubur, West Java, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Radiology Departement, Eka Hospital Cibubur, West Java, Indonesia; Faculty of Medicine, University of Mataram, Mataram, West Nusa Tenggara, Indonesia |
Susanto, A.D., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia, Lung Clinic, Eka Hospital Cibubur, West Java, Indonesia; Triyoga, P.A., Lung Clinic, Eka Hospital Cibubur, West Java, Indonesia; Isbaniah, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia; Fairuz, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cendikiawan, H., Radiology Departement, Eka Hospital Cibubur, West Java, Indonesia; Zaron, F., Radiology Departement, Eka Hospital Cibubur, West Java, Indonesia; Aryanti, I., Radiology Departement, Eka Hospital Cibubur, West Java, Indonesia; Irbah, S.N., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hidayat, M., Faculty of Medicine, University of Mataram, Mataram, West Nusa Tenggara, Indonesia |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that causes coronavirus diseases 2019 (COVID-19). The SARS-CoV-2 is very contagious and nobody is known to be immune to it. The post-infected lung would leave a scar known as fibrosis, a scar tissue. A study from Wuhan, China suggested the development of fibrosis, though it was too early to label these lung changes as irreversible fibrosis in a time range of 3 weeks. The occurrence of fibrosis indicates a chronic infection which greatly contributes to the hallmark symptom of COVID-19 induced ARDS such as shortness of breath and chest pain. However, many of those studies have not yet explained the condition of the patient's lung after total recovery from the COVID-19. This report demonstrates the clinical symptoms, chest CT scan, spirometry, and blood gas analysis of patient after total recovery from the COVID-19 with appearance lung fibrosis. Copyright © 2021 Susanto et al. |
COVID-19; Lung fibrosis; Recovery |
ascorbic acid plus vitamin B complex; azithromycin; beta 2 adrenergic receptor stimulating agent; chloroquine; corticosteroid; hemoglobin; levofloxacin; meropenem; oseltamivir; adult; adult respiratory distress syndrome; Article; blood gas analysis; breathing rate; case report; cell count; clinical article; computer assisted tomography; coronavirus disease 2019; coughing; dyspnea; fever; forced expiratory volume; forced vital capacity; ground glass opacity; headache; hospitalization; human; lung examination; lung fibrosis; male; middle aged; nose smear; oropharyngeal swab; oxygen saturation; oxygen therapy; physical examination; pneumonia; quality of life; real time polymerase chain reaction; rhinorrhea; Severe acute respiratory syndrome coronavirus 2; spirometry; thorax pain; thorax radio |
Journal of Infection in Developing Countries |
20366590 |
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33839710 |
Article |
Q3 |
322 |
14136 |
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