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301 |
Utami P.D., Hadi U., Dachlan Y.P., Suryokusumo G., Loeki Enggar Fitri R., Yudo V. |
57221766908;55804160500;6602868510;57205444996;57226796443;57226798501; |
Protection against brain histopathological damage in experimental cerebral malaria models after exposure to hyperbaric oxigent |
2021 |
Research Journal of Pharmacy and Technology |
14 |
7 |
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3833 |
3838 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112730263&doi=10.52711%2f0974-360X.2021.00665&partnerID=40&md5=1e7f971b7e62fc8286374b6c4e534dd9 |
Department of Parasitology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia; Department of Internal Medicine, Dr. Soetomo Hospital, Universitas Airlangga, Surabaya, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Occupational Health, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Microbiology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia |
Utami, P.D., Department of Parasitology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia; Hadi, U., Department of Internal Medicine, Dr. Soetomo Hospital, Universitas Airlangga, Surabaya, Indonesia; Dachlan, Y.P., Department of Parasitology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Suryokusumo, G., Department of Occupational Health, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Loeki Enggar Fitri, R., Department of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Yudo, V., Department of Microbiology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia |
In this study, brain damage caused by cerebral malaria was induced by parasitized erythrocyte rupture and sequestration, which led to inflammation and blood vessel damage. Therefore, this research objective to determine the effect of oxygen administration on the histopathological features and sequestration of CD3 lymphocyte T cells on Plasmodium berghei ANKA/PbA-infected vascular endothelial brain tissue of mice. The study samples consisted of 39 C57BL/6 mice, which were divided into 3 groups: G1 contained normal mice; G2 contained PbA-infected mice; G3 were mice infected with PbA, and administered HBO 2.4 ATA for 10 days straight. Histopathological examination of the of brain tissue and CD3 lymphocyte T cell expression was carried out using immuno-histochemical at the end of the study. Therefore, the results of this study indicate that HBO administration can reduce the level of parasites, can improve the histopathological features of the brain, and can reduce the sequestration of CD3 cells in the brain's blood vessels. According to the results, it can be concluded that 10 sessions of HBO 2.4 ATA exposure can reduce the level of parasites, enhance the histopathological features of brain tissue and decrease the sequestration of CD3 lymphocyte T cells. © RJPT All right reserved. |
CD3 cells; Cerebral malaria; Endothel; Histopathological; Hyperbaric oxygen |
CD3 antigen; cytotoxic T lymphocyte antigen 4; ketamine; reactive oxygen metabolite; tumor necrosis factor; animal cell; animal experiment; animal model; animal tissue; Article; blood brain barrier; blood smear; blood vessel injury; brain damage; brain protection; brain tissue; CD4+ T lymphocyte; CD8+ T lymphocyte; cell adhesion; cerebral malaria; consciousness; controlled study; endothelium; endothelium cell; erythrocyte count; female; gene expression; hematological parameters; histochemistry; histopathology; hyperbaric oxygen therapy; immunohistochemistry; inflammation; leukocyte count; malaria; mortality rate; neutrophil lymphocyte ratio; nonhuman; oxygen therapy; parasitemia; phagocytosis; Plasmodium berghei ANKA; protein expression; T lymphocyte |
Research Journal of Pharmacy and Technology |
09743618 |
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Article |
Q3 |
225 |
17916 |
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302 |
Menaldi S.L., Dinakrisma A.A., Thio H.B., Rengganis I., Oktaria S. |
57192918198;57208817505;6603706049;8449988000;57189897691; |
Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection |
2021 |
PLoS Neglected Tropical Diseases |
15 |
7 |
e0009453 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112233539&doi=10.1371%2fjournal.pntd.0009453&partnerID=40&md5=ca1861c9fbca4ae66dbabcdc89952023 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Dermatology, Erasmus University Medical Center, Rotterdam, Netherlands |
Menaldi, S.L., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dinakrisma, A.A., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Thio, H.B., Department of Dermatology, Erasmus University Medical Center, Rotterdam, Netherlands; Rengganis, I., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oktaria, S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Dermatology, Erasmus University Medical Center, Rotterdam, Netherlands |
AU: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly: We describe an unusual case of type 2 leprosy reaction (T2R) with septic shock–like features induced by helminth infection in a 31-year-old Moluccan male patient with a history of completed treatment of WHO multidrug therapy (MAU: PleasenotethatMDThasbeendefinedasmultidrugt DT)–multibacillary (MB) regimen 2 years before admission. During the course of illness, the patient had numerous complications, including septic shock, anemia, and disseminated intravascular coagulation (DIC). Nevertheless, antibiotic therapies failed to give significant results, and the source of infection could not be identified. Helminth infection was subsequently revealed by endoscopic examination followed by parasitological culture. Resolution of symptoms and normal level of organ function–specific markers were resolved within 3 days following anthelmintic treatment. This report demonstrated the challenge in the diagnosis and treatment of severe T2R. Given that helminth infections may trigger severe T2R that mimics septic shock, health professionals need to be aware of this clinical presentation, especially in endemic regions of both diseases. © 2021 Fongwen et al. |
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leprostatic agent; adult; animal; case report; classification; complication; genetics; helminth; helminthiasis; human; isolation and purification; leprosy; male; opportunistic infection; parasitology; sepsis; Adult; Animals; Helminthiasis; Helminths; Humans; Leprostatic Agents; Leprosy; Male; Opportunistic Infections; Sepsis |
Public Library of Science |
19352727 |
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34314436 |
Article |
Q1 |
1990 |
1322 |
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304 |
Gunawan S., Aulia A., Soetikno V. |
57226331078;57201441066;36769252100; |
Development of rat metabolic syndrome models: A review |
2021 |
Veterinary World |
14 |
7 |
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1774 |
1783 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111179239&doi=10.14202%2fvetworld.2021.1774-1783&partnerID=40&md5=609e64dbfe9d6c9660d991f611abbd71 |
Department of Pharmacology, Faculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia; Doctoral Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Gunawan, S., Department of Pharmacology, Faculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia, Doctoral Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Aulia, A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soetikno, V., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Metabolic syndrome (MetS) has become a global problem. With the increasing prevalence of MetS worldwide, understanding its pathogenesis and treatment modalities are essential. Animal models should allow an appropriate representation of the clinical manifestations of human conditions. Rats are the most commonly used experimental animals for the study. The development of a proper MetS model using rats will contribute to the successful application of research findings to the clinical setting. Various intervention methods are used to induce MetS through diet induction with various compositions, chemicals, or a combination of both. This review will provide a comprehensive overview of several studies on the development of rat MetS models, along with the characteristics of the clinical manifestations resulting from each study. © 2021 Veterinary World. All rights reserved. |
High-fat diet; High-fructose diet; High-sucrose diet; Metabolic syndrome; Rat models |
cholesterol; diacylglycerol; glucose; high density lipoprotein cholesterol; leptin receptor; low density lipoprotein cholesterol; triacylglycerol; abdominal circumference; abdominal obesity; animal model; bipolar disorder; body weight; bone metabolism; caloric intake; carbohydrate intake; cardiovascular disease; diastolic blood pressure; dyslipidemia; exercise; fat mass; food intake; gene; glucose blood level; glucose tolerance; high-fructose diet; human; hyperglycemia; insulin resistance; insulin sensitivity; insulin tolerance test; lipid diet; lipid metabolism; lipid storage; lipogenesis; major depression; male; mental disease; metabolic syndrome X; nonalcoholic fatty liver; nonhuman; osmotic stress; oxidative stress; pathogenesis; physical activity; prevalence; rat; Review; risk factor; |
Veterinary World |
09728988 |
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Review |
Q2 |
550 |
9187 |
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307 |
Wiguna T., Ismail R.I., Kaligis F., Minayati K., Murtani B.J., Wigantara N.A., Pradana K., Bahana R., Dirgantoro B.P., Nugroho E. |
24367785700;55996895500;36604651700;57218681686;57216652176;57218679014;57220165625;56400946100;57202082268;56493037400; |
Developing and feasibility testing of the Indonesian computer-based game prototype for children with attention deficit/hyperactivity disorder |
2021 |
Heliyon |
7 |
7 |
e07571 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110552291&doi=10.1016%2fj.heliyon.2021.e07571&partnerID=40&md5=8eca39aaa9e8ed828955cacd6838b22f |
Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Computer Science, Bina Nusantara University, Jakarta, Indonesia; Kummara Game Design Studio, Bandung, West Java, Indonesia |
Wiguna, T., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Ismail, R.I., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Kaligis, F., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Minayati, K., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Wigantara, N.A., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pradana, K., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Bahana, R., Department of Computer Science, Bina Nusantara University, Jakarta, Indonesia; Dirgantoro, B.P., Department of Computer Science, Bina Nusantara University, Jakarta, Indonesia; Nugroho, E., Kummara Game Design Studio, Bandung, West Java, Indonesia |
The aim of this study was to develop an Indonesian computer-based game prototype, including feasibility testing, targeted on attention deficit/hypersensitivity disorder (ADHD) clinical symptoms and executive function. The study comprised five steps. The first to third steps used an exploratory qualitative research design. The Delphi technique with FGD was applied to collect qualitative data. During the study, seven experts participated in ten FGDs. Feasibility testing was conducted as a one group pre- and post-test design that included ten children with drug-naïve ADHD without other mental or physical disorders. Feasibility data were collected before and after 20 training sessions with the Indonesian computer-based game prototype. The framework analysis was performed for qualitative data. Quantitative data were analyzed using the paired t-test, Pearson's correlation and Spearman's rank-order correlation. Outputs of the exploratory qualitative study were the Indonesian computer-based game prototype constructs and general agreements of the prototype,. The Indonesian computer-based game prototype construct comprised six components: reward-related processing, control inhibition, improved sustained attention, specific timing, increased arousal, and improved emotional regulation. After 20 sessions of training, several indicators decreased significantly, such as CATPRS-teacher rating (18.5 [5.31] vs. 12.9 [5.51], p = 0.047), BRIEF-GEC (64.80 [10.21] vs. 57.50 [7.51], p = 0.02), BRIEF-MI (66.1 [7.61] vs. 58.4 [7.56], p = 0.014), BRIEF-Initiate (66.6 [10.15] vs. 54.1 [6.49], p = 0.008), BRIEF-Working Memory (68.0 [6.89] vs. 60.9 [10.05], p = 0.02), and BRIEF-Organization of Material (60.7 [12.88] vs. 49.3 [11.79], p = 0.04). There was a low to moderate correlation between CATPRS-teacher and -parent rating and several BRIEF domains. Feasibility testing output also included the training procedure guideline. The present study indicated that the Indonesian computer-based game prototype could be used as a framework to develop a fixed computer-based game intervention for children with ADHD. However, further randomized controlled studies need to be conducted to show its effectiveness. © 2021 The Author(s) |
ADHD; Behavioral Rating Inventory for Executive Function; Computer-based game; Connors Abbreviated Teacher; Executive function; Indonesia |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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309 |
Putri N.M., Kreshanti P., Aulia I., Syarif A.N., Tunjung N., Sukasah C.L. |
57192904294;36192866200;57204495153;57247430600;57208446370;57218391534; |
Use of local perforator flaps for closure of a thoraco-omphalopagus conjoined twin defect after separation during the COVID-19 pandemic |
2021 |
Heliyon |
7 |
7 |
e07443 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109574685&doi=10.1016%2fj.heliyon.2021.e07443&partnerID=40&md5=8fe6d81617877cb017dabe11c561c536 |
Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Putri, N.M., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kreshanti, P., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Aulia, I., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Syarif, A.N., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Tunjung, N., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sukasah, C.L., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: Conjoined twins are a rare medical phenomenon that poses unique challenges for surgeons. Separation of conjoined twins involves multidisciplinary teamwork, complex medical management and surgical planning, and multi-stage operations and often still has a high mortality and morbidity rate. In the times of the COVID-19 pandemic, separation of conjoined twins pose even greater challenges. Aiming for the best outcome possible, while minimizing the risk of COVID transmission and ensuring the safety of the personnel, is paramount. This case report presents thoraco-omphalopagus twins who were successfully separated at 4 months of age. The preoperative planning, operative details, postoperative follow-ups, and outcomes are discussed. Methods: The absence of a tissue expander and the inability to acquire it due to travel restrictions from COVID-19 further complicated the management on this patient. A Routine Polymerase Chain Reaction (PCR) swab test was performed on the patients and personnel. Standardized personnel protective equipment (PPE) was worn during ward and surgical care. After separation of the twins by cardiothoracic and pediatric surgeons, one twin underwent immediate skin closure using a double keystone perforator island flap and a lower abdominal perforator flap. Due to extensive defects, closure was delayed for the second twin. After a series of dressing changes, eventually local perforator flaps could be raised to close the defect using staged tension sutures and skin grafts for secondary defects. Results: Both twins were discharged with no significant morbidity, and no personnel were exposed to COVID-19 infection during the management. Conclusion: Preoperative coordination and planning, multidisciplinary effort, adherence to screening protocols for COVID, and strict use of standardized PPE all contributed to the successful separation of thoraco-omphalopagus conjoined twins during the COVID-19 pandemic. © 2021 The Author(s) |
Case report; COVID-19; Negative pressure wound therapy; Perforator flaps; Thoraco-omphalopagus conjoined twins |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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311 |
Sunardi D., Bardosono S., Basrowi R.W., Wasito E., Vandenplas Y. |
57192075078;21933841000;57024210400;6506940239;57223670656; |
Dietary determinants of anemia in children aged 6–36 months: A cross-sectional study in Indonesia |
2021 |
Nutrients |
13 |
7 |
2397 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109524537&doi=10.3390%2fnu13072397&partnerID=40&md5=2e8ac565ce8b6f3dd3f70a2de509a9ad |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Medical Nutrition for Danone Specialized Nutrition, Yogyakarta, 55165, Indonesia; Vrije Universiteit Brussel (VUB), UZ Brussels, KidZ Health Castle, Brussels, 1090, Belgium |
Sunardi, D., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Basrowi, R.W., Medical Nutrition for Danone Specialized Nutrition, Yogyakarta, 55165, Indonesia; Wasito, E., Medical Nutrition for Danone Specialized Nutrition, Yogyakarta, 55165, Indonesia; Vandenplas, Y., Vrije Universiteit Brussel (VUB), UZ Brussels, KidZ Health Castle, Brussels, 1090, Belgium |
Anemia has been acknowledged as worldwide problem, including in Indonesia. This cross-sectional study aims to explore dietary determinants as risk factors for anemia in children aged 6–36 months living in a poor urban area of Jakarta. The study was done in Kampung Melayu sub-district in Jakarta, Indonesia. Data was collected within two weeks in September–October 2020. A structured questionnaire for a 24-h recall and a semi-quantitative Food Frequency Questionnaire (FFQ) were used to collect the dietary intake data, and venous blood was withdrawn to determine the hemoglobin levels. Bivariate chi-square and multiple logistic regression tests were executed to explore the dietary determinant factors for anemia. We recruited 180 subjects. The average hemoglobin concentration was 11.4 ± 1.7 mg/dL; the anemia prevalence was 29.4%. The following variables were significantly associated with higher risk of anemia: no cow’s milk formula consumption, inadequate intake of fats, protein, calcium, vitamin D, iron, zinc, vitamin A, vitamin C, vitamin B6, and vitamin B12. Only cow’s milk formula consumption and zinc intake were revealed as the determinant factors of anemia. In conclusion, the prevalence of anemia was 29.4% among children aged 6–36 months old. Anemia was significantly associated with two dietary determinants as risk factors that are cow’s milk formula consumption and zinc intake. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Anemia; Cow’s milk; Cow’s milk formula; Indonesia; Toddler; Zinc |
biological marker; hemoglobin; zinc; adverse event; age; anemia; artificial milk; blood; bottle feeding; cross-sectional study; diet; female; human; Indonesia; infant; infant nutrition; male; metabolism; nutritional status; pathophysiology; preschool child; prevalence; risk assessment; risk factor; urban health; Age Factors; Anemia; Biomarkers; Bottle Feeding; Child, Preschool; Cross-Sectional Studies; Diet; Diet Surveys; Female; Hemoglobins; Humans; Indonesia; Infant; Infant Formula; Infant Nutritional Physiological Phenomena; Male; Nutritional Status; Prevalence; Risk Assessment; Risk Factors; Urban Health; Zinc |
MDPI AG |
20726643 |
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34371908 |
Article |
Q1 |
1418 |
2497 |
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315 |
Purnomo G.A., Mitchell K.J., O’connor S., Kealy S., Taufik L., Schiller S., Rohrlach A., Cooper A., Llamas B., Sudoyo H., Teixeira J.C., Tobler R. |
56262110300;55937278100;57192065848;57016654100;57225108034;57225091129;56674549200;57225849511;8695218700;6603548824;56290678400;55780763900; |
Mitogenomes reveal two major influxes of papuan ancestry across wallacea following the last glacial maximum and austronesian contact |
2021 |
Genes |
12 |
7 |
965 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109185551&doi=10.3390%2fgenes12070965&partnerID=40&md5=046fa96fdfa7683fb4a23714ea942197 |
Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia; Genome Diversity and Diseases Laboratory, Eijkman Institute of Molecular Biology, Jakarta, 10430, Indonesia; ARC Centre of Excellence for Australian Biodiversity and Heritage, University of Adelaide, Adelaide, 5005, Australia; Archaeology and Natural History, School of Culture, History and Language, College of Asia and the Pacific, Australian National University, Canberra, 2601, Australia; ARC Centre of Excellence for Australian Biodiversity and Heritage, Australian National University, Canberra, 2601, Australia; Evolution of Cultural Diversity Initiative, Australian National University, Canberra, 2601, Australia; ARC Centre of Excellence for Mathematical and Statistical Frontiers, School of Mathematical Sciences, The University of Adelaide, Adelaide, 5005, Australia; Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, 07745, Germany; Blue Sky Genetics, P.O. Box 287, Adelaide, 5137, Australia; South Australian Museum, Adelaide, 5000, Australia; Environment Institute, University of Adelaide, Adelaide, 5005, Australia; National Centre for Indigenous Genomics, Australian National University, Canberra, 2601, Australia; Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Sydney Medical School, University of Sydney, Sydney, 2050, Australia |
Purnomo, G.A., Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia, Genome Diversity and Diseases Laboratory, Eijkman Institute of Molecular Biology, Jakarta, 10430, Indonesia; Mitchell, K.J., Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage, University of Adelaide, Adelaide, 5005, Australia; O’connor, S., Archaeology and Natural History, School of Culture, History and Language, College of Asia and the Pacific, Australian National University, Canberra, 2601, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage, Australian National University, Canberra, 2601, Australia; Kealy, S., Archaeology and Natural History, School of Culture, History and Language, College of Asia and the Pacific, Australian National University, Canberra, 2601, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage, Australian National University, Canberra, 2601, Australia, Evolution of Cultural Diversity Initiative, Australian National University, Canberra, 2601, Australia; Taufik, L., Genome Diversity and Diseases Laboratory, Eijkman Institute of Molecular Biology, Jakarta, 10430, Indonesia; Schiller, S., ARC Centre of Excellence for Mathematical and Statistical Frontiers, School of Mathematical Sciences, The University of Adelaide, Adelaide, 5005, Australia; Rohrlach, A., ARC Centre of Excellence for Mathematical and Statistical Frontiers, School of Mathematical Sciences, The University of Adelaide, Adelaide, 5005, Australia, Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, 07745, Germany; Cooper, A., Blue Sky Genetics, P.O. Box 287, Adelaide, 5137, Australia, South Australian Museum, Adelaide, 5000, Australia; Llamas, B., Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage, University of Adelaide, Adelaide, 5005, Australia, Environment Institute, University of Adelaide, Adelaide, 5005, Australia, National Centre for Indigenous Genomics, Australian National University, Canberra, 2601, Australia; Sudoyo, H., Genome Diversity and Diseases Laboratory, Eijkman Institute of Molecular Biology, Jakarta, 10430, Indonesia, Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia, Sydney Medical School, University of Sydney, Sydney, 2050, Australia; Teixeira, J.C., Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage, University of Adelaide, Adelaide, 5005, Australia, Evolution of Cultural Diversity Initiative, Australian National University, Canberra, 2601, Australia; Tobler, R., Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage, University of Adelaide, Adelaide, 5005, Australia, Evolution of Cultural Diversity Initiative, Australian National University, Canberra, 2601, Australia |
The tropical archipelago of Wallacea contains thousands of individual islands interspersed between mainland Asia and Near Oceania, and marks the location of a series of ancient oceanic voyages leading to the peopling of Sahul—i.e., the former continent that joined Australia and New Guinea at a time of lowered sea level—by 50,000 years ago. Despite the apparent deep antiquity of human presence in Wallacea, prior population history research in this region has been hampered by patchy archaeological and genetic records and is largely concentrated upon more recent history that follows the arrival of Austronesian seafarers ~3000–4000 years ago (3–4 ka). To shed light on the deeper history of Wallacea and its connections with New Guinea and Australia, we performed phylogeographic analyses on 656 whole mitogenomes from these three regions, including 186 new samples from eight Wallacean islands and three West Papuan populations. Our results point to a surprisingly dynamic population history in Wallacea, marked by two periods of extensive demographic change concentrated around the Last Glacial Maximum ~15 ka and post-Austronesian contact ~3 ka. These changes appear to have greatly diminished genetic signals informative about the original peopling of Sahul, and have important implications for our current understanding of the population history of the region. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Human migrations; Mitochondria; MtDNA; Phylogeography; Sahul |
mitochondrial DNA; ancestry group; Article; Asia; Australia; Austronesian people; biogeographic region; gene sequence; haplotype; human; last glacial maximum; migration; mitochondrial genome; Papua New Guinea; Philippines; phylogeny; phylogeography; polymerase chain reaction; population size; population structure; sailor; sequence alignment; simulation; Wallacea; animal; archeology; beetle; female; genetics; history; male; mitochondrial genome; Pacific islands; phylogeny; phylogeography; population genetics; Animals; Archaeology; Asia; Australia; Coleoptera; Female; Genetics, Population; Genome, Mitochondrial; Haplotypes; History, Ancient; Humans; Male; New Guinea; Oceania; Phylogeny; Phylogeography |
MDPI |
20734425 |
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34202821 |
Article |
Q2 |
1337 |
2737 |
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433 |
Jiamsakul A., Azwa I., Zhang F., Yunihastuti E., Ditangco R., Kumarasamy N., Ng O.T., Chan Y.-J., Ly P.S., Choi J.Y., Lee M.-P., Pujari S., Kiertiburanakul S., Chaiwarith R., Merati T.P., Sangle S., Khusuwan S., Sim B.L.H., Avihingsanon A., Do C.D., Tanuma J., Ross J., Law M., the TREAT Asia HIV Observational Database of IeDEA Asia-Pacific |
55285745500;55553159100;55503803800;57221273925;55406840800;7003549856;57203665233;33667461800;9743902800;48761023600;56143671100;57205894660;6506539792;57203665049;57203678680;6602877716;56166613100;9242778900;57200282477;56658396600;57208428839;57193109926;57222965808; |
Treatment modification after second-line failure among people living with HIV in Asia-Pacific |
2021 |
Antiviral Therapy |
25 |
7 |
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377 |
387 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106544855&doi=10.3851%2fIMP3388&partnerID=40&md5=485e6ef464b90e2346135f1d92ba9394 |
The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia; University of Malaya Medical Centre, Kuala Lumpur, Malaysia; Beijing Ditan Hospital, Capital Medical University, Beijing, China; Working Group on AIDS, Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Research Institute for Tropical Medicine, Manila, Philippines; Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), The Voluntary Health Services (VHS), Chennai, India; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore; Taipei Veterans General Hospital, Taipei, Taiwan; National Center for HIV/AIDS, Dermatology and STDs, University of Health Sciences, Phnom Penh, Cambodia; Division of Infectious Diseases, Department of Internal Medicine, Yonsei University, College of Medicine, Seoul, South Korea; Queen Elizabeth Hospital, Yau Ma Tei, Hong Kong; Institute of Infectious Diseases, Pune, India; Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Research Institute for Health Sciences, Chiang Mai, Thailand; Faculty of Medicine, Udayana University, Sanglah Hospital, Bali, Indonesia; BJ Government Medical College, Sassoon General Hospital, Pune, India; Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Hospital Sungai Buloh, Sungai Buloh, Malaysia; HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Bach Mai Hospital, Hanoi, Viet Nam; National Center for Global Health and Medicine, Tokyo, Japan; TREAT Asia, AmfAR, The Foundation for AIDS Research, Bangkok, Thailand |
Jiamsakul, A., The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia; Azwa, I., University of Malaya Medical Centre, Kuala Lumpur, Malaysia; Zhang, F., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Yunihastuti, E., Working Group on AIDS, Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ditangco, R., Research Institute for Tropical Medicine, Manila, Philippines; Kumarasamy, N., Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), The Voluntary Health Services (VHS), Chennai, India; Ng, O.T., Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore; Chan, Y.-J., Taipei Veterans General Hospital, Taipei, Taiwan; Ly, P.S., National Center for HIV/AIDS, Dermatology and STDs, University of Health Sciences, Phnom Penh, Cambodia; Choi, J.Y., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University, College of Medicine, Seoul, South Korea; Lee, M.-P., Queen Elizabeth Hospital, Yau Ma Tei, Hong Kong; Pujari, S., Institute of Infectious Diseases, Pune, India; Kiertiburanakul, S., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Chaiwarith, R., Research Institute for Health Sciences, Chiang Mai, Thailand; Merati, T.P., Faculty of Medicine, Udayana University, Sanglah Hospital, Bali, Indonesia; Sangle, S., BJ Government Medical College, Sassoon General Hospital, Pune, India; Khusuwan, S., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Sim, B.L.H., Hospital Sungai Buloh, Sungai Buloh, Malaysia; Avihingsanon, A., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Do, C.D., Bach Mai Hospital, Hanoi, Viet Nam; Tanuma, J., National Center for Global Health and Medicine, Tokyo, Japan; Ross, J., TREAT Asia, AmfAR, The Foundation for AIDS Research, Bangkok, Thailand; Law, M., The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia; the TREAT Asia HIV Observational Database of IeDEA Asia-Pacific |
Background: The World Health Organization recommends continuation with the failing second-line regimen if third-line option is not available. We investigated treatment outcomes among people living with HIV in Asia who continued with failing second-line regimens compared with those who had treatment modifications after failure. Methods: Treatment modification was defined as a change of two antiretrovirals, a drug class change or treatment interruption (TI), all for >14 days. We assessed factors associated with CD4 changes and undetectable viral load (UVL <1,000 copies/ml) at 1 year after second-line failure using linear and logistic regression, respectively. Survival time was analysed using competing risk regression. Results: Of the 328 patients who failed second-line ART in our cohorts, 208 (63%) had a subsequent treatment modification. Compared with those who continued the failing regimen, the average CD4 cell increase was higher in patients who had a modification without TI (difference =77.5, 95% CI 35.3, 119.7) while no difference was observed among those with TI (difference =-5.3, 95% CI -67.3, 56.8). Compared with those who continued the failing regimen, the odds of achieving UVL was lower in patients with TI (OR=0.18, 95% CI 0.06, 0.60) and similar among those who had a modification without TI (OR=1.97, 95% CI 0.95, 4.10), with proportions of UVL 60%, 22% and 75%, respectively. Survival time was not affected by treatment modifications. Conclusions: CD4 cell improvements were observed in those who had treatment modification without TI compared with those on the failing regimen. When no other options are available, maintaining the same failing ART combination provided better VL control than interrupting treatment. © 2020 International Medical Press |
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Human immunodeficiency virus proteinase inhibitor; nonnucleoside reverse transcriptase inhibitor; RNA directed DNA polymerase inhibitor; adult; antiretroviral therapy; Article; Asia; CD4 lymphocyte count; clinical outcome; cohort analysis; confidence interval; controlled study; female; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; linear regression analysis; logistic regression analysis; major clinical study; male; odds ratio; survival time; treatment duration; treatment modification; undetectable virus load; virus load |
International Medical Press Ltd |
13596535 |
|
33843656 |
Article |
Q2 |
747 |
6553 |
|
|
|
921 |
Li S., Tarlac V., Christanto R.B.I., French S.L., Hamilton J.R. |
57211771149;6505711498;57218589212;56115043700;7403703575; |
Determination of PAR4 numbers on the surface of human platelets: no effect of the single nucleotide polymorphism rs773902 |
2021 |
Platelets |
32 |
7 |
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988 |
991 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089693705&doi=10.1080%2f09537104.2020.1810654&partnerID=40&md5=3b941631d42818b3c0eeae356d7833eb |
Australian Centre for Blood Diseases, Monash University, Melbourne, Australia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Li, S., Australian Centre for Blood Diseases, Monash University, Melbourne, Australia; Tarlac, V., Australian Centre for Blood Diseases, Monash University, Melbourne, Australia; Christanto, R.B.I., Australian Centre for Blood Diseases, Monash University, Melbourne, Australia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; French, S.L., Australian Centre for Blood Diseases, Monash University, Melbourne, Australia; Hamilton, J.R., Australian Centre for Blood Diseases, Monash University, Melbourne, Australia |
The thrombin receptor, protease-activated receptor 4 (PAR4), is important for platelet activation and is the target of emerging anti-thrombotic drugs. A frequently occurring single nucleotide polymorphism (SNP; rs773902) causes a function-altering PAR4 sequence variant (NC_000019.10:p.Ala120Thr), whereby platelets from Thr120-expressing individuals are hyper-responsive to PAR4 agonists and hypo-responsive to some PAR4 antagonists than platelets from Ala120-expressing individuals. This altered pharmacology may impact PAR4 inhibitor development, yet the underlying mechanism(s) remain unknown. We tested whether PAR4 surface expression contributes to the altered receptor function. Quantitative flow cytometry was used to determine the absolute number of PAR4 on platelets from individuals subsequently genotyped at rs773902. We detected 539 ± 311 PAR4 per platelet (mean ± SD, n = 84). This number was not different across rs773902 genotypes. This first determination of cellular PAR4 numbers indicates variations in platelet surface expression do not explain the altered pharmacology of the rs773902 PAR4 sequence variant. © 2020 Taylor & Francis Group, LLC. |
Platelets; protease-activated receptors; thrombin |
proteinase activated receptor 4; protease-activated receptor 4; thrombin receptor; adult; Article; cell surface; controlled study; flow cytometry; genetic association; genotype; human; human cell; protein expression; quantitative analysis; sequence analysis; single nucleotide polymorphism; thrombocyte activation; thrombocyte membrane; blood; metabolism; single nucleotide polymorphism; thrombocyte; Blood Platelets; Humans; Polymorphism, Single Nucleotide; Receptors, Thrombin |
Taylor and Francis Ltd. |
09537104 |
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32819173 |
Article |
Q2 |
939 |
4803 |
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