675 |
Anton J., Sudibio S., Handoko H., Permata T.B.M., Kodrat H., Nuryadi E., Sofyan H., Susanto E., Mulyadi R., Aman R.A., Gondhowiardjo S. |
57328462500;57283461500;57204105168;57197808751;57210639849;57197806814;57328366500;57204423225;56403164500;36848942500;6508327402; |
Overexpression of c-Met is Associated with Poor Prognosis in Glioblastoma Multiforme: A Systematic Review and Meta-Analyses |
2021 |
Asian Pacific Journal of Cancer Prevention |
22 |
10 |
|
3075 |
3080 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118768203&doi=10.31557%2fAPJCP.2021.22.10.3075&partnerID=40&md5=1f49d5bfee87f5293659fdc801e6d63a |
Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Neurology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pathology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radiology, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Anton, J., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sudibio, S., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Handoko, H., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Permata, T.B.M., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kodrat, H., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sofyan, H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Neurology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Susanto, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Pathology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Mulyadi, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiology, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Aman, R.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Neurology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gondhowiardjo, S., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: The aim of this study is to evaluate the association of c-Met overexpression with survival of glioblastoma multiforme (GBM) patients. Methods: A systematic review with meta-analyses was conducted on related articles from PubMed, EBSCOhost, Scopus, and Cochrane databases with last updated search on October 31, 2020. A total of 7 studies regarding c-Met overexpression and overall survival (OS) and/or progression free survival (PFS) are included in this study. Results: All studies used immunohistochemistry to examine the expression of c-Met protein. The results showed that the positive rate of c-Met overexpression was detected in approximately 33,9% - 60,5% of GBM patients. c-Met overexpression was related to worse OS (HR: 1,74; 95% CI: 1,482-2,043; Z=6,756; p<0,001) and PFS (HR: 1,66; 95% CI: 1,327-2,066; Z=4,464; p<0,001) in GBM patients. Low heterogeneity of subjects was found in both OS and PFS analyses, I2 values were 7,8% and 0,0%, respectively. Conclusion: In conclusion, c-Met overexpression is significantly related to shorter OS and PFS in GBM patients, so c-Met can be considered as a potential prognostic indicator in GBM. © 2021. All Rights Reserved. |
c-Met; glioblastoma multiforme; prognosis; survival |
MET protein, human; scatter factor receptor; brain tumor; glioblastoma; human; Kaplan Meier method; meta analysis; metabolism; mortality; prognosis; Brain Neoplasms; Glioblastoma; Humans; Kaplan-Meier Estimate; Prognosis; Progression-Free Survival; Proto-Oncogene Proteins c-met |
Asian Pacific Organization for Cancer Prevention |
15137368 |
|
34710981 |
Article |
Q2 |
512 |
9866 |
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