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876 |
Sari I.P., Audindra S., Zhafira A.S., Rahma A.A., Syarira C.V., Wahdini S. |
57197543698;57222006228;57205515532;57222005612;57222010715;57203684068; |
Nutritional status of school-aged children with intestinal parasite infection in South Jakarta, Indonesia |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
E |
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95 |
100 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100938719&doi=10.3889%2foamjms.2021.5711&partnerID=40&md5=1772780d39afba8ba66dd65e8997f0b4 |
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sari, I.P., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Audindra, S., Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Zhafira, A.S., Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahma, A.A., Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Syarira, C.V., Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wahdini, S., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: The prevalence of intestinal parasitic infection still high in Indonesia and lead to nutritional disorder, especially in the school-aged children. AIM: This research conducted to find the association of intestinal parasitic infection to the nutritional status of the children. METHODS: This was a cross sectional study, conducted in January 2016 in one primary school in South Jakarta, Jakarta, Indonesia, by collecting the children’s stool from 1st to 5th grade. Direct examination of the stool was conducted in the Parasitology Department, Faculty of Medicine, Universitas Indonesia, by Lugol and eosin staining. Nutritional status categorized using BMI chart. Data were analyzed using Chi-square test, Statistical Product, and Service Solutions version 20. RESULTS: From the total 157 stool examined in the laboratory, there were 60 (38.2%) children positively infected with various kinds of intestinal parasites. Mostly the infection is caused by Blastocystis hominis, which infects 44 children (69.4%). The other infection is caused by Giardia lamblia (15.3%), Trichuris trichiura (1.4%), and hookworm (1.4%), and mixed infection of B. hominis and Escherichia coli (4.2%) and B. hominis with G. lamblia (4.2%). From the total of infected children, 17 children (28.3%) have BMI below 5th percentile, and it was considered as malnourished. Moreover, 67 uninfected children have normal nutritional status. Statistically, there is an association between intestinal parasitic infection and nutritional status in school-aged children in South Jakarta (P < 0.05). CONCLUSION: The incidence of intestinal parasitic infection in school-aged children is 38.2%. Moreover, 28.3% of the infected children were malnourished and it is suggested that children with intestinal parasite infection have low nutritional status. © 2021 Ika Puspa Sari, Sacha Audindra, Aqila S. Zhafira, Arin A. Rahma, Cut V. Syarira, Sri Wahdini. |
Malnourish; Parasitic Infection; Primary Schools; South Jakarta |
Article; Blastocystis hominis; body mass; child; cross-sectional study; disease association; Escherichia coli; feces analysis; female; Giardia intestinalis; human; Indonesia; intestine parasite; major clinical study; male; malnutrition; mixed infection; nutritional status; obesity; parasitosis; prevalence; primary school; questionnaire; seasonal variation; Trichuris trichiura; underweight |
Open Access Macedonian Journal of Medical Sciences |
18579655 |
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Article |
Q3 |
288 |
15252 |
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909 |
Sugianto J.A., Hadipranata T., Lazarus G., Amrullah A.H. |
57221192052;57221199976;57214599425;57221196528; |
Proximal fibular osteotomy for the management of medial compartment knee osteoarthritis: A systematic review and meta-analysis |
2021 |
Knee |
28 |
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169 |
185 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098481652&doi=10.1016%2fj.knee.2020.11.020&partnerID=40&md5=3036d47b70bc39dabc84ff7ada033e00 |
Ngimbang General Hospital, LamonganEast Java, Indonesia; Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Orthopaedic and Traumatology Surgeon, Ngimbang General HospitalEast Java, Indonesia |
Sugianto, J.A., Ngimbang General Hospital, LamonganEast Java, Indonesia; Hadipranata, T., Ngimbang General Hospital, LamonganEast Java, Indonesia; Lazarus, G., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Amrullah, A.H., Orthopaedic and Traumatology Surgeon, Ngimbang General HospitalEast Java, Indonesia |
Background: The promising prospects of proximal fibular osteotomy (PFO) as an alternative treatment of knee osteoarthritis (KOA), which has gained popularity in recent years, has yet to be systematically evaluated. Hence, this meta-analysis aims to critically assess the clinical and radiological outcome of PFO in the management of medial compartment KOA. Methods: Literature searches through PubMed, Scopus, CENTRAL, CINAHL, Google Scholar, and ProQuest databases were conducted, searching for eligible studies published from inception up to April 2020. Risk of bias assessments of randomized trials were performed via Cochrane RoB 2, while those of non-randomized studies with ROBINS-I tool. Random-effects model was utilized to estimate effect sizes. Results: A total of 907 patients and 1012 knees were included in this meta-analysis. PFO successfully ameliorated patients’ knee function (Hedges’ g 1.90; 95% confidence interval (CI) 1.62–2.18; I2 = 67%) and pain (visual analog scale: mean difference (MD) −4.13; 95% CI: −5.29 to −2.97), and also resulted in minimal complication rates, with peroneal nerve paresthesia being the most prevalent adverse event (5.93%; 95% CI: 2.15–11.25%), followed by peroneal nerve palsy (2.25%; 95% CI: 0.14–6.14%), fracture (0.56%; 95% CI: 0–1.74%), and recurrent deformity (0.54%; 95% CI: 0–1.74%). Furthermore, PFO was also associated with improved medial/lateral joint space ratio (MD 0.17; 95% CI: 0.15–0.19). Conclusion: PFO yielded promising prospects in the management of medial compartment KOA, as shown by substantial improvements in clinical and radiological outcomes. However, considering the low quality of evidence, further studies with more diverse populations and higher quality of body evidence are required to confirm these findings. © 2020 Elsevier B.V. |
High fibular osteotomy; Knee osteoarthritis; Osteotomy; Proximal fibular osteotomy; Upper partial fibulectomy |
anthropometric parameters; bone malformation; fracture; human; joint cavity; knee function; knee osteoarthritis; knee pain; lateral joint space; medial joint space; meta analysis; osteotomy; peroneus nerve paralysis; postoperative complication; prevalence; priority journal; proximal fibular osteotomy; radiological procedures; randomized controlled trial (topic); recurrent disease; Review; systematic review; treatment outcome; visual analog scale; adverse event; fibula; knee osteoarthritis; osteotomy; postoperative complication; procedures; Fibula; Humans; Osteoarthritis, Knee; Osteotomy; Postoperative Complications; Visual Analog Scale |
Elsevier B.V. |
09680160 |
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33387808 |
Review |
Q1 |
1012 |
4317 |
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918 |
Ramani S., McKimm J., Findyartini A., Nadarajah V.D., Hays R., Chisolm M.S., Filipe H.P., Fornari A., Kachur E.K., Kusurkar R.A., Thampy H., Wilson K.W. |
56186462600;26433565200;56543777300;14048599600;7202509928;25957566100;36657108400;6701517660;6603938626;6603461994;55349958700;56926010000; |
Twelve tips for developing a global community of scholars in health professions education |
2021 |
Medical Teacher |
43 |
8 |
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966 |
971 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094560355&doi=10.1080%2f0142159X.2020.1839034&partnerID=40&md5=5cfe14caf9b8e1e02d7e63fd250a2375 |
Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States; Swansea University Medical School, United Kingdom; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; International Medical University, Kuala Lumpur, Malaysia; James Cook University, Townesville, QLD, Australia; Johns Hopkins University School of Medicine, Baltimore, MD, United States; University of Lisbon, Lisbon, Portugal; Donald and Barbara Zucker SOM at Hofstra/Northwell, Hempstead, NY, United States; Medical Education Development, Global Consulting, New York, NY, United States; Faculty of Medicine, Vrije Universiteit Amsterdam, Netherlands; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom; Dalhousie University, Halifax, NS, Canada |
Ramani, S., Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States; McKimm, J., Swansea University Medical School, United Kingdom; Findyartini, A., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Nadarajah, V.D., International Medical University, Kuala Lumpur, Malaysia; Hays, R., James Cook University, Townesville, QLD, Australia; Chisolm, M.S., Johns Hopkins University School of Medicine, Baltimore, MD, United States; Filipe, H.P., University of Lisbon, Lisbon, Portugal; Fornari, A., Donald and Barbara Zucker SOM at Hofstra/Northwell, Hempstead, NY, United States; Kachur, E.K., Medical Education Development, Global Consulting, New York, NY, United States; Kusurkar, R.A., Faculty of Medicine, Vrije Universiteit Amsterdam, Netherlands; Thampy, H., Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom; Wilson, K.W., Dalhousie University, Halifax, NS, Canada |
Scholarship in Health Professions Education is not just original research, it also includes study of educational processes, and application of new knowledge to practice. The pathways to successful scholarship are not always clear to novice educators. In this article, we describe strategies to establish a Community of Scholars (CoS), where more experienced and senior members guide junior members in scholarship to advance the field. Drawing on Lave and Wenger’s concepts of Communities of Practice (CoP), we describe twelve practical tips, which include generation of a shared vision, formation of a global community of scholars, engagement in scholarly initiatives, and development of a professional identity, categorised under three major steps: establish, grow, and sustain the community. The tips embrace inclusivity for diverse cultural contexts which further provide opportunities for Health Professions Educators, interested in forming communities of practice, to work on scholarly outputs and add value to the professional arena. © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
continuing; Leadership; mentoring; staff development |
article; drawing; human; human experiment; leadership; mentoring; occupation; personnel management; vision; medical education; medical profession; Fellowships and Scholarships; Health Occupations; Humans |
Taylor and Francis Ltd. |
0142159X |
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33108740 |
Article |
Q1 |
1355 |
2689 |
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923 |
Hidayati E.L., Utami M.D., Rohsiswatmo R., Tridjaja B. |
57200542624;57217291921;55533574600;6504507193; |
Cystatin C compared to serum creatinine as a marker of acute kidney injury in critically ill neonates |
2021 |
Pediatric Nephrology |
36 |
1 |
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181 |
186 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087002032&doi=10.1007%2fs00467-020-04668-3&partnerID=40&md5=45ca525dfa7a5bd6f6f0c1d995fe7930 |
Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Hidayati, E.L., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Utami, M.D., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rohsiswatmo, R., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Tridjaja, B., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Acute kidney injury (AKI) is one of the most common causes of neonatal morbidity and mortality. Diagnosing AKI in neonates is challenging as it lacks specific signs, symptoms, and biomarkers. However, detecting AKI in critically ill neonates is crucial to determine appropriate management and prevent complications. Cystatin C (CysC) has been recognized as a superior kidney biomarker reflecting kidney function in neonates. The objective of this study is to evaluate the diagnostic value of CysC as an AKI biomarker in critically ill neonates. Methods: We performed a diagnostic test between cystatin C-based estimated glomerular filtration rate (eGFR-CysC) and serum creatinine-based estimated glomerular filtration rate (eGFR-SCr) as the gold standard to diagnose AKI in 135 critically ill neonates treated in Cipto Mangunkusumo National Hospital from July 2017 to January 2018. Results: Prevalence of AKI was 23.7% predominantly in neonates with a very preterm gestational age, low birthweight, probable sepsis, and those receiving invasive oxygen therapy or nephrotoxic drugs. The proportion of AKI based on neonate RIFLE criteria was 72.7% risk, 18.9% injury, and 9% failure. eGFR-CysC had the following parameters: sensitivity, 84.8%; specificity, 61.8%; PPV, 41.8%; NPV, 89.7%; LR(+), 2.2; LR(−), 0.24; and accuracy, 67.4%. The AUROC for CysC was 84.9%. The optimal cut-off value for CysC was 1.605 mg/l. Conclusions: CysC may be used as a screening biomarker of AKI in critically ill neonates; yet, it was not superior to serum creatinine. [Figure not available: see fulltext.]. © 2020, IPNA. |
Acute kidney injury; Critically ill neonates; Cystatin C; Serum creatinine |
creatinine; cystatin C; biological marker; creatinine; cystatin C; epidermal growth factor receptor; acute kidney failure; area under the curve; Article; controlled study; creatinine blood level; critically ill patient; diagnostic accuracy; diagnostic test; diagnostic test accuracy study; diagnostic value; estimated glomerular filtration rate; extremely low birth weight; female; gestational age; human; low birth weight; major clinical study; male; negative likelihood ratio; newborn; oxygen therapy; positive likelihood ratio; predictive value; prematurity; prevalence; priority journal; receiver operating characteristic; sensitivity and specificity; sepsis; very low birth weight; acute kidney failure; critical illness; prospective study; Acute Kidney Injury; Biomarkers; Creatinine; Critical |
Springer Science and Business Media Deutschland GmbH |
0931041X |
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32594242 |
Article |
Q1 |
831 |
5739 |
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925 |
Surja S.S., Adawiyah R., Houbraken J., Rozaliyani A., Sjam R., Yunihastuti E., Wahyuningsih R. |
57209258108;57208658742;12770401000;57203065912;23398458200;57221273925;6507268400; |
Talaromyces atroroseus in HIV and non-HIV patient: A first report from Indonesia |
2021 |
Medical Mycology |
58 |
4 |
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560 |
563 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085715396&doi=10.1093%2fMMY%2fMYZ090&partnerID=40&md5=9fec23d3506804c0bc622f42e14314ff |
Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia; Westerdijk Fungal Biodiversity Institute, Netherlands; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Parasitology, School of Medicine and Health Sciences, Universitas Katolik Indonesia, Atma Jaya, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Kristen Indonesia, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Kristen Indonesia, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia |
Surja, S.S., Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Indonesia, Department of Parasitology, School of Medicine and Health Sciences, Universitas Katolik Indonesia, Atma Jaya, Indonesia; Adawiyah, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia; Houbraken, J., Westerdijk Fungal Biodiversity Institute, Netherlands; Rozaliyani, A., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia; Sjam, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia; Yunihastuti, E., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia, Department of Internal Medicine, Faculty of Medicine, Universitas Kristen Indonesia, Indonesia; Wahyuningsih, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Kristen Indonesia, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia |
We performed morphology, molecular study and antifungal susceptibility test on 10 Talaromyces sp. isolates: eight clinical isolates (human immunodeficiency virus (HIV) and non-HIV-patient) and two isolates from rats. All strains produced red soluble pigment and microscopically showed Penicillium-like structure in room temperature and yeast-like structure in 37â—¦C. Based on molecular analysis, nine isolates were identified as Talaromyces atroroseus (including the isolates from rats) and one as T. marneffei. Our susceptibility result of T. marneffei supports the use of amphotericin B, itraconazole for talaromycosis marneffei management. Talaromyces atroroseus showed variable MIC to echinocandin, azole derivatives, 5-flucytosine and amphotericin B. © The Author(s) 2019. |
BenA; Indonesia; ITS; Talaromyces atroroseus; Talaromyces marneffei |
amphotericin B; anidulafungin; caspofungin; echinocandin; fluconazole; flucytosine; itraconazole; micafungin; posaconazole; pyrrole derivative; voriconazole; antifungal agent; antifungal susceptibility; Article; fungus isolation; human; Human immunodeficiency virus infected patient; Indonesia; mycosis; nonhuman; room temperature; Talaromyces; Talaromyces atroroseus; Talaromyces marneffei; talaromycosis; animal; classification; drug effect; genetics; Human immunodeficiency virus infection; Indonesia; isolation and purification; microbial sensitivity test; microbiology; pigmentation; rat; Talaromyces; Animals; Antifungal Agents; HIV Infections; Humans; Indonesia; Microbial Sensitivity Tests; Mycoses; Pigmentation; Rats; Talaromyces |
Oxford University Press |
13693786 |
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31504774 |
Article |
Q1 |
1004 |
4362 |
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No records
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79 |
Saharman Y.R., Karuniawati A., Severin J.A., Verbrugh H.A. |
55980934300;54886816200;8700385500;7103296623; |
Infections and antimicrobial resistance in intensive care units in lower-middle income countries: a scoping review |
2021 |
Antimicrobial Resistance and Infection Control |
10 |
1 |
22 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100075262&doi=10.1186%2fs13756-020-00871-x&partnerID=40&md5=137569c4bc3b7584a1b51042515f7130 |
Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Dr. Molewaterplein 40, Rotterdam, 3015 GD, Netherlands |
Saharman, Y.R., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Dr. Molewaterplein 40, Rotterdam, 3015 GD, Netherlands; Karuniawati, A., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Severin, J.A., Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Dr. Molewaterplein 40, Rotterdam, 3015 GD, Netherlands; Verbrugh, H.A., Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Dr. Molewaterplein 40, Rotterdam, 3015 GD, Netherlands |
Background: Intensive care units (ICUs) in lower-middle income countries (LMICs) are suspected to constitute a special risk for patients of acquiring infection due to multiple antibiotic resistant organisms. The aim of this systematic scoping review was to present the data published on ICU-acquired infections and on antimicrobial resistance observed in ICUs in LMICs over a 13-year period. A systematic scoping review was conducted according to the PRISMA extension guideline for scoping reviews and registered in the Open Science Framework. Main body of the abstract: Articles were sought that reported on ICU-acquired infection in LMICs between 2005 and 2018. Two reviewers parallelly reviewed 1961 titles and abstracts retrieved from five data banks, found 274 eligible and finally included 51. Most LMICs had not produced reports in Q1 or Q2 journals in this period, constituting a large gap in knowledge. However, from the reported evidence it is clear that the rate of ICU-acquired infections was comparable, albeit approximately 10% higher, in LMICs compared to high income countries. In contrast, ICU mortality was much higher in LMICs (33.6%) than in high income countries (< 20%). Multidrug-resistant Gram-negative species, especially Acinetobacter baumannii and Pseudomonas aeruginosa, and Klebsiella pneumoniae played a much more dominant role in LMIC ICUs than in those in high income countries. However, interventions to improve this situation have been shown to be feasible and effective, even cost-effective. Conclusions: Compared to high income countries the burden of ICU-acquired infection is higher in LMICs, as is the level of antimicrobial resistance; the pathogen distribution is also different. However, there is evidence that interventions are feasible and may be quite effective in these settings. Protocol Registration The protocol was registered with Open Science Framework (https://osf.io/c8vjk) © 2021, The Author(s). |
Acinetobacter; Bacterial drug resistance; Cross infection; Infection control; Intensive care units |
antibiotic agent; Acinetobacter baumannii; adult; antibiotic resistance; bacterial infection; cross infection; female; high income country; hospital mortality; human; infection control; intensive care unit; Klebsiella pneumoniae; major clinical study; male; middle income country; multidrug resistance; nonhuman; priority journal; Pseudomonas aeruginosa; Review; bacterial infection; cross infection; developing country; Acinetobacter baumannii; Adult; Bacterial Infections; Cross Infection; Developing Countries; Drug Resistance, Bacterial; Humans; Intensive Care Units; Klebsiella pneumoniae; Pseudomonas aeruginosa |
BioMed Central Ltd |
20472994 |
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33514432 |
Review |
Q1 |
1456 |
2381 |
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176 |
Nakhaei P., Margiana R., Bokov D.O., Abdelbasset W.K., Jadidi Kouhbanani M.A., Varma R.S., Marofi F., Jarahian M., Beheshtkhoo N. |
57226413840;56685900600;56845561300;57208873763;57219274421;7201793587;57199650994;16241593900;57201547070; |
Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol |
2021 |
Frontiers in Bioengineering and Biotechnology |
9 |
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705886 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115653337&doi=10.3389%2ffbioe.2021.705886&partnerID=40&md5=0d6cee3ed2be3a97e6c2beb3d6c668b5 |
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia; Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation; Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology, and Food Safety, Moscow, Russian Federation; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Czech Republic; Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacký University in Olomouc, Olomouc, Czech Republic; Department of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany |
Nakhaei, P., School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia, Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia, Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Bokov, D.O., Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation, Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology, and Food Safety, Moscow, Russian Federation; Abdelbasset, W.K., Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia, Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Jadidi Kouhbanani, M.A., Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Czech Republic; Varma, R.S., Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacký University in Olomouc, Olomouc, Czech Republic; Marofi, F., Department of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Jarahian, M., Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany; Beheshtkhoo, N., Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Czech Republic |
Liposomes are essentially a subtype of nanoparticles comprising a hydrophobic tail and a hydrophilic head constituting a phospholipid membrane. The spherical or multilayered spherical structures of liposomes are highly rich in lipid contents with numerous criteria for their classification, including structural features, structural parameters, and size, synthesis methods, preparation, and drug loading. Despite various liposomal applications, such as drug, vaccine/gene delivery, biosensors fabrication, diagnosis, and food products applications, their use encounters many limitations due to physico-chemical instability as their stability is vigorously affected by the constituting ingredients wherein cholesterol performs a vital role in the stability of the liposomal membrane. It has well established that cholesterol exerts its impact by controlling fluidity, permeability, membrane strength, elasticity and stiffness, transition temperature (Tm), drug retention, phospholipid packing, and plasma stability. Although the undetermined optimum amount of cholesterol for preparing a stable and controlled release vehicle has been the downside, but researchers are still focused on cholesterol as a promising material for the stability of liposomes necessitating explanation for the stability promotion of liposomes. Herein, the prior art pertaining to the liposomal appliances, especially for drug delivery in cancer therapy, and their stability emphasizing the roles of cholesterol. © Copyright © 2021 Nakhaei, Margiana, Bokov, Abdelbasset, Jadidi Kouhbanani, Varma, Marofi, Jarahian and Beheshtkhoo. |
cholesterol; compounds; lipids; liposome; stability |
Automobile manufacture; Chemical stability; Controlled drug delivery; Food products; Liposomes; Medical applications; Phospholipids; Plasma stability; Targeted drug delivery; Application parameters; Biomedical applications; Compound; Hydrophilic heads; Hydrophobic tails; Liposome structures; Multi-layered; Phospholipid membrane; Spherical structures; Stability parameters; Cholesterol |
Frontiers Media S.A. |
22964185 |
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Review |
Q1 |
1081 |
3891 |
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267 |
Quek S.X.Z., Loo E.X.L., Demutska A., Chua C.E., Kew G.S., Wong S., Lau H.X., Low E.X.S., Loh T.L., Lung O.S., Hung E.C.W., Rahman M.M., Ghoshal U.C., Wong S.H., Cheung C.K.Y., Syam A.F., Tan N., Xiao Y., Liu J.-S., Lu F., Chen C.-L., Lee Y.Y., Maralit R.M., Kim Y.-S., Oshima T., Miwa H., Pang J., Siah K.T.H. |
57222222782;50162082500;36136970000;56816437200;56611839100;57222223736;57218857855;57201335892;57222224359;57222226377;7004256338;57216556340;7005966711;55451145400;8714367400;8443384400;56417185400;23500436000;57196288418;36120914800;23495616400;56191149300;57202206761;57196171210;7401663152;56921458500;57224357479;35757936600; |
Impact of the coronavirus disease 2019 pandemic on irritable bowel syndrome |
2021 |
Journal of Gastroenterology and Hepatology (Australia) |
36 |
8 |
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2187 |
2197 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101935332&doi=10.1111%2fjgh.15466&partnerID=40&md5=4f7271b5d9e13c1b4bdea5a3463fd019 |
Department of Medicine, Yong Loo Lin School of Medicine, National University Hospital, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore; Department of Clinical Psychology, James Cook University, Singapore; Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore; Department of Medicine, Ng Teng Fong General Hospital, Singapore; Department of Otorhinolarygology, Head and Neck Surgery, Universiti Putra Malaysia, Seri Kembangan, Malaysia; Department of Anaesthesiology, Columbia Asia Hospital, Miri, Sarawak, Malaysia; Cambridge Paediatrics, Shatin, Hong Kong; Department of Gastroenterology, Sheikh Russel National Gastroliver Institute and Hospital, Dhaka, Bangladesh; Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute Medical Science, Lucknow, India; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong; Department of Medicine, The University of Hong Kong, Hong Kong; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Departments of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Department of Gastroenterology, Wuhan Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei, China; Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Department of Medicine, Buddhist Tzu Chi Hospital and University School of Medicine, Hualien, Taiwan; St George and Sutherland Clinical School, University of New South Wales, Sydney, NSW, Australia; Gut Research Group, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; The Medical City, Metro Manila, Philippines; Wonkwang Digestive Disease Research Institute, Gut and Food Healthcare, Wonkwang University School of Medicine, Iksan, South Korea; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore; Centre for Infectious Disease Epidemiology and Research, National University of Singapore, Singapore |
Quek, S.X.Z., Department of Medicine, Yong Loo Lin School of Medicine, National University Hospital, Singapore; Loo, E.X.L., Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore; Demutska, A., Department of Clinical Psychology, James Cook University, Singapore; Chua, C.E., Department of Medicine, Yong Loo Lin School of Medicine, National University Hospital, Singapore; Kew, G.S., Department of Medicine, Yong Loo Lin School of Medicine, National University Hospital, Singapore, Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore; Wong, S., Department of Medicine, Ng Teng Fong General Hospital, Singapore; Lau, H.X., Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore; Low, E.X.S., Department of Medicine, Ng Teng Fong General Hospital, Singapore; Loh, T.L., Department of Otorhinolarygology, Head and Neck Surgery, Universiti Putra Malaysia, Seri Kembangan, Malaysia; Lung, O.S., Department of Anaesthesiology, Columbia Asia Hospital, Miri, Sarawak, Malaysia; Hung, E.C.W., Cambridge Paediatrics, Shatin, Hong Kong; Rahman, M.M., Department of Gastroenterology, Sheikh Russel National Gastroliver Institute and Hospital, Dhaka, Bangladesh; Ghoshal, U.C., Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute Medical Science, Lucknow, India; Wong, S.H., Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong; Cheung, C.K.Y., State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, Department of Medicine, The University of Hong Kong, Hong Kong; Syam, A.F., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Tan, N., Departments of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Xiao, Y., Departments of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Liu, J.-S., Department of Gastroenterology, Wuhan Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei, China; Lu, F., Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Chen, C.-L., Department of Medicine, Buddhist Tzu Chi Hospital and University School of Medicine, Hualien, Taiwan; Lee, Y.Y., St George and Sutherland Clinical School, University of New South Wales, Sydney, NSW, Australia, Gut Research Group, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; Maralit, R.M., The Medical City, Metro Manila, Philippines; Kim, Y.-S., Wonkwang Digestive Disease Research Institute, Gut and Food Healthcare, Wonkwang University School of Medicine, Iksan, South Korea; Oshima, T., Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan; Miwa, H., Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore; Pang, J., Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Centre for Infectious Disease Epidemiology and Research, National University of Singapore, Singapore; Siah, K.T.H., Department of Medicine, Yong Loo Lin School of Medicine, National University Hospital, Singapore, Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore |
Background and Aim: Gastrointestinal manifestations of the coronavirus disease 2019 (COVID-19) pandemic may mimic irritable bowel syndrome (IBS), and social distancing measures may affect IBS patients negatively. We aimed to study the impact of COVID-19 on respondents with self-reported IBS. Methods: We conducted an anonymized survey from May to June 2020 in 33 countries. Knowledge, attitudes, and practices on personal hygiene and social distancing as well as psychological impact of COVID-19 were assessed. Statistical analysis was performed to determine differences in well-being and compliance to social distancing measures between respondents with and without self-reported IBS. Factors associated with improvement or worsening of IBS symptoms were evaluated. Results: Out of 2704 respondents, 2024 (74.9%) did not have IBS, 305 (11.3%) had self-reported IBS, and 374 (13.8%) did not know what IBS was. Self-reported IBS respondents reported significantly worse emotional, social, and psychological well-being compared with non-IBS respondents and were less compliant to social distancing measures (28.2% vs 35.3%, P = 0.029); 61.6% reported no change, 26.6% reported improvement, and 11.8% reported worsening IBS symptoms. Higher proportion of respondents with no change in IBS symptoms were willing to practice social distancing indefinitely versus those who deteriorated (74.9% vs 51.4%, P = 0.016). In multivariate analysis, willingness to continue social distancing for another 2–3 weeks (vs longer period) was significantly associated with higher odds of worsening IBS. Conclusion: Our study showed that self-reported IBS respondents had worse well-being and compliance to social distancing measures than non-IBS respondents. Future research will focus on occupational stress and dietary changes during COVID-19 that may influence IBS. © 2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd |
COVID-19; IBS; Social distancing |
adult; Article; attitude to health; clinical assessment; clinical evaluation; clinical practice; comparative study; controlled study; coronavirus disease 2019; disease severity; emotion regulation; female; general condition deterioration; health survey; human; irritable colon; major clinical study; male; pandemic; personal hygiene; psychological aspect; psychological well-being; risk factor; self report; social distancing; symptom; clinical trial; cross-sectional study; irritable colon; multicenter study; pandemic; patient compliance; questionnaire; retrospective study; self report; Singapore; Adult; COVID-19; Cross-Sectional Studies; Female; Humans; Irritable Bowel Syndrome; Male; Pandemics; Patient Compliance; Retrospective Studies; SARS-CoV-2; Self Report; Singapore; Surveys and Questio |
John Wiley and Sons Inc |
08159319 |
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33615534 |
Article |
Q1 |
1214 |
3242 |
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361 |
Sasmono R.T., Johar E., Yohan B., Ma'Roef C.N., Pronyk P., Hadinegoro S.R., Soepardi E.J., Bouckenooghe A., Hawley W.A., Rosenberg R., Powers A.M., Soebandrio A., Myint K.S.A. |
6506482032;57204001174;55843037500;6507740388;6602466584;57226218772;57191174412;18233281300;7004280510;35578810900;7005770718;8602893200;7003758970; |
Spatiotemporal heterogeneity of zika virus transmission in indonesia: Serosurveillance data from a pediatric population |
2021 |
American Journal of Tropical Medicine and Hygiene |
104 |
6 |
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2220 |
2223 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107590950&doi=10.4269%2fajtmh.21-0010&partnerID=40&md5=31e9b723a56e45315c1b9d58055ee86b |
Eijkman Institute for Molecular Biology, Jakarta, Indonesia; UNICEF Indonesia, Jakarta, Indonesia; Faculty of Medicine and Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Ministry of Health of the Republic of Indonesia, Jakarta, Indonesia; Sanofi Pasteur, Lyon, Rhône-Alpes, France; Centers for Disease Control and Prevention, Atlanta, GA, United States; Centers for DiseaseControl and Prevention, Fort Collins, CO, United States |
Sasmono, R.T., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Johar, E., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Yohan, B., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Ma'Roef, C.N., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Pronyk, P., UNICEF Indonesia, Jakarta, Indonesia; Hadinegoro, S.R., Faculty of Medicine and Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Soepardi, E.J., Ministry of Health of the Republic of Indonesia, Jakarta, Indonesia; Bouckenooghe, A., Sanofi Pasteur, Lyon, Rhône-Alpes, France; Hawley, W.A., Centers for Disease Control and Prevention, Atlanta, GA, United States; Rosenberg, R., Centers for DiseaseControl and Prevention, Fort Collins, CO, United States; Powers, A.M., Centers for DiseaseControl and Prevention, Fort Collins, CO, United States; Soebandrio, A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Myint, K.S.A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
The presence of Zika virus (ZIKV) in Indonesia has been recognized since the 1970s, but its transmission dynamics there have been poorly understood. To understand more fully the geographic distribution and burden of ZIKV infection, we performed retrospective serological tests on specimens collected from asymptomatic children age 5 to 9 years old living at 30 sites in 14 provinces. Of 870 serum samples tested, 9.2% were found to be positive for anti-ZIKV antibodies, as confirmed by plaque reduction neutralization assays. This was the same overall prevalence reported previously for 1- to 4-year-old children collected at the same sites at the same time. Together with geographic differences in seroprevalence between the age groups, these data suggest that, although ZIKV might be endemic in Indonesia, its occurrence has been focal and episodic. © 2021 by The American Society of Tropical Medicine and Hygiene. |
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Article; asymptomatic disease; blood sampling; disease burden; geographic distribution; human; Indonesia; nonhuman; plaque reduction neutralization test; serological surveillance; serology; seroprevalence; virus transmission; Zika fever; Zika virus; blood; child; epidemiological monitoring; immunology; preschool child; retrospective study; seroepidemiology; spatiotemporal analysis; Zika fever; Zika virus; immunoglobulin M; virus antibody; Antibodies, Viral; Child; Child, Preschool; Epidemiological Monitoring; Humans; Immunoglobulin M; Indonesia; Retrospective Studies; Seroepidemiologic Studies; Spatio-Temporal Analysis; Zika Virus; Zika Virus Infection |
American Society of Tropical Medicine and Hygiene |
00029637 |
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33939632 |
Article |
Q1 |
1015 |
4298 |
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