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Riset dan Pengabdian Masyarakat Do Research Sosial Service and Innovation

Id	Authors	Author S Id	Title	Year	Source Title	Volume	Issue	Page Start	Page End	Cited By	Link	Affiliations	Authors With Affiliations	Abstract	Author Keywords	Index Keywords	Publisher	Issn	Pubmed Id	Document Type	Sjr Best Quartile	Sjr	Sjr Rank
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98	Yusharyahya S.N., Bramono K., Indriatmi W., Prasetyo M., Ascobat P., Hestiantoro A., Wiraguna A.A.G.P.	57211780941;9843236700;57189888041;57192905252;55795863600;8743255100;20437026700;	Anti-aging effects of fenugreek cream on postmenopausal skin: A randomized controlled trial	2021	Journal of Applied Pharmaceutical Science	11	11	95	103		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119480025&doi=10.7324%2fJAPS.2021.1101113&partnerID=40&md5=020217cd5f217dbc98ba3162ac9d99f1	Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana – Sanglah General Hospital, Denpasar, Indonesia	Yusharyahya, S.N., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bramono, K., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Indriatmi, W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prasetyo, M., Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ascobat, P., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Indonesia; Hestiantoro, A., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wiraguna, A.A.G.P., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana – Sanglah General Hospital, Denpasar, Indonesia	Postmenopausal hypoestrogenism is associated with skin aging, for which phytoestrogen derived from the seeds of Trigonella foenum graecum (fenugreek) is expected to be an alternative solution to reduce wrinkles and increase the thickness of postmenopausal women’s skin. This study was a randomized, double-blind, controlled 12-weeks trial conducted at a general hospital in Jakarta, Indonesia, from January to November 2019. Subjects were 50 postmenopausal women divided into two groups: the intervention group was given 5% fenugreek cream and base cream was given to the placebo group. The results of the independent t-test showed that both groups were able to achieve statistically significant improvement in wrinkle scores on the forehead, crow’s feet, and nasolabial folds which was assessed by photography scoring based on Bazin’s skin aging atlas for Asian skin volume 2 but there was no significant disparity between both groups at all time points. Dermal thickness was assessed by high-resolution ultrasound GE LOGIQ E9 (18 MHz), which showed similar results for both groups with significant improvements in the 8th week compared to baseline and a significant decrease by the 12th week. No significant differences were observed in the skin wrinkle score and skin thickness after the application of fenugreek cream compared to placebo.We suspect that a concentration of 5% was not adequate for the expected antiskin aging effects. Further studies are necessary to determine a more appropriate fenugreek concentration to permit clinical use as an antiskin aging therapy in postmenopausal women. © 2021 Shannaz Nadia Yusharyahya et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License	Dermal thickness; fenugreek; postmenopausal skin; skin wrinkle		Open Science Publishers LLP Inc.	22313354		Article	Q2	286	15310	View
555	Susanto A.D., Winardi W., Hidayat M., Wirawan A.	57190425587;57211654146;56435992700;57221412258;	The use of indoor plant as an alternative strategy to improve indoor air quality in Indonesia	2021	Reviews on Environmental Health	36	1	95	99	3	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094149752&doi=10.1515%2freveh-2020-0062&partnerID=40&md5=a7a8a53669f01afb3fc072e87f174a11	Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia/Persahabatan Hospital, Jl. Persahabatan Raya No.1, Jakarta, 13230, Indonesia; Department of Pulmonology and Respiratory Medicine, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Mataram, Mataram, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia/Persahabatan Hospital, Jakarta, Indonesia	Susanto, A.D., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia/Persahabatan Hospital, Jl. Persahabatan Raya No.1, Jakarta, 13230, Indonesia; Winardi, W., Department of Pulmonology and Respiratory Medicine, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Hidayat, M., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Mataram, Mataram, Indonesia; Wirawan, A., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia/Persahabatan Hospital, Jakarta, Indonesia	Indoor air pollution marked with decreased air quality below the set standard. The quality of indoor air is determined by ambient air quality as well as by a harmful substance resulting from the household activity. Indoor air pollution may cause several problems such as sick building syndrome, chronic obstructive pulmonary disease (COPD), asthma, lung cancer, and is responsible for nearly two million death in developing countries. One of the interesting research topics to overcome the indoor air pollution problem is the application of indoor plants. Although there are no established criteria to specify the best indoor plant, several studies have revealed the capability of a particular indoor plant to remove the harmful substances. This paper summarizes important information about indoor air pollution and provides the evidence-based insight of indoor plant usefulness as an alternative way for indoor air remediation. © 2021 De Gruyter. All rights reserved.	Air pollution; Air quality; Indoor air pollution	ecosystem restoration; human; Indonesia; indoor air pollution; plant; prevention and control; procedures; Air Pollution, Indoor; Environmental Restoration and Remediation; Humans; Indonesia; Plants	De Gruyter Open Ltd	00487554	32920542	Review	Q2	644	7826	View
876	Sari I.P., Audindra S., Zhafira A.S., Rahma A.A., Syarira C.V., Wahdini S.	57197543698;57222006228;57205515532;57222005612;57222010715;57203684068;	Nutritional status of school-aged children with intestinal parasite infection in South Jakarta, Indonesia	2021	Open Access Macedonian Journal of Medical Sciences	9	E	95	100	3	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100938719&doi=10.3889%2foamjms.2021.5711&partnerID=40&md5=1772780d39afba8ba66dd65e8997f0b4	Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Sari, I.P., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Audindra, S., Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Zhafira, A.S., Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahma, A.A., Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Syarira, C.V., Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wahdini, S., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	BACKGROUND: The prevalence of intestinal parasitic infection still high in Indonesia and lead to nutritional disorder, especially in the school-aged children. AIM: This research conducted to find the association of intestinal parasitic infection to the nutritional status of the children. METHODS: This was a cross sectional study, conducted in January 2016 in one primary school in South Jakarta, Jakarta, Indonesia, by collecting the children’s stool from 1st to 5th grade. Direct examination of the stool was conducted in the Parasitology Department, Faculty of Medicine, Universitas Indonesia, by Lugol and eosin staining. Nutritional status categorized using BMI chart. Data were analyzed using Chi-square test, Statistical Product, and Service Solutions version 20. RESULTS: From the total 157 stool examined in the laboratory, there were 60 (38.2%) children positively infected with various kinds of intestinal parasites. Mostly the infection is caused by Blastocystis hominis, which infects 44 children (69.4%). The other infection is caused by Giardia lamblia (15.3%), Trichuris trichiura (1.4%), and hookworm (1.4%), and mixed infection of B. hominis and Escherichia coli (4.2%) and B. hominis with G. lamblia (4.2%). From the total of infected children, 17 children (28.3%) have BMI below 5th percentile, and it was considered as malnourished. Moreover, 67 uninfected children have normal nutritional status. Statistically, there is an association between intestinal parasitic infection and nutritional status in school-aged children in South Jakarta (P < 0.05). CONCLUSION: The incidence of intestinal parasitic infection in school-aged children is 38.2%. Moreover, 28.3% of the infected children were malnourished and it is suggested that children with intestinal parasite infection have low nutritional status. © 2021 Ika Puspa Sari, Sacha Audindra, Aqila S. Zhafira, Arin A. Rahma, Cut V. Syarira, Sri Wahdini.	Malnourish; Parasitic Infection; Primary Schools; South Jakarta	Article; Blastocystis hominis; body mass; child; cross-sectional study; disease association; Escherichia coli; feces analysis; female; Giardia intestinalis; human; Indonesia; intestine parasite; major clinical study; male; malnutrition; mixed infection; nutritional status; obesity; parasitosis; prevalence; primary school; questionnaire; seasonal variation; Trichuris trichiura; underweight	Open Access Macedonian Journal of Medical Sciences	18579655		Article	Q3	288	15252	View
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91	Renaldi K., Simadibrata M., Rahadiani N., Handjari D.R., William A., Sinuraya F., Makmun D.	57190963547;23499598400;16426455700;56160657900;57209025962;57212478117;16638046900;	Prognostic Value of COX-2, NF-κB, and Sp1 Tissue Expressions in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-analysis	2021	The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology	32	11	956	970		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122454127&doi=10.5152%2ftjg.2021.211106&partnerID=40&md5=869f590f4b509a9d15f5495cd1423389	Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Division of Gastroenterology and Hepato Billiary Pathology, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral HospitalJakarta, Indonesia; Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia	Renaldi, K., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Simadibrata, M., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Rahadiani, N., Division of Gastroenterology and Hepato Billiary Pathology, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral HospitalJakarta, Indonesia; Handjari, D.R., Division of Gastroenterology and Hepato Billiary Pathology, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral HospitalJakarta, Indonesia; William, A., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Sinuraya, F., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Makmun, D., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia	BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is deadly cancer with a poor prognosis. Molecular prognostic markers are needed to predict the patient's survival. The cyclooxygenase-2 enzyme (COX-2) and its 2 major transcription factors--nuclear factorkappa B (NF-κB) and specificity protein 1 (Sp1)--are activated during inflammation caused by neoplasia. Several studies have investigated the association between the COX-2, NF-κB, and Sp1 tissue expressions with the patient's overall survival. Therefore, we conducted this systematic review and meta-analysis to evaluate those studies. METHODS: We searched for relevant articles from the MEDLINE database through June 2020. Studies were eligible if they included dichotomized tissue protein expression status and the overall survival as the outcome. We used RevMan and ProMeta programs to perform the meta-analysis. RESULTS: We identified 11 eligible studies. The meta-analysis showed that COX-2 tissue expression was associated with decreased overall survival (crude HR = 1.35; 95% CI, 1.05-1.74), although the result was not significant when controlling for other covariates. The NF-κB tissue expression was associated with decreased overall survival (crude HR = 2.18; 95% CI, 1.49-3.18), although it was not significant when controlling for other covariates. The Sp1 tissue expression showed significantly decreased overall survival even when adjusted with other covariates (aHR = 3.47; 95% CI, 1.52-7.94). The limitations included searching only for English publications and the substantial heterogeneity among the studies. CONCLUSION: COX-2, NF-κB, and Sp1 tissue expressions have the potential to be used as prognostic markers in PDAC. Further studies are still needed to clarify the associations.		cyclooxygenase 2; immunoglobulin enhancer binding protein; Sp1 protein, human; transcription factor Sp1; tumor marker; human; meta analysis; metabolism; pancreas carcinoma; pancreas tumor; prognosis; tissue distribution; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cyclooxygenase 2; Humans; NF-kappa B; Pancreatic Neoplasms; Prognosis; Sp1 Transcription Factor; Tissue Distribution	NLM (Medline)	21485607	34872897	Article	#N/A	#N/A	#N/A	View
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30	Alinda M.D., Christopher P.M., Listiawan M.Y., Endaryanto A., Suroto H., Rantam F.A., Hendradi E., Notobroto H.B., Menaldi S.L.S.W., Prakoeswa C.R.S.	57202009260;57222755186;57202006621;55043187100;57148243900;6506692524;6507663471;56444366000;57192918198;57189894608;	Comparative efficacy of topical adipocyte-derived mesenchymal stem cells-conditioned medium (Admsc-cm) and amniotic membrane mesenchymal stem cells-conditioned medium (amsc-cm) on chronic plantar ulcers in leprosy: A randomized controlled trial	2021	Bali Medical Journal	10	3	958	963		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121976659&doi=10.15562%2fbmj.v10i3.2747&partnerID=40&md5=2cb312268e5b8b08565af75e187acace	Post Graduate Doctoral Program, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia; Leprosy Study Group, Institute of Tropical Diseases, Universitas Airlangga, Surabaya, Indonesia; Universitas Airlangga Teaching Hospital, Surabaya, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Banten, Tangerang, Indonesia; Department of Pediatric, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia; Cell and Tissue Bank, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia; Department of Orthopaedic & Traumatology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia; Stem Cell Research and Development Center, Universitas Airlangga, East Java, Surabaya, Indonesia; Faculty of Pharmacy, Universitas Airlangga, East Java, Surabaya, Indonesia; Faculty of Public Health, Universitas Airlangga, East Java, Surabaya, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Jakarta, Indonesia	Alinda, M.D., Post Graduate Doctoral Program, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia, Leprosy Study Group, Institute of Tropical Diseases, Universitas Airlangga, Surabaya, Indonesia, Universitas Airlangga Teaching Hospital, Surabaya, Indonesia; Christopher, P.M., Faculty of Medicine, Universitas Pelita Harapan, Banten, Tangerang, Indonesia; Listiawan, M.Y., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia, Leprosy Study Group, Institute of Tropical Diseases, Universitas Airlangga, Surabaya, Indonesia; Endaryanto, A., Department of Pediatric, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia; Suroto, H., Cell and Tissue Bank, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia, Department of Orthopaedic & Traumatology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia; Rantam, F.A., Stem Cell Research and Development Center, Universitas Airlangga, East Java, Surabaya, Indonesia; Hendradi, E., Faculty of Pharmacy, Universitas Airlangga, East Java, Surabaya, Indonesia; Notobroto, H.B., Faculty of Public Health, Universitas Airlangga, East Java, Surabaya, Indonesia; Menaldi, S.L.S.W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Jakarta, Indonesia; Prakoeswa, C.R.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia, Leprosy Study Group, Institute of Tropical Diseases, Universitas Airlangga, Surabaya, Indonesia	Introduction: Chronic Plantar Ulcer of Leprosy (CPUL), one of the debilitating disabilities and complications, poses a treatment challenge. Utilization of stem cells, specifically adipocyte-derived mesenchymal stem cells-conditioned medium (ADMSC-CM) and amniotic membrane mesenchymal stem cells-conditioned medium (AMSC-CM), may serve as a novel therapeutic option. This study aims to compare the efficacy of topical ADMSC-CM, topical AMSC-CM, and farmazertin gauze dressing (FGD) only on the healing of CPUL. Methods: In this randomized controlled trial, our study recruited 54 subjects with CPUL. Subjects were randomly assigned to topical ADMSC-CM (n = 16), topical AMSC-CM (n = 22), or FGD (n = 16) applied every three days for up to 8 weeks. Data were analyzed using SPSS version 20 for Windows. Results: Healing percentage increased each week in all groups. Statistic differences between groups (p <0.05) were observed for ulcer mean size and depth reduction from week three onwards. No adverse reactions or complications were reported. At the end of the study, based on clinically improved ulcers, topical ADMSC-CM (100.0%) were superior in improving the healing of CPULs compared to topical AMSC-CM (54.55%) and FGD only (50.0%). Conclusion: ADMSC-CM and AMSC-CM are potential therapeutic agents in the management of CPUL, with ADMSC-CM being superior in overall ulcer improvement. © 2021, Sanglah General Hospital. All rights reserved.	ADMSC-CM; AMSC-CM; CPUL; Leprosy; Tropical Disease		Sanglah General Hospital	20891180		Article	#N/A	#N/A	#N/A	View
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256	Farani M., Saldi S.R.F., Maulahela H., Abdullah M., Syam A.F., Makmum D.	57226146409;55201904000;57189612709;7103393434;8443384400;57226163778;	Survival, stent patency, and cost-effectiveness of plastic biliary stent versus metal biliary stent for palliation in malignant biliary obstruction in a developing country tertiary hospital	2021	JGH Open	5	8	959	965		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110682374&doi=10.1002%2fjgh3.12618&partnerID=40&md5=af5645f91acde4bbed01da739a4f2b1f	Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia	Farani, M., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Saldi, S.R.F., Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Maulahela, H., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Abdullah, M., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Syam, A.F., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Makmum, D., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia	Background and Aim: Patients with advanced malignant obstructive jaundice often require biliary drainage. Resources restraint makes clinicians need to outweigh effectiveness of each biliary stents and their costs. Hence, a cost-effectiveness analysis is necessary. Methods: A retrospective cohort study was done on malignant biliary obstruction patients undergoing palliative biliary stenting between January 2015 and December 2018. We evaluated 180-day survival rate using log-rank test and stent patency duration using Mann–Whitney U test. Effectiveness was defined as stent patency, while cost was calculated using hospital perspective using decision tree model and reported as incremental cost-effectiveness ratio. Results: A total of 81 men and 83 women were enrolled in this study. One hundred and eighty days survival rate was 35.9% (median 76 days, 95% confidence interval [CI] 50–102 days) and 33.3% (median 55 days, 95% CI 32–78 days), while average stent patency was 123 (8) days versus 149 (13) days for plastic and metal stent groups, respectively (P > 0.05). Metal stent could save Indonesian Rupiah (IDR) 1 217 750 to get additional 26 days of patency. Conclusion: There were no differences in survival and stent patency between the two groups. Metal biliary stent is more cost-effective than plastic stent for palliation in malignant biliary obstruction. © 2021 The Authors. JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.	biliary stent; cost-effectiveness; malignant biliary obstruction	bilirubin; Article; brain ischemia; cohort analysis; controlled study; cost effectiveness analysis; developing country; endoscopic retrograde cholangiopancreatography; hemodialysis; human; jaundice; liver cirrhosis; log rank test; major clinical study; mortality rate; observational study; overall survival; percutaneous coronary intervention; rank sum test; retrospective study; survival rate	John Wiley and Sons Inc	23979070		Article	Q3	546	9258	View
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331	Irdam G.A., Febriyani, Rasyid N., Taher A.	57194729795;57226319849;56245069300;7005269743;	A systematic review of intracavernosal injection of mesenchymal stem cells for diabetic erectile dysfunction	2021	Medical Journal of Indonesia	30	2	96	105	1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110674329&doi=10.13181%2fmji.oa.204475&partnerID=40&md5=41f468eff0f07099de19a39da32f2a41	Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia	Irdam, G.A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Febriyani, Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rasyid, N., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Taher, A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia	BACKGROUND As current erectile dysfunction (ED) treatments are limited, other treatment such as stem cells should be explored. Hence, this study aimed to review the sources, method of administration, and therapeutic effect of mesenchymal stem cells (MSCs) for diabetic ED treatment. METHODS All relevant articles regarding the use of MSCs for diabetic ED were searched in PubMed and Google Scholar databases from December 15, 2019 to January 1, 2020 published in the past 10 years. The keywords were “mesenchymal stem cells” and “diabetic ED”. The selection and critical appraisal of the studies were discussed. Diabetic ED was evaluated for functional and structural outcome. Functional outcome in animal studies was assessed by intracavernosal pressure/mean arterial pressure (ICP/ MAP) ratio, meanwhile the structural outcome was done microscopically. In human study, the assessments were done using international index of erectile function score (IIEF-5) to erection hardness score and penile Doppler ultrasonography. RESULTS There were 10 animal studies and 3 human studies. The studies used MSCs from adipose (n = 6), bone marrow (n = 4), placenta (n = 1), umbilical cord (n = 1), and muscle tissue (n = 1). The MSCs were administrated through intracavernosal injection in all studies. In all animal studies, functional outcome was improved, shown in higher ICP/MAP ratio. Microscopically, there were an increase of cavernosal endothelial cells, vascular endothelial growth factor, nitric oxide synthase, and smooth muscle cells. In human studies, IIEF-5 and erection hardness score were improved. Peak systolic velocity was also higher. CONCLUSIONS MSCs may be a promising therapy for diabetic ED; however, long-term safety concerns still need further investigations. © 2021, Faculty of Medicine, Universitas Indonesia. All rights reserved.	Diabetes mellitus; Erectile dysfunction; Mesenchymal stem cells	arterial pressure; Article; body mass; bone marrow; data extraction; DNA damage; Doppler ultrasonography; echography; erectile dysfunction; genomic instability; hardness; histochemistry; human; insulin sensitivity; International Index of Erectile Function; intracavernous pressure; mesenchymal stem cell; nonhuman; peak systolic velocity; placenta; questionnaire; shock wave therapy; smooth muscle cell; systematic review; umbilical cord	Faculty of Medicine, Universitas Indonesia	08531773		Article	Q4	164	21905	View
828	Suryana K.D., Simadibrata M., Renaldi K.	57222750873;23499598400;57190963547;	Impact of COVID-19 on the Gut: A Review of the Manifestations, Pathology, Management, and Challenges	2021	Acta medica Indonesiana	53	1	96	104	4	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103994291&partnerID=40&md5=8f9253303dd7921abe223346263c353b	Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/ Dr. Cipto Mangunkusumo General Hospital National HospitalJakarta, Indonesia	Suryana, K.D., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/ Dr. Cipto Mangunkusumo General Hospital National HospitalJakarta, Indonesia; Simadibrata, M.; Renaldi, K.	SARS-CoV-2 is a virus that can enter its hosts through the Angiotensin Converting Enzyme-2 (ACE2) receptor. ACE2 is mainly expressed in cells of the gastrointestinal tract, such as the esophageal epithelium and enterocytes from the ileum-colon. Coronavirus Disease 2019 (COVID-19) has varying clinical symptoms and presents differently in individuals, ranging from asymptomatic carriers to moderate clinical spectrum with mild pneumonia clinical features, and to a severe clinical presentation with dyspnea and hypoxia, leading to death due to respiratory or multi-organ failure. COVID-19 infection can also manifest themselves in the form of gastrointestinal symptoms such as diarrhea, vomiting, nausea, and abdominal pain. Severe complications of gastrointestinal COVID-19 infections include hemorrhage or perforation of the gastrointestinal tract and severe inflammation, which can adversely affect the intestinal immune system, and therefore the systemic immune system of the host. Furthermore, COVID-19 has also shown to affect microbiota homeostasis in the digestive tract. To date, no clear explanation is available regarding the pathophysiology of gastrointestinal SARS-CoV-2 infection, fecal RNA detection, and the possibility of fecal-oral transmission of SARS-CoV-2. This review aims to discuss the effects of SARS-CoV-2 infection on the digestive tract, microbiota, and lung, and the possibility of fecal-oral transmission in COVID-19.	Gastroenterology; Hepatology; Infection; Internal medicine; Pulmonology; Tropical disease	feces; gastrointestinal disease; gastrointestinal tract; human; immunology; isolation and purification; pathogenicity; pathophysiology; physiology; prevention and control; virology; COVID-19; Feces; Gastrointestinal Diseases; Gastrointestinal Tract; Humans; SARS-CoV-2	NLM (Medline)	01259326	33818412	Review	Q3	321	14162	View
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147	Merati T.P., Karyana M., Tjitra E., Kosasih H., Aman A.T., Alisjahbana B., Lokida D., Arlinda D., Maldarelli F., Neal A., Arif M., Gasem M.H., Lukman N., Sudarmono P., Lau C.-Y., Hadi U., Lisdawati V., Wulan W.N., Lane H.C., Siddiqui S.	57203678680;24449083500;57204151009;6507043017;6701594071;6506944516;57190663838;57218444330;57210198407;57220466230;56740206600;6508371601;57190737414;6507855437;16245242000;55804160500;56786334300;57204491118;57197596240;8707129300;	Prevalence of HIV infection and resistance mutations in patients hospitalized for febrile illness in Indonesia	2021	American Journal of Tropical Medicine and Hygiene	105	4	960	965		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117017901&doi=10.4269%2fajtmh.20-1595&partnerID=40&md5=f52639e32eebbadb71cd505b119b26d4	Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia; National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia; Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Department of Clinical Pathology, Tangerang District Hospital, Tangerang, Indonesia; National Cancer Institute, National Institutes of Health, Bethesda, MD, United States; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; Faculty of Medicine, Universitas Hasanudin, Makassar, Indonesia; Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Sulianti Saroso, Infectious Disease Hospital, Jakarta, Indonesia; Indonesia Research Partnership on Infections Disease, Jalan Percetakan Negara No. 29, Jakarta, 10560, Indonesia	Merati, T.P., Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia; Karyana, M., National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia, Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Tjitra, E., National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia; Kosasih, H., Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia, Indonesia Research Partnership on Infections Disease, Jalan Percetakan Negara No. 29, Jakarta, 10560, Indonesia; Aman, A.T., Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Alisjahbana, B., Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Lokida, D., Department of Clinical Pathology, Tangerang District Hospital, Tangerang, Indonesia; Arlinda, D., National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia, Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Maldarelli, F., National Cancer Institute, National Institutes of Health, Bethesda, MD, United States; Neal, A., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; Arif, M., Faculty of Medicine, Universitas Hasanudin, Makassar, Indonesia; Gasem, M.H., Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Lukman, N., Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Sudarmono, P., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lau, C.-Y., National Cancer Institute, National Institutes of Health, Bethesda, MD, United States; Hadi, U., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Lisdawati, V., Sulianti Saroso, Infectious Disease Hospital, Jakarta, Indonesia; Wulan, W.N., Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Lane, H.C., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; Siddiqui, S., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States	HIV prevalence in Indonesia is increasing, and only 64% of infected individuals know their status. In a prospective cohort of 1,453 hospitalized patients with unexplained fever, 46 (3.2%) had HIV, including 15 (1.1%) patients without a prior HIV diagnosis. Among 31 subjects previously known to have HIV, 21 (68%) had been receiving combination antiretroviral therapy (cART) at the time of enrollment. Of 39 HIV cases with HIV RNA levels $ 100 copies/mL, sequencing for genotype analysis and resistance testing was successful in 30 (77%) subjects. The most common HIV subtypes were AE (90%) and B (10%). Five (16.7%) subjects had resistance mutations to nucleoside and non-nucleoside reverse transcriptase inhibitors, and all of them were on cART. No evidence of transmitted drug resistance was found in newly diagnosed individuals. Hospital-based screening may be an efficient method to expand HIV testing and identify a significant number of new cases. Access to care, close monitoring, expansion of anti-retroviral options, and ensuring availability of CD4 determinations, viral load testing, and genotyping are crucial to control of the epidemic in Indonesia. © 2021 by The American Society of Tropical Medicine and Hygiene		nonnucleoside reverse transcriptase inhibitor; RNA directed DNA polymerase inhibitor; virus RNA; anti human immunodeficiency virus agent; adolescent; adult; aged; antiretroviral therapy; Article; child; cohort analysis; combination drug therapy; female; fever; genotype; hospital patient; hospitalization; human; Human immunodeficiency virus infection; Indonesia; major clinical study; male; nonhuman; prevalence; prospective study; virus mutation; virus resistance; antiviral resistance; drug effect; genetics; Human immunodeficiency virus 1; Human immunodeficiency virus infection; infant; middle aged; mutation; preschool child; very elderly; virology; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Child; Child, Preschool; Drug Resistance, Viral; Female; HIV Infection	American Society of Tropical Medicine and Hygiene	00029637	34460416	Article	Q1	1015	4298	View
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306	Rosmalena, Widyastuti P.A., Yazid F., Ambarwati N.S.S., Ahmad I.	56891769500;57226249984;57207890516;57193830343;57190669391;	Phytochemicals and antioxidant activities evaluation of origanum vulgare (L.) stem bark extracts	2021	Pharmacognosy Journal	13	4	965	970		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110932652&doi=10.5530%2fpj.2021.13.124&partnerID=40&md5=01f50c35c8a94d648081fcd99e50d8fa	Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Medical Student, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Department of Cosmetology, Faculty of Engineering, Universitas Negeri Jakarta, East Jakarta, Jakarta, 13220, Indonesia; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, East Kalimantan, Samarinda, 75119, Indonesia	Rosmalena, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Widyastuti, P.A., Medical Student, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Yazid, F., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Ambarwati, N.S.S., Department of Cosmetology, Faculty of Engineering, Universitas Negeri Jakarta, East Jakarta, Jakarta, 13220, Indonesia; Ahmad, I., Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, East Kalimantan, Samarinda, 75119, Indonesia	The present study aimed to evaluate phytochemical and antioxidant activity (in vitro and in vivo) of Origanum vulgare (L.) ethanolic extract. The phytochemical test was assessed using the Clule method in ethanol, ethyl acetate, and hexane. In vitro evaluation of antioxidant activity was determined by radical scavenging assay using DPPH (2,2-diphenyl-1-picrylhydrazyl) as an artificial free radical activity. In vivo test was conducted to evaluate the effect of malondialdehyde (MDA) level in blood plasma during maximum physical activity treatment. In vivo test was done using 25 male Sprague Dawley rats in pre and post-test control group design. The phytochemical test of O. vulgare ethanol extract was showed some compounds, such as a flavonoid, alkaloid, triterpenoid/steroid, essential oil, and tannin, then in ethyl acetate and hexane. In vitro assay showed that O. vulgare extract has strong antioxidant activity with an IC50 value of 133.47 µg/mL. While in the in vivo test, the most effective dosage is 20 mg/200 gr B.W., represented by a significant decrease of MDA level (0.509 nmol/mL) before and after treatment. So, the ethanolic extract of clove has potency as an herbal antioxidant because of the low level of IC50 and can decrease the MDA level. © 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.	2; 2-diphenyl-1-picrylhydrazyl; Antioxidant activity; Malondialdehyde; Origanum vulgare (L.); Phytochemical	1,1 diphenyl 2 picrylhydrazyl; acetic acid ethyl ester; alcohol; alkaloid; antioxidant; ascorbic acid; essential oil; flavonoid; free radical; hexane; malonaldehyde; Origanum vulgare ethanolic extract; phytochemical; plant extract; saponin; steroid; tannin; triterpenoid; unclassified drug; animal experiment; animal tissue; antioxidant activity; Article; bark; blood sampling; clove; controlled study; DPPH radical scavenging assay; drug potency; in vitro study; in vivo study; male; nonhuman; physical activity; pretest posttest design; rat; Sprague Dawley rat	EManuscript Technologies	09753575		Article	Q3	268	15961	View

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