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692 |
Harapan H., Fajar J.K., Supriono S., Soegiarto G., Wulandari L., Seratin F., Prayudi N.G., Dewi D.P., Monica Elsina M.T., Atamou L., Wiranata S., Aprianto D.P., Friska E., Sari Firdaus D.F., Alaidin M., Wardhani F.A., Husnah M., Hidayati N.W., Hendriyanti Y., Wardani K., Evatta A., Manugan R.A., Pradipto W., Rahmawati A., Tamara F., Mahendra A.I., Nainu F., Santoso B., Irawan Primasatya C.A., Tjionganata N., Budiman H.A. |
55844857500;56156139600;57218591523;57193717004;52464692000;57291538600;57291762600;57291994900;57291762700;57292451200;57220591122;57292451300;57291762800;57292675300;57291538700;57291315100;57194724156;57291315200;57292218900;57292909500;57292451400;57292219000;57292219100;57292675400;57192950403;57202301766;57120069200;57291762900;57291995000;57291538800;57291763000; |
The prevalence, predictors and outcomes of acute liver injury among patients with COVID-19: A systematic review and meta-analysis |
2021 |
Reviews in Medical Virology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116888408&doi=10.1002%2frmv.2304&partnerID=40&md5=8da649362695a47bd93802e3d5061df1 |
Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Internal Medicine, Division of Gastro-Entero-Hepatology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Internal Medicine, Division of Allergy & Immunology, Universitas Airlangga, Surabaya, Indonesia; Department of Pulmonology and Respiratory Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Paediatric, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Department of Urology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Faculty of Nursing, Universitas Indonesia, Depok, Indonesia; Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia; Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Department of Nursing, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Master Program of Biology, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia; Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia; Department of Internal Medicine, RSUD Bangil, Pasuruan, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia |
Harapan, H., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia, Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia, Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Fajar, J.K., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Supriono, S., Department of Internal Medicine, Division of Gastro-Entero-Hepatology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Soegiarto, G., Department of Internal Medicine, Division of Allergy & Immunology, Universitas Airlangga, Surabaya, Indonesia; Wulandari, L., Department of Pulmonology and Respiratory Medicine, Universitas Airlangga, Surabaya, Indonesia; Seratin, F., Department of Paediatric, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Prayudi, N.G., Department of Urology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Dewi, D.P., Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Monica Elsina, M.T., Faculty of Nursing, Universitas Indonesia, Depok, Indonesia; Atamou, L., Faculty of Nursing, Universitas Indonesia, Depok, Indonesia; Wiranata, S., Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia; Aprianto, D.P., Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Friska, E., Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Sari Firdaus, D.F., Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Alaidin, M., Department of Nursing, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Wardhani, F.A., Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Husnah, M., Master Program of Biology, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia; Hidayati, N.W., Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Hendriyanti, Y., Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Wardani, K., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Evatta, A., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Manugan, R.A., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Pradipto, W., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Rahmawati, A., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Tamara, F., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Mahendra, A.I., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Nainu, F., Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia; Santoso, B., Department of Internal Medicine, RSUD Bangil, Pasuruan, Indonesia; Irawan Primasatya, C.A., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Tjionganata, N., Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Budiman, H.A., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia |
The data on the predictors and prognosis of acute liver injury (ALI) among patients in coronavirus disease 2019 (COVID-19) patients are limited. The aim of this study was to determine the prevalence, predictors and outcomes of ALI among patients with COVID-19. A systematic review was conducted up to 10 June 2021. The relevant papers were searched from PubMed, Embase, Cochrane and Web of Science, and the data were analysed using a Z test. A total of 1331 papers were identified and 16 papers consisting of 1254 COVID-19 with ALI and 4999 COVID-19 without ALI were analysed. The cumulative prevalence of ALI among patients with COVID-19 was 22.8%. Male and having low lymphocyte levels were more likely to be associated with ALI compared with female and having higher lymphocyte level, odds ratio (OR): 2.70; 95% confidence interval (CI): 2.03, 3.60 and mean difference (MD) −125; 95% CI: −207, −43, respectively. COVID-19 patients with ALI had higher risk of developing severe COVID-19 compared with those without ALI (OR: 3.61; 95% CI: 2.60, 5.02). Our findings may serve as the additional evaluation for the management of ALI in COVID-19 patients. © 2021 John Wiley & Sons Ltd. |
acute liver injury; COVID-19; outcome; predictor; prevalence |
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John Wiley and Sons Ltd |
10529276 |
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Review |
Q1 |
2060 |
1246 |
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699 |
Putri K.T., Prasetyono T.O.H. |
57205299147;26646993900; |
A critical review on the potential role of adipose-derived stem cells for future treatment of hypertrophic scars |
2021 |
Journal of Cosmetic Dermatology |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116423050&doi=10.1111%2fjocd.14385&partnerID=40&md5=76adc3d0cee033ca6ae3fe7ec706fe72 |
Undergraduate Study Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Plastic Surgery, Department of Surgery, Cipto Mangunkusumo Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Putri, K.T., Undergraduate Study Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prasetyono, T.O.H., Division of Plastic Surgery, Department of Surgery, Cipto Mangunkusumo Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: Adipose-derived stem cells (ASCs) have recently gained researchers’ interest as a solution to various diseases and conditions, including hypertrophic scar. This literature review aims to elucidate ASCs as a potential solution to alleviate hypertrophic scar in human subjects. Methods: Literature search was done in databases which includes PubMed, MEDLINE, and ProQuest using terms ‘adipose derived stem cells’, ‘adipose cells’, ‘fat graft’, ‘fat grafting’, ‘autologous fat graft’, ‘fat injection’, ‘lipofilling’, ‘scar management’, ‘scar treatment’, ‘burn scar’, and ‘wound management’. The included articles which were published during year 2000-November 2020 must describe the use of ASCs or fat grafting or lipofilling as an attempt to alleviate hypertrophic scar. Remarks: Clinically, ASCs improve hypertrophic scars in terms of scar color, elasticity, texture, thickness, and size. Histologically, ASCs promotes healthy tissue regeneration, reduction in fibroblasts, and reorganisation of collagen, resembling those of normal skin. In terms of molecular aspects, ASCs alleviates hypertrophic scars through direct differentiation and paracrine mechanisms. Conclusion: Adipose-derived stem cells, emerge to be a potential solution for alleviating hypertrophic scar, as demonstrated in various studies. However, there has been no studies conducted in human subjects to investigate the effect of ASCs on hypertrophic scar. © 2021 Wiley Periodicals LLC |
adipocytes; cicatrix; fibroblast; intercellular signaling peptides and proteins; stem cells |
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John Wiley and Sons Inc |
14732130 |
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Review |
Q2 |
626 |
8066 |
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700 |
Rinaldi I., Prasetyawaty F., Fazlines S., Winston K., Samudera Nurrobi Y.A., Leoni J., Restu Tulus Maha I.H., Wicaksono S., Wicaksono A.Y., Aslani A.O., Ikhsani R. |
23475122400;57285017300;57284131900;57224165400;57283687900;57285017400;57285017500;57204717310;57283688000;57283914100;57283688100; |
Diagnosis and Management of Acquired Hemophilia A: Case Reports and a Literature Review |
2021 |
Case Reports in Medicine |
2021 |
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5554664 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116367653&doi=10.1155%2f2021%2f5554664&partnerID=40&md5=dd3f8e177d1b2f8c901c2f67e106f921 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rinaldi, I., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prasetyawaty, F., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fazlines, S., Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Winston, K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Samudera Nurrobi, Y.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Leoni, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Restu Tulus Maha, I.H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wicaksono, S., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wicaksono, A.Y., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Aslani, A.O., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ikhsani, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background. Acquired hemophilia A (AHA) is a potentially life-threatening autoimmune hemostatic disorder where autoantibodies that disrupt the functions of factor VIII (FVIII) are present in the circulation. The early diagnosis of AHA is difficult since the symptoms of AHA differ from those of congenital hemophilia A. Furthermore, the management of AHA is also more complex due to the presence of autoantibodies against FVIII (FVIII inhibitors). Here, we present three case reports and conduct a literature review of AHA with the aim to increase awareness and knowledge regarding the diagnosis and treatment of AHA. Case Presentations. We present three patients diagnosed with AHA in these case reports. The first patient was a young female, while the second and third patients were middle-aged and elderly males, respectively. All patients presented with a chief complaint of bruises without hemarthrosis and a history of bleeding. Laboratory examinations of the patients revealed isolated prolonged aPTT, normal PT, and the presence of autoantibodies against factor VIII, which are characteristics of AHA. Patients were then treated with corticosteroids to reduce the titer level of autoantibodies and received factor VIII transfusion to stop bleeding. Conclusion. AHA can be suspected in patients presenting with symptoms of bruises without hemarthrosis and without the history of bleeding. Isolated aPTT elevation with normal PT should raise high suspicion of AHA. The presence of FVIII inhibitors can help to confirm the diagnosis of AHA. Treatment consists of factor VIII transfusion and corticosteroid therapy. Bypassing agents are recommended as an alternative to FVIII transfusion. © 2021 Ikhwan Rinaldi et al. |
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autoantibody; blood clotting factor 8; blood clotting factor 8 antibody; blood clotting factor 8 inhibitor; cyclophosphamide; fresh frozen plasma; methylprednisolone; mycophenolate mofetil; prednisone; prothrombin; recombinant blood clotting factor 8; tranexamic acid; acquired hemophilia A; activated partial thromboplastin time; adult; aged; antibody titer; bleeding; blood cell count; case report; chronic kidney failure; clinical article; contusion; corticosteroid therapy; drug dose reduction; erythrocyte concentrate; erythrocyte transfusion; female; follow up; hand swelling; hemarthrosis; hemophilia A; human; laboratory test; male; medical history; middle aged; ovariectomy; ovary cyst; physical examination; prothrombin time; Review; surgical wound; treatment duration; very elderly; young |
Hindawi Limited |
16879627 |
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Review |
Q4 |
200 |
19317 |
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714 |
S. Sitohang I.B., Legiawati L., Suseno L.S., Safira F.D. |
56734569200;57202804484;57202804092;57261863100; |
Trichloroacetic Acid Peeling for Treating Photoaging: A Systematic Review |
2021 |
Dermatology Research and Practice |
2021 |
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3085670 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115103407&doi=10.1155%2f2021%2f3085670&partnerID=40&md5=9d2fa9a3d858b06aaf4bba3cc0802e10 |
Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
S. Sitohang, I.B., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Legiawati, L., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suseno, L.S., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Safira, F.D., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Photoaging can significantly contribute to lower quality of life. Medium-deep peeling using trichloroacetic acid allows controlled keratocoagulation through the dermis and into the dermal papillary layer that is effective for skin rejuvenation. The purpose of this article is to give updates regarding the efficacy, possible adverse events, and patient satisfaction of trichloroacetic acid (TCA) peeling for skin rejuvenation by assessing various photoaging parameters. A systematic review of prospective trial articles collected from PubMed, MEDLINE, EMBASE, Cochrane, and Scopus databases was conducted on November 2, 2020. Treatment efficacy was assessed based on the photoaging parameters used by each study. Adverse events and patient satisfaction as the secondary outcome were assessed based on patients-perceived improvements. Five studies included three randomized comparison studies and two prospective cohort studies. These studies show that TCA peeling significantly improve the cosmesis of photoaged facial skin. Low concentration is effective for superficial sun damage. Medium-depth peels using a higher concentration of TCA or as combination therapy are effective as skin resurfacing agents to reduce wrinkles. Some adverse effects may occur but usually resolve within weeks. Overall patients were satisfied with the treatment result. An equivalent basic skin preparation such as topical retinoic acid skin priming prior to intervention is necessary for more objective comparison. Further research studies with a larger sample size and longer follow-up period are required. This evidence suggests that TCA peeling is effective in photoaging treatment, either as monotherapy or as combination therapy with other modalities. © 2021 Irma Bernadette S. Sitohang et al. |
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melanin; trichloroacetic acid; actinic keratosis; adult; bacterial superinfection; burning sensation; chemexfoliation; cohort analysis; edema; erythema; female; human; hydration status; hyperpigmentation; hypopigmentation; male; monotherapy; outcome assessment; pain; patient satisfaction; photoaging; quality of life; randomized controlled trial (topic); Review; systematic review; treatment outcome; wrinkle |
Hindawi Limited |
16876113 |
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Review |
Q3 |
456 |
10893 |
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717 |
Kadharusman M.M., Antarianto R.D., Hardiany N.S. |
57222724597;57190862806;57192910605; |
A review of the impact of calorie restriction on stem cell potency |
2021 |
Malaysian Journal of Medical Sciences |
28 |
4 |
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5 |
13 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114744628&doi=10.21315%2fmjms2021.28.4.2&partnerID=40&md5=f082ca9d61a167cf3fec646a0e6012b7 |
Undergraduate Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kadharusman, M.M., Undergraduate Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Antarianto, R.D., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hardiany, N.S., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Calorie restriction (CR) prolongs lifespan in various species and also minimises pathologies caused by aging. One of the characteristics seen in age-related pathologies is stem cell exhaustion. Here, we review the various impacts of CR on mammalian health mediated through stem cell potency in various tissues. This study comprised of a literature search through NCBI, Science Direct, Google Scholar and PubMed, focusing on the impact of CR on pluripotency. In the skeletal muscle, CR acts as an anti-inflammatory agent and increases the presence of satellite cells endogenously to improve regeneration, thus causing a metabolic shift to oxidation to meet oxygen demand. In the intestinal epithelium, CR suppresses the mechanistic target of rapamycin complex 1 (mTORC1) signalling in Paneth cells to shift the stem cell equilibrium towards self-renewal at the cost of differentiation. In haematopoiesis, CR prevents deterioration or maintains the function of haematopoietic stem cells (HSCs) depending on the genetic variation of the mice. In skin and hair follicles, CR increases the thickness of the epidermis and hair growth and improves hair retention through stem cells. CR mediates the proliferation and self-renewal of stem cells in various tissues, thus increasing its regenerative ability. © Penerbit Universiti Sains Malaysia, 2021. |
Calorie restriction; Pluripotency; Stem cell |
apoptosis; caloric restriction; cell differentiation; cell proliferation; deterioration; epidermis; fluorescence activated cell sorting; gene expression; genetic variation; hair follicle; hematopoietic stem cell; insulin sensitivity; intestine epithelium; microenvironment; nonhuman; oxidative phosphorylation; oxidative stress; oxygen consumption; physical activity; regenerative ability; Review; signal transduction; skeletal muscle; stem cell; thermal conductivity; upregulation |
Penerbit Universiti Sains Malaysia |
1394195X |
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Review |
Q3 |
394 |
12287 |
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720 |
Hariyanto A.D., Permata T.B.M., Gondhowiardjo S.A. |
57253039400;57197808751;6508327402; |
Role of CD4+CD25+FOXP3+ TReg cells on tumor immunity |
2021 |
Immunological Medicine |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114605951&doi=10.1080%2f25785826.2021.1975228&partnerID=40&md5=dee345614c66584e8dcc9d94211b7f1f |
Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Hariyanto, A.D., Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Permata, T.B.M., Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Gondhowiardjo, S.A., Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Not all T cells are effector cells of the anti-tumor immune system. One of the subpopulations of CD4+ T cells that express CD25+ and the transcription factor FOXP3, known as Regulator T cells (TReg), plays an essential role in maintaining tolerance and immune homeostasis preventing autoimmune diseases, minimalize chronic inflammatory diseases by enlisting various immunoregulatory mechanisms. The balance between effector T cells (Teff) and regulator T cells is crucial in determining the outcome of an immune response. Regarding tumors, activation or expansion of TReg cells reduces anti-tumor immunity. TReg cells inhibit the activation of CD4+ and CD8+ T cells and suppress anti-tumor activity in the tumor microenvironment. In addition, TReg cells also promote tumor angiogenesis both directly and indirectly to ensure oxygen and nutrient transport to the tumor. There is accumulating evidence showing a positive result that removing or suppressing TReg cells increases anti-tumor immune response. However, depletion of TReg cells will cause autoimmunity. One strategy to improve or restore tumor immunity is targeted therapy on the dominant effector TReg cells in tumor tissue. Various molecules such as CTLA-4, CD4, CD25, GITR, PD-1, OX40, ICOS are in clinical trials to assess their role in attenuating TReg cells’ function. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of the Japanese Society of Clinical Immunology. |
anti-tumor immunity; immunotherapy; regulatory T cells; TReg; TReg-targeting therapy |
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Taylor and Francis Ltd. |
25785826 |
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Review |
Q3 |
419 |
11666 |
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722 |
Haifa G.Z., Wardoyo S. |
57249982200;57211106608; |
Surgical management in tetralogy of Fallot with rare unilateral pulmonary anomalies: A literature review |
2021 |
Asian Cardiovascular and Thoracic Annals |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114401204&doi=10.1177%2f02184923211039732&partnerID=40&md5=777078337b7532f398e346223b7685f6 |
Training Program of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia; Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia |
Haifa, G.Z., Training Program of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia; Wardoyo, S., Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia |
Tetralogy of Fallot with unilateral pulmonary anomalies such as the unilateral absence of pulmonary artery or unilateral pulmonary agenesis is an extremely rare complex congenital heart anomaly. There is no established surgical algorithm for tetralogy of Fallot with concomitant unilateral pulmonary anomalies. This condition is still challenging, especially in the surgical field. In this review we also present our experiences in our center, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia. This literature review aimed to discuss systematic treatment options and hoped to help the decision-making process when surgeons face these rare anomalies. © The Author(s) 2021. |
Tertralogy of Fallot; unilateral absence of pulmonary artery; unilateral pulmonary agenesis; unilateral pulmonary anomalies |
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SAGE Publications Inc. |
02184923 |
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Review |
Q3 |
203 |
19132 |
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723 |
Rohsiswatmo R., Widodo A.D., Munasir Z., Medise B.E. |
55533574600;57117722400;7801694370;57226215370; |
Prebiotic supplementation supports immunity & growth-development in preterm infants: A review and expert perspectives |
2021 |
Bali Medical Journal |
10 |
2 |
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785 |
792 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114340415&doi=10.15562%2fbmj.v10i2.2490&partnerID=40&md5=cffe54e9756788dc9eeb8ca22d1e3c5a |
Department of Child Health, Faculty of Medicine, Universitas Indonesia – Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Harapan Kita National Center for Woman and Child Health Care, Jakarta, Indonesia |
Rohsiswatmo, R., Department of Child Health, Faculty of Medicine, Universitas Indonesia – Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Widodo, A.D., Harapan Kita National Center for Woman and Child Health Care, Jakarta, Indonesia; Munasir, Z., Department of Child Health, Faculty of Medicine, Universitas Indonesia – Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Medise, B.E., Department of Child Health, Faculty of Medicine, Universitas Indonesia – Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Preterm birth still causes significant mortality and morbidity in newborns, despite modern advancements in preterm care. The gut microbiota is the most significant microbial colonization in the human body and plays a significant role in supporting a healthy body. Preterm infants are susceptible to gut dysbiosis, which is thought to contribute to the many adverse outcomes of prematurity, such as necrotizing enterocolitis (NEC), late-onset sepsis (LOS), and developmental delays. Human breast milk is considered the ideal nutrition source for newborns and can help create ideal microbiota in preterm infants. Breast milk contains human milk oligosaccharides (HMO), prebiotics that promote beneficial bacteria growth, absent in cow’s milk. Supplementation of non-milk oligosaccharides such as long-chain fructo-oligosaccharides (lcFOS) and small-chain galacto-oligosaccharides (scGOS) in formula milk for preterm infants is found to be beneficial with a favourable safety profile. This review discusses gut microbiota in preterm neonates, its role in developing immune systems, growth and development, and the benefits of prebiotic supplementation. © 2021, Sanglah General Hospital. All rights reserved. |
Development; Growth; Immunity; Prebiotic; Prematurity; Preterm birth |
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Sanglah General Hospital |
20891180 |
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Review |
#N/A |
#N/A |
#N/A |
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727 |
Pratomo I.P., Noor D.R., Kusmardi K., Rukmana A., Paramita R.I., Erlina L., Fadilah F., Gayatri A., Fitriani M., Purnomo T.T.H., Ariane A., Heryanto R., Tedjo A. |
57192904477;57214096801;56966625300;35491487100;54882436900;57190181680;56966708600;57204275086;57233517300;57234248500;57210643323;23392757600;57189320451; |
Xanthine Oxidase-Induced Inflammatory Responses in Respiratory Epithelial Cells: A Review in Immunopathology of COVID-19 |
2021 |
International Journal of Inflammation |
2021 |
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1653392 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113632856&doi=10.1155%2f2021%2f1653392&partnerID=40&md5=37c46cd8f6ff191ba785fa8abb7052a3 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; COVID-19 Task Force-Pulmonology and Respiratory Medicine Unit, Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Ipb University, Bogor, Indonesia; Tropical Biopharmaca Research Center, Ipb University, Bogor, Indonesia |
Pratomo, I.P., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, COVID-19 Task Force-Pulmonology and Respiratory Medicine Unit, Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia, Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Noor, D.R., Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kusmardi, K., Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rukmana, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Paramita, R.I., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Erlina, L., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Fadilah, F., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Gayatri, A., Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fitriani, M., Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Purnomo, T.T.H., Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Ariane, A., Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Indonesia; Heryanto, R., Department of Chemistry, Faculty of Mathematics and Natural Sciences, Ipb University, Bogor, Indonesia, Tropical Biopharmaca Research Center, Ipb University, Bogor, Indonesia; Tedjo, A., Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia |
Xanthine oxidase (XO) is an enzyme that catalyzes the production of uric acid and superoxide radicals from purine bases: hypoxanthine and xanthine and is also expressed in respiratory epithelial cells. Uric acid, which is also considered a danger associated molecule pattern (DAMP), could trigger a series of inflammatory responses by activating the inflammasome complex path and NF-B within the endothelial cells and by inducing proinflammatory cytokine release. Concurrently, XO also converts the superoxide radicals into hydroxyl radicals that further induce inflammatory responses. These conditions will ultimately sum up a hyperinflammation condition commonly dubbed as cytokine storm syndrome (CSS). The expression of proinflammatory cytokines and neutrophil chemokines may be reduced by XO inhibitor, as observed in human respiratory syncytial virus (HRSV)-infected A549 cells. Our review emphasizes that XO may have an essential role as an anti-inflammation therapy for respiratory viral infection, including coronavirus disease 2019 (COVID-19). © 2021 Irandi Putra Pratomo et al. |
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allopurinol; uric acid; xanthine oxidase; airway epithelium cell; antiinflammatory activity; catalysis; coronavirus disease 2019; cytokine release; enzyme activity; human; hypoxia; immunopathology; inflammation; neutrophil; nonhuman; pathogenesis; protein function; protein targeting; Review; RNA virus infection |
Hindawi Limited |
20908040 |
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Review |
Q2 |
1106 |
3761 |
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728 |
Amin L.Z., Amin H.Z., Amin Z. |
57193005548;56217714300;16309125900; |
Beta-blocker attenuates cardiotoxicity related anthracycline usage |
2021 |
Journal of the Medical Association of Thailand |
104 |
8 |
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1389 |
1392 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113310208&doi=10.35755%2fjmedassocthai.2021.08.9268&partnerID=40&md5=ee18aa74520b3a2ce8f163a390c84499 |
Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia |
Amin, L.Z., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Amin, H.Z., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Amin, Z., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia |
To summarize the recent trials and studies of the role of beta-blocker on the treatment for cancer patients treated with anthracycline to decrease morbidity and mortality rate. Good management of cancer will result in large numbers of cancer survivors. On the other hand, cancer therapy also has side effects, one of which is cardiotoxicity. Cardiotoxicity could reduce therapy effectiveness, hence, increase disease progression and mortality rate. Anthracyclines is one of the chemotherapy agents with cardiotoxicity as a side effect. Beta-blocker has the ability to reduce cardiotoxicity due to anthracyclines usage. © JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND. |
Anthracyclines; Beta-blocker; Cardiotoxicity |
alprenolol; amino terminal pro brain natriuretic peptide; anthracycline; beta adrenergic receptor; beta adrenergic receptor blocking agent; beta arrestin; carvedilol; deubiquitinase; DNA topoisomerase (ATP hydrolysing); doxorubicin; epidermal growth factor receptor; epirubicin; G protein coupled receptor; guanosine triphosphatase; histone deacetylase; hydroxyl radical; nebivolol; peroxisome proliferator; protein p53; reactive nitrogen species; reactive oxygen metabolite; reduced nicotinamide adenine dinucleotide phosphate oxidase; sodium chloride; apoptosis; autophagy (cellular); blood pressure; breast cancer; cancer therapy; cancer tissue; cardiac muscle cell; cardiac stem cell; cardiomyopathy; cardiotoxicity; cardiovascular disease; cardiovascular risk factor; cell death; cell membrane; |
Medical Association of Thailand |
01252208 |
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Review |
#N/A |
#N/A |
#N/A |
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