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Riset dan Pengabdian Masyarakat Do Research Sosial Service and Innovation

Id	Authors	Author S Id	Title	Year	Source Title	Volume	Issue	Page Start	Page End	Cited By	Link	Affiliations	Authors With Affiliations	Abstract	Author Keywords	Index Keywords	Publisher	Issn	Pubmed Id	Document Type	Sjr Best Quartile	Sjr	Sjr Rank
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University of the Philippines Manila(1)
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196	Alie I.R., Andriantoro H., Timan I.S., Sulistomo A.W., Illyas E.I., Mansyur M.	57288933200;55037171500;6602793366;57024018500;57288423500;37085506800;	Potency biomarker effect of endothelial microparticles (emps) for early prediction of cardiovascular risk in shift worker nurses	2021	Acta Medica Philippina	55	6	616	620		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116671512&doi=10.47895%2fAMP.V55I6.3142&partnerID=40&md5=10ceaf9c58aabc0ce93083d831644fe1	Program of Universitas Indonesia; Department of Cardiology and Vascular Faculty of Medicine, Universitas Indonesia; Department of Pathology Clinic, Faculty of Medicine, Universitas Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia; Department of Physiology, Faculty of Medicine, Universitas Indonesia	Alie, I.R., Program of Universitas Indonesia; Andriantoro, H., Department of Cardiology and Vascular Faculty of Medicine, Universitas Indonesia; Timan, I.S., Department of Pathology Clinic, Faculty of Medicine, Universitas Indonesia; Sulistomo, A.W., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia; Illyas, E.I., Department of Physiology, Faculty of Medicine, Universitas Indonesia; Mansyur, M., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia	Objectives. Shift work results in changing worker's behavior, food, and sleep patterns, which can cause circadian rhythm disturbance, which is a cardiovascular risk. Until now, a biomarker of early prediction of cardiovascular risk on shift workers is still not developed. This study aimed to assess the cardiovascular risk of shift worker nurses by detecting endothelial microparticles (EMPs). Methods. This longitudinal study compared six shift nurses and five non-shift nurses by measuring the EMPs using antigen CD31+ flow cytometry. All met the inclusion criteria consisting of 28 blood samples followed in one week shift. Results. EMPs among non-shift nurses were below 200 μL. However, shift nurses' EMPs increased above 200 μL with Man-Whitney U p = 0.000 on days 4 and 7 following a one shift per week schedule. Conclusion. There was an increase in shift workers' endothelial microparticles (EMP) which was a sign of cardiovascular risk. © 2021 University of the Philippines Manila. All rights reserved.	Cardiovascular risk; CD31+; Endothelial microparticles (EMPs); Nurse; Shift work		University of the Philippines Manila	00016071		Article	Q4	128	25603	View
Varastegan Institute for Medical Sciences(1)
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659	Dewi S., Yulhasri Y., Mulyawan W.	57192904541;57225180520;57192910410;	The Impact of Intermittent Hypobaric Hypoxia Exposures on Triacylglycerol Synthesis in Rat Liver	2021	Reports of Biochemistry and Molecular Biology	10	3	437	444		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120058392&partnerID=40&md5=0ff2179c774f4a9d0d0a1c462ec80dc4	Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Aerophysiology, Lakespra Saryanto, Air Force Indonesian National Army, Jakarta, Indonesia	Dewi, S., Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Yulhasri, Y., Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Mulyawan, W., Department of Aerophysiology, Lakespra Saryanto, Air Force Indonesian National Army, Jakarta, Indonesia	Background: In a hypoxic state, fatty acid breakdown reaction may be inhibited due to a lack of oxygen. It is likely that the fatty acids will be stored as triacylglycerol. The aim of this study was to analyse triacylglycerol synthesis in the liver after intermittent hypobaric hypoxia (HH) exposures. Methods: Samples are liver tissues from 25 male Wistar rats were divided into 5 groups: controlgroup (normoxia), group I (once HH exposure), group II (twice HH exposures), group III (three-times HH exposures) and group IV (four-times HH exposures). The triacylglycerol level, mRNA expression of HIF-1α and PPAR-γ were measured in rat liver from each group.Results: We demonstrated that triacylglycerol level, mRNA expression of HIF-1α and PPAR-γ is elevated in group I significantly compared to control group. In the intermittent HH groups (group II, III and IV), mRNA expression of HIF-1α and PPAR-γ tends to downregulate near to control group. However, the triacylglycerol level is still found increased in the intermittent HH exposures groups. Significant increasing of triacylglycerol level was found especially in group IV compared to control group.Conclusions: We conclude that intermittent HH exposures will increase the triacylglycerol level in rat liver, supported by the increasing of HIF-1α and PPAR-γ mRNA expression that act as transcription factor to promote triacylglycerol synthesis © 2021. Reports of Biochemistry & Molecular Biology. All Rights Reserved.	HIF-1α; Hypoxia; Liver; PPAR-γ; Triacylglycerol		Varastegan Institute for Medical Sciences	23223480		Article	Q3	467	10677	View
Verduci Editore s.r.l(2)
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725	Dakota I., Munawar M., Pranata R., Raffaello W.M., Sukmawan R.	55796663700;57240564000;57201973901;57219975426;8651025300;	Diagnostic prediction model in subjects with low-risk unstable angina pectoris/Non-ST Segment Elevation Myocardial Infarction	2021	European Review for Medical and Pharmacological Sciences	25	16	5145	5152		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113915274&doi=10.26355%2feurrev_202108_26528&partnerID=40&md5=c20c979784718826df68abcc9a197526	Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Binawaluya Cardiac Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia	Dakota, I., Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Munawar, M., Binawaluya Cardiac Hospital, Jakarta, Indonesia; Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Raffaello, W.M., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Sukmawan, R., Binawaluya Cardiac Hospital, Jakarta, Indonesia	OBJECTIVE: This study aims to construct a prediction model based on non-invasive examination and cardiovascular risk factors, to predict the presence of coronary artery disease (CAD) and its severity in patients with low-risk unstable angina pectoris (UAP)/ Non-ST Segment Elevation Myocardial Infarction (NSTEMI). PATIENTS AND METHODS: This cross-sectional study aimed to assess the association between non-invasive examinations and cardiovascular risk factors in predicting CAD. Model constructed based on non-invasive assessment and cardiovascular risk factors was compared to coronary angiography, the reference standard. RESULTS: This study included 104 patients, comprising 60 men and 44 women, who fulfilled the inclusion criteria. The mean age was 52.3 (6.8) years. Two diagnostic prediction models were constructed after series of analyses. The main model consists of NO, CIMT, history of smoking, and Age-Gender, while the alternative model consists of CIMT, history of smoking, and Age-Gender. The main model has AUC of 74.5% (95% CI: 64.9-84.1), sensitivity of 72.7% (95% CI: 57.2-85.0), specificity 65.0% (95% CI: 51.6 -76.9 for a cut-off point of 74.5. While the alternative model has 69.0% AUC (95% CI: 58.9-79.1), sensitivity of 65.9% (95%: 50.1-79, 5), a specificity of 56.7% (95% CI: 43.2-69.4) for a cut-off point of 69. The main model and the alternative model have similar diagnostic prediction performance based on the ROC comparison test (p = 0.70). CONCLUSIONS: Based on these results, we conclude that NO, CIMT, smoking history, and age-gender have a value of diagnostic validity in subjects with low-risk UAP/NSTEMI. © 2021 Verduci Editore s.r.l. All rights reserved.	Acute coronary syndrome; Coronary artery disease; Diagnosis; Non-invasive; Unstable angina pectoris	nitric oxide; adult; age distribution; Article; cardiovascular risk factor; carotid intima-media thickness; coronary angiography; coronary artery disease; cross-sectional study; diagnostic test accuracy study; diagnostic value; disease risk assessment; disease severity; female; Gensini score; human; low risk patient; major clinical study; male; non invasive measurement; non ST segment elevation myocardial infarction; prediction; receiver operating characteristic; sensitivity and specificity; sex difference; smoking; unstable angina pectoris	Verduci Editore s.r.l	11283602	34486689	Article	Q2	768	6336	View
740	Firman D., Arilaksono D.G., Ambari A.M., Radi B., Indriyani S., Siagian S.N., Pranata R., Alkatiri A.A., Iryuza N., Mangkuanom A.S.	54898724100;57226523719;57189576921;6603494019;57226541031;57214134720;57201973901;57210302708;57226539663;57226528371;	The obesity paradox: Effect of body mass index on 2-years clinical outcome after primary percutaneous coronary intervention in Indonesia	2021	European Review for Medical and Pharmacological Sciences	25	15	4973	4982		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111855215&doi=10.26355%2feurrev_202108_26454&partnerID=40&md5=3cd82622fd51f3bf48902176f689eb4e	Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia	Firman, D., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Arilaksono, D.G., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Ambari, A.M., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Radi, B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Indriyani, S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Siagian, S.N., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Alkatiri, A.A., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Iryuza, N., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Mangkuanom, A.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia	OBJECTIVE: Several studies demonstrated that a high body mass index (BMI) might actually benefit patients with cardiovascular disease, including coronary heart disease. However, other studies were unable to confirm this paradoxical phenomenon in all populations. Therefore, this study aims to determine the association between BMI and long-term clinical outcomes in ST-segment elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI). PATIENTS AND METHODS: This was a retrospective cohort study of 400 STEMI patients undergoing PCI. Clinical outcome evaluation was done by face-to-face or phone interview and collecting objective data. Statistical analysis was performed to compare the outcomes between underweight-normal group with overweight- obese group. RESULTS: The incidence of major adverse cardiovascular events (MACE) was lower in patients with higher BMI group in 2-years evaluation (24.1% vs. 39.9%; p < 0.001). Multivariate analysis showed that BMI was an independent predictor of MACE and the incidence of recurrent infarction (OR 2.322 [CI 95% 1.505-3.584; p < 0.001]). The risk of MACE reduces as the weight increases, with a nadir of risk reduction for MACE at 28 to 29.0 kg/m2, in which the curve rises after, but remained below the risk associated with BMI of 23 kg/m2. CONCLUSIONS: In our population, patients with high BMI have a lower incidence of longterm MACE, especially recurrent myocardial infarction, in patients with STEMI undergoing PCI. © 2021 Verduci Editore s.r.l. All rights reserved.	Body mass index; Obesity; Percutaneous coronary intervention; STEMI	adverse event; body mass; cohort analysis; female; human; Indonesia; male; middle aged; multivariate analysis; obesity; percutaneous coronary intervention; retrospective study; treatment outcome; Body Mass Index; Cohort Studies; Female; Humans; Indonesia; Male; Middle Aged; Multivariate Analysis; Obesity; Percutaneous Coronary Intervention; Retrospective Studies; Treatment Outcome	Verduci Editore s.r.l	11283602	34355369	Article	Q2	768	6336	View
Veterinary World(2)
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94	Subahar R., Susanto L., Aidilla R., Aulia A.P., Yulhasri Y., Winita R., Lubis N.S., Sari I.P.	6508197883;6507704130;57365800900;57366528800;57225180520;57220782528;57222661567;57197543698;	In vitro experiments of Pediculus humanus capitis (Phthiraptera: Pediculidae) resistance to permethrin and 6-paradol in East Jakarta: Detoxification enzyme activity and electron microscopic changes in lice	2021	Veterinary World	14	11	3065	3075		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120814548&doi=10.14202%2fvetworld.2021.3065-3075&partnerID=40&md5=1d1646983a8b7f7da98a7d4f5896e795	Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jln. Salemba Raya 4, Jakarta, 10430, Indonesia	Subahar, R., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Susanto, L., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Aidilla, R., Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Aulia, A.P., Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Yulhasri, Y., Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jln. Salemba Raya 4, Jakarta, 10430, Indonesia; Winita, R., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Lubis, N.S., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Sari, I.P., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia	Background and Aim: Pediculus humanus capitis, the human head louse, remains a global health problem. This study evaluated the resistance of head lice to permethrin and 6-paradol mediated by in vitro detoxification enzyme activity experiments and to describe physical changes in the lice using scanning electron microscopy (SEM). Materials and Methods: The adult stages of P. h. capitis were collected from patients exposed to 1% permethrin and three different concentrations of 6-paradol (0.00005%, 0.0001%, and 0.00015%) using a filter paper diffusion bioassay. Healthy P. h. capitis adults served as the control. The in vitro bioassays were conducted after 10, 20, 30, and 60 min of exposure. The activities of acetylcholinesterase (AChE), glutathione S-transferase (GST), and oxidase were analyzed. Physical changes in the lice were analyzed using SEM. Results: Permethrin and 6-paradol exhibited low toxicity against the lice. At 60 min, 1% permethrin had killed 36.7% of the lice present, while 6-paradol had killed 66.7-86.7%. Permethrin induced significantly elevated AChE, GST, and oxidase activity; 6-paradol also caused significantly elevated AChE, GST, and oxidase activity. Permethrin did not cause any ultrastructural morphological changes on the lice, while 6-paradol severely damaged the head, thorax, respiratory spiracles, and abdomen of the dead lice. Conclusion: This in vitro experimental of P. h. capitis is the first study to report P. h. capitis in East Jakarta shows complete resistance to permethrin and 6-paradol, and to describe the associated increase in AChE, GST, and oxidase activity. It was observed that 6-paradol severely damaged the head, thorax, respiratory spiracles, and abdomen of the dead lice. © 2021 Veterinary World. All rights reserved.	6-paradol; Detoxifying enzyme; Electron microscopy; Pediculus humanus capitis; Permethrin; Resistance	6 paradol; acetylcholinesterase; chitin; glutathione transferase; oxidoreductase; permethrin; phenol derivative; unclassified drug; Article; bioassay; controlled study; detoxification; diffusion; enzyme activity; enzyme linked immunosorbent assay; hair loss; LT50; LT90; nonhuman; Pediculus humanus capitis; scanning electron microscopy; ultrastructure	Veterinary World	09728988		Article	Q2	550	9187	View
304	Gunawan S., Aulia A., Soetikno V.	57226331078;57201441066;36769252100;	Development of rat metabolic syndrome models: A review	2021	Veterinary World	14	7	1774	1783	1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111179239&doi=10.14202%2fvetworld.2021.1774-1783&partnerID=40&md5=609e64dbfe9d6c9660d991f611abbd71	Department of Pharmacology, Faculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia; Doctoral Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Gunawan, S., Department of Pharmacology, Faculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia, Doctoral Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Aulia, A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soetikno, V., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Metabolic syndrome (MetS) has become a global problem. With the increasing prevalence of MetS worldwide, understanding its pathogenesis and treatment modalities are essential. Animal models should allow an appropriate representation of the clinical manifestations of human conditions. Rats are the most commonly used experimental animals for the study. The development of a proper MetS model using rats will contribute to the successful application of research findings to the clinical setting. Various intervention methods are used to induce MetS through diet induction with various compositions, chemicals, or a combination of both. This review will provide a comprehensive overview of several studies on the development of rat MetS models, along with the characteristics of the clinical manifestations resulting from each study. © 2021 Veterinary World. All rights reserved.	High-fat diet; High-fructose diet; High-sucrose diet; Metabolic syndrome; Rat models	cholesterol; diacylglycerol; glucose; high density lipoprotein cholesterol; leptin receptor; low density lipoprotein cholesterol; triacylglycerol; abdominal circumference; abdominal obesity; animal model; bipolar disorder; body weight; bone metabolism; caloric intake; carbohydrate intake; cardiovascular disease; diastolic blood pressure; dyslipidemia; exercise; fat mass; food intake; gene; glucose blood level; glucose tolerance; high-fructose diet; human; hyperglycemia; insulin resistance; insulin sensitivity; insulin tolerance test; lipid diet; lipid metabolism; lipid storage; lipogenesis; major depression; male; mental disease; metabolic syndrome X; nonalcoholic fatty liver; nonhuman; osmotic stress; oxidative stress; pathogenesis; physical activity; prevalence; rat; Review; risk factor;	Veterinary World	09728988		Review	Q2	550	9187	View
W.B. Saunders(4)
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71	Tandaju J.R., Li W., Pateras K., Georgiopoulos G.	57222662533;57369633600;57200224369;57188877741;	Deriving cut-off values for continuous predictors of severe outcomes in COVID-19 through meta-analysis of individual studies	2021	American Journal of Emergency Medicine	50		799		1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104938971&doi=10.1016%2fj.ajem.2021.03.029&partnerID=40&md5=b4a3015c95a454387a73134ab5845aa6	Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia; The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Department of Biostatistics and Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom; Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Athen, Greece	Tandaju, J.R., Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia; Li, W., The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Pateras, K., Department of Biostatistics and Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Georgiopoulos, G., School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Athen, Greece	[No abstract available]		clinical outcome; coronavirus disease 2019; disease severity; human; Letter; COVID-19; Humans; SARS-CoV-2	W.B. Saunders	07356757	33958246	Letter	Q1	725	6828	View
260	Saharman Y.R., Karuniawati A., Sedono R., Aditianingsih D., Qi H., Verbrugh H.A., Severin J.A.	55980934300;54886816200;56660590500;56312263600;57200516838;7103296623;8700385500;	Multimodal intervention to reduce acquisition of carbapenem-non-susceptible Gram-negative bacteria in intensive care units in the National Referral Hospital of Indonesia: An interrupted time series study	2021	Journal of Critical Care	64		237	244	1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107783916&doi=10.1016%2fj.jcrc.2021.04.016&partnerID=40&md5=5958a3646b6b7e60f517ca3456c7f72a	Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Critical Care Division, Department of Anesthesia and Intensive Care, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Biostatistics, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands	Saharman, Y.R., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Karuniawati, A., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sedono, R., Critical Care Division, Department of Anesthesia and Intensive Care, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Aditianingsih, D., Critical Care Division, Department of Anesthesia and Intensive Care, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Qi, H., Department of Biostatistics, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands, Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Verbrugh, H.A., Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Severin, J.A., Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands	Purpose: To evaluate a low-cost multimodal intervention on the acquisition of carbapenem-non-susceptible Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa by patients in low-resource intensive care units. Materials and methods: We performed a quasi-experimental study in a referral hospital in Jakarta, Indonesia: pre-intervention phase 1 (2013–2014), intervention phase 2 (2014–2015) and post-intervention phase 3 (2015–2016). The intervention was hand hygiene promotion and environmental cleaning and disinfection combined with patient disinfection and cohorting. The primary outcome was acquisition of resistant bacteria per 100 patient-days at risk, which was assessed by active microbiological surveillance and analysed with a multilevel Poisson segmented regression model. Results: In phase 1 (387 patients), the acquisition rate was 4.3/100 days for carbapenem-non-susceptible A. baumannii versus 1.1/100 days for both K. pneumoniae and P. aeruginosa. There was a significant step change from phase 1 to phase 3 (361 patients) in the acquisition of carbapenem-non-susceptible strains, the incidence rate ratio (IRR) was 0.343 (99%CI: 0.164–0.717). This significant change was mainly due to reduced acquisitions of resistant A. baumannii (IRR 0.4, 99%CI: 0.181–1.061). Negative confounding was observed. Conclusion: A multimodal intervention to prevent acquisition of resistant pathogens is feasible and may be effective in ICUs in lower-middle income countries. © 2021 The Authors	Acinetobacter baumannii-calcoaceticus complex; Acquisition rate; Carbapenem-non-susceptible; ICU; Indonesia; Klebsiella pneumoniae; Multimodal interventions; Pseudomonas aeruginosa	carbapenem; antiinfective agent; carbapenem derivative; Acinetobacter baumannii; Acinetobacter calcoaceticus-baumannii complex; adult; aged; antibiotic sensitivity; Article; artificial ventilation; bacterium isolation; cleaning; controlled study; disease surveillance; disinfection; emergency ward; female; human; hygiene; incidence; infection control; information processing; intensive care unit; Klebsiella pneumoniae; length of stay; major clinical study; male; multidrug resistance; outcome assessment; phase 1 clinical trial; phase 2 clinical trial; phase 3 clinical trial; Pseudomonas aeruginosa; quasi experimental study; remission; Sequential Organ Failure Assessment Score; systemic inflammatory response syndrome; time series analysis; cross infection; Gram negative bacterium; hospital; In	W.B. Saunders	08839441	34044188	Article	Q1	1149	3541	View
271	Yonas E., Alwi I., Pranata R., Huang I., Lim M.A., Gutierrez E.J., Yamin M., Siswanto B.B., Virani S.S.	57201987097;15055173800;57201973901;57208576645;57216039756;57200435964;23475706300;14422648800;6701757915;	Effect of heart failure on the outcome of COVID-19 — A meta analysis and systematic review	2021	American Journal of Emergency Medicine	46		204	211	43	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090893264&doi=10.1016%2fj.ajem.2020.07.009&partnerID=40&md5=08c8139ca7f811f915c445cf5c2e3f1c	Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Department of Critical Care Medicine, Baptist Medical Center, Jacksonville, FL, United States; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Michael E. DeBakey Veterans Affairs Medical Center & Baylor College of Medicine, Houston, TX, United States; Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia	Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Alwi, I., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Huang, I., Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Gutierrez, E.J., Department of Critical Care Medicine, Baptist Medical Center, Jacksonville, FL, United States; Yamin, M., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Siswanto, B.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Virani, S.S., Michael E. DeBakey Veterans Affairs Medical Center & Baylor College of Medicine, Houston, TX, United States	Background: Several comorbidities have been associated with an increased risk of severity and mortality in coronavirus disease 2019 (COVID-19), including hypertension, diabetes, cerebrovascular disease, chronic kidney disease, and chronic obstructive pulmonary disease. Purpose: In this systematic review and meta-analysis, we attempted to investigate the association between heart failure (HF) and poor outcome in patients with COVID-19. Methods: We performed a systematic literature search from PubMed, EuropePMC, SCOPUS, Cochrane Central Database, and medRxiv with the search terms, “Heart failure” and “COVID-19”. The outcome of interest was mortality and poor prognosis (defined by incidence of severe COVID-19 infection, admission to ICU, and use of ventilator) in patients with preexisting heart failure with coronavirus disease. Results: We identified 204 potential articles from our search, and 22 duplicates were removed. After screening of the titles and abstracts of the remaining 182 articles we identified 92 potentially relevant articles. We excluded 74 studies due to the following reasons: four studies were systematic reviews, two studies were meta-analyses, three articles were literature reviews, and 65 articles did not report on the outcome of interest. Finally, we included the remaining 18 studies in our qualitative synthesis and meta-analysis. There were 21,640 patients from 18 studies. HF was associated with hospitalization in COVID19 HR was 2.37 [1.48, 3.79; p < 0.001], high heterogeneity [I2, 82%; p < 0.001]. HF was associated with a poor outcome demonstrated by an OR of 2.86 [2.07; 3.95; p < 0.001] high heterogeneity [I2, 80%; p < 0.001]. Patient with preexisting HF was associated with higher mortality OR of 3.46 [2.52, 4.75; p < 0.001] moderately high heterogeneity [I2, 77%; p < 0.001]. Conclusion: Patients with heart failure are at increased risk for hospitalization, poor outcome, and death from COVID-19. A significant difference in mortality between patients with and without heart failure was observed, patients with heart failure having a higher mortality. © 2020 Elsevier Inc.	Coronavirus disease 2019; Heart failure; Poor outcomes	apnea hypopnea index; Article; artificial ventilation; coronavirus disease 2019; heart failure; hospitalization; human; incidence; meta analysis; mortality; outcome assessment; prevalence; prognosis; questionnaire; risk factor; systematic review; comorbidity; global health; heart failure; pandemic; procedures; risk assessment; survival rate; Comorbidity; COVID-19; Global Health; Heart Failure; Humans; Pandemics; Risk Assessment; Risk Factors; SARS-CoV-2; Survival Rate	W.B. Saunders	07356757	33071085	Article	Q1	725	6828	View
485	Simadibrata D.M., Calvin J., Wijaya A.D., Ibrahim N.A.A.	57202134322;57221411392;57221411463;57221410260;	Neutrophil-to-lymphocyte ratio on admission to predict the severity and mortality of COVID-19 patients: A meta-analysis	2021	American Journal of Emergency Medicine	42		60	69	22	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099401846&doi=10.1016%2fj.ajem.2021.01.006&partnerID=40&md5=9764e041c3a47b836e3ffc766efdf406	Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Simadibrata, D.M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Calvin, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wijaya, A.D., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ibrahim, N.A.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Background: The neutrophil-to-lymphocyte ratio (NLR), an inflammatory marker, was suggested to be predictive of severity and mortality in COVID-19 patients. Here, we investigated whether NLR levels on admission could predict the severity and mortality of COVID-19 patients. Methods: A literature search was conducted on 23 July 2020 to retrieve all published articles, including grey literature and preprints, investigating the association between on-admission NLR values and severity or mortality in COVID-19 patients. A meta-analysis was performed to determine the overall standardized mean difference (SMD) in NLR values and the pooled risk ratio (RR) for severity and mortality with the 95% Confidence Interval (95%CI). Results: A total of 38 articles, including 5699 patients with severity outcomes and 6033 patients with mortality outcomes, were included. The meta-analysis showed that severe and non-survivors of COVID-19 had higher on-admission NLR levels than non-severe and survivors (SMD 0.88; 95%CI 0.72–1.04; I2 = 75.52% and 1.87; 95%CI 1.25–2.49; I2 = 97.81%, respectively). Regardless of the different NLR cut-off values, the pooled mortality RR in patients with elevated vs. normal NLR levels was 2.74 (95%CI 0.98–7.66). Conclusion: High NLR levels on admission were associated with severe COVID-19 and mortality. Further studies need to focus on determining the optimal cut-off value for NLR before clinical use. © 2021 Elsevier Inc.	COVID-19; Meta-analysis; Mortality; Neutrophil-to-lymphocyte ratio; Severity	Article; coronavirus disease 2019; disease association; disease severity; hospital admission; human; meta analysis; mortality; mortality risk; neutrophil lymphocyte ratio; outcome assessment; prediction; priority journal; quality control; risk assessment; sensitivity and specificity; sex ratio; survivor; systematic review; blood; diagnosis; hospitalization; lymphocyte count; neutrophil; severity of illness index; survival rate; COVID-19; Hospitalization; Humans; Lymphocyte Count; Neutrophils; Severity of Illness Index; Survival Rate	W.B. Saunders	07356757	33453617	Article	Q1	725	6828	View

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