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No records
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600 |
Kusuma F., Matondang S.B., Nuranna L., Purwoto G., Khonsa O., Hyaswicaksono P. |
57192911548;57192085914;55301184300;14720170400;57268401500;57221907604; |
Postradiotherapy outcome on cervical cancer stage IIIB patients with and without paraaortic lymph nodes enlargement [Hasil Pascaradioterapi pada Pasien Kanker Serviks Stadium IIIB dengan dan tanpa Pembesaran Nodus Paraaorta] |
2021 |
Indonesian Journal of Obstetrics and Gynecology |
9 |
1 |
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55 |
58 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115385362&doi=10.32771%2finajog.v9i1.1438&partnerID=40&md5=4fe5c698192ed33c7d6916029327fcbf |
Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Kusuma, F., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Matondang, S.B., Department of Radiology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Nuranna, L., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Purwoto, G., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Khonsa, O., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hyaswicaksono, P., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Objective: To determine whether there are differences in clinical response after radiotherapy and 1 year survival in patients with advanced cervical cancer with and without enlargement of PALN. Methods: An observational analytic study using a retrospective cohort method was done using consecutive sampling. The subjects of this study were all women with a primary diagnosis of stages IIB to IVB cervical cancer who came to the gynecological oncology clinic of Dr. Cipto Mangunkusumo National General Hospital and underwent MRI examination before undergoing treatment in January 2016 to May 2017. Results: Among 76 subjects studied, there were 4 (5.1%) subjects who had enlarged PALN. There were no significant differences between the enlargement status of PALN and age (p = 0.829), age of first sexual intercourse (p = 0.33), parity (p = 0.642), mass diameter (p = 0.777). Patients with PALN enlargement have 2.13 times risk of having negative radiotherapy outcome (p = 0.02, OR 2.13, CI95% 1.12 - 4.07). There was no difference in 1-year survival between patients with and without enlargement of PALN (median 201 vs. 293, p = 0.072). Conclusions: Patients with PALN enlargement have increased risk of having negative radiotherapy outcome (p < 0.05). There were no differences in 1 year survival between patients with advanced cervical cancer with enlargement PALN. © Indonesian Journal of Obstetrics and Gynecology 2021. |
Cervical cancer; Lymph node enlargement; Paraaortic; Radiotherapy |
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Indonesian Society of Obstetrics and Gynecology |
23386401 |
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Article |
#N/A |
#N/A |
#N/A |
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610 |
Lisnawati L., Billianti Y.D., Manatar A.F. |
57215311695;57398065300;57398065400; |
Association between foxp3 tumor infiltrating lymphocyte expression and response after chemoradiation in nasopharyngeal carcinoma |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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1285 |
1291 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122331446&doi=10.3889%2foamjms.2021.7639&partnerID=40&md5=966b01cb054ca6692343d8dda3943b56 |
Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Lisnawati, L., Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Billianti, Y.D., Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Manatar, A.F., Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a carcinoma originating from the surface epithelium of the nasopharynx with the highest incidence in China and South East Asia. Currently, many researchers are developing tumor microenvironment which can be assessed by tumor-infiltrating lymphochyte, and its association with treatment response in several tumors, including NPC. Foxp3, known as a regulatory T cell (Treg) marker, plays a role in the immunoregulatory environment of tumor cells and can be used as a prognostic factor. The relationship between Foxp3 expression and treatment response is considered as one of the factors affecting the prognosis of NPC. AIM: This study aims to determine the relationship between Foxp3 expression and treatment response in NPC. MATERIALS AND METHODS: A cross-sectional study was done to analyze the association between Foxp3 and treatment response in NPC. This study included 60 samples who were diagnosed with non-keratinizing NPC at the Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital from January 2018 until December 2020. Immunohistochemistry was done to evaluate the expression of Foxp3. Foxp3 expression was evaluated in the intratumoral and peritumoral areas. RESULTS: Among 60 patients, the number of males were more than females (66.7%, 33.3%, respectively) with a ratio of 2:1. There was statistically significant difference between intratumoral and total Foxp3 expression and treatment response (p < 0.05, p = 0.001, respectively); however, no significant differences found between peritumoral Foxp3 expression and treatment response (p = 0.114). CONCLUSION: Foxp3 expression had a statistically significant relationship with response therapy after chemoradiation. © 2021 Lisnawati Lisnawati, Yayi Dwina Billianti, Amelia Fossetta Manatar. |
Chemoradiation therapy; Foxp3; Nasopharyngeal carcinoma |
transcription factor FOXP3; adolescent; adult; Article; cancer infiltration; cancer prognosis; chemoradiotherapy; chemotherapy; child; complete response; computer assisted tomography; cross-sectional study; female; gene expression; histopathology; human; human tissue; immunohistochemistry; lymph vessel metastasis; lymphocytic infiltration; major clinical study; male; nasopharynx carcinoma; nuclear magnetic resonance imaging; partial response; pathologist; progressive response; protein expression; radiodiagnosis; regulatory T lymphocyte; rehydration; stable disease; treatment response; tumor associated leukocyte; tumor microenvironment; tumor volume |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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611 |
Indarti J., Surya R., Aditya R., Ikhsan M., Alda K., Antoniman M.A. |
39161587400;56986345100;57384331700;36518708700;57218391373;57385259100; |
Successfully pregnancy outcome after lletz in women with cervical intraepithelial neoplasia: A case series |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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308 |
312 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121712103&doi=10.3889%2foamjms.2021.7770&partnerID=40&md5=c8d73616847c9c707c197e7f03bfed5e |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Indarti, J., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Surya, R., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Aditya, R., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ikhsan, M., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Alda, K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Antoniman, M.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Human papillomavirus (HPV) has an important role in cervical cancer development and the incidence of cervical intraepithelial neoplasia (CIN) was 1.3–2.7/1000 pregnancies. The HPV and its treatments such as loop electrosurgical excisional procedure (LEEP) or large loop electrosurgical excisional procedure (LLETZ) have an association with poor obstetric outcomes. CASE REPORT: Here, we present four case studies of successful live birth after treatment of CIN. We reported that four patients had been performed LLETZ, with abnormal colposcopy results and liquidbased cytology results were one ASCUS, one ASCH, and two HSIL. The histopathology results were one CIN 1, one CIN 2, and two CIN 3. There was a higher rate of pregnancy for treated women than untreated women. The higher the CIN grades, the more prevalence of cesarean section rate. CONCLUSION: The HPV testing or cotesting at 3-year intervals is recommended after treatment due to the sensitivity of HPV testing. Although pregnancy could delay the progression of precancerous lesions, it is recommended to follow the individualized algorithm in the ASCCP guideline to reduce the risk of cervical cancer progression. © 2021 Junita Indarti, Raymond Surya, Reyhan Aditya, Muhammad Ikhsan, Kristian Alda, Mohammad Agassi Antoniman. |
Infant outcome; Precancerous lesion; Pregnancy profile |
adult; algorithm; Article; birth weight; cancer growth; case report; case study; cesarean section; clinical article; colposcopy; cytology; family planning; female; histopathology; human; live birth; loop electrosurgical excision; practice guideline; preeclampsia; pregnancy outcome; uterine cervix carcinoma in situ; Wart virus |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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612 |
Astuti S.W., Liem I.K., Ramli Y. |
57385798200;55802927800;57197869497; |
The effect of intravenously and intra-arterially delivered human umbilical cord blood mononuclear cell on cortical neurogenesis of post-ischemic stroke rat brain |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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1245 |
1251 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121681681&doi=10.3889%2foamjms.2021.6555&partnerID=40&md5=33a2aafda87f7fa7e1e4defa3f943842 |
Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Gunadarma University, Depok, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Stem Cell and Tissue Engineering Cluster, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Astuti, S.W., Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Gunadarma University, Depok, Indonesia; Liem, I.K., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Stem Cell and Tissue Engineering Cluster, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ramli, Y., Stem Cell Medical Technology Integrated Service Unit, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Department of Neurology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
BACKGROUND: Stroke is the second most cause of death in the world. There are several treatments but they often end up with disabilities. Recently, cell therapy has become a new hope as an alternative treatment as it could improve the patients neurological deficits and daily living activities. Cord blood mononuclear cells (CB-MNCs) are one of the cell therapies for post-ischemic neurogenesis by intravenous or intra-arterial administration; however, it is not clear which one is better. AIM: This study aims to compare the effects of intra-arterial and intravenous administration of human CB-MNC on cortical neurogenesis of rat brain after ischemic stroke. METHODS: Twenty-four rats were divided into four groups, that is, control, middle cerebral artery obstruction (MCAO) without treatment, MCAO with intra-arterial CB-MNC injection (MCAO-IA), and MCAO with intravenous CB-MNC injection (MCAO-IV). Two weeks after injection, all rats were sacrificed, the brain was harvested, histologically process and stained with hematoxylin eosin (HE) to determine cellular and tissue morphology changes, and immunohistochemical staining, anti-NeuN antibody to determine the number of cortical neurons. The HE showed that MCAO rat brain had gliosis and shrunken cells. RESULTS: The results showed that MCAO-IA and MCAO-IV had fewer areas of gliosis and shrunken cells when compared to the MCAO group. The number of neurons also showed an increase. However, there was no difference between the MCAO-IA and MCAO-IV groups. It was concluded both of them could improve neurogenesis. CONCLUSION: CB-MNC administration can be an alternative for stroke ischemic therapy because it is proven to increase neurogenesis and reduce gliosis areas. However, there was no difference in neurogenesis in the brain tissue of mice injected with CB-MNC intravenously or intra-arterially. © 2021, Scientific Foundation SPIROSKI. All rights reserved. |
Cord blood mononuclear cells; Ischemic stroke; NeuN; Neurogenesis |
anti NeuN antibody; ketamine; neuron specific nuclear protein; unclassified drug; xylazine; animal experiment; animal model; animal tissue; Article; brain cell; cell therapy; controlled study; gliosis; immunohistochemistry; intraarterial drug administration; intravenous drug administration; ischemic stroke; male; middle cerebral artery occlusion; mononuclear cell; nervous system development; nonhuman; rat; umbilical cord blood |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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613 |
Margiana R., Alawiyah K., Ima K., Fitriana R., Widodo A.R., Wibowo T.D. |
56685900600;57212465522;57210444835;57377515100;57377515200;57377674000; |
Improvement of walking analysis using the sciatic function index for sciatic nerve function in injured rat model treated with low-intensity aerobics |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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1162 |
1168 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121438837&doi=10.3889%2foamjms.2021.7289&partnerID=40&md5=16b490d881d3f49901d8a12bcb6ef892 |
Departement of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Salemba, Indonesia; Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Margiana, R., Departement of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Salemba, Indonesia; Alawiyah, K., Departement of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Salemba, Indonesia; Ima, K., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fitriana, R., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Widodo, A.R., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wibowo, T.D., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Sciatica is a disease of the peripheral nerves. Sciatica shows that there is damage to the peripheral nerves in the sciatic nerves. Factors that can affect this disease include gender, posture, parity, age, genetic factors, and occupation. Some of the pathophysiological conditions of sciatica include the pathology of the intervertebral disc, dorsal root, and sciatic nerve itself. The results of standard therapy with surgery have not been effective and very expensive. Therefore, research on therapy in sciatica cases still needs to be done and evaluated. Physical exercise treatment (aerobic) is necessary for this therapy in sciatica cases due to promote the function of peripheral nerves. AIM: This study aimed to determine the effect of aerobic exercise treatment on peripheral nerve injury and its relationship to walking function during injury-induced peripheral nerve regeneration. METHODS: This study was an experimental study with a post-test. The study sample comprised male Sprague-Dawley rats with an age of about 2–3 months divided into three groups. The control group was conducted by surgery without clamping/injuring the peripheral nerves. The treatment for the second group (P1) was clamping/injury of peripheral nerve and given the treatment of physical exercise with aerobics. The treatment for the third group (P2) was clamping/injury of peripheral nerve and not given the treatment of physical exercise with aerobics. The intensity of giving physical exercise treatment with aerobic that is carried out is for 42 days. Nerve functional evaluation was carried out using the sciatic function index (SFI) method. Histological staining for sciatic was used for hematoxylin-eosin staining and immunohistochemistry with growth-associated protein 43 (GAP43) [Bioss, bs-0154R] and S100 antibody [ab52642]. This research was approved by the Animal Ethics Committee of the University of Indonesia protocol (No.19-07-0852). RESULTS: There was a significant change between the 7th and 14th days (p < 0.001; paired t-test) in the P1 treatment. Improvement in nerve function was found on the 14th day after being given aerobic treatment. This is showed by the data average change in SFI scores on days 7 and 4 was from −144 to 34. These data are also supported by footprint changes for injured hindfoot data. CONCLUSION: Low-intensity aerobics treatment improves the walking function and nerve function in sciatic nerve injury on day 14. This is due to the effect of physical exercise on the injured sciatic nerve. © 2021 Ria Margiana, Kamila Alawiyah, Khoirul Ima, Rizni Fitriana, Arif Rahmat Widodo, Theresa Devi Wibowo. |
Aerobics; Physical exercise; Sciatic fuction index; Sciatic nerve injury |
eosin; hematoxylin; neuromodulin; aerobic exercise; animal experiment; animal model; Article; controlled study; demyelination; histology; histopathology; immunohistochemistry; ischiadicus function index; kinesiotherapy; low intensity aerobics; male; muscle weakness; nerve function; nerve injury; nerve regeneration; nonhuman; parameters; peripheral nerve injury; physical activity; rat; rat model; sciatic function index; sciatic nerve; Sprague Dawley rat; walking function |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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614 |
Rhatomy S., Setyawan R., Romulo M.A. |
57204509883;57206249736;57221505201; |
Enhancement of chondrogenesis in hypoxic precondition culture: A systematic review |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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492 |
504 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118498577&doi=10.3889%2foamjms.2021.5850&partnerID=40&md5=a767ee0e694f65e29d11b57b920b1f48 |
Department of Orthopaedics and Traumatology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Orthopaedics and Traumatology, Sport and Adult Reconstructive Division, Dr. Soeradji, Tirtonegoro General Hospital, Klaten, Indonesia; Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Soeradji Tirtonegoro Sport Center and Research Unit, Dr. Soeradji Tirtonegoro General Hospital, Klaten, Indonesia |
Rhatomy, S., Department of Orthopaedics and Traumatology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia, Department of Orthopaedics and Traumatology, Sport and Adult Reconstructive Division, Dr. Soeradji, Tirtonegoro General Hospital, Klaten, Indonesia, Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Setyawan, R., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Romulo, M.A., Soeradji Tirtonegoro Sport Center and Research Unit, Dr. Soeradji Tirtonegoro General Hospital, Klaten, Indonesia |
BACKGROUND: Cartilage tear has begun to be treated with stem cells. However, stem cell oxygen level culture has not been evaluated for the best environment to enhance chondrogenesis. AIM: The purpose of this review is to focus on the hypoxic oxygen level of stem cells culture as a treatment for cartilage tear. METHODS: A literature search was systemically conducted on PubMed (MEDLINE), OVID, EMBASE, the Cochrane Library, Scopus, Web of Science, Science Direct, Wiley Online Library, Google Scholar, and bibliography of selected articles with the terms (“culture”) AND (“stem cell” OR “mesenchymal stem cell” OR “MSC”) AND (“hypoxic” OR “hypoxia”) AND (“cartilage” OR “chondro*”) as the main keywords. A total of 438 articles were reviewed. Thirty-six articles were considered relevant for this systematic review. RESULTS: The result of this review supports stimulation effects of hypoxic oxygen level stem cell culture in chondrogenesis process. Most studies used 5% oxygen concentration for culture, both of in vivo and in vitro studies. Due to the heterogeneity nature of the included studies, meta-analysis was unable to be conducted. CONCLUSION: Hypoxia state seems to play an important role in chondrocytes proliferation, differentiation, and matrix production. © 2021 Sholahuddin Rhatomy,. |
Cartilage; Hypoxic; Oxygen level; Stem cell |
amphotericin; collagen type 1; collagen type 10; collagen type 2; elastin; glycosaminoglycan; hydroxyproline; oxygen; penicillin G; probiotic agent; streptomycin; stromal cell derived factor 1; Thy 1 membrane glycoprotein; adipose derived stem cell; biomechanics; cell culture technique; cell differentiation; cell isolation; cell proliferation; chondrogenesis; Cochrane Library; Embase; flow cytometry; gene expression; histology; human; human cell; hypoxia; hypoxic precondition culture; iliac crest; in vitro fertilization; in vitro study; in vivo study; mesenchymal stem cell; mesenchymal stem cell transplantation; natural killer cell; osteoblast; oxygen concentration; oxygen tension; phylogenetic tree; protein expression; quality control; Review; ScienceDirect; Scopus; search engine; stem ce |
Scientific Foundation SPIROSKI |
18579655 |
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Review |
Q3 |
288 |
15252 |
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615 |
Rahadiani N., Retnowulan I.A., Stephanie M., Handjari D.R., Krisnuhoni E. |
16426455700;57313230400;57192369336;56160657900;35310982200; |
β-Catenin Expression and Its Association with Prognostic Factors in Hepatocellular Carcinoma: A Study on Alpha-fetoprotein, Histologic Grade, and Microvascular Invasion |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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887 |
893 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117945095&doi=10.3889%2foamjms.2021.6123&partnerID=40&md5=76f7c7436e4af55617330cb33cb4138f |
Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
Rahadiani, N., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Retnowulan, I.A., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Stephanie, M., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Handjari, D.R., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Krisnuhoni, E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
BACKGROUND: Hepatocellular carcinoma (HCC) is the most common primary liver cancer. In addition to its high incidence, the disease burden is high due to its poor prognosis and high recurrence rate. Some of the currently known clinicopathologic prognostic factors include alpha-fetoprotein (AFP) level, histologic grade, and microvascular invasion. At the molecular level, β-catenin is one of the most common driver mutations found in HCC. The Wnt/β-catenin pathway regulates cellular processes related to initiation, growth, survival, migration, differentiation, and apoptosis. Although the underlying pathogenesis of hepatocarcinogenesis is known, clinical application warrants a greater understanding of the molecular characteristics and tumor phenotype, especially for determining the prognosis. AIM: This study aims to analyze the expression of β-catenin and its association with AFP, histologic grade, and microvascular invasion. METHODS: Thirty-five samples of surgically resected HCCs at Cipto Mangunkusumo National Referral Hospital were examined. Diagnoses were made based on histopathological and immunohistochemical findings followed by β-catenin staining. β-catenin expression was analyzed to determine difference between variables. RESULTS: Here, we show that β-catenin expression is significantly associated with low serum AFP and well to moderate differentiation implications. Strong nuclear β-catenin expression implies better prognosis in HCC. CONCLUSION: β-catenin expression is significantly associated with low serumAFP and well-to-moderate differentiation, but not with microvascular invasion. Strong nuclear β-catenin expression implies better prognosis in HCC. © 2021 Nur Rahadiani, Ignasia Andhini Retnowulan, Marini Stephanie, Diah Rini Handjari, Ening Krisnuhoni. |
Alpha-fetoprotein; Hepatocellular carcinoma; Microvascular invasion; Tumor grade; β-catenin |
alpha fetoprotein; beta catenin; adult; aged; alpha fetoprotein blood level; Article; cancer grading; cancer prognosis; cell invasion; clinical article; controlled study; female; hepatitis B; hepatitis C; histology; histopathology; human; human tissue; immunohistochemistry; liver cell carcinoma; liver cirrhosis; lymph vessel; male; microvasculature; prevalence; protein expression; risk factor; tumor growth; tumor volume |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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616 |
Soetandyo N., Rinaldi I., Sari R.M., Kosasih A.S., Setiawan L., Winston K. |
6505525162;23475122400;57208474079;55879389300;57053036100;57224165400; |
Rare case of multiple lineage dysplasia myelodysplastic syndrome presenting with only anemia: A case report |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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182 |
188 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117611464&doi=10.3889%2foamjms.2021.6969&partnerID=40&md5=690591c95626ca9c62d16cbf0e9616bb |
Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Dharmais National Cancer Hospital, Jakarta, Indonesia; Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dharmais National Cancer Hospital, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Soetandyo, N., Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Dharmais National Cancer Hospital, Jakarta, Indonesia; Rinaldi, I., Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Sari, R.M., Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Dharmais National Cancer Hospital, Jakarta, Indonesia; Kosasih, A.S., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dharmais National Cancer Hospital, Jakarta, Indonesia; Setiawan, L., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dharmais National Cancer Hospital, Jakarta, Indonesia; Winston, K., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
BACKGROUND: Myelodysplastic syndrome (MDS) is a heterogeneous group of hematopoietic stem cell disorders which is characterized by ineffective hematopoiesis and risk of progression into acute myeloid leukemia. The diagnosis and classification of MDS are determined from the findings of dysplasia in one or more cell lineage and the percentage of blast cell on bone marrow examination. However, it should be noted that an abnormality in one marrow cell lineage does not necessarily translate to the corresponding clinical phenotype. Here, we present a case of MDS with multilineage dysplasia (MLD) (erythrocyte, leukocyte, and thrombocyte) from bone marrow aspiration, but with anemia as the sole clinical manifestation (single cytopenia). CASE REPORT: A 78-year-old male patient came to our clinic on July 10, 2020, with chief complaint of worsening fatigue which started approximately 1 year before visit. His vital signs during the visit were stable and no other abnormalities observed other than pale conjunctivae. Complete blood count showed macrocytic anemia with no abnormalities in leukocyte count and thrombocyte count, which suggested a single cytopenia. Peripheral blood smear was negative for megaloblasts and hypersegmented neutrophils. The patient’s bone marrow examination showed MDS with MLD. This result was in contrast to complete blood count examination which only showed anemia (single cytopenia). CONCLUSION: This case showed that there could be discrepancy between clinical manifestations of the cytopenia with bone marrow dysplasia, which highlighted the importance of conducting bone marrow examination to properly classify MDS type. © 2021 Noorwati Soetandyo, Ikhwan Rinaldi, Resti Mulya Sari, Agus Susanto Kosasih, Lyana Setiawan, Kevin Winston. |
Anemia; Elderly; Lenalidomide; Leukemia; Myelodysplastic syndrome |
alanine aminotransferase; albumin; aspartate aminotransferase; creatinine; cyanocobalamin; erythropoietin; ferritin; globulin; hemoglobin; lenalidomide; protein; activated partial thromboplastin time; aged; anemia; Article; bleeding time; blood cell count; blood smear; bone marrow examination; case report; chromosome deletion; cytogenetics; cytopenia; dysplasia; erythrocyte concentrate; erythrocyte count; erythrocyte transfusion; estimated glomerular filtration rate; fatigue; granulopoiesis; hematocrit; human; human,clinical article; immunophenotyping; International Prognostic Scoring System; karyotype; leukocyte count; macrocytic anemia; male; mean corpuscular hemoglobin concentration; mean corpuscular volume; megakaryocyte; megakaryopoiesis; metamyelocyte; multiple lineage dysplasia; mye |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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617 |
Lestari H.M., Gustinanda J., Tejaputri N.A., Tumpu N.A., Radifan T., Louisa M. |
57223631169;57283903400;57212584722;57212585928;57283679000;41461551400; |
Stool antigen examination as a diagnostic tool for dyspeptic patient caused by helicobacter pylori infection: A case-based literature review |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
F |
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305 |
309 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116395737&doi=10.3889%2foamjms.2021.5568&partnerID=40&md5=fab7a62274bf5e7787c0ca4a61924b0d |
Undergraduate Medical Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Lestari, H.M., Undergraduate Medical Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Gustinanda, J., Undergraduate Medical Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tejaputri, N.A., Undergraduate Medical Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tumpu, N.A., Undergraduate Medical Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Radifan, T., Undergraduate Medical Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Today, the gold standard for diagnosing Helicobacter pylori infection is by urea breath test (UBT). However, UBT tests are not widely available in several remote areas in Indonesia. Stool antigen test (SAT) is an alternative diagnostic test for H. pylori infection. However, it is unclear whether the performance of SAT to diagnose H. pylori infection can be comparable with UBT accuracy. This report was aimed to determine the accuracy of SAT to diagnose H. pylori infection as an alternative to UBT. Our case-based literature review indicates that SAT has high sensitivity (79–96.4%); therefore, SAT can help doctors in ruling out H. pylori infection. SAT also demonstrates remarkable specificity of stool antigen examination (98.6–100%), suggesting that SAT can help doctors in ruling in H. pylori infection. © 2021 Haifa Mayang Lestari, Jatmiko Gustinanda, Nadzila Anindya Tejaputri, Nur Afiahuddin Tumpu, Taris Radifan, Melva Louisa. |
Helicobacter pylori; Stool antigen test; Urea breath test |
antigen; adult; breath analysis; case report; clinical article; decreased appetite; diagnostic accuracy; dyspepsia; enzyme immunoassay; epigastric pain; feces analysis; Helicobacter infection; human; male; meta analysis; nausea and vomiting; predictive value; prevalence; Review; systematic review; urea breath test; validity |
Scientific Foundation SPIROSKI |
18579655 |
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Review |
Q3 |
288 |
15252 |
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618 |
Djusad S., Meutia A.P., Suastika A., Hidayah G.N., Surya I.U., Priangga M., Fadhly R., Harzif A.K. |
57192276788;57203368133;57226722016;57222671850;57226288663;56320839200;57226710149;57191493435; |
Maternal death caused by severe-critical covid-19 in jakarta: Case series |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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103 |
108 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112449077&doi=10.3889%2foamjms.2021.6250&partnerID=40&md5=e9b76ca77220d8ad24d7f5514bcc5d0d |
Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia |
Djusad, S., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Meutia, A.P., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Suastika, A., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Hidayah, G.N., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Surya, I.U., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Priangga, M., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Fadhly, R., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Harzif, A.K., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia |
BACKGROUND: As of January 2021, Indonesia had the 21st highest number of total COVID-19 cases and the 17th highest total deaths among all countries. COVID-19 infection in pregnant women seems to negatively affect both maternal and neonatal outcomes. CASE REPORT: We describe four cases of pregnant women confirmed with severe and critical COVID-19 that resulted in maternal death from November until December 2020. The first case was complicated with thrombocytopenia, her condition quickly deteriorated post-delivery. Pulmonary embolism was suspected as the cause of death. Second and third cases were complicated with preeclampsia, obesity, and advanced maternal age. Second case came in sepsis condition. Her SARS CoV-2 RTPCR swab test came out after her death. Third patient did not have COVID-19 symptoms at admission. She starts having symptoms on second day and was confirmed positive a day after. She falls in septic shock. Fourth patient has history of fever, cough, and dyspnea. She was confirmed positive on first day and her condition worsened, diagnosed with bacterial co-infection sepsis on day eight. All patients underwent cesarean section. CONCLUSION: Limited information and studies for COVID-19 management in pregnant women are challenging for obstetricians. Management should be individualized weighing the benefit and risks in presence of comorbidities or accompanying disease. © Suskhan Djusad, Alfa Putri Meutia, Arresta Suastika, Gita Nurul Hidayah, Ilham Utama Surya, Muhammad Priangga, Raden Fadhly, Achmad Kemal Harzif. |
Case Series; COVID-19; Indonesia; Maternal Death |
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Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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