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No records
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323 |
Rizka A., Setiati S., Sadikin M., Mansur I.G. |
57203243658;14325991900;57205093115;6603222374; |
Immunomodulatory effect of in vitro calcitriol in fit and frail elderly |
2021 |
International Immunopharmacology |
96 |
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107737 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105325886&doi=10.1016%2fj.intimp.2021.107737&partnerID=40&md5=bd310cacaf61c4b89ad48ac61ee52389 |
Division of Geriatric Medicine, Department of Internal Medicine Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta 10430, Indonesia; Metabolic Vascular and Aging Cluster, Indonesian Medical Education and Research Institute Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; Department of Biochemistry Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; Department of Biology Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia |
Rizka, A., Division of Geriatric Medicine, Department of Internal Medicine Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta 10430, Indonesia, Metabolic Vascular and Aging Cluster, Indonesian Medical Education and Research Institute Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; Setiati, S., Division of Geriatric Medicine, Department of Internal Medicine Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta 10430, Indonesia; Sadikin, M., Department of Biochemistry Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; Mansur, I.G., Department of Biology Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia |
Introduction: Effect of calcitriol on PBMCs of healthy adults have been well studied but not much is known about its effect on the PBMCs of elderly patients with various degree of frailty syndrome and immune senescence. This study was aimed to assess the effect of in vitro calcitriol immunomodulatory effect on IL-6, IL-10 and IFN-γ in elderly patients who were fit, pre-frail and frail to see which group of patients might get the most benefit of calcitriol. Methods: This study was an experimental study on the PBMCs of 24 elderly people, of which 8 subjects each were in fit, pre-frail and frail categories based on the Cardiovascular Health Study criteria. IL-6, IL-10, and IFN-γ were examined by ELISA, before and after administration of lipopolysaccharide and 100 pg/mL calcitriol into PBMC cultures in vitro. Result: The mean serum vitamin D level was 26.2 (2.4) ng/ml. Vitamin D level is decreasing along with worsening of frailty status. After LPS induction, calcitriol did not reduce IL-6 and IFN-γ in all the groups. Calcitriol increased IL-10 in all groups, with the most observed change in the pre-frail group. Conclusion: In vitro administration of calcitriol showed anti-inflammatory potential by increasing IL-10 mainly in pre-frail subjects. © 2021 Elsevier B.V. |
Calcitriol; Elderly; Frail; In vitro |
calcitriol; gamma interferon; interleukin 10; interleukin 6; lipopolysaccharide; vitamin D; calcitriol; gamma interferon; IFNG protein, human; IL10 protein, human; IL6 protein, human; interleukin 10; interleukin 6; vitamin D; aged; Article; cell culture; clinical article; controlled study; enzyme linked immunosorbent assay; experimental study; female; frail elderly; frailty; human; human cell; immunomodulation; in vitro study; male; peripheral blood mononuclear cell; priority journal; protein blood level; vitamin blood level; age; blood; drug effect; frail elderly; immunology; immunomodulation; metabolism; mononuclear cell; pharmacology; physiology; Age Factors; Aged; Calcitriol; Calcium-Regulating Hormones and Agents; Female; Frail Elderly; Humans; Immunomodulation; In Vitro Techniques; I |
Elsevier B.V. |
15675769 |
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33965881 |
Article |
Q1 |
1152 |
3523 |
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353 |
Auer S., Haelterman N.A., Weissgerber T.L., Erlich J.C., Susilaradeya D., Julkowska M., Gazda M.A., Schwessinger B., Jadavji N.M., Abitua A., Niraulu A., Shahb A., Clyburne-Sherinb A., Guiquel B., Alicea B., Lamanna C., Ganguly D., Perkins E., Jambor H., Li I.M.H., Tsang J., Kamens J., Teytelman L., Paul M., Cronin M., Schmelling N., Crisp P., Kutum R., Phuyal S., Sarabipour S., Roy S., Bachle S.M., Tran T., Ford T., Steeves V., Ilangovan V., Baburamani A., Bachle S. |
57224755481;43961196400;6506688349;54396932600;57208325289;54787902500;57194268384;24438486300;8866064800;57224999223;57224994032;57224999963;57224992543;57224993799;51563211500;57225409050;56514870300;57224997775;25421754600;57224994090;57224992895;57224995287;57205247619;57216221631;57224995069;57193626389;36933973000;56871221600;55388614600;16053538000;57224999908;55516154900;57224994106;57224992308;57092624000;57216037751;26867552100;55516154900; |
Science forum: A community-led initiative for training in reproducible research |
2021 |
eLife |
10 |
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e64719 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108881951&doi=10.7554%2feLife.64719&partnerID=40&md5=86ee0e85a4e402a7d89730773f6396b8 |
Department of Plant Physiology, Institute of Botany, Faculty of Biology, TU Dresden, Dresden, Germany; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States; Berlin Institute of Health at Charité – Universitätsmedizin Berlin, QUEST Center, Berlin, Germany; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai, China; Medical Technology Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Boyce Thompson Institute, United States; CIBO/InBIOO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade do Portio, Campus Agrário de Vairão, Porto, Portugal; Departamento de Biologia, Faculdade de Ciências, Universidade do Portio, Porto, Portugal; Research School of Biology, Australian National University, Canberra, Australia; Department of Biomedical Science, Midwestern University, Glendale, United States; Addgene, Boston, United States; Neuroscience Graduate Program, Ohio State UniversityOH, United States; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, United States; Reproducibility for EveryoneNY, United States; Addgene, London, United Kingdom; Orthogonal Research and Education Laboratory, Champaign, United States; Research School of Biology, Australian National University, Canberra, Australia; Centre for Regenerative Therapies Dresden, Dresden, Germany; Massachusetts General Hospital, Harvard University, Boston, United States; Protocols.io, San Francisco, United States; Psychology of Language Group, University of Gottingen, Gottingen, Germany; Institute for Synthetic Microbiology, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany; Institute of Basic Medical Science, University of Oslo, Oslo, Norway; Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States; Plant Biotechnology, Tennessee State University, Nashville, United States; School of Mechanical & Aerospace Engineering, Nanyang Technological University, Nanyang, Singapore; Picture as Portal, San Francisco, United States; Research Data Management and Reproducibility, New York UniversityNY, United States; Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany; Centre for the Development of Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom; Department of Neuroscience, Carleton University, Ottawa, Canada |
Auer, S., Department of Plant Physiology, Institute of Botany, Faculty of Biology, TU Dresden, Dresden, Germany; Haelterman, N.A., Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States; Weissgerber, T.L., Berlin Institute of Health at Charité – Universitätsmedizin Berlin, QUEST Center, Berlin, Germany; Erlich, J.C., NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai, China; Susilaradeya, D., Medical Technology Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Julkowska, M., Boyce Thompson Institute, United States; Gazda, M.A., CIBO/InBIOO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade do Portio, Campus Agrário de Vairão, Porto, Portugal, Departamento de Biologia, Faculdade de Ciências, Universidade do Portio, Porto, Portugal; Schwessinger, B., Research School of Biology, Australian National University, Canberra, Australia; Jadavji, N.M., Department of Biomedical Science, Midwestern University, Glendale, United States, Department of Neuroscience, Carleton University, Ottawa, Canada; Abitua, A., Addgene, Boston, United States; Niraulu, A., Neuroscience Graduate Program, Ohio State UniversityOH, United States; Shahb, A., The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, United States; Clyburne-Sherinb, A., Reproducibility for EveryoneNY, United States; Guiquel, B., Addgene, London, United Kingdom; Alicea, B., Orthogonal Research and Education Laboratory, Champaign, United States; Lamanna, C., Addgene, Boston, United States; Ganguly, D., Research School of Biology, Australian National University, Canberra, Australia; Perkins, E., Addgene, Boston, United States; Jambor, H., Centre for Regenerative Therapies Dresden, Dresden, Germany; Li, I.M.H., Massachusetts General Hospital, Harvard University, Boston, United States; Tsang, J., Addgene, Boston, United States; Kamens, J., Addgene, Boston, United States; Teytelman, L., Protocols.io, San Francisco, United States; Paul, M., Psychology of Language Group, University of Gottingen, Gottingen, Germany; Cronin, M., Addgene, Boston, United States; Schmelling, N., Institute for Synthetic Microbiology, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany; Crisp, P., Research School of Biology, Australian National University, Canberra, Australia; Kutum, R., Institute of Basic Medical Science, University of Oslo, Oslo, Norway; Phuyal, S., Institute of Basic Medical Science, University of Oslo, Oslo, Norway; Sarabipour, S., Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States; Roy, S., Plant Biotechnology, Tennessee State University, Nashville, United States; Bachle, S.M., Addgene, Boston, United States, Addgene, Boston, United States; Tran, T., School of Mechanical & Aerospace Engineering, Nanyang Technological University, Nanyang, Singapore; Ford, T., Picture as Portal, San Francisco, United States; Steeves, V., Research Data Management and Reproducibility, New York UniversityNY, United States; Ilangovan, V., Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany; Baburamani, A., Centre for the Development of Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom; Bachle, S., Addgene, Boston, United States, Addgene, Boston, United States |
Open and reproducible research practices increase the reusability and impact of scientific research. The reproducibility of research results is influenced by many factors, most of which can be addressed by improved education and training. Here we describe how workshops developed by the Reproducibility for Everyone (R4E) initiative can be customized to provide researchers at all career stages and across most disciplines levels and across disciplines with education and training in reproducible research practices. The R4E initiative, which is led by volunteers, has reached more than 2000 researchers worldwide to date, and all workshop materials, including accompanying resources, are available under a CC-BY 4.0 license at www.repro4everyone.org. © 2021, eLife Sciences Publications Ltd. All rights reserved. |
Accessible protocols; FAIR data; Reproducibility; Rigor; Transparency; Transparent data processing |
biomaterial; Article; bioinformatics; FAIR principles; reproducibility; software; training; education; human; medical research; methodology; personnel; procedures; reproducibility; Biomedical Research; Humans; Reproducibility of Results; Research Design; Research Personnel |
eLife Sciences Publications Ltd |
2050084X |
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34151774 |
Article |
Q1 |
5879 |
219 |
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359 |
Priyatini T., Roziana |
57192265423;57218684529; |
A case report: Common channel anomaly with vaginal agenesis and rectal stone after posterior sagittal anorectoplasty (PSARP) |
2021 |
International Journal of Surgery Case Reports |
83 |
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106032 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107780089&doi=10.1016%2fj.ijscr.2021.106032&partnerID=40&md5=28cc4fe008ececf074994d080ed05597 |
Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia/ Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Priyatini, T., Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia/ Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Roziana, Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia/ Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction and importance: We reported a case of common channel anomaly complicated with vaginal agenesis and rectal stone, which is a long-term complication of PSARP, a combination of very rare conditions with high morbidity and especially difficult treatment. Presentation of case: A 15-year-old female presented with a chief complaint of cyclic abdominal pain. The patient had no history of menstruation before. Physical examination showed a common channel. The diameter of the common channel was approximately 1 cm and 0.3 cm in length. A sound (±2 mm thickness) was inserted to the small opening between the urethra and anal mucosa with the length of the canal 6 cm. At the end of the opening, a stone-like structure was felt. The management of this case was abdominal hysterectomy with right salpingectomy and stone evacuation. Discussion: Cloacal malformation is thought to be associated with vaginal agenesis since both malformations are considered to have a similar pathophysiologic background. Treatment can be performed using posterior sagittal combined with laparotomy approach. After surgery, patients will need a long-term follow-up since the conditions may be associated with many possible urologic and gynecologic comorbidities, including recurrent urinary tract infections, hematosalpinx, and vesicourethral reflux, including stone formation. Conclusion: Our case was considered one of the most complex common channel anomalies because it was complicated with a rare condition called vaginal agenesis and rectal stone after PSARP. A multidiscipline approach was necessary. © 2021 The Authors |
Common channel anomaly; Rectal stone; Vaginal agenesis |
analgesic agent; abdominal hysterectomy; abdominal pain; adolescent; anal canal; anal mucosa; anus surgery; Article; case report; chronic inflammation; clinical article; colostomy; cystoscopy; echography; enterolithiasis; female; follow up; goblet cell; hematometra; histopathology; human; human tissue; labia minora; nuclear magnetic resonance imaging; physical examination; posterior sagittal anorectoplasty; pubic hair; rectal tissue; salpingectomy; treatment outcome; urethra; uterus; uterus cavity; vagina aplasia; vagina atresia |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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366 |
Moegni F., Quzwain S., Rustamadji P. |
55450456100;57224084579;55321572200; |
Transverse vaginal septum managed by simple flap surgery technique: A case report |
2021 |
International Journal of Surgery Case Reports |
83 |
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105990 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106902483&doi=10.1016%2fj.ijscr.2021.105990&partnerID=40&md5=4b34257622117eec368834315e672694 |
Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Moegni, F., Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Quzwain, S., Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rustamadji, P., Department of Anatomic Pathology, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Transverse Vaginal Septum (TVS) is a rare congenital abnormality, classified as the Mullerian duct anomaly development.1,2 TVS incidence range from 1:2.000 to 1:72.000. Management of TVS may only requirement local excision with a simple end to end anastomosis of the vagina, and use of skin grafts, but this technique has been reported has common complications of secondary tissue contracture, which often lead to stenosis of the vagina.3 In this case we managed TVS with simple flap technique to avoid such postoperative complications and maintain caliber of vagina. Case: A 11 years old girl complained cyclical abdominal pain since a year ago without history of menstrual blood. Patient already had vaginal surgery for removing menstrual blood, but after vaginal surgery the menstrual blood cannot be removed, then referred to our hospital. Ultrasound examination revealed hematometra and hemocolpos. The septum location was 3,38 cm proximal distance from vaginal introitus with the thickness of 8.1 mm. We performed simple excision of the septum with formerly performed distal vaginal septum mucosa preparation creating lateral flaps, then approximating the flaps to the edge of the proximal vaginal mucosa with interrupted suture continued with hymenorraphy. The patient has no complaint 6 months after surgery with vaginal length 8 cm, and had regular menstrual cycle. Conclusion: A simple flap surgery technique can be done in transverse vaginal septum, with no complication such as tissue contracture, vaginal stenosis, or insightly scarring. This is a simple technique and can be done with hymenorraphy to restore normal anatomy of hymen. © 2021 The Author(s) |
Simple flap vaginal technique; Surgery management; Transverse vaginal septum |
abdominal pain; abdominal ultrasound; Article; case report; child; clinical article; congenital disorder; echography; excision; female; follow up; hematocolpos; hematometra; histopathology; human; human tissue; menstrual cycle; priority journal; school child; spinal anesthesia; tissue flap; transperineal ultrasound; transrectal ultrasonography; transverse vaginal septum; vagina disease; vagina mucosa |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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367 |
Lestari D.A., Rahadiani N., Syaiful R.A. |
57223975816;16426455700;57214818481; |
Isolated spleen tuberculosis in an immunocompetent patient, a rare case report |
2021 |
International Journal of Surgery Case Reports |
83 |
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105966 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106577439&doi=10.1016%2fj.ijscr.2021.105966&partnerID=40&md5=f05086fe8ba1008071d740065a24ddd6 |
Digestive Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo Hospital, Jl Diponegoro No 71, Salemba, Jakarta Pusat, 10430, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo Hospital, Jl Diponegoro No 71, Salemba, Jakarta Pusat, 10430, Indonesia |
Lestari, D.A., Digestive Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo Hospital, Jl Diponegoro No 71, Salemba, Jakarta Pusat, 10430, Indonesia; Rahadiani, N., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo Hospital, Jl Diponegoro No 71, Salemba, Jakarta Pusat, 10430, Indonesia; Syaiful, R.A., Digestive Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo Hospital, Jl Diponegoro No 71, Salemba, Jakarta Pusat, 10430, Indonesia |
Introduction: Tuberculosis (TB), as a major public health concern, is affecting almost 10 million people globally. At present, diagnostic and screening efforts mainly focus on positive smear results. Therefore, the number of extra pulmonary and negative sputum TB is rising and hampering the diagnosis and treatment process due to the large number of false negatives. Rare cases such as solitary splenic TB are usually seen in patients with splenic abnormalities, spleen trauma, immunosuppression, sickle cell disease, pyogenic infections, etc. Presentation of case: A 40-year-old female with no comorbidity came with chief complaint of early satiety every mealtime and epigastric pain in the last 6 months prior to admission. There was no significant positive examination except for positive IGRA test and enlargement of spleen with multiple cystic lesions on abdominal CT. We performed laparotomy with splenectomy followed by a histopathology examination which showed features of primary tubercular abscess. Discussion: In the immunocompromised patient, the visceral abdomen is usually involved and a part of miliary TB. However, this case revealed the rare possibility of a healthy person with primary isolated tubercular splenic abscess while being immunocompetent and lacking any comorbidity. Conclusion: Splenic TB diagnosis is difficult in patients lacking pulmonary involvement and without specific symptoms. Thorough examinations and clinical expertise are needed to provide accurate diagnosis and treat uncommon forms of TB and cases with negative smear results in consideration of rising prevalence and difficult disease control. © 2021 The Authors |
Case report; Immunocompetent; Infection; Spleen; Tuberculosis |
gamma interferon; tuberculostatic agent; vaccine; adult; antibiotic therapy; Article; case report; clinical article; clinical feature; diagnostic imaging; epigastric pain; female; granulomatous inflammation; histopathology; hospital admission; human; human cell; human tissue; immunocompromised patient; infection risk; interferon gamma release assay; Langhans giant cell; laparotomy; leukocytosis; lymph node biopsy; lymphadenopathy; operative blood loss; pancreas cyst; priority journal; rare disease; risk reduction; satiety; spleen abscess; spleen cyst; splenectomy; splenic tuberculosis; splenomegaly; thrombocytosis; tissue necrosis; vaccination; x-ray computed tomography |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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368 |
Fuady A. |
37085331400; |
Call for more investment in cost-effective tuberculosis care |
2021 |
The Lancet Regional Health - Western Pacific |
11 |
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100157 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105966355&doi=10.1016%2fj.lanwpc.2021.100157&partnerID=40&md5=7437dce7d74e8d800265cc28c5c9af76 |
Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands |
Fuady, A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands |
[No abstract available] |
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Elsevier Ltd |
26666065 |
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Note |
#N/A |
#N/A |
#N/A |
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370 |
Purbadi S., Rustamadji P., Purwoto G., Kusuma F., Putra A.D., Scovani L., Sianturi E.T. |
6505677307;55321572200;14720170400;57192911548;57208996180;57223440213;57223430479; |
Skin metastases originated from cervical cancer: A rare case report |
2021 |
Annals of Medicine and Surgery |
66 |
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102363 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105852603&doi=10.1016%2fj.amsu.2021.102363&partnerID=40&md5=6edeeefd66a3289a6bb1540f0adc31fe |
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo National Referral Hospital, Indonesia |
Purbadi, S., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rustamadji, P., Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo National Referral Hospital, Indonesia; Purwoto, G., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kusuma, F., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Putra, A.D., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Scovani, L., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sianturi, E.T., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Metastases in cervical cancer could be spread through direct local invasion, lymphatic dissemination, or hematogenous dissemination. The most common sites of distant metastases are lungs, bone, and liver. Skin metastases from cervical cancer are categorized as a rare occurrence of metastases. This rarity of the cases has led us to report it. Case description: A 66-year-old multiparous woman diagnosed with stage IIA cervical cancer seven years ago, then she came into our outpatient clinic complained about a brownish white color mass on the left side of the neck that keeps getting bigger over time came from a skin lesion. The lesion was first treated with topical steroid but there was no improvement. Biopsy was done and the result showed a carcinoma metastasis that led to adenosquamous carcinoma or cervical adenocarcinoma. The patient went through chemoradiation with biosensitizer paclitaxel 120 mg/m2 for six cycles, which began in August 2019 until October 2019. The treatment progress showed a promising result. We observed the patient during treatment until two months after finishing the treatment. At the last visit, the patient came to our outpatient clinic, the mass size decreased significantly, and the skin showed an excellent regeneration sign. Conclusion: The physicians should always consider the patient's history and pay more attention to skin lesions in patients with a history of cervical cancer. The physicians should also perform a thorough physical examination and biopsy to confirm the diagnosis. © 2021 The Author(s) |
Cervical cancer; Skin lesion; Skin metastasis |
paclitaxel; adenocarcinoma; adenosquamous carcinoma; aged; anemia; Article; attention; body weight; brain metastasis; cancer patient; case report; chemoradiotherapy; clinical article; cutaneous leishmaniasis; distant metastasis; drug industry; female; histopathology; human; human tissue; hysterectomy; laparotomy; mammography; metastasis; multipara; ovariectomy; physical examination; physician; regeneration; sexual behavior; skin defect; skin metastasis; thrombocytopenia; uterine cervix adenocarcinoma; uterine cervix cancer; vaginal secretion |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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371 |
Solichin I., Prabowo I., Laras S., Putra N.H.D., Rhatomy S. |
57202813479;57221098612;57221107761;57223369199;57204509883; |
Early ambulatory Duchenne muscular dystrophy: First symptomatic stage of ambulation - A case report |
2021 |
International Journal of Surgery Open |
33 |
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100349 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105724819&doi=10.1016%2fj.ijso.2021.100349&partnerID=40&md5=63b5fb970c994ebc6ab98bdfa879fb05 |
Department of Orthopaedics and Traumatology, Purwokerto Orthopaedics Hospital, Purwokerto, Central Java, Indonesia; Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sport and Adult Reconstruction Division, Department of Orthopaedics and Traumatology, Dr. Soeradji Tirtonegoro General Hospital, Klaten, Indonesia; Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia |
Solichin, I., Department of Orthopaedics and Traumatology, Purwokerto Orthopaedics Hospital, Purwokerto, Central Java, Indonesia; Prabowo, I., Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Laras, S., Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Putra, N.H.D., Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rhatomy, S., Sport and Adult Reconstruction Division, Department of Orthopaedics and Traumatology, Dr. Soeradji Tirtonegoro General Hospital, Klaten, Indonesia, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia |
Introduction and importance: Duchenne muscular dystrophy (DMD) is a rare neuromuscular disease, affected male at young age, progressive and deteriorating symptoms followed the age and usually died in age 20. The early sign of DMD or early ambulatory DMD appeared lately after walking age, and progressively deteriorated by the time of aging. Case presentation: A 9 years old boy with symptoms of waddling gait, toe walking and difficulty to climb the stairs came to our center to seek medical help. He initially walked with assistance at 18 months, but always fell down when he tried to walk for distance. No family history of developmental delay. He still has the ability to stand up after sitting on the floor and run even with the difficulty. Behavioral problem or academic achievement was according to his age. The way he did to get down the stairs, he had to sit down and the get back up when he finished. His parents’ status of economic and education is low, which brought them difficult to understand their child is in suffer. Clinical discussion: The diagnosis and staging of DMD are quite challenging. A consistency and knowledge to gathered all the information related to history, symptoms, and signs provided the qualified data to overcome the complexity of the case, and to managed the spectrum of the disease appropriately, thus avoid the unnecessary treatment. The symptomatic stage of DMD is distinguished by the spectrum of ambulation. The effective and efficacy of the treatment are depending on good clinical assessment of neuromuscular function. Multidisciplinary team to diagnose and manage the case was needed to create to solve the problem became easier. Conclusion: The early ambulatory DMD is the first symptomatic early warning signs to treat DMD. The oral corticosteroids believed could mainstay the functional outcome the upper limb, avoid severe scoliosis, and maintain the respiratory function as normal as possible. Occupational and physical therapies were proposed to maintain the good quality of life. © 2021 The Author(s) |
Duchenne muscular dystrophy; Early ambulatory; Waddling gait |
methylprednisolone; academic achievement; Article; case report; child; clinical article; clinical assessment; daily life activity; Duchenne muscular dystrophy; gestational age; human; male; mobilization; multidisciplinary team; neuromuscular function; physical examination; physiotherapist; physiotherapy; priority journal; problem behavior; running; school child; waddling gait; walking |
Elsevier Ltd |
24058572 |
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Article |
Q4 |
187 |
20224 |
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372 |
Reksodiputro M.H., Harahap A.R., Siregar N.C., Malik S.G., Bashirudin J., Boesoirie M.T.S., Widodo D.W., Iljanto S., Sajuthi D., Sukrisman L., Yosia M. |
35090488800;6507325543;6508087790;7402973374;57223288901;57223301168;56644646600;57223273746;6603075144;8661764000;57204933098; |
Comparison between PRP and PRFM on FTSG healing profile: Macroscopic, microscopic and ELISA evaluation |
2021 |
Annals of Medicine and Surgery |
66 |
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102350 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105502675&doi=10.1016%2fj.amsu.2021.102350&partnerID=40&md5=632e6c1f802e9603336c9a0770ecc410 |
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, University of Padjajaran, Hasan Sadikin Hospital, Bandung, Indonesia; Faculty of Public Health, Centre for Health Administration, Management and Policy, Universitas Indonesia, Jakarta, Indonesia; Department of Clinics, Reproduction, and Pathology, Faculty of Veterinary Medicine, Institute Pertanian Bogor, Bogor, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Reksodiputro, M.H., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harahap, A.R., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Siregar, N.C., Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Malik, S.G., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Bashirudin, J., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Boesoirie, M.T.S., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, University of Padjajaran, Hasan Sadikin Hospital, Bandung, Indonesia; Widodo, D.W., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Iljanto, S., Faculty of Public Health, Centre for Health Administration, Management and Policy, Universitas Indonesia, Jakarta, Indonesia; Sajuthi, D., Department of Clinics, Reproduction, and Pathology, Faculty of Veterinary Medicine, Institute Pertanian Bogor, Bogor, Indonesia; Sukrisman, L., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yosia, M., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Studies had shown the benefit of PRFM and PRP in wound healing but their use in skin graft healing was rarely studied. This study aims to compare the use of PRP and PRFM in accelerating wound healing process of skin full-thickness skin graft (FTSG). Materials and methods: Five pigs were used to look at the wound healing effect of PRP and PRFM usage prior to FTSG implantation. Subsequent punch biopsies were then conducted on the 1st, 3rd, 7th, 14th, and 30th day to obtain samples for macroscopic (skin color), extracellular matrix (collagen), microscopic (PMN, macrophage, and fibroblast), and ELISA (TGFβ1 and PDGF) analysis to determine the level of wound healing activity. ImageJ software was used to photograph for macroscopic and extracellular matrix analysis. Results: Macroscopic, extracellular matrix, and ELISA evaluation show no significant difference in FTSG survival rates for all treatment groups. Microscopic examination showed an increase in PMN, macrophage, and fibroblast levels with PRFM application showing higher increases in all observed microscopic variables compared to PRP and control. Conclusion: This study observed that both PRFM and PRP as autologous platelet preparation accelerate wound healing in FTSG, with PRFM being superior due to the higher number of PMN, macrophage, and fibroblast. © 2021 The Authors |
FTSG; PRFM; PRP; Wound healing |
atropine; collagen; collagen type 1; hemoglobin; isoflurane; ketamine; lidocaine; platelet derived growth factor; platelet-rich fibrin; transforming growth factor beta1; xylazine; animal experiment; animal model; animal tissue; Article; enzyme linked immunosorbent assay; exosome; extracellular matrix; female; fibroblast; full thickness skin graft; glomerulus filtration rate; graft survival; histology; macrophage; male; microscopy; neutrophil; nonhuman; platelet-rich plasma cell; punch biopsy; scientific literature; skin injury; survival rate; thrombocyte; wound healing |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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373 |
Dewi R., Kaswandani N., Karyanti M.R., Setyanto D.B., Pudjiadi A.H., Hendarto A., Djer M.M., Prayitno A., Yuniar I., Indawati W., Prawira Y., Handryastuti S., Sjakti H.A., Hidayati E.L., Muktiarti D., Soebadi A., Puspaningtyas N.W., Muhaimin R., Rahmadhany A., Octavius G.S., Puspitasari H.A., Jasin M.R., Tartila T., Putri N.D. |
57190859324;57195941745;56290680800;57203009929;18435202300;57204142249;12771087900;57193342301;57222295046;57190171077;55455747000;18434003700;57195720458;57200542624;57189047743;56986580800;57223288515;57223307995;57223290366;57221016506;57214119502;57223292665;57223304533;57200573842; |
Mortality in children with positive SARS-CoV-2 polymerase chain reaction test: Lessons learned from a tertiary referral hospital in Indonesia |
2021 |
International Journal of Infectious Diseases |
107 |
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78 |
85 |
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9 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105478543&doi=10.1016%2fj.ijid.2021.04.019&partnerID=40&md5=6ef75a9ece8a84ed984ec94cf9c3f923 |
Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Dewi, R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kaswandani, N., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Karyanti, M.R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setyanto, D.B., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pudjiadi, A.H., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hendarto, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Djer, M.M., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prayitno, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yuniar, I., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Indawati, W., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prawira, Y., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Handryastuti, S., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sjakti, H.A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hidayati, E.L., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muktiarti, D., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soebadi, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Puspaningtyas, N.W., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muhaimin, R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmadhany, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Octavius, G.S., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Puspitasari, H.A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jasin, M.R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tartila, T., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Putri, N.D., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: The incidence of coronavirus disease 2019 (COVID-19) is still increasing rapidly, but little is known about the prevalence and characteristics of fatal cases in children in Indonesia. This study aimed to describe the characteristics of children with COVID-19 with fatal outcomes in a tertiary referral hospital in Indonesia. Methods: This cross-sectional study used data collected from the medical records of patients with COVID-19 admitted to Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia from March to October 2020. Results: During the study period, 490 patients were admitted and diagnosed with suspected and probable COVID-19. Of these patients, 50 (10.2%) were confirmed to have COVID-19, and 20 (40%) had a fatal outcome. The fatality rate was higher in patients aged ≥10 years, categorized with severe disease upon admission, PaO2/FiO2 ratio ≤300 mmHg and chronic underlying diseases. The most common clinical manifestations were generalized symptoms, while acute respiratory distress syndrome (8/20) and septic shock (7/20) were the two most common causes of death. Increased procalcitonin, D-dimer, lactate dehydrogenase and presepsin levels were found in all fatal cases. One patient met the criteria of multisystem inflammatory syndrome in children. Conclusion: Our work highlights the high mortality rate in paediatric patients with positive SARS-CoV-2 polymerase chain reaction test. These findings might be related to or co-incided with COVID-19 infection. Further studies are needed to improve understanding of the role of severe acute respiratory syndrome coronavirus-2 in elaborating the mechanisms leading to death in children with comorbidities. © 2021 The Author(s) |
Children; COVID-19; Indonesia; Outcome; SARS-CoV-2 |
antibiotic agent; biological marker; D dimer; dobutamine; dopamine; enoxaparin; epinephrine; hydrocortisone; immunoglobulin; lactate dehydrogenase; lopinavir; noradrenalin; presepsin; procalcitonin; ritonavir; steroid; unclassified drug; adolescent; adult; adult respiratory distress syndrome; age; Article; artificial ventilation; cause of death; child; childhood mortality; clinical feature; coronavirus disease 2019; cross-sectional study; disease severity; fatality; female; Horowitz index; hospital admission; human; Indonesia; infant; major clinical study; male; mortality rate; newborn; pediatric multisystem inflammatory syndrome; polymerase chain reaction; preschool child; real time polymerase chain reaction; school child; septic shock; tertiary care center; complication; mortality; Adole |
Elsevier B.V. |
12019712 |
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33857609 |
Article |
Q1 |
1278 |
2980 |
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