|
No records
|
|
91 |
Renaldi K., Simadibrata M., Rahadiani N., Handjari D.R., William A., Sinuraya F., Makmun D. |
57190963547;23499598400;16426455700;56160657900;57209025962;57212478117;16638046900; |
Prognostic Value of COX-2, NF-κB, and Sp1 Tissue Expressions in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-analysis |
2021 |
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology |
32 |
11 |
|
956 |
970 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122454127&doi=10.5152%2ftjg.2021.211106&partnerID=40&md5=869f590f4b509a9d15f5495cd1423389 |
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Division of Gastroenterology and Hepato Billiary Pathology, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral HospitalJakarta, Indonesia; Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Renaldi, K., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Simadibrata, M., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Rahadiani, N., Division of Gastroenterology and Hepato Billiary Pathology, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral HospitalJakarta, Indonesia; Handjari, D.R., Division of Gastroenterology and Hepato Billiary Pathology, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral HospitalJakarta, Indonesia; William, A., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Sinuraya, F., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Makmun, D., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia |
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is deadly cancer with a poor prognosis. Molecular prognostic markers are needed to predict the patient's survival. The cyclooxygenase-2 enzyme (COX-2) and its 2 major transcription factors--nuclear factorkappa B (NF-κB) and specificity protein 1 (Sp1)--are activated during inflammation caused by neoplasia. Several studies have investigated the association between the COX-2, NF-κB, and Sp1 tissue expressions with the patient's overall survival. Therefore, we conducted this systematic review and meta-analysis to evaluate those studies. METHODS: We searched for relevant articles from the MEDLINE database through June 2020. Studies were eligible if they included dichotomized tissue protein expression status and the overall survival as the outcome. We used RevMan and ProMeta programs to perform the meta-analysis. RESULTS: We identified 11 eligible studies. The meta-analysis showed that COX-2 tissue expression was associated with decreased overall survival (crude HR = 1.35; 95% CI, 1.05-1.74), although the result was not significant when controlling for other covariates. The NF-κB tissue expression was associated with decreased overall survival (crude HR = 2.18; 95% CI, 1.49-3.18), although it was not significant when controlling for other covariates. The Sp1 tissue expression showed significantly decreased overall survival even when adjusted with other covariates (aHR = 3.47; 95% CI, 1.52-7.94). The limitations included searching only for English publications and the substantial heterogeneity among the studies. CONCLUSION: COX-2, NF-κB, and Sp1 tissue expressions have the potential to be used as prognostic markers in PDAC. Further studies are still needed to clarify the associations. |
|
cyclooxygenase 2; immunoglobulin enhancer binding protein; Sp1 protein, human; transcription factor Sp1; tumor marker; human; meta analysis; metabolism; pancreas carcinoma; pancreas tumor; prognosis; tissue distribution; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cyclooxygenase 2; Humans; NF-kappa B; Pancreatic Neoplasms; Prognosis; Sp1 Transcription Factor; Tissue Distribution |
NLM (Medline) |
21485607 |
|
34872897 |
Article |
#N/A |
#N/A |
#N/A |
|
|
|
92 |
Habiburrahman M., Ariq H., Handayani R.R.D. |
57204537114;57252668400;57394104600; |
Combining LAMP and Au-Nanoprobe to detect INH-RIF resistance accurately in tuberculosis: An evidence-based review |
2021 |
Journal of Infection in Developing Countries |
15 |
11 |
|
1555 |
1568 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122149394&doi=10.3855%2fJIDC.15188&partnerID=40&md5=6f29dbd01464318f481e0062398c92a4 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; National Respiratory Center Persahabatan Hospital, Jakarta, Indonesia |
Habiburrahman, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ariq, H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Handayani, R.R.D., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia, National Respiratory Center Persahabatan Hospital, Jakarta, Indonesia |
Approximately 1.41 million people die annually due to tuberculosis. One of the main problems in Tuberculosis eradication is the development of resistance to various antibiotics. However, current efforts to detect resistances face challenges such as limited equipment, budget, and time. This evidence-based review investigated loop-mediated isothermal amplification, an alternative molecular diagnostic tool with promising performance and applicability in developing countries, and its use combined with Au-Nanoprobe to detect antibiotic resistance in tuberculosis. The literature search was conducted through four databases (Proquest, EBSCOhost, Scopus, and Pubmed) for useful articles on loop-mediated isothermal amplification and Au-Nanoprobe in detecting tuberculosis and tuberculosis resistance. After filtering the result with inclusion and exclusion criteria, the search produced three papers that best answer the clinical question. Loop-mediated isothermal amplification amplifies a target sequence, and Au-Nanoprobe responds to the DNA specific to the target mutant, producing an observable color change. Loop-mediated isothermal amplification and Au-Nanoprobe showed 100% sensitivity and specificity in detecting rifampicin and isoniazid resistance. Another study investigated its viability to detect tuberculosis and found 98.2% sensitivity and 88.2% specificity. Combining loop-mediated isothermal amplification and Au-Nanoprobe had a shorter time to get results and should also be relatively cheaper because it does not need a high temperature to work and requires less equipment. In conclusion, loop-mediated isothermal amplification and Au-Nanoprobe can be used as an efficient and accurate method to detect isoniazid and rifampicin-resistant tuberculosis strains. The new technology is promising for developing countries due to their high disease burden but facing several healthcare barriers. Copyright © 2021 Habiburrahman et al. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Au-Nanoprobes; Diagnosis; Isoniazid; Loop-mediated isothermal amplification; Multidrug-resistant tuberculosis; Rifampicin |
aflatoxin B1; antibiotic agent; betaine; catalase; gold; gold nanoparticle; isoniazid; isoniazid plus rifampicin; penicillin derivative; rifampicin; rifapentine; bacterial DNA; isoniazid; rifampicin; tuberculostatic agent; antibiotic resistance; blood culture; cost effectiveness analysis; developing country; disease burden; DNA extraction; filtration; gene amplification; genotype; high temperature; human; loop mediated isothermal amplification; Medline; molecular diagnosis; multiplex polymerase chain reaction; Mycobacterium tuberculosis; nonhuman; nucleotide sequence; polymerase chain reaction; Review; rifampicin resistance; Scopus; sputum cytodiagnosis; sputum smear; Streptococcus pneumoniae; surface plasmon resonance; systematic review; temperature; tuberculosis; multidrug resistant tube |
Journal of Infection in Developing Countries |
20366590 |
|
34898479 |
Review |
Q3 |
322 |
14136 |
|
|
|
93 |
Zizlavsky S., Anam K., Suwento R., Rahmawati I. |
57195721920;57474576600;55743638800;57372516200; |
The effects of Goldenhar Syndrome on hearing and speech development |
2021 |
Medical Journal of Malaysia |
76 |
6 |
|
946 |
949 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121118699&partnerID=40&md5=ccde190cb788d0255d331b7adfe1295c |
Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Zizlavsky, S., Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Anam, K., Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Suwento, R., Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmawati, I., Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Goldenhar syndrome is a congenital abnormality with an incidence of 1 in 5,200 to 26,500 births. This syndrome is characterized by facial asymmetry, ear malformation, and/or defects in the eyes and vertebrae. The hearing disorder manifests as both conductive or sensorineural due to the abnormalities occurring in the inner and outer ear. We report a case of a 1-year-3-month-old child presenting with left anotia and right microtia, severe bilateral conductive hearing loss, and global delayed development. The patient was also found to have a hemifacial microsomia, a secundum atrial septal defect (ASD), and a ventricular septal defect (VSD). The patient was advised to use hearing aids and participate in speech therapy. The management of this Goldenhar syndrome patient should be done comprehensively, appropriate to the abnormalities found to achieve the best result. © 2021, Malaysian Medical Association. All rights reserved. |
|
anterior inferior cerebellar artery; Article; audiology; babbling; blue light; brainstem evoked response audiometry; case report; clinical article; conduction deafness; cranial nerve paralysis; dyspnea; ear malformation; electrophysiological response; face asymmetry; face deformity; Goldenhar syndrome; hearing; hearing disorder; hearing examination; hearing function; heart atrium septum defect; heart disease; heart ventricle septum defect; hemifacial microsomia; human; hyperbilirubinemia; infant; lagophthalmos; loud noise; male; micrognathia; microtia; motor development; nuclear magnetic resonance imaging; parasystolic murmur; perception deafness; ptosis (eyelid); radiodiagnosis; speech development; speech therapy |
Malaysian Medical Association |
03005283 |
|
34806693 |
Article |
Q4 |
193 |
19818 |
|
|
|
94 |
Subahar R., Susanto L., Aidilla R., Aulia A.P., Yulhasri Y., Winita R., Lubis N.S., Sari I.P. |
6508197883;6507704130;57365800900;57366528800;57225180520;57220782528;57222661567;57197543698; |
In vitro experiments of Pediculus humanus capitis (Phthiraptera: Pediculidae) resistance to permethrin and 6-paradol in East Jakarta: Detoxification enzyme activity and electron microscopic changes in lice |
2021 |
Veterinary World |
14 |
11 |
|
3065 |
3075 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120814548&doi=10.14202%2fvetworld.2021.3065-3075&partnerID=40&md5=1d1646983a8b7f7da98a7d4f5896e795 |
Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jln. Salemba Raya 4, Jakarta, 10430, Indonesia |
Subahar, R., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Susanto, L., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Aidilla, R., Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Aulia, A.P., Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Yulhasri, Y., Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jln. Salemba Raya 4, Jakarta, 10430, Indonesia; Winita, R., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Lubis, N.S., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Sari, I.P., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia |
Background and Aim: Pediculus humanus capitis, the human head louse, remains a global health problem. This study evaluated the resistance of head lice to permethrin and 6-paradol mediated by in vitro detoxification enzyme activity experiments and to describe physical changes in the lice using scanning electron microscopy (SEM). Materials and Methods: The adult stages of P. h. capitis were collected from patients exposed to 1% permethrin and three different concentrations of 6-paradol (0.00005%, 0.0001%, and 0.00015%) using a filter paper diffusion bioassay. Healthy P. h. capitis adults served as the control. The in vitro bioassays were conducted after 10, 20, 30, and 60 min of exposure. The activities of acetylcholinesterase (AChE), glutathione S-transferase (GST), and oxidase were analyzed. Physical changes in the lice were analyzed using SEM. Results: Permethrin and 6-paradol exhibited low toxicity against the lice. At 60 min, 1% permethrin had killed 36.7% of the lice present, while 6-paradol had killed 66.7-86.7%. Permethrin induced significantly elevated AChE, GST, and oxidase activity; 6-paradol also caused significantly elevated AChE, GST, and oxidase activity. Permethrin did not cause any ultrastructural morphological changes on the lice, while 6-paradol severely damaged the head, thorax, respiratory spiracles, and abdomen of the dead lice. Conclusion: This in vitro experimental of P. h. capitis is the first study to report P. h. capitis in East Jakarta shows complete resistance to permethrin and 6-paradol, and to describe the associated increase in AChE, GST, and oxidase activity. It was observed that 6-paradol severely damaged the head, thorax, respiratory spiracles, and abdomen of the dead lice. © 2021 Veterinary World. All rights reserved. |
6-paradol; Detoxifying enzyme; Electron microscopy; Pediculus humanus capitis; Permethrin; Resistance |
6 paradol; acetylcholinesterase; chitin; glutathione transferase; oxidoreductase; permethrin; phenol derivative; unclassified drug; Article; bioassay; controlled study; detoxification; diffusion; enzyme activity; enzyme linked immunosorbent assay; hair loss; LT50; LT90; nonhuman; Pediculus humanus capitis; scanning electron microscopy; ultrastructure |
Veterinary World |
09728988 |
|
|
Article |
Q2 |
550 |
9187 |
|
|
|
95 |
Laksmita Y.A., Sidik M., Siregar N.C., Nusanti S. |
57209279067;57257519600;6508087790;57189727162; |
Neuroprotective Effects of Citicoline on Methanol-Intoxicated Retina Model in Rats |
2021 |
Journal of Ocular Pharmacology and Therapeutics |
37 |
9 |
|
534 |
541 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120545903&doi=10.1089%2fjop.2021.0018&partnerID=40&md5=cfe07289839f2866220d3438db7fac57 |
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia; Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Laksmita, Y.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia; Sidik, M., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia; Siregar, N.C., Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nusanti, S., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia |
Purpose: This study aims to evaluate the effect of citicoline administration in suppressing retinal damage due to methanol intoxication. This study hypothesizes that citicoline will minimize the loss of retinal ganglion cells (RGCs), minimize disruption of photoreceptors, suppress ganglion layer edema, increase expression of bcl-2 as the antiapoptotic protein, and decrease expression of caspase-3 as the proapoptotic protein. Methods: Fifteen Sprague-Dawley rats were divided into 5 groups, including the control group (A); methanol groups, observed on day 3 (B1) and day 7 (B2); and methanol+citicoline groups, observed on day 3 (C1) and day 7 (C2). Rats in groups B and C were placed in an inhalation chamber filled with N2O:O2 during the experiment, then methanol was administered orally. Citicoline, 1 g/kg every 24 h, was orally administered for group C. Enucleation was performed and retinas of rats were prepared for histology and immunohistochemistry examination to evaluate photoreceptor morphology and RGC density, as well as bcl-2 and caspase-3 expression. Results: RGC density of citicoline-treated intoxicated rats was higher than no-citicoline methanol-intoxicated rats on both day 3 (P < 0.001) and day 7 (P < 0.001). The ganglion layer thickness of citicoline-treated intoxicated rats was thinner than no-citicoline intoxicated rats, which means citicoline-treated rats had milder ganglion layer edema. Citicoline-treated rats showed higher bcl-2 and lower caspase-3 expression than no-citicoline rats. No differences were found in photoreceptor findings among groups. Conclusions: This study demonstrated citicoline's potential benefits for management of ocular methanol intoxication. However, more preclinical and clinical trials are needed to obtain a preferred dosage and timing of citicoline administration. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
citicoline; methanol intoxication; methanol optic neuropathy; neuroprotector; retina; toxic optic neuropathy |
|
Mary Ann Liebert Inc. |
10807683 |
|
34495749 |
Article |
Q2 |
727 |
6812 |
|
|
|
96 |
Irwinda R., Hiksas R., Lokeswara A.W., Wibowo N. |
57190855256;57226152029;57200937543;15049026900; |
Maternal and fetal characteristics to predict c-section delivery: A scoring system for pregnant women |
2021 |
Women's Health |
17 |
|
|
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120494500&doi=10.1177%2f17455065211061969&partnerID=40&md5=24bd3b15eeeb46e6e6583c50495d671b |
Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Irwinda, R., Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hiksas, R., Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Lokeswara, A.W., Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wibowo, N., Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Cesarean section is one of the most common obstetrical interventions that has been performed at an increasing rate globally, due to both medical and non-medical reasons. This study aims to develop a prediction tool for pregnant women potentially needing c-section, such that necessary preparations from the mothers, families, and health providers can be made. Methods: A total of 603 pregnant women were recruited in the first phase of c-section prediction tool development. The association between the maternal and fetal factors on the risk of c-section were analyzed, followed by a stepwise multivariate regression analysis. In the next phase, 61 pregnant women were enrolled for external validation. Discrimination was assessed using area under the curve. The calibration plot was then made and assessed using the Hosmer–Lemeshow test. Results: There were 251 (41.6%) cases of vaginal delivery and 352 (58.4%) of c-section assessed. Multivariate analysis showed that gestational age < 37 wg (OR: 1.66, 95% CI: 1.10–2.51), pre-pregnancy body mass index (underweight) (OR: 0.40, 95% CI: 0.22–0.76), no history of vaginal delivery (OR: 2.66, 95% CI: 1.76–4.02), history of uterine surgery (OR: 8.34, 95% CI: 4.54–15.30), obstetrical complications (OR: 5.61, 95% CI: 3.53–8.90), birthweight ⩾ 3500 g (OR: 4.28, 95% CI: 2.16–8.47), and non-cephalic presentation (OR: 2.74, 95% CI: 1.53–4.89) were independently associated with c-section delivery. Those parameters were included in a 7-item scoring tool, with consecutive predictive scores of 1,–1,2,3,3,2,2,1. The area under the curve result was 0.813 (95% CI: 0.779–0.847), indicating a good predictive ability. The external validation showed AUC: 0.806, 95% CI: 0.694–0.917, Hosmer–Lemeshow test p = 0.666 and calibration plot coefficient of r = 0.939. Conclusion: A total of 7 maternal-fetal factors were found to be strongly associated with c-section delivery, including gestational age < 37, maternal underweight body mass index, previous uterine surgery, obstetrical complications, birthweight ⩾ 3500, history of vaginal delivery, and non-cephalic presentation. Using these factors, a prediction tool was developed and validated with good quality. © The Author(s) 2021. |
cesarean section; maternal-fetal characteristics; mode of delivery; prediction; scoring system |
7 point scoring system; abdominal circumference; adult; area under the curve; Article; biological activity; birth weight; body mass; cesarean section; clinical examination; cohort analysis; diagnostic test accuracy study; exploratory factor analysis; female; fetus weight; forceps delivery; gestational age; human; major clinical study; maternal fetal characteristics; mortality; myomectomy; non cephalic presentation; obstetrical complication; prediction; pregnancy complication; pregnant woman; prenatal care; questionnaire; receiver operating characteristic; retrospective study; risk factor; scoring system; sensitivity and specificity; underweight; urologic surgery; vaginal delivery; obstetric delivery; pregnancy; Cesarean Section; Delivery, Obstetric; Female; Gestational Age; Humans; Pregnan |
SAGE Publications Ltd |
17455057 |
|
34818932 |
Article |
Q1 |
1363 |
2670 |
|
|
|
97 |
Miranda A.V., Wiyono L., Rocha I.C.N., Cedeño T.D.D., Lucero-Prisno D.E., III |
57222664687;57207889054;57223283646;57224097138;56051373800; |
Strengthening virology research in the association of Southeast Asian nations: Preparing for future pandemics |
2021 |
American Journal of Tropical Medicine and Hygiene |
105 |
5 |
|
1141 |
1143 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119604704&doi=10.4269%2fajtmh.21-0589&partnerID=40&md5=98ad7364acccdc95ee57ef0ea9e65ed9 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; School of Medicine, Centro Escolar University, Manila, Philippines; Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom; Faculty of Management and Development Studies, University of the Philippines Open University, Los Baños, Laguna, Philippines |
Miranda, A.V., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiyono, L., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rocha, I.C.N., School of Medicine, Centro Escolar University, Manila, Philippines; Cedeño, T.D.D., School of Medicine, Centro Escolar University, Manila, Philippines; Lucero-Prisno, D.E., III, Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom, Faculty of Management and Development Studies, University of the Philippines Open University, Los Baños, Laguna, Philippines |
The Association of Southeast Asian Nations (ASEAN) region is known to be a global hotspot to viral outbreaks because of many factors. To limit the impact of future outbreaks, it is crucial for the ASEAN governments to strengthen regional virology research capacity. The ASEAN governments have collaborated in several virology initiatives, with the most recent being the establishment of the ASEAN Regional Center for Public Health Emergencies and Emerging Diseases. However, several challenges, including technology disparities, nationalistic tendencies, and the lack of public acceptance toward virus sharing, need to be addressed to maximize the region’s collaboration potential in virology research. We recommend the governments to 1) prioritize the strengthening of research capacities; 2) develop stronger cooperation and possible centralization of efforts on top of national capacities; 3) develop an equitable and secure research framework; and 4) improve the public awareness regarding the importance of regional public health responses. Copyright © 2021 by The American Society of Tropical Medicine and Hygiene |
|
epidemic; human; medical research; organization and management; pandemic; Southeast Asia; virology; Asia, Southeastern; Biomedical Research; Disease Outbreaks; Humans; Pandemics; Virology |
American Society of Tropical Medicine and Hygiene |
00029637 |
|
34506300 |
Article |
Q1 |
1015 |
4298 |
|
|
|
98 |
Yusharyahya S.N., Bramono K., Indriatmi W., Prasetyo M., Ascobat P., Hestiantoro A., Wiraguna A.A.G.P. |
57211780941;9843236700;57189888041;57192905252;55795863600;8743255100;20437026700; |
Anti-aging effects of fenugreek cream on postmenopausal skin: A randomized controlled trial |
2021 |
Journal of Applied Pharmaceutical Science |
11 |
11 |
|
95 |
103 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119480025&doi=10.7324%2fJAPS.2021.1101113&partnerID=40&md5=020217cd5f217dbc98ba3162ac9d99f1 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana – Sanglah General Hospital, Denpasar, Indonesia |
Yusharyahya, S.N., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bramono, K., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Indriatmi, W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prasetyo, M., Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ascobat, P., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Indonesia; Hestiantoro, A., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wiraguna, A.A.G.P., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana – Sanglah General Hospital, Denpasar, Indonesia |
Postmenopausal hypoestrogenism is associated with skin aging, for which phytoestrogen derived from the seeds of Trigonella foenum graecum (fenugreek) is expected to be an alternative solution to reduce wrinkles and increase the thickness of postmenopausal women’s skin. This study was a randomized, double-blind, controlled 12-weeks trial conducted at a general hospital in Jakarta, Indonesia, from January to November 2019. Subjects were 50 postmenopausal women divided into two groups: the intervention group was given 5% fenugreek cream and base cream was given to the placebo group. The results of the independent t-test showed that both groups were able to achieve statistically significant improvement in wrinkle scores on the forehead, crow’s feet, and nasolabial folds which was assessed by photography scoring based on Bazin’s skin aging atlas for Asian skin volume 2 but there was no significant disparity between both groups at all time points. Dermal thickness was assessed by high-resolution ultrasound GE LOGIQ E9 (18 MHz), which showed similar results for both groups with significant improvements in the 8th week compared to baseline and a significant decrease by the 12th week. No significant differences were observed in the skin wrinkle score and skin thickness after the application of fenugreek cream compared to placebo.We suspect that a concentration of 5% was not adequate for the expected antiskin aging effects. Further studies are necessary to determine a more appropriate fenugreek concentration to permit clinical use as an antiskin aging therapy in postmenopausal women. © 2021 Shannaz Nadia Yusharyahya et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License |
Dermal thickness; fenugreek; postmenopausal skin; skin wrinkle |
|
Open Science Publishers LLP Inc. |
22313354 |
|
|
Article |
Q2 |
286 |
15310 |
|
|
|
99 |
Herawati F., Yulia R., Wiyono H., Massey F.K., Muliani N., Kantono K., Soemantri D., Andrajati R. |
57194722742;56768083700;57321279000;57321051400;57222261946;56580346400;36640659100;9940247700; |
Discordance to ashp therapeutic guidelines increases the risk of surgical site infection |
2021 |
Pharmaceuticals |
14 |
11 |
1088 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118387727&doi=10.3390%2fph14111088&partnerID=40&md5=f3621ba3decf103d84295afa3e55e549 |
Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Faculty of Medicine, Universitas Surabaya, Surabaya, 60293, Indonesia; Department of Food Science, Auckland University of Technology, Private Bag 92006, Auckland, 1142, New Zealand; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
Herawati, F., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Yulia, R., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Wiyono, H., Faculty of Medicine, Universitas Surabaya, Surabaya, 60293, Indonesia; Massey, F.K., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Muliani, N., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Kantono, K., Department of Food Science, Auckland University of Technology, Private Bag 92006, Auckland, 1142, New Zealand; Soemantri, D., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia; Andrajati, R., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia |
Clean surgery without contamination does not require prophylactic antibiotics, but there are high-risk surgical procedures that may cause infection and/or involve vital organs such as the heart, brain, and lungs, and these indeed require the use of antibiotics. This study aimed to determine the quantity of antibiotic use based on the defined daily dose (DDD) per 100 bed days and the quality of antibiotic use based on the percentage of concordance with The American Society of Health-System Pharmacists (ASHP) therapeutic guidelines (i.e., route of administration, time of administration, selection, dose, and duration). This includes the profiles of surgical site infection (SSI) in surgical patients from January through June 2019. The study subjects were 487 surgical patients from two hospitals who met the inclusion criteria. There were 322 patients out of 487 patients who had a clean surgical procedure. Ceftriaxone (J01DD04) was the most used antibiotic, with a total DDD/100 bed days value in hospitals A and B, respectively: pre-surgery: 14.71, 77.65, during surgery: 22.57, 87.31, and postsurgery: 38.34, 93.65. In addition, 35% of antibiotics were given more than 120 min before incision. The lowest concordance to ASHP therapeutic guideline in hospital A (17.6%) and B (1.9%) was antibiotic selection. Two patients experienced SSI with bacterial growths of Proteus spp., Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli. The usage of prophylactic antibiotics for surgical procedures was high and varied between hospitals. Hospital B had significantly lower concordance to antibiotic therapeutic guidelines, resulting to a higher infection rate, compared with hospital A. ASHP adherence components were then further investigated, after which antibiotic dosing interval and injection time was found to be a significant predictor for positive bacterial growth based on logit–logistic regression. Further interventions and strategies to implement antibiotic stewardship is needed to improve antibiotic prescriptions and their use. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Antibiotic stewardship; Defined daily dose; Hospital; Surgical site infection |
amoxicillin; amoxicillin plus clavulanic acid; ampicillin; antibiotic agent; beta lactamase inhibitor; cefadroxil; cefazolin; cefepime; cefixime; cefoperazone; cefotaxime; cefoxitin; ceftazidime; ceftriaxone; chloramphenicol; ciprofloxacin; clindamycin; cotrimoxazole; fosfomycin; gentamicin; levofloxacin; meropenem; metronidazole; moxifloxacin; norfloxacin; ofloxacin; oxacillin; sulbactam; sultamicillin; tetracycline; vancomycin; adult; aged; antibiotic sensitivity; antimicrobial stewardship; Article; bacterial growth; bacterium culture; drug choice; drug use; Escherichia coli; female; human; infection rate; infection risk; intraoperative period; length of stay; major clinical study; male; medical society; middle aged; observational study; postoperative period; practice guideline; preopera |
MDPI |
14248247 |
|
|
Article |
Q1 |
1295 |
2918 |
|
|
|
100 |
Irawati Y., Paramita C., Daniel H. |
57201260313;57219380835;57316812600; |
Challenging eyelid reconstruction in malignancies: Case reports |
2021 |
Annals of Medicine and Surgery |
71 |
|
102987 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118265765&doi=10.1016%2fj.amsu.2021.102987&partnerID=40&md5=d761c9b6bbfe6b7a5a498e07f9e22253 |
Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Irawati, Y., Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Paramita, C., Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Daniel, H., Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Eye is one of the most crucial organs in need of protection. The most important function of eyelids is designed to protect the eyeball. Despite their small and thin surface area, they are among the most sunlight-exposed area of skins, hence, it is prone to develop eyelid tumors. As the malignant tumors have the tendency of growing aggressively and have a high mortality, we have to meticulously remove the lesion along with its surrounding tissue, if needed, to ensure the clearance of tumor margin. To strike a suitable outcome between the cosmetic and function after tumor removal is a quite challenging task. Compromise on aesthetics and eyelids’ indispensable function of protecting the eyes during management, may lead to unfavorable cosmetic deformity and loss of vision. Therefore, it is imperative that wise selection of appropriate techniques be discussed and managed accordingly. In this article, the authors reported two case scenarios of eyelid reconstruction which was performed to show the management of full-thickness defect after removal of the malignant neoplasms. Skin flaps and graft technique used to reconstruct the eyelid in each patient was different to emphasize that eyelid malignancies require an individualized management. © 2021 |
Eyelid malignancies; Eyelid reconstruction; Full-thickness defect; Skin flaps; Skin graft |
adult,human; Article; case report; clinical article; ectropion; eyelid cancer; eyelid reconstruction; female; follow up; histopathology; human; human tissue; human,clinical article; keratinocyte; lower eyelid; lymph node biopsy; middle aged; muscle graft; palpation; reconstructive surgery; sentinel lymph node biopsy; skin flap; solid mass; squamous cell carcinoma; telangiectasia; tissue flap |
Elsevier Ltd |
20490801 |
|
|
Article |
Q3 |
391 |
12334 |
|
|
