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278 |
Saroyo Y.B., Harzif A.K., Anisa B.M., Charilda F.E. |
57164888400;57191493435;57195936232;57222329284; |
Thyroid storm in the second stage of labour: A case report |
2021 |
BMJ Case Reports |
14 |
7 |
e243159 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111078258&doi=10.1136%2fbcr-2021-243159&partnerID=40&md5=e3ec18b255c13bcad0e9401bfa44b499 |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia |
Saroyo, Y.B., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia; Harzif, A.K., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia; Anisa, B.M., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia; Charilda, F.E., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia |
A thyroid storm (or thyroid crisis) is an emergency in endocrinology. It is a form of complication of hyperthyroidism that can be life-threatening. Inadequate control of hyperthyroidism in pregnancy could develop into thyroid storm, especially in the peripartum period. We present a woman came in the second stage of labour, with thyroid storm, superimposed pre-eclampsia, acute lung oedema and impending respiratory failure. Treatment for thyroid storm, pre-eclampsia protocol and corticosteroid was delivered. The baby was born uneventfully, while the mother was discharged after 5 days of hospitalisation. Delivery is an important precipitant in the development of thyroid storm in uncontrolled hyperthyroidism in pregnancy. Although very rare, it can cause severe consequences. Diagnosis and treatment guidelines for thyroid storm were available and should be done aggressively and immediately. Uncontrolled hyperthyroidism should be prevented by adequate control in thyroid hormone levels, especially before the peripartum period. © |
endocrinology; obstetrics and gynaecology; thyroid disease |
alanine aminotransferase; aspartate aminotransferase; bicarbonate; corticosteroid; creatinine; dexamethasone; lactate dehydrogenase; lugol; magnesium sulfate; nifedipine; propranolol; propylthiouracil; thyroid hormone; thyrotropin; thyroxine; adult; alanine aminotransferase blood level; ambient air; amnion fluid; Apgar score; Article; aspartate aminotransferase blood level; auscultation; birth length; birth weight; bleeding; blood carbon dioxide tension; blood gas analysis; blood pressure; body temperature; breathing rate; case report; clinical article; clinical examination; clinical feature; consciousness level; continuous positive airway pressure; coronavirus disease 2019; creatinine blood level; diagnostic procedure; disease course; disease duration; disease severity; electrography; epi |
BMJ Publishing Group |
1757790X |
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34290023 |
Article |
Q4 |
231 |
17583 |
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391 |
Wente-Schulz S., Aksenova M., Awan A., Ambarsari C.G., Becherucci F., Emma F., Fila M., Francisco T., Gokce I., Gülhan B., Hansen M., Jahnukainen T., Kallash M., Kamperis K., Mason S., Mastrangelo A., Mencarelli F., Niwinska-Faryna B., Riordan M., Rus R.R., Saygili S., Serdaroglu E., Taner S., Topaloglu R., Vidal E., Woroniecki R., Yel S., Zieg J., Pape L., Boyer O., Buder K., Bulut İ.K., Cornelissen E.A.M., del Mar Espino Hernández M., Hooman N., Kemper M., Maquet J., Santos F., Walden U., The international TIN study group |
57219293227;56461027300;7005794049;57211850895;23391748500;6701866332;47760976500;55642167100;16238883200;16244621000;57026872000;6602193869;55189985500;6507713677;56025783100;16245571200;23989069700;24402868000;36828392800;56126830800;36926397400;55910586900;57204046122;7005610220;57200885825;8351699100;43861951500;37762449000;7007073757;8509255100;57423156500;42360924700;7003896668;56868570600;22634317400;55946766900;57199406014;7202141204;57189522337; |
Aetiology, course and treatment of acute tubulointerstitial nephritis in paediatric patients: A cross-sectional web-based survey |
2021 |
BMJ Open |
11 |
5 |
e047059 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107244372&doi=10.1136%2fbmjopen-2020-047059&partnerID=40&md5=8b9d8549b7d6c5d3a71a823dffc235d5 |
Department of Pediatric Nephrology, MHH, Hannover, Germany; Department of Pediatric Nephrology, Veltischev Research and Clinical Institute for Pediatrics, The Pirogov Russian National Research Medical University, Moskva, Russian Federation; Department of Pediatric Nephrology, Temple Street Children's University Hospital, Dublin, Ireland; Department of Pediatric Nephrology, Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Central Jakarta, Indonesia; Department of Pediatric Nephrology, Meyer Children's Hospital, Florence, Italy; Department of Pediatric Nephrology, Bambino Gesù Children's Hospital, Roma, Italy; Department of Pediatric Nephrology, Montpellier University, Arnaud de Villeneuve Hospital, Montpellier, France; Department of Pediatric Nephrology, Dona Estefânia Hospital, Lisboa, Portugal; Department of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkey; Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey; KfH Centre of Pediatric Nephrology, Clementine Kinderhospital, Frankfurt am Main, Germany; Department of Pediatric Nephrology and Transplantation, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland; Department of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, OH, United States; Department of Pediatric Nephrology, Aarhus University Hospital, Aarhus, Denmark; Department of Pediatric Nephrology, Connecticut Children's Medical Center, Hartford, CT, United States; Department of Pediatric Nephrology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pediatric Nephrology, Azienda Ospedaliero-Universitaria di Bologna, Ospedale S. Orsola-Malpighi, Bologna, Italy; Department of Pediatric Nephrology, Karolinska University Hospital, Stockholm, Sweden; Department of Pediatric Nephrology, University Children's Hospital, Ljubljana, Slovenia; Department of Pediatric Nephrology, Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey; Department of Pediatric Nephrology, Dr Behcet Uz Children Hospital, Izmir, Turkey; Department of Pediatric Nephrology, Faculty of Medicine, Ege University, Izmir, Turkey; Department of Pediatric Nephrology, University Hospital of Padova, Padova, Italy; Department of Pediatric Nephrology, Stony Brook Children's Hospital, Stony Brook, NY, United States; Department of Pediatric Nephrology, Faculty of Medicine, Erciyes University, Kayseri, Turkey; Department of Pediatric Nephrology, 2nf Faculty of Medicine, University Hospital Motol, Charles University, Praha, Czech Republic; Department of Pediatrics II, University Hospital Essen, Essen, Germany; Hôpital Necker-Enfants malades, MARHEA, Institut Imagine, Université de Paris, Paris, France; Pediatric Department, University Hospital Carl Gustav Carus, Technical University, Dresden, Germany; Ege University Faculty of Medicine, Izmir, Turkey; Radboud University Medical Center, Nijmegen, Netherlands; Hospital Universitario 12 de Octubre, Madrid, Spain; Ali-Asghar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran; Asklepios Medical School, Hamburg, Germany; CHC Liège, Belgium; Pediatric Nephrology, Hospital Universitario Central de Asturias, University of Oviedo, Spain; Universitätsklinikum Kinderklinik Augsburg, Germany |
Wente-Schulz, S., Department of Pediatric Nephrology, MHH, Hannover, Germany; Aksenova, M., Department of Pediatric Nephrology, Veltischev Research and Clinical Institute for Pediatrics, The Pirogov Russian National Research Medical University, Moskva, Russian Federation; Awan, A., Department of Pediatric Nephrology, Temple Street Children's University Hospital, Dublin, Ireland; Ambarsari, C.G., Department of Pediatric Nephrology, Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Central Jakarta, Indonesia; Becherucci, F., Department of Pediatric Nephrology, Meyer Children's Hospital, Florence, Italy; Emma, F., Department of Pediatric Nephrology, Bambino Gesù Children's Hospital, Roma, Italy; Fila, M., Department of Pediatric Nephrology, Montpellier University, Arnaud de Villeneuve Hospital, Montpellier, France; Francisco, T., Department of Pediatric Nephrology, Dona Estefânia Hospital, Lisboa, Portugal; Gokce, I., Department of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkey; Gülhan, B., Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey; Hansen, M., KfH Centre of Pediatric Nephrology, Clementine Kinderhospital, Frankfurt am Main, Germany; Jahnukainen, T., Department of Pediatric Nephrology and Transplantation, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland; Kallash, M., Department of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, OH, United States; Kamperis, K., Department of Pediatric Nephrology, Aarhus University Hospital, Aarhus, Denmark; Mason, S., Department of Pediatric Nephrology, Connecticut Children's Medical Center, Hartford, CT, United States; Mastrangelo, A., Department of Pediatric Nephrology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Mencarelli, F., Department of Pediatric Nephrology, Azienda Ospedaliero-Universitaria di Bologna, Ospedale S. Orsola-Malpighi, Bologna, Italy; Niwinska-Faryna, B., Department of Pediatric Nephrology, Karolinska University Hospital, Stockholm, Sweden; Riordan, M., Department of Pediatric Nephrology, Temple Street Children's University Hospital, Dublin, Ireland; Rus, R.R., Department of Pediatric Nephrology, University Children's Hospital, Ljubljana, Slovenia; Saygili, S., Department of Pediatric Nephrology, Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey; Serdaroglu, E., Department of Pediatric Nephrology, Dr Behcet Uz Children Hospital, Izmir, Turkey; Taner, S., Department of Pediatric Nephrology, Faculty of Medicine, Ege University, Izmir, Turkey; Topaloglu, R., Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey; Vidal, E., Department of Pediatric Nephrology, University Hospital of Padova, Padova, Italy; Woroniecki, R., Department of Pediatric Nephrology, Stony Brook Children's Hospital, Stony Brook, NY, United States; Yel, S., Department of Pediatric Nephrology, Faculty of Medicine, Erciyes University, Kayseri, Turkey; Zieg, J., Department of Pediatric Nephrology, 2nf Faculty of Medicine, University Hospital Motol, Charles University, Praha, Czech Republic; Pape, L., Department of Pediatrics II, University Hospital Essen, Essen, Germany; Boyer, O., Hôpital Necker-Enfants malades, MARHEA, Institut Imagine, Université de Paris, Paris, France; Buder, K., Pediatric Department, University Hospital Carl Gustav Carus, Technical University, Dresden, Germany; Bulut, İ.K., Ege University Faculty of Medicine, Izmir, Turkey; Cornelissen, E.A.M., Radboud University Medical Center, Nijmegen, Netherlands; del Mar Espino Hernández, M., Hospital Universitario 12 de Octubre, Madrid, Spain; Hooman, N., Ali-Asghar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran; Kemper, M., Asklepios Medical School, Hamburg, Germany; Maquet, J., CHC Liège, Belgium; Santos, F., Pediatric Nephrology, Hospital Universitario Central de Asturias, University of Oviedo, Spain; Walden, U., Universitätsklinikum Kinderklinik Augsburg, Germany; The international TIN study group |
Background Acute tubulointerstitial nephritis (TIN) is a significant cause of acute renal failure in paediatric and adult patients. There are no large paediatric series focusing on the aetiology, treatment and courses of acute TIN. Patients, design and setting We collected retrospective clinical data from paediatric patients with acute biopsy-proven TIN by means of an online survey. Members of four professional societies were invited to participate. Results Thirty-nine physicians from 18 countries responded. 171 patients with acute TIN were included (54% female, median age 12 years). The most frequent causes were tubulointerstitial nephritis and uveitis syndrome in 31% and drug-induced TIN in 30% (the majority of these caused by non-steroidal anti-inflammatory drugs). In 28% of patients, no initiating noxae were identified (idiopathic TIN). Median estimated glomerular filtration rate (eGFR) rose significantly from 31 at time of renal biopsy to 86 mL/ min/1.73 m2 3-6 months later (p<0.001). After 3-6 months, eGFR normalised in 41% of patients (eGFR ≥90 mL/ min/1.73 m2), with only 3% having severe or end-stage impairment of renal function (<30 mL/min/1.73 m2). 80% of patients received corticosteroid therapy. Median eGFR after 3-6 months did not differ between steroid-treated and steroid-untreated patients. Other immunosuppressants were used in 18% (n=31) of patients, 21 of whom received mycophenolate mofetil. Conclusions Despite different aetiologies, acute paediatric TIN had a favourable outcome overall with 88% of patients showing no or mild impairment of eGFR after 3-6 months. Prospective randomised controlled trials are needed to evaluate the efficacy of glucocorticoid treatment in paediatric patients with acute TIN. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
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aciclovir; amoxicillin plus clavulanic acid; antiinfective agent; bee venom; chlorpheniramine maleate; corticosteroid; cotrimoxazole; flurbiprofen; herbaceous agent; hydrochlorothiazide; ibuprofen; immunosuppressive agent; ketoprofen; levetiracetam; mesalazine; methylprednisolone; midecamycin; morniflumate; mycophenolate mofetil; nonsteroid antiinflammatory agent; oxcarbazepine; paracetamol; penicillin G potassium; prednisolone; prednisone; toxic substance; anuria; arthralgia; Article; child; clinical feature; cohort analysis; controlled study; corticosteroid therapy; cross-sectional study; disease course; end stage renal disease; enuresis; estimated glomerular filtration rate; eye disease; fatigue; female; fever; flank pain; glucosuria; headache; health care survey; hematuria; human; huma |
BMJ Publishing Group |
20446055 |
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34049919 |
Article |
Q1 |
1132 |
3624 |
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394 |
Abdullah M., Sudrajat D.G., Muzellina V.N., Kurniawan J., Rizka A., Utari A.P., Pribadi R.R., Idrus M.F., Yusra Y., Meilany S., Surandy A., Shatri H., Rinaldi I., Pitoyo C.W., Renaldi K. |
7103393434;54893136100;57223968527;57193251655;57203243658;57113585900;57194732282;57223976376;57220998367;57193709281;57223964417;28767986500;23475122400;26022606900;57190963547; |
The value of anal swab RT-PCR for COVID-19 diagnosis in adult Indonesian patients |
2021 |
BMJ Open Gastroenterology |
8 |
1 |
e000590 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106611204&doi=10.1136%2fbmjgast-2020-000590&partnerID=40&md5=cc17ce689ac73f1e46021151c9319871 |
Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Indonesia Medical Education and Research Institute - Human Cancer Research Center, University of Indonesia Faculty of Medicine, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Hepatobilliary Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Geriatric Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Department of Clinical Pathology, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region Jakarta, Indonesia; Research Center for Virology and Cancer Pathobiology, University of Indonesia Faculty of Medicine, Jakarta, Special Capital Region of Jakarta, Indonesia; Psychosomatic and Palliative Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Special Capital Region of Jakarta, Central Jakarta, Indonesia; Hematology and Medical Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Respirology and Critical Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia |
Abdullah, M., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia, Indonesia Medical Education and Research Institute - Human Cancer Research Center, University of Indonesia Faculty of Medicine, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Sudrajat, D.G., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Muzellina, V.N., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Kurniawan, J., Hepatobilliary Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Rizka, A., Geriatric Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Utari, A.P., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Pribadi, R.R., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Idrus, M.F., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Yusra, Y., Department of Clinical Pathology, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region Jakarta, Indonesia; Meilany, S., Research Center for Virology and Cancer Pathobiology, University of Indonesia Faculty of Medicine, Jakarta, Special Capital Region of Jakarta, Indonesia; Surandy, A., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Shatri, H., Psychosomatic and Palliative Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Special Capital Region of Jakarta, Central Jakarta, Indonesia; Rinaldi, I., Hematology and Medical Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Pitoyo, C.W., Respirology and Critical Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Renaldi, K., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia |
Objective This study will test the performance of the anal swab PCR test when compared with the nasopharyngeal swab PCR test as a diagnostic tool for COVID-19. Design An observational descriptive study which included hospitalised suspected, or probable cases of hopitalised COVID-19 patients, conducted in Dr. Cipto Mangunkusumo National Hospital, Ciputra Hospital, Mitra Keluarga Depok Hospital and Mitra Keluarga Kelapa Gading Hospital, Indonesia. Epidemiological, clinical, laboratory and radiology data were obtained. Nasopharyngeal and anal swabs specimens were collected for SARS-CoV-2 RNA detection. Results We analysed 136 subjects as part of this study. The clinical spectrum of COVID-19 manifesation in this study was typical of hospitalised patients, with 25% classified as mild cases, 14.7% in severe condition and 12.5% of subjects classified as having acute respiratory distress syndrome. When compared with nasopharyngeal swab as the standard specimen for reverse transcription polymerase chain reaction (RT-PCR) detection of SARS-CoV-2 antigen, the sensitivity and specificity of the anal swab was 36.7% and 93.8%, respectively. The positive and negative predictive value were 97.8% and 16.5 %, respectively. The performance of the anal swab remained similar when only the subgroup of patients with gastrointestinal symptoms (n=92, 67.6%) was analysed (sensitivity 40% and specificity 91.7%). Out of all the subjects included in analysis, 67.6% had gastrointestinal symptoms. Similarly, 73.3% of patients in the anal swab-positive group had gastrointestinal symptoms. The two most common gastrointestinal symptoms in the subjects' population were nausea and anorexia. Conclusion Anal swab specimen has low sensitivity (36.7%) but high specificity (93.8%) for detecting SARS-CoV-2 antigen by RT-PCR. Only one additional positive result was found by anal swab among the nasopharyngeal swab-negative group. Anal swab may not be needed as an additional test at the beginning of a patient's diagnostic investigation and nasopharyngeal swab RT-PCR remains as the standard diagnostic test for COVID-19. © 2020 American Society of Mechanical Engineers (ASME). All rights reserved. |
anal; COVID-19; diagnostic virology |
abdominal pain; adult; adult respiratory distress syndrome; anal swab; anorexia; Article; body mass; clinical laboratory; controlled study; coronavirus disease 2019; coughing; COVID-19 testing; current smoker; diagnostic test accuracy study; diarrhea; ex-smoker; female; fever; gastrointestinal symptom; headache; heart disease; hospital patient; human; hypertension; Indonesian; lung disease; major clinical study; malaise; male; mortality rate; nasopharyngeal swab; nausea; non insulin dependent diabetes mellitus; practice guideline; predictive value; priority journal; respiratory tract infection; reverse transcription polymerase chain reaction; sensitivity and specificity; sore throat |
BMJ Publishing Group |
20544774 |
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Article |
Q1 |
1240 |
3126 |
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520 |
Jamtani I., Nugroho A., Rahadiani N., Manangka R.S.W. |
57220165203;57192888914;16426455700;57222276868; |
Challenging retrovesical mass in men: Report of a rare liposarcoma case with concurrent COVID-19 infection |
2021 |
BMJ Case Reports |
14 |
3 |
e241466 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102142953&doi=10.1136%2fbcr-2020-241466&partnerID=40&md5=d155998c0d1b2e9350e4a10623455925 |
Department of Surgery, Fatmawati Central General Hospital, Jakarta Selatan, DKI Jakarta, Indonesia; Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National Referral Hostpital, Jakarta, Indonesia; Radiology Department, Mayapada Hospital, DKI Jakarta, Indonesia |
Jamtani, I., Department of Surgery, Fatmawati Central General Hospital, Jakarta Selatan, DKI Jakarta, Indonesia; Nugroho, A., Department of Surgery, Fatmawati Central General Hospital, Jakarta Selatan, DKI Jakarta, Indonesia; Rahadiani, N., Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National Referral Hostpital, Jakarta, Indonesia; Manangka, R.S.W., Radiology Department, Mayapada Hospital, DKI Jakarta, Indonesia |
We describe a case of retrovesical liposarcoma in a male patient with concurrent COVID-19. A 50-year-old man had lower urinary tract symptoms and dull pain along his right gluteus. Due to COVID-19 infection, management was delayed. During self-isolation, the patient developed urinary retention and his pain level was an eight on the Visual Analogue Scale. A urinary catheter and an epidural catheter were inserted without any difficulty. Abdominal-pelvic MRI revealed a retrovesical mass suspected of liposarcoma with clear borders from surrounding organs. Following two consecutive negative SARS-CoV-2 PCR tests, we proceeded with surgery. Histopathology was dedifferentiated liposarcoma. Postoperatively, the patient suffered reactivation of COVID-19, and he was eventually discharged after two consecutive negative results on the PCR test on Post Operative Day (POD)-10. Retrovesical dedifferentiated liposarcoma is rare and considered as high-grade liposarcoma. Although surgery may exacerbate COVID-19 infection, surgical resection of symptomatic high-grade sarcoma is prioritised and performed as soon as no infection detected. © |
cancer intervention; COVID-19; pathology; radiology; surgery |
docetaxel; gemcitabine; adult; Article; bladder catheterization; case report; clinical article; common cold; comorbidity; coronavirus disease 2019; decreased appetite; differential diagnosis; echography; erythrocyte concentrate; fatigue; fever; follow up; histopathology; home quarantine; hospital discharge; human; human tissue; impaired bladder emptying; liposarcoma; lower urinary tract symptom; male; middle aged; multiple cycle treatment; myalgia; neurilemoma; nuclear magnetic resonance imaging; patient history of surgery; physical examination; polymerase chain reaction; positron emission tomography; recurrent disease; retrovesical liposarcoma; retrovesical liposarcoma; surgical approach; urine retention; virus reactivation; visual analog scale; adjuvant chemoradiotherapy; cancer grading; |
BMJ Publishing Group |
1757790X |
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33653868 |
Article |
Q4 |
231 |
17583 |
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534 |
Lamontagne F., Agoritsas T., Siemieniuk R., Rochwerg B., Bartoszko J., Askie L., MacDonald H., Amin W., Bausch F.J., Burhan E., Cecconi M., Chanda D., Dat V.Q., Du B., Geduld H., Gee P., Nerina H., Hashimi M., Hunt B.J., Kabra S., Kanda S., Kawano-Dourado L., Kim Y.-J., Kissoon N., Kwizera A., Leo Y.-S., Mahaka I., Manai H., Mino G., Nsutebu E., Pshenichnaya N., Qadir N., Ranganathan S.S., Sabzwari S., Sarin R., Sharland M., Shen Y., Souza J.P., Stegemann M., Ugarte S., Venkatapuram S., Vuyiseka D., Preller J., Brignardello-Petersen R., Kum E., Qasim A., Zeraatkar D., Owen A., Guyatt G., Lytvyn L., Diaz J., Vandvik P.O., Jacobs M. |
15829826700;9734624300;23981410900;24345132600;56940778900;6603045596;57223601603;57221910483;57192706123;36058554600;16505953800;26029327700;56046962100;36131305900;36544760800;57204935223;57222260351;57222257762;55246203600;36488033400;57218352115;45561384900;7410198066;57221100878;35208486000;7004240142;56957092900;57211044922;57222258682;6603293930;6504380233;55622346400;6506124670;35240808700;23006204200;57203106412;16744841200;13205307600;23480876400;25654264800;25937500100;57079260800;55318241800;45161122100;57221470276;57206787520;57190033017;7202052634;8841196600;56600867200;13404130400;6602321455;36848322200; |
A living WHO guideline on drugs to prevent covid-19 |
2021 |
The BMJ |
372 |
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n526 |
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29 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102047389&doi=10.1136%2fbmj.n526&partnerID=40&md5=4b6b72a2cd8535abedd1f2abe649c5ac |
Université de Sherbrooke, Centre de Recherche Due Chu de Sherbrooke, Sherbrooke, QC, Canada; Division of General Internal Medicine, Division of Clinical Epidemiology, University Hospitals of Geneva, Geneva, Switzerland; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Magic Evidence Ecosystem Foundation, Oslo, Norway; Department of Medicine, McMaster University, Hamilton, ON, Canada; World Health Organization, Geneva, Switzerland; The Bmj, London, United Kingdom; Ministry of Health and Population, Cairo, Egypt; Geneva University Hospital, Switzerland; Infection Division, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Anesthesia and Intensive Care Medicine, Humanitas Clinical and Research Center-IRCCS, Rozzano, Italy; Adult Infectious Disease Centre, University Teaching Hospital, Lusaka, Zambia; Department of Infectious Diseases, Hanoi Medical University, Hanoi, Viet Nam; Peking Union Medical College Hospital, Beijing, China; Division of Emergency Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; United States; Royal Melbourne Hospital, Melbourne, Australia; Ziauddin University, Karachi, Pakistan; Guy's and St Thomas' Nhs Foundation Trust, London, United Kingdom; All India Institute of Medical Sciences, New Delhi, India; McMaster University (Alumnus), Canada; Pulmonary Division, Heart Institute (InCor)- Hcfmusp, Medical School, University of Sao Paulo, São Paulo, Brazil; Sungkyunkwan University, School of Medicine, Samsung Medical Center, Seoul, South Korea; Department of Paediatrics and Emergency Medicine, University of British Columbia, Vancouver, Canada; Department of Anaesthesia and Critical Care, College of Health Sciences, Makerere University, Kampala, Uganda; National Center for Infectious Diseases, Singapore, Singapore; Pangaea Harare, Zimbabwe; Emergency Medical Services, Faculty of Medicine, Tunis, Tunisia; Alcivar Hospital, Guayaquil, Ecuador; Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates; Central Research Institute of Epidemiology of Rospotrebnadzor, Moscow, Russian Federation; Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States; University of Colombo, Colombo, Sri Lanka; Aga Khan University, Karachi, Pakistan; National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India; St. George's University Hospital, London, United Kingdom; Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; University of Sao Paulo, Sao Paulo, Brazil; Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany; Faculty of Medicine, Andres Bello University, Indisa Clinic, Santiago, Chile; King's College, London, United Kingdom; University of Stellenbosch, South Africa; University of Liverpool, Liverpool, United Kingdom; Department of Health Economics and Health Management, Institute for Health and Society, University of Oslo, Oslo, Norway; Royal Free London Nhs Foundation Trust, London, United Kingdom; Research Institute, Hospital Do Coração (HCor), São Paulo, Brazil |
Lamontagne, F., Université de Sherbrooke, Centre de Recherche Due Chu de Sherbrooke, Sherbrooke, QC, Canada; Agoritsas, T., Division of General Internal Medicine, Division of Clinical Epidemiology, University Hospitals of Geneva, Geneva, Switzerland, Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada, Magic Evidence Ecosystem Foundation, Oslo, Norway; Siemieniuk, R., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada, Department of Medicine, McMaster University, Hamilton, ON, Canada; Rochwerg, B., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada, Department of Medicine, McMaster University, Hamilton, ON, Canada; Bartoszko, J., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Askie, L., World Health Organization, Geneva, Switzerland; MacDonald, H., The Bmj, London, United Kingdom; Amin, W., Ministry of Health and Population, Cairo, Egypt; Bausch, F.J., Geneva University Hospital, Switzerland; Burhan, E., Infection Division, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Cecconi, M., Department of Anesthesia and Intensive Care Medicine, Humanitas Clinical and Research Center-IRCCS, Rozzano, Italy; Chanda, D., Adult Infectious Disease Centre, University Teaching Hospital, Lusaka, Zambia; Dat, V.Q., Department of Infectious Diseases, Hanoi Medical University, Hanoi, Viet Nam; Du, B., Peking Union Medical College Hospital, Beijing, China; Geduld, H., Division of Emergency Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; Gee, P., United States; Nerina, H., Royal Melbourne Hospital, Melbourne, Australia; Hashimi, M., Ziauddin University, Karachi, Pakistan; Hunt, B.J., Guy's and St Thomas' Nhs Foundation Trust, London, United Kingdom; Kabra, S., All India Institute of Medical Sciences, New Delhi, India; Kanda, S., McMaster University (Alumnus), Canada; Kawano-Dourado, L., Pulmonary Division, Heart Institute (InCor)- Hcfmusp, Medical School, University of Sao Paulo, São Paulo, Brazil, Research Institute, Hospital Do Coração (HCor), São Paulo, Brazil; Kim, Y.-J., Sungkyunkwan University, School of Medicine, Samsung Medical Center, Seoul, South Korea; Kissoon, N., Department of Paediatrics and Emergency Medicine, University of British Columbia, Vancouver, Canada; Kwizera, A., Department of Anaesthesia and Critical Care, College of Health Sciences, Makerere University, Kampala, Uganda; Leo, Y.-S., National Center for Infectious Diseases, Singapore, Singapore; Mahaka, I., Pangaea Harare, Zimbabwe; Manai, H., Emergency Medical Services, Faculty of Medicine, Tunis, Tunisia; Mino, G., Alcivar Hospital, Guayaquil, Ecuador; Nsutebu, E., Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates; Pshenichnaya, N., Central Research Institute of Epidemiology of Rospotrebnadzor, Moscow, Russian Federation; Qadir, N., Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States; Ranganathan, S.S., University of Colombo, Colombo, Sri Lanka; Sabzwari, S., Aga Khan University, Karachi, Pakistan; Sarin, R., National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India; Sharland, M., St. George's University Hospital, London, United Kingdom; Shen, Y., Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; Souza, J.P., University of Sao Paulo, Sao Paulo, Brazil; Stegemann, M., Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany; Ugarte, S., Faculty of Medicine, Andres Bello University, Indisa Clinic, Santiago, Chile; Venkatapuram, S., King's College, London, United Kingdom; Vuyiseka, D., University of Stellenbosch, South Africa; Preller, J., World Health Organization, Geneva, Switzerland; Brignardello-Petersen, R., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Kum, E., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Qasim, A., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Zeraatkar, D., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Owen, A., University of Liverpool, Liverpool, United Kingdom; Guyatt, G., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada, Department of Medicine, McMaster University, Hamilton, ON, Canada; Lytvyn, L., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Diaz, J., World Health Organization, Geneva, Switzerland; Vandvik, P.O., Magic Evidence Ecosystem Foundation, Oslo, Norway, Department of Health Economics and Health Management, Institute for Health and Society, University of Oslo, Oslo, Norway; Jacobs, M., Royal Free London Nhs Foundation Trust, London, United Kingdom |
Clinical question What is the role of drugs in preventing covid-19? Why does this matter? There is widespread interest in whether drug interventions can be used for the prevention of covid-19, but there is uncertainty about which drugs, if any, are effective. The first version of this living guideline focuses on the evidence for hydroxychloroquine. Subsequent updates will cover other drugs being investigated for their role in the prevention of covid-19. Recommendation The guideline development panel made a strong recommendation against the use of hydroxychloroquine for individuals who do not have covid-19 (high certainty). How this guideline was created This living guideline is from the World Health Organization (WHO) and provides up to date covid-19 guidance to inform policy and practice worldwide. Magic Evidence Ecosystem Foundation (MAGIC) provided methodological support. A living systematic review with network analysis informed the recommendations. An international guideline development panel of content experts, clinicians, patients, an ethicist and methodologists produced recommendations following standards for trustworthy guideline development using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Understanding the new recommendation The linked systematic review and network meta-analysis (6 trials and 6059 participants) found that hydroxychloroquine had a small or no effect on mortality and admission to hospital (high certainty evidence). There was a small or no effect on laboratory confirmed SARS-CoV-2 infection (moderate certainty evidence) but probably increased adverse events leading to discontinuation (moderate certainty evidence). The panel judged that almost all people would not consider this drug worthwhile. In addition, the panel decided that contextual factors such as resources, feasibility, acceptability, and equity for countries and healthcare systems were unlikely to alter the recommendation. The panel considers that this drug is no longer a research priority and that resources should rather be oriented to evaluate other more promising drugs to prevent covid-19. Updates This is a living guideline. New recommendations will be published in this article and signposted by update notices to this guideline. Readers note This is the first version of the living guideline for drugs to prevent covid-19. It complements the WHO living guideline on drugs to treat covid-19. When citing this article, please consider adding the update number and date of access for clarity. © Published by the BMJ Publishing Group Limited. |
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hydroxychloroquine; hydroxychloroquine; immunologic factor; coronavirus disease 2019; drug use; health care policy; high risk patient; human; immune response; infection prevention; nonhuman; practice guideline; Review; Severe acute respiratory syndrome coronavirus 2; World Health Organization; chemoprophylaxis; clinical decision making; drug effect; epidemiology; practice guideline; prevention and control; procedures; risk assessment; uncertainty; Chemoprevention; Clinical Decision-Making; COVID-19; Humans; Hydroxychloroquine; Immunologic Factors; Risk Assessment; SARS-CoV-2; Uncertainty; World Health Organization |
BMJ Publishing Group |
09598146 |
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33649077 |
Review |
Q1 |
1831 |
1579 |
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601 |
Siswanto J.E., Bos A.F., Dijk P.H., Rohsiswatmo R., Irawan G., Sulistijono E., Sianturi P., Wisnumurti D.A., Wilar R., Sauer P.J.J. |
57205060577;36839156800;6701798049;55533574600;57221815645;57218101844;57192896614;57200574807;57201130415;57221818237; |
Multicentre survey of retinopathy of prematurity in Indonesia |
2021 |
BMJ Paediatrics Open |
5 |
1 |
e000761 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100318807&doi=10.1136%2fbmjpo-2020-000761&partnerID=40&md5=0c40a01ee7a27d4289754e988161b732 |
Neonatology, Universitair Medisch Centrum Groningen, Groningen, Netherlands; Neonatology, Harapan Kita National Centre for Women and Children's Health, Jakarta, Indonesia; Neonatology, University Medical Center Groningen Intensive Care Medicine, Groningen, Netherlands; Pediatric, University of Indonesia Faculty of Medicine, Jakarta, Indonesia; Pediatric, Dr Kariadi General Hospital Medical Center, Semarang, Central Java, Indonesia; Pediatric, Dr Saiful Anwar General Hospital, Malang, Jawa Timur, Indonesia; Pediatric, University of Sumatera Utara Faculty of Medicine, Medan, North Sumatera, Indonesia; Pediatric, University of Riau Faculty of Medicine, Pekanbaru, Riau, Indonesia; Pediatric, Sam Ratulangi University Faculty of Medicine, Manado, North Sulawesi, Indonesia |
Siswanto, J.E., Neonatology, Universitair Medisch Centrum Groningen, Groningen, Netherlands, Neonatology, Harapan Kita National Centre for Women and Children's Health, Jakarta, Indonesia; Bos, A.F., Neonatology, University Medical Center Groningen Intensive Care Medicine, Groningen, Netherlands; Dijk, P.H., Neonatology, Universitair Medisch Centrum Groningen, Groningen, Netherlands; Rohsiswatmo, R., Pediatric, University of Indonesia Faculty of Medicine, Jakarta, Indonesia; Irawan, G., Pediatric, Dr Kariadi General Hospital Medical Center, Semarang, Central Java, Indonesia; Sulistijono, E., Pediatric, Dr Saiful Anwar General Hospital, Malang, Jawa Timur, Indonesia; Sianturi, P., Pediatric, University of Sumatera Utara Faculty of Medicine, Medan, North Sumatera, Indonesia; Wisnumurti, D.A., Pediatric, University of Riau Faculty of Medicine, Pekanbaru, Riau, Indonesia; Wilar, R., Pediatric, Sam Ratulangi University Faculty of Medicine, Manado, North Sulawesi, Indonesia; Sauer, P.J.J., Neonatology, Universitair Medisch Centrum Groningen, Groningen, Netherlands |
Background: The incidence of retinopathy of prematurity (ROP) is higher in Indonesia than in high-income countries. In order to reduce the incidence of the disease, a protocol on preventing, screening and treating ROP was published in Indonesia in 2010. To assist the practical implementation of the protocol, meetings were held in all Indonesia regions, calling attention to the high incidence of ROP and the methods to reduce it. In addition, national health insurance was introduced in 2014, making ROP screening and treatment accessible to more infants. Objective To evaluate whether the introduction of both the guideline drawing attention to the high incidence of ROP and national health insurance may have influenced the incidence of the disease in Indonesia. Setting Data were collected from 34 hospitals with different levels of care: national referral centres, university-based hospitals, and public and private hospitals. Methods: A survey was administered with questions on admission numbers, mortality rates, ROP incidence, and its stages for 2016-2017 in relation to gestational age and birth weight. Results: We identified 12 115 eligible infants with a gestational age of less than 34 weeks. Mortality was 24% and any stage ROP 6.7%. The mortality in infants aged less than 28 weeks was 67%, the incidence of all-stage ROP 18% and severe ROP 4%. In the group aged 28-32 weeks, the mortality was 24%, all-stage ROP 7% and severe ROP 4%-5%. Both mortality and the incidence of ROP were highest in university-based hospitals. Conclusions: In the 2016-2017 period, the infant mortality rate before 32 weeks of age was higher in Indonesia than in high-income countries, but the incidence of ROP was comparable. This incidence is likely an underestimation due to the high mortality rate. The ROP incidence in 2016-2017 is lower than in surveys conducted before 2015. This decline is likely due to a higher practitioner awareness about ROP and national health insurance implementation in Indonesia. © Author(s) (or their employer(s)) 2021. |
epidemiology; health services research; mortality; neonatology; ophthalmology |
birth weight; controlled study; data collection method; disease severity; female; gestational age; health services research; health survey; high income country; human; incidence; Indonesia; infant; infant mortality; major clinical study; male; mortality rate; multicenter study; national health insurance; patient referral; physician; practice guideline; prematurity; priority journal; private hospital; public hospital; retrolental fibroplasia; Review; teaching hospital; university hospital |
BMJ Publishing Group |
23999772 |
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Review |
Q1 |
821 |
5832 |
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No records
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180 |
Marwali E.M., Rayhan M., Roebiono P.S. |
36608535400;57219904946;57192895321; |
Nitroglycerin inhalation for acute treatment of pulmonary arterial hypertension in children with congenital heart disease |
2021 |
Cardiology in the Young |
31 |
9 |
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1381 |
1385 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107847583&doi=10.1017%2fS1047951121002092&partnerID=40&md5=7d11731cfb6493c4e772840e615e164a |
Pediatric Cardiac Intensive Care Division, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia; Division of Pediatric Cardiology and Congenital Heart Disease, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia |
Marwali, E.M., Pediatric Cardiac Intensive Care Division, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia; Rayhan, M., Pediatric Cardiac Intensive Care Division, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia; Roebiono, P.S., Division of Pediatric Cardiology and Congenital Heart Disease, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia |
Abstract Objectives: Acute pulmonary hypertension and pulmonary hypertensive crisis may result in adverse clinical outcomes if unsuccessfully treated. Inhaled nitric oxide has long been considered as the standard pharmacotherapy for acute pulmonary hypertension, but lack of feasibility in some settings and evidences challenging its benefits lead to the use of alternative treatment, amongst which is nitroglycerin inhalation. The purpose of this review article is to discuss available data on the use of nitroglycerin inhalation for acute treatment of pulmonary hypertension in children with CHD and its potential benefit in post-operative setting. Data sources: Literatures included in this review were acquired by searching in PubMed online database. Keywords used were Pulmonary Hypertension, Congenital heart defects, Pediatrics, Inhaled nitroglycerin, and its synonyms. Study selection: Title and abstract were screened to select relevant literatures including the three paediatric clinical trials on nitroglycerin inhalation. Critical appraisal of the clinical trials was then done using the University of Oxford Centre of Evidence-Based Medicine Critical Appraisal Tools. Conclusions: Paediatric studies showed the benefit of nitroglycerin inhalation in uncorrected cases of CHD during catheterisation procedures. Until recently, there have been no studies conducted in paediatric post-operative CHD cases. Further study is required to provide evidence for inhaled nitroglycerin use in this setting including the appropriate dosing and potential side effects with repeated administration, © |
aerosolised nitroglycerin; congenital heart disease; corrective surgery; exogenous nitric oxide; Nitroglycerin inhalation; pulmonary arterial hypertension |
glyceryl trinitrate; nitric oxide; phosphodiesterase V inhibitor; prostacyclin; prostacyclin derivative; prostaglandin E1; glyceryl trinitrate; clinical trial (topic); congenital heart disease; drug safety; emergency care; evidence based practice; heart catheterization; human; postoperative care; publication; pulmonary hypertension; Review; child; complication; congenital heart malformation; inhalational drug administration; pulmonary hypertension; Administration, Inhalation; Child; Heart Defects, Congenital; Humans; Hypertension, Pulmonary; Nitroglycerin; Pulmonary Arterial Hypertension |
Cambridge University Press |
10479511 |
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34082850 |
Review |
Q3 |
386 |
12454 |
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594 |
Marwali E.M., Caesa P., Rayhan M., Roebiono P.S., Fakhri D., Haas N.A., Kajimoto M., Portman M.A. |
36608535400;57204921746;57219904946;57192895321;8599513100;7103216848;56202804200;7004985824; |
The effect of oral triiodothyronine supplementation on lactate and pyruvate after paediatric cardiac surgery |
2021 |
Cardiology in the Young |
31 |
2 |
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205 |
211 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85095997599&doi=10.1017%2fS1047951120003698&partnerID=40&md5=ec7d88033ff87cad7cdbbc609d229529 |
Pediatric Cardiac Intensive Care Division, National Cardiovascular Center Harapan Kita, Jl. Let. Jend. S. Parman Kav. 87, Jakarta, 11420, Indonesia; Department of Cardiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Thoracic Cardiovascular Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pediatric Cardiology and Pediatric Intensive Care, Medical Hospital of the University of Munich, Munich, Germany; Department of Pediatrics, University of Washington School of Medicine and Division of Cardiology, Seattle Children's Hospital, Seattle, WA, United States |
Marwali, E.M., Pediatric Cardiac Intensive Care Division, National Cardiovascular Center Harapan Kita, Jl. Let. Jend. S. Parman Kav. 87, Jakarta, 11420, Indonesia; Caesa, P., Pediatric Cardiac Intensive Care Division, National Cardiovascular Center Harapan Kita, Jl. Let. Jend. S. Parman Kav. 87, Jakarta, 11420, Indonesia; Rayhan, M., Pediatric Cardiac Intensive Care Division, National Cardiovascular Center Harapan Kita, Jl. Let. Jend. S. Parman Kav. 87, Jakarta, 11420, Indonesia; Roebiono, P.S., Pediatric Cardiac Intensive Care Division, National Cardiovascular Center Harapan Kita, Jl. Let. Jend. S. Parman Kav. 87, Jakarta, 11420, Indonesia, Department of Cardiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fakhri, D., Department of Thoracic Cardiovascular Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Haas, N.A., Department of Pediatric Cardiology and Pediatric Intensive Care, Medical Hospital of the University of Munich, Munich, Germany; Kajimoto, M., Department of Pediatrics, University of Washington School of Medicine and Division of Cardiology, Seattle Children's Hospital, Seattle, WA, United States; Portman, M.A., Department of Pediatrics, University of Washington School of Medicine and Division of Cardiology, Seattle Children's Hospital, Seattle, WA, United States |
Abstract Objective: To determine if triiodothyronine alters lactate, glucose, and pyruvate metabolism, and if serum pyruvate concentration could serve as a predictor of low cardiac output syndrome in children after cardiopulmonary bypass procedures. Methods: This study was ancillary to the Oral Triiodothyronine for Infants and Children undergoing Cardiopulmonary bypass (OTICC) trial. Serum pyruvate was measured in the first 48 patients and lactate and glucose were measured in all 208 patients enrolled in the OTICC study on the induction of anaesthesia, 1 and 24 hours post-aortic cross-clamp removal. Patients were also defined as having low cardiac output syndrome according to the OTICC trial protocol. Result: Amongst the designated patient population for pyruvate analysis, 22 received placebo, and 26 received triiodothyronine (T3). Lactate concentrations were nearly 20 times greater than pyruvate. Lactate and pyruvate levels were not significantly different between T3 and placebo group. Glucose levels were significantly higher in the placebo group mainly at 24-hour post-cross-clamp removal. Additionally, lactate and glucose levels peaked at 1-hour post-cross-clamp removal in low cardiac output syndrome and non-low cardiac output syndrome patients, but subsequently decreased at a slower rate in low cardiac output syndrome. Lactate and pyruvate concentrations correlated with glucose only prior to surgery. Conclusion: Thyroid supplementation does not alter systemic lactate/pyruvate metabolism after cardiopulmonary bypass and reperfusion. Pyruvate levels are not useful for predicting low cardiac output syndrome. Increased blood glucose may be regarded as a response to hypermetabolic stress, seen mostly in patients with low cardiac output syndrome. © 2021 Cambridge University Press. All rights reserved. |
cardiopulmonary bypass; congenital heart disease; euthyroid sick syndrome; Keywords: Lactate; low cardiac output syndrome; pyruvate; thyroid hormone replacement |
glucose; lactic acid; liothyronine; placebo; pyruvic acid; aortic clamping; Article; cardiopulmonary bypass; child; childhood; clinical article; female; forward heart failure; glucose blood level; heart muscle reperfusion; heart surgery; human; infant; lactate blood level; male; metabolism |
Cambridge University Press |
10479511 |
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33168128 |
Article |
Q3 |
386 |
12454 |
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697 |
Mulyani E.Y., Hardinsyah, Briawan D., Santoso B.I., Jus'At I. |
57193083043;7409543837;56157628600;56653822500;6506270119; |
Effect of dehydration during pregnancy on birth weight and length in West Jakarta |
2021 |
Journal of Nutritional Science |
10 |
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e70 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116628377&doi=10.1017%2fjns.2021.59&partnerID=40&md5=1de2e2cc37d1b69be0cd84f9859bffa5 |
Department of Nutrition, Faculty of Health Sciences, Esa Unggul University, Jalan Arjuna Utara No.9, West Jakarta, Kebon Jeruk, 11510, Indonesia; Department of Community Nutrition, Faculty of Human Ecology, Bogor Agricultural University, Bogor, Indonesia; Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Depok, Indonesia |
Mulyani, E.Y., Department of Nutrition, Faculty of Health Sciences, Esa Unggul University, Jalan Arjuna Utara No.9, West Jakarta, Kebon Jeruk, 11510, Indonesia; Hardinsyah, Department of Community Nutrition, Faculty of Human Ecology, Bogor Agricultural University, Bogor, Indonesia; Briawan, D., Department of Community Nutrition, Faculty of Human Ecology, Bogor Agricultural University, Bogor, Indonesia; Santoso, B.I., Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Depok, Indonesia; Jus'At, I., Department of Nutrition, Faculty of Health Sciences, Esa Unggul University, Jalan Arjuna Utara No.9, West Jakarta, Kebon Jeruk, 11510, Indonesia |
Nutrition and maternal behavior are critical factors in fetal development. Maternal water intake is necessary to regulate metabolism and may influence fetal growth. This study aims to determine the effect of dehydration during pregnancy on birth weight and length. This cohort-prospective study took place in the area of Kebon Jeruk District Health Centre. A total of 38 subjects of pregnant women in their second trimester were examined. Subject characteristics were collected through direct measurements and interviews. Urine and blood samples were collected at the sixth trimester (32-34 and 35-37 weeks) to determine hydration status. Nutritional status was collected through food recall, while birth weight and length were obtained from the anthropometric measurements 30 min after birth. From a total of 38 subjects, 20 were dehydrated, and 18 were well hydrated. There was a significant relationship between hydration status and water intake, birth weight and length, head circumference, and chest circumference. After being corrected to the level of water intake, the difference in birth weight and length between the two groups were 500.6 g and 0.4 cm, and 0.8 cm and 1.4 cm for the head circumference and chest circumference (P < 0.05). It is recommended for mothers to monitor their weight and ensure fluid intake of 3.0 l per day. Further research requires more subjects to observe the effects of chronic maternal dehydration on pregnancy output and a cohort study that monitors infant development in the first six months of life. © The Author(s), 2021. |
Dehydration; Fetal growth; Maternal nutrition; Pregnancy; Water intake |
biological marker; drinking water; adult; arm circumference; Article; birth length; birth weight; blood sampling; body temperature; calcium intake; caloric intake; carbohydrate intake; chest circumference; child development; clinical article; cohort analysis; controlled study; dehydration; dietary intake; fat intake; female; fluid intake; gestational age; head circumference; hip circumference; human; hydration status; Indonesia; iron intake; maternal nutrition; newborn; nutritional status; placenta weight; plasma osmolality; pregnancy; pregnancy outcome; pregnant woman; prospective study; protein intake; renal system parameters; second trimester pregnancy; serum osmolality; sodium blood level; systolic blood pressure; third trimester pregnancy; urine color; urine osmolality; urine sampling |
Cambridge University Press |
20486790 |
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34527228 |
Article |
Q1 |
749 |
6541 |
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