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No records
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172 |
Mustika S., Pratama M.Z., Lesmana C.R.A. |
37063469000;56993540600;8977683000; |
Diagnostic challenge in a patient presenting with ascites and hypergammaglobulinemia |
2021 |
Case Reports in Gastroenterology |
15 |
3 |
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810 |
818 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116089151&doi=10.1159%2f000518384&partnerID=40&md5=abcdfe47d8eee85899e25c7644e30957 |
Gastroenterohepatology Division, Department of Internal Medicine, Faculty of Medicine Universitas Brawijaya, Saiful Anwar General Hospital, Malang, Indonesia; Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Mustika, S., Gastroenterohepatology Division, Department of Internal Medicine, Faculty of Medicine Universitas Brawijaya, Saiful Anwar General Hospital, Malang, Indonesia; Pratama, M.Z., Gastroenterohepatology Division, Department of Internal Medicine, Faculty of Medicine Universitas Brawijaya, Saiful Anwar General Hospital, Malang, Indonesia; Lesmana, C.R.A., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Ascites is defined as the accumulation of intra-peritoneal fluid that can be caused by several diseases. We described a 47-year-old female presenting with low serum-ascites albumin gradient (SAAG) and a markedly high level of serum globulin. Serum protein electrophoresis revealed an M spike in the gamma region. Other laboratory results showed a marked increase in aspartate aminotransferase and alanine aminotransferase and predominantly conjugated hyperbilirubinemia without a sign of dilatation of bile ducts from abdominal ultrasonography examination. Furthermore, the follow-up showed a positive result for the anti-nuclear antibody test. The patient was assessed with autoimmune hepatitis, and the cause of ascites was suggested from portal hypertension although the level of SAAG was low. The ascites condition got improved after salt restriction, diuretics treatment, and abdominal paracentesis. However, the patient passed away because of the intracranial hemorrhage as a result of prolonged INR and APTT due to liver failure. © 2021 |
Ascites; Autoimmune hepatitis; Hypergammaglobulinemia |
alanine aminotransferase; albumin; alkaline phosphatase; antinuclear antibody; aspartate aminotransferase; bilirubin; creatinine; diuretic agent; furosemide; gamma glutamyltransferase; lactate dehydrogenase; prednisone; serum globulin; spironolactone; triacylglycerol; urobilinogen; ursodeoxycholic acid; abdominal circumference; activated partial thromboplastin time; adult,human; Article; ascites; autoimmune hepatitis; bile duct dilatation; body weight loss; bone marrow biopsy; brain hemorrhage; case report; echography; enzyme linked immunosorbent assay; female; follow up; gastrointestinal hemorrhage; human; human tissue; human,clinical article; hyperbilirubinemia; hypergammaglobulinemia; international normalized ratio; jaundice; leg swelling; leukocytosis; liver failure; liver function tes |
S. Karger AG |
16620631 |
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Article |
Q3 |
247 |
16829 |
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175 |
Tamba R.P., Moenadjat Y. |
47761736600;57190371576; |
Oral Spermine Supplementation in Gestated Rabbit: A Study on Villi Height of Immature Intestines |
2021 |
Frontiers in Surgery |
8 |
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721560 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115713070&doi=10.3389%2ffsurg.2021.721560&partnerID=40&md5=ef2b810fab926ddb3b4313b8d20045f5 |
Faculty of Medicine, Department of Surgery Cipto, Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Tamba, R.P., Faculty of Medicine, Department of Surgery Cipto, Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Moenadjat, Y., Faculty of Medicine, Department of Surgery Cipto, Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Immature intestines are the major problem in prematurity. Postnatal oral spermine has been shown in studies to improve intestinal maturation in rats and piglets. This study aimed to find out the efficacy of spermine in rabbits during gestation. Method: An experimental study was done in an unblinded, randomized manner on those treated with and without spermine administration. A morphological examination of hematoxylin–eosin-stained villi was performed under a light microscope with a focus on villi height. Data were subjected to analysis. Results: The median of the spermine-treated group was found to be higher at 24, 26, and 28 days than the non-spermine group, but was not significantly different. Conclusion: Oral spermine supplementation during gestation might improve intestinal villi height in immature rabbit intestines. © Copyright © 2021 Tamba and Moenadjat. |
gestation; immature intestines; rabbit; spermine; villi height |
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Frontiers Media S.A. |
2296875X |
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Article |
Q2 |
483 |
10376 |
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176 |
Nakhaei P., Margiana R., Bokov D.O., Abdelbasset W.K., Jadidi Kouhbanani M.A., Varma R.S., Marofi F., Jarahian M., Beheshtkhoo N. |
57226413840;56685900600;56845561300;57208873763;57219274421;7201793587;57199650994;16241593900;57201547070; |
Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol |
2021 |
Frontiers in Bioengineering and Biotechnology |
9 |
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705886 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115653337&doi=10.3389%2ffbioe.2021.705886&partnerID=40&md5=0d6cee3ed2be3a97e6c2beb3d6c668b5 |
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia; Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation; Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology, and Food Safety, Moscow, Russian Federation; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Czech Republic; Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacký University in Olomouc, Olomouc, Czech Republic; Department of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany |
Nakhaei, P., School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia, Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia, Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Bokov, D.O., Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation, Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology, and Food Safety, Moscow, Russian Federation; Abdelbasset, W.K., Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia, Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Jadidi Kouhbanani, M.A., Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Czech Republic; Varma, R.S., Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacký University in Olomouc, Olomouc, Czech Republic; Marofi, F., Department of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Jarahian, M., Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany; Beheshtkhoo, N., Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Czech Republic |
Liposomes are essentially a subtype of nanoparticles comprising a hydrophobic tail and a hydrophilic head constituting a phospholipid membrane. The spherical or multilayered spherical structures of liposomes are highly rich in lipid contents with numerous criteria for their classification, including structural features, structural parameters, and size, synthesis methods, preparation, and drug loading. Despite various liposomal applications, such as drug, vaccine/gene delivery, biosensors fabrication, diagnosis, and food products applications, their use encounters many limitations due to physico-chemical instability as their stability is vigorously affected by the constituting ingredients wherein cholesterol performs a vital role in the stability of the liposomal membrane. It has well established that cholesterol exerts its impact by controlling fluidity, permeability, membrane strength, elasticity and stiffness, transition temperature (Tm), drug retention, phospholipid packing, and plasma stability. Although the undetermined optimum amount of cholesterol for preparing a stable and controlled release vehicle has been the downside, but researchers are still focused on cholesterol as a promising material for the stability of liposomes necessitating explanation for the stability promotion of liposomes. Herein, the prior art pertaining to the liposomal appliances, especially for drug delivery in cancer therapy, and their stability emphasizing the roles of cholesterol. © Copyright © 2021 Nakhaei, Margiana, Bokov, Abdelbasset, Jadidi Kouhbanani, Varma, Marofi, Jarahian and Beheshtkhoo. |
cholesterol; compounds; lipids; liposome; stability |
Automobile manufacture; Chemical stability; Controlled drug delivery; Food products; Liposomes; Medical applications; Phospholipids; Plasma stability; Targeted drug delivery; Application parameters; Biomedical applications; Compound; Hydrophilic heads; Hydrophobic tails; Liposome structures; Multi-layered; Phospholipid membrane; Spherical structures; Stability parameters; Cholesterol |
Frontiers Media S.A. |
22964185 |
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Review |
Q1 |
1081 |
3891 |
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177 |
Karina K., Ekaputri K., Albert Biben J., Rosadi I., Rosliana I., Sobariah S., Sulaeha A.D., Andrew H., Afini I., Widyastuti T., Jusryanti J., Prestiani S.I., Donna I.M., Mutiara M.S., Habibi H. |
57212146678;57285088000;57284643500;57204720098;57186671400;57203547382;57226286645;57226282534;57211068324;57211074403;57284643600;57283770100;57284210300;57284210400;57222314524; |
Evaluation of plasma pdgf and vegf levels after systemic administration of activated autologous platelet-rich plasma |
2021 |
Biomedicine (India) |
41 |
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409 |
412 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116318936&doi=10.51248%2f.v41i2.1047&partnerID=40&md5=b63a888f3eb59bb12b87fdd1bfa4f091 |
Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Hayandra Lab, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Pusat Kajian Stem Cell, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Mulawarman University, Samarinda, 752424, Indonesia; Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya no. 6, Jakarta Pusat, 10430, Indonesia |
Karina, K., Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia, Hayandra Lab, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia, Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia, Pusat Kajian Stem Cell, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Ekaputri, K., Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Albert Biben, J., Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Rosadi, I., Hayandra Lab, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia, Department of Biology, Faculty of Mathematics and Natural Sciences, Mulawarman University, Samarinda, 752424, Indonesia; Rosliana, I., Hayandra Lab, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Sobariah, S., Hayandra Lab, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Sulaeha, A.D., Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Andrew, H., Hayandra Lab, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya no. 6, Jakarta Pusat, 10430, Indonesia; Afini, I., Hayandra Lab, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Widyastuti, T., Hayandra Lab, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Jusryanti, J., Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Prestiani, S.I., Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Donna, I.M., Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Mutiara, M.S., Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Habibi, H., Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia |
Introduction and Aim: Activated autologous platelet-rich plasma (aaPRP) is becoming a popular therapy to accelerate healing in the field of plastic surgery. Platelets, which are abundant in aaPRP, can release many growth factors including platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF). This study aims to examine the plasma levels of PDGF and VEGF in healthy subjects after intravenous administration of aaPRP. Materials and Methods: Nine healthy patients with no prior history of metabolic disease were divided into two groups (control and experiment group). The treatment group which consists of six patients received intravenous aaPRP treatment. The preparation of aaPRP starts with the collection of 24 mL of whole blood in sodium citrate tubes followed a two-step centrifugation procedure and subsequent chemical activation. aaPRP was then administered intravenously to patients. Meanwhile, the control group received no intervention. Venous blood samples were taken before and one week after the treatment and the plasma PDGF and VEGF levels were determined by enzyme-linked immunosorbent assay (ELISA). Results: The treatment group showed statistically significant increase in VEGF after 7 days compared to before aaPRP administration. However, the change in PDGF levels of the treatment group was unnotable. Conclusion: The present findings indicate that intravenous administrations of activated aaPRP may increase plasma VEGF level up to 1 week after aaPRP administration. © 2021, Indian Association of Biomedical Scientists. All rights reserved. |
Activated autologous platelet-rich plasma (aaPRP); Platelet derived growth factor (PDGF); Vascular endothelial growth factor (VEGF) |
activated autologous platelet rich plasma; citrate sodium; platelet derived growth factor; thrombocyte concentrate; unclassified drug; vasculotropin; adult; Article; blood autotransfusion; blood chemistry; blood sampling; case control study; centrifugation; cohort analysis; controlled study; enzyme linked immunosorbent assay; female; human; human cell; male; metabolic disorder; middle aged; observational study; prospective study; protein blood level; thrombocyte rich plasma; venous blood |
Indian Association of Biomedical Scientists |
09702067 |
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Article |
Q4 |
106 |
29384 |
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182 |
Wati N.S., Wongsasuluk P., Soewondo P. |
57391635900;55760632100;23475336100; |
A cross-sectional study on the telemedicine usage and glycemic status of diabetic patients during the COVID-19 pandemic |
2021 |
Medical Journal of Indonesia |
30 |
3 |
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215 |
220 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122007380&doi=10.13181%2fmji.oa.215558&partnerID=40&md5=2c18f04217c9ac4e93032fe573c7bff2 |
College of Public Health Sciences, Chulalongkorn University, Bangkok, Thailand; Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Wati, N.S., College of Public Health Sciences, Chulalongkorn University, Bangkok, Thailand; Wongsasuluk, P., College of Public Health Sciences, Chulalongkorn University, Bangkok, Thailand; Soewondo, P., Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND The coronavirus disease 2019 (COVID-19) pandemic disrupts self-management in diabetic patients in Indonesia. This study aimed to determine the telemedicine usage and factors contributing to glycemic control in type 2 diabetes mellitus (T2DM) patients during the pandemic. METHODS A cross-sectional study was conducted in T2DM patients aged 25–54 years. The questionnaire included general characteristics, diabetes conditions, consultation factors, and self-care management. Glycemic status was evaluated using glycated hemoglobin (HbA1c) levels, which was categorized into poor (HbA1c≥7%) and good glycemic control (HbA1c<7%). Data were analyzed using chi-square and binary logistic regression. RESULTS Of 264 patients, only 19.2% used telemedicine and 60.2% had poor glycemic control during the pandemic. Overweight or obesity (odds ratio [OR] = 5.740 [95% confidence interval [CI] = 2.554–12.899]; p<0.001), insulin injection (OR = 3.083 [95% CI = 1.238–7.677]; p = 0.016), and frequent fried food consumption (OR = 5.204 [95% CI = 1.631–16.606]; p = 0.005) were the factors contributing to poor glycemic control. The risk is lower if exercised regularly (OR = 0.036 [95% CI = 0.007–0.195]; p<0.001) and consulted with a doctor using telemedicine (OR = 0.193 [95% CI = 0.044–0.846]; p = 0.029) or in-person visits (OR = 0.065 [95% CI = 0.016–0.260]; p<0.001). CONCLUSIONS Glycemic control was not optimal during the COVID-19 pandemic. Therefore, keeping a healthy lifestyle and staying connected with a doctor are important to ensure optimal blood glucose control and reduce the risk of diabetes-related complications. © 2021 Authors. |
COVID-19; Diabetes mellitus; Glycemic control; Indonesia; Telemedicine |
hemoglobin A1c; insulin; adult; Article; blood glucose monitoring; body mass; consultation; coronavirus disease 2019; cross-sectional study; diabetes mellitus; diabetic patient; disease duration; education; employment status; exercise; female; food intake; glycemic control; human; income; Indonesia; major clinical study; marriage; mass communication; meal; medication compliance; non insulin dependent diabetes mellitus; obesity; pandemic; questionnaire; self care; smoking; telemedicine |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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183 |
Raharjanti N.W., Purwadianto A., Soemantri D., Bardosono S., Mahajudin M.S., Poerwandari E.K., Levania M.K., Silalahi H.M.T.S., Rumthi P.T.S., Manulang T.K.P., Ramadianto A.S., Wiguna T. |
57226872499;18635479200;36640659100;21933841000;57218600581;25628305200;57226868672;57368578800;57368162800;57367333500;57226862690;24367785700; |
Self-confidence in conducting forensic psychiatric evaluations among general psychiatrists in Indonesia |
2021 |
Heliyon |
7 |
9 |
e08045 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120891523&doi=10.1016%2fj.heliyon.2021.e08045&partnerID=40&md5=2915417d45113bc152dbacad697562ef |
Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Forensic Department, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Nutrition Department, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Psychiatry, Airlangga University, Surabaya, East Java, Indonesia; Faculty of Psychology, Universitas Indonesia, Jakarta, Indonesia |
Raharjanti, N.W., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Purwadianto, A., Forensic Department, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soemantri, D., Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Bardosono, S., Nutrition Department, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Mahajudin, M.S., Department of Psychiatry, Airlangga University, Surabaya, East Java, Indonesia; Poerwandari, E.K., Faculty of Psychology, Universitas Indonesia, Jakarta, Indonesia; Levania, M.K., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Silalahi, H.M.T.S., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rumthi, P.T.S., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Manulang, T.K.P., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Ramadianto, A.S., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wiguna, T., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Objective: Several general psychiatrists experience lack of confidence when they perform forensic psychiatric evaluations that may be due to limited or insufficient training. This study aimed to determine whether structured forensic psychiatry educational modules are associated with general psychiatrists’ self-confidence in conducting forensic psychiatric evaluations in Indonesia. Method: A cross-sectional study was conducted with 246 general psychiatrists. A questionnaire was developed exclusively for this study by a group of experts based on relevant references and it was distributed online. Sample questions included: “How often do you perform forensic psychiatric evaluations?”, “As a general psychiatrist, are you confident in conducting forensic psychiatric evaluations?”, and “Do you experience any difficulties when conducting forensic psychiatric evaluations?” Data were analyzed through SPSS 20 for Windows; a p-value <0.05 indicated statistical significance. Results: Compared to general psychiatrists who did not study structured forensic psychiatry educational modules during their residency training, those exposed to such modules reported confidence in conducting forensic psychiatric evaluations in the following cases: insanity defense in cases of violence, insanity defense, fitness to stand trial, malingering, capacity to consent to treatment, risk of recidivism, guardianship, and parenting capacity. Furthermore, those with higher self-confidence were less likely to experience difficulties in conducting forensic psychiatric evaluations. Conclusion: Structured forensic psychiatry educational modules during general psychiatry residency training played an important role in the development of psychiatrists’ self-confidence. © 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license |
Forensic psychiatry module; Indonesia; Psychiatric evaluation; Self-confidence |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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184 |
Octaviana F., Harisman J., Wiratman W., Budikayanti A. |
26029958700;57368215900;57191920526;57194713932; |
Altered mental status in moderate-severe traumatic brain injury in Indonesia: the clinical manifestation and EEG features of non-convulsive status epilepticus |
2021 |
Heliyon |
7 |
9 |
e08067 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120866388&doi=10.1016%2fj.heliyon.2021.e08067&partnerID=40&md5=87d284823bcddaa9acf0b35b27598f23 |
Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia; Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Octaviana, F., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Harisman, J., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia; Wiratman, W., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Budikayanti, A., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Introduction: Moderate-to-severe traumatic brain injury (msTBI) can cause non-convulsive status epilepticus (NCSE). Electroencephalography (EEG) is employed as a diagnostic tool due to the non-specificity of clinical symptoms. This study aimed to identify clinical and EEG features related to NCSE in patients with msTBI. Methods: This was a cross-sectional study. Suspected NCSE in msTBI was examined using EEG data collected in consecutive patients from January 2017 to December 2019 at Dr. Cipto Mangunkusumo Hospital, Jakarta. Diagnoses of NCSE were made based on clinical manifestations and EEG features using the modified Salzburg Consensus Criteria for NCSE (mSCNC). Results: Of the 39 msTBI patients, 19 were diagnosed with NCSE; only two fulfilled the definitive criteria, and the remaining were possible NCSE. Delirium and perceptual impairment were only found in NCSE, while psychomotor agitation was higher (12.8% vs. 5.1% in NCSE vs. non-NCSE). The most common EEG feature was rhythmic activity (>0.5 Hz) without fluctuation, which improved with anti-epileptic drug administration. The Glasgow Coma Scale (GCS) score at onset and at hospitalisation discharge was significantly lower in patients with NCSE. The lesions in NCSE mostly originated from the temporal lobe. Injury to the temporal lobe had a significant relationship with NCSE occurrence (p ¼ 0.036, odds ratio 11.45 [95% confidence interval 1.17–111.6]). In this study, delirium, perceptual impairment, and psychomotor agitation were confirmed as NCSE using The most common discharge originated from the injured temporal lobe, and this site was a significant factor NCSE in patients with msTBI. in msTBI cases with clinical manifestations of altered mental status, psychomotor An injured temporal lobe was a susceptible site for the development of NCSE © 2021,Heliyon.All Rights Reserved. |
Altered mental status; Moderate-severe TBI; mSCNC; Non-convulsive status epilepticus |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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185 |
Kartika R.W., Alwi I., Suyatna F.D., Yunir E., Waspadji S., Immanuel S., Silalahi T., Sungkar S., Rachmat J., Reksodiputro M.H., Bardosono S. |
57223447932;15055173800;56039633100;36520254800;8678136400;57272979000;56275255400;57016857300;6507225348;35090488800;21933841000; |
The Role Of Vegf, Pdgf And Il-6 On Diabetic Foot Ulcer After Platelet Rich Fibrin Þ Hyaluronic Therapy |
2021 |
Heliyon |
7 |
9 |
e07934 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120851420&doi=10.1016%2fj.heliyon.2021.e07934&partnerID=40&md5=0080e19d2c656e3452c7827d2fab24ba |
Doctoral Program in Medical Science, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Department of Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Thorcic Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kartika, R.W., Doctoral Program in Medical Science, Faculty of Medicine, Universitas Indonesia, Indonesia; Alwi, I., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suyatna, F.D., Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Waspadji, S., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Silalahi, T., Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Sungkar, S., Department of Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rachmat, J., Department of Thorcic Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Reksodiputro, M.H., Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Current standard management of diabetic foot ulcers (DFUs) consists of surgical debridement followed by soak NaCl 0.9% gauzes tight infection and glycaemic control. Nowadays the use of advanced plateletrich fibrin (A-PRF) has emerged as an adjunctive method for treating DFUs. This study was conducted to demonstrate the ability of combine A-PRF þ HA as a complementary therapy in DFUs healing related with angiogenesis,inflammation and granulation index process. Methods: This open label randomized controlled trial was conducted in Koja District Hospital and Gatot Soebroto Hospital Jakarta, Indonesia on July 2019–April 2020. DFUs patients with wound duration of three months, Wagner-2, with size of ulcer less than 40 cm2 were included in the study. The number of subjects was calculated based on the rule of thumb and allocated randomly into three groups, namely topical A-PRF þ HA, A-PRF an Sodium Chloride 0.9% as a control, for each of 10 subjects. A-PRF made by 10 mL venous blood, centrifuge 200 G in 10 min, meanwhile A-PRF þ HA though mix both them with vertex machine around 5 min. Biomarker such as VEGF, PDGF and IL-6 examined from DFU taken by cotton swab and analysis using ELISA. Granulation Index was measured using ImageJ. Biomarkers and granulation index were evaluated on day 0, 3, 7 and 14. Data were analysed using SPSS version 20 with Anova and Kruskal Wallis test to compare the angiogenesis and inflammation effect between the three groups. Result: In topical dressing A-PRF þ HA, there is an increase in delta VEGF on day-3 (43.1 pg/mg protein) and day-7 (275,8 pg/mg protein) compared to A-PRF on day-3 (1.8 pg/mg protein) and day-7 (104.7 pg/mg protein), also NaCl (control) on day-3 (-4.9 pg/mg protein) and day-7 (28.3 pg/mg protein). So that the delta VEGF of A-PRF þ HA group increase significantly compared with others on day-3 (p ¼ 0.003) and day-7 (p < 0.001). Meanwhile APRF þ AH group, there is also a decrease in delta IL-6 after therapy on day-3 (-10.9 pg/mg protein) and day-7 (-18.3 pg/mg protein) compared to A-PRF in delta IL-6 on day-3 (-3.7 pg/mg protein) and on day-7 (-7.8 pg/ mg protein). In NaCl (control) group there is a increase delta IL-6 on day-3 (4.3 pg/mg protein) and on day-7 (35.5 pg/mg protein). So that the delta IL-6 of A-PRF þ HA group decrease significantly compared with others only on day-7 (p ¼ 0.015). In PDGF le level analysis, A-PRF þ HA group increase significantly (p ¼ 0.012) only in day -7 compare with other group (5.5 pg/mg protein). Conclusion: The study shows the superior role of combined A-PRF þ HA in the treatment DFU though increase angiogenesis and decrease inflammation pathway. The advantage of using A-PRF þ HA is that it accelerates wound healing by increasing granulation tissue compared to A-PRF alone © 2021 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
Diabetic foot ulcer; Hyaluronic acid; Platelet-rich fibrin |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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186 |
Sauriasari R., Madani R.A., Rozaliyani A., Sudiana D. |
16246507200;57367966600;57203065912;21934788800; |
The effect of repeated education using live demonstrations and videos of how to use inhalation drugs on quality of life for COPD patients |
2021 |
Heliyon |
7 |
9 |
e07870 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120850425&doi=10.1016%2fj.heliyon.2021.e07870&partnerID=40&md5=9a57b37dd2d801600bfd6633e55ec700 |
Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia |
Sauriasari, R., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia; Madani, R.A., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia; Rozaliyani, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sudiana, D., Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia |
Repeated education regarding the proper use of inhalers can reduce the error rate in inhaler-using patients and improve COPD patients’ quality of life. This study investigates the effect of repeated education on the quality of life of COPD patients during the pandemic of COVID-19 from February to June 2020. Repeated education is provided using direct demonstrations to patients through educational media in the form of short videos made by the researchers for each inhaler type. This is a pre-experimental study design which was carried out prospectively at Grha Permata Ibu Hospital, Depok. The quality of life of 22 subjects was examined using the COPD assessmenttest (CAT) questionnaire. Each patient was given a direct verbal demonstration of the appropriate use of the inhaler. One month later, each patient was provided further education using less than 2 min of video sent to them online via the WhatsApp application. Final quality-of-life examination and assessment of inhaler technique were carried out three months after the initial examination. Assessment of proper inhaler technique was carried out using a specific checklist regarding the use of inhaler translated by the researcher. Before and after delivery of repeated education, the mean CAT score showed a decrease of two points, i.e., 12.8 ± 1.3 and 10.8 ± 2.0, respectively. This indicated that quality of life of the patients had significant improvement. However, as many as 63.6% of patients still made mistakes in using inhaler even though they had been educated. For DPI-type inhalers, mistake mostly happened at step “breath out gently, away from inhaler”. For pMDI-type inhalers, mistake mostly happened at step “while holding breath, remove inhaler from mouth”. It can be concluded that repeated education regarding proper inhaler technique with direct demonstrations and further maintained by videos can improve the quality of life in COPD patients. © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/). |
CAT (COPD Assessment test); Demonstration video; Inhaler; Repeated education |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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187 |
Utami T.W., Suwartono H., Umami E.A., Mahardika A., Surya R., Nurana L. |
57195720528;57218391609;57353182200;57352623800;56986345100;57352963000; |
Management of ovarian yolk sac tumor in pregnancy in a limited resource setting: Case report |
2021 |
Middle East Journal of Cancer |
12 |
4 |
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597 |
601 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119909750&doi=10.30476%2fmejc.2021.84039.1195&partnerID=40&md5=272b65775967af66a20f779444cac466 |
Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Utami, T.W., Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suwartono, H., Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Umami, E.A., Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Mahardika, A., Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Surya, R., Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nurana, L., Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Ovarian yolk sac tumor in pregnancy is a very rare case (<5%). The management could be very challenging since studies regarding the disease are very limited. This case report is written in order to report a rare case of yolk sac tumor in pregnancy and its management. A 29-year-old woman with a 16 weeks gestational age (WGA) in her first pregnancy presented in the emergency room with severe lower abdominal pain. Next, she underwent exploratory laparotomy, and a biopsy was performed, which indicated an ovarian yolk sac tumor. The patient was then given neoadjuvant chemotherapy with carboplatin and paclitaxel. The pregnancy resulted in an intrauterine growth restriction (IUGR) baby, delivered on 33 WGA. The baby was delivered through C-section and the mother continued to undergo optimally debulked laparotomy, total hysterectomy, bilateral salphingo-oophorectomy, omentectomy, and rectosigmoid tumor resection. In dealing with a rare case with limited resources, tailor-made management is required. The most ideal treatment may not be performed, but the clinician should be more adaptive for the patient to have a better outcome. © 2021. |
Intrauterine growth restriction; Neoadjuvant chemotherapy; Ovarian yolk sac tumor |
bleomycin; carboplatin; cisplatin; etoposide; Ki 67 antigen; paclitaxel; abdominal pain; abdominal tenderness; adjuvant therapy; adult; Apgar score; Article; bilateral salpingo-oophorectomy; biometry; biopsy; bleeding; body mass; cancer surgery; case report; cesarean section; clinical article; echography; ectopic pregnancy; emergency ward; endometriosis; female; fetus weight; gestational age; human; human experiment; human tissue; hysterectomy; intrauterine growth retardation; laparotomy; liver metastasis; lower abdominal pain; multiple cycle treatment; neoadjuvant chemotherapy; omentectomy; physical examination; pregnancy; pregnant woman; prenatal care; salpingooophorectomy; scoring system; yolk sac tumor |
Shriaz University of Medical Sciences |
20086709 |
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Article |
Q4 |
227 |
17796 |
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