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Miftahussurur M., Windia A., Syam A.F., Nusi I.A., Alfaray R.I., Fauzia K.A., Kahar H., Purbayu H., Sugihartono T., Setiawan P.B., Maimunah U., Kholili U., Thamrin H., Vidyani A., Doohan D., Waskito L.A., Rezkitha Y.A.A., Siregar G.A., Yamaoka Y. |
56323903000;57224923195;8443384400;56543515200;57215962996;57204649404;57218903823;57194162048;57194156387;6507682592;56543645400;57209663659;57204648560;57211316314;57204644036;57192177367;56543533600;56483277100;55183784100; |
Diagnostic value of 14C urea breath test for Helicobacter pylori detection compared by histopathology in indonesian dyspeptic patients |
2021 |
Clinical and Experimental Gastroenterology |
14 |
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291 |
296 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108652378&doi=10.2147%2fCEG.S306626&partnerID=40&md5=ed8411e8e8e3e089aef5e0d750c1da27 |
Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Faculty of Medicine, University of Muhammadiyah Surabaya, East Java, Surabaya, 60113, Indonesia; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatra Utara, Medan, 20155, Indonesia |
Miftahussurur, M., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia, Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Windia, A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Syam, A.F., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Nusi, I.A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Alfaray, R.I., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Fauzia, K.A., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Kahar, H., Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Purbayu, H., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Sugihartono, T., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Setiawan, P.B., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Maimunah, U., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Kholili, U., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Thamrin, H., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Vidyani, A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Doohan, D., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Waskito, L.A., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Rezkitha, Y.A.A., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia, Faculty of Medicine, University of Muhammadiyah Surabaya, East Java, Surabaya, 60113, Indonesia; Siregar, G.A., Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatra Utara, Medan, 20155, Indonesia; Yamaoka, Y., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan |
Purpose: Histopathology method is often used as a gold standard diagnostic for Helicobacter pylori infection in Indonesia. However, it requires an endoscopic procedure which is limited in Indonesia. A non-invasive method, such as14C Urea Breath Test (UBT), is more favorable; however, this particular method has not been validated yet. Patients and Methods: A total of 55 dyspeptic patients underwent gastroscopy and14C-UBT test. We used Heliprobe® UBT for UBT test. As for the histology, May-Giemsa staining of two gastric biopsies (from the antrum and corpus) were evaluated following the Updated Sydney System. Results: The Receiver Operating Characteristics analysis showed that the optimum cut-off value was 57 with excellence Area under Curve = 0.955 (95% CI = 0.861–1.000). By applying the optimum cut-off value, Heliprobe® UBT showed 92.31% for sensitivity, 97.62% for specificity, 92.31% for positive predictive value, 97.62% for negative predictive value, 38.77 for positive likelihood ratio, 0.0788 for negative likelihood ratio, and 96.36% for the accuracy. Conclusion: The14C-UBT is an accurate test for H. pylori diagnosis with excellent sensitivity, specificity, and accuracy. The different optimum cut-off points suggested that a validation is absolutely necessary for new test prior application to the new population. © 2021 Miftahussurur et al. |
Diagnostic; Helicobacter pylori; Infectious disease; UBT |
urea c 14; adult; Article; bacterium identification; controlled study; cross-sectional study; diagnostic accuracy; diagnostic value; dyspepsia; female; gastroscopy; Helicobacter infection; Helicobacter pylori; histopathology; human; human tissue; Indonesian; intermethod comparison; major clinical study; male; May Giemsa staining; middle aged; negative likelihood ratio; nonhuman; positive likelihood ratio; predictive value; receiver operating characteristic; sensitivity and specificity; statistical analysis; stomach antrum; stomach biopsy; stomach corpus; urea breath test; validation study |
Dove Medical Press Ltd |
11787023 |
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