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48 |
Wijaya I.P., Karim B., Azizi M.S., Ariyanto I., Mansjoer A., Yunihastuti E., Harimurti K., Alwi I., Lee S., Price P. |
57193731572;57192910797;57209578916;57193538110;24335647800;57221273925;23473513200;15055173800;56272877300;57201814264; |
Cytomegalovirus may influence vascular endothelial health in Indonesian HIV-infected patients after 5 years on ART |
2021 |
AIDS Research and Therapy |
18 |
1 |
83 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119002384&doi=10.1186%2fs12981-021-00410-7&partnerID=40&md5=9b7b4701ffbdd4086f464a8411ac8de3 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Virology and Cancer Pathobiology Research Centre, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; School of Medicine, Curtin University, Bentley, 6102, Australia |
Wijaya, I.P., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Karim, B., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Azizi, M.S., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ariyanto, I., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Virology and Cancer Pathobiology Research Centre, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mansjoer, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yunihastuti, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harimurti, K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Alwi, I., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Lee, S., School of Medicine, Curtin University, Bentley, 6102, Australia; Price, P., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, School of Medicine, Curtin University, Bentley, 6102, Australia |
Objectives: Accelerated atherosclerosis in older HIV-infected patients has been attributed to persistent immune activation and high burden cytomegalovirus (CMV), as demonstrated in transplant recipients and the general population. Here we assess CMV and inflammatory markers linked with vascular health in young adult patients treated in Indonesia. Study design: HIV-infected adults (n = 32) were examined when they began antiretroviral therapy (ART) with < 200 CD4 T-cells/µl (V0) and after 60 months (V60). Age-matched healthy controls (HC, n = 32) were assessed once. Methods: Flow Mediated Dilatation (FMD) was assessed by ultrasound on brachial arteries at V60 and in HC. Plasma markers of immune activation and endothelial activation, and CMV antibodies (lysate, gB, IE-1) were assessed in all samples. Results were assessed using bivariate (non-parametric) and multivariable analyses. Results: Levels of inflammatory biomarkers and CMV antibodies declined on ART, but the antibodies remained higher than in HC. FMD values were similar in patients and HC at V60. In HIV patients, levels of CMV lysate antibody correlated inversely (r = − 0.37) with FMD. The optimal model predicting lower FMD values (adjusted R2 = 0.214, p = 0.012) included CMV lysate antibodies and chondroitin sulphate. In HC, levels of sTNFR correlated inversely with FMD (r = − 0.41) and remained as a risk factor in the optimal multivariable model, with CMV glycoprotein-B (gB) antibody predicting a healthier FMD (adjusted R2 = 0.248, p = 0.013). Conclusions: Higher levels CMV antibodies optimally predict vascular health measured by FMD in HIV patients. However in healthy controls, sTNFR marks risk and CMV gB antibody may be protective. © 2021, The Author(s). |
CMV; Endothelial function; HIV; Inflammatory biomarkers |
virus antibody; aged; Cytomegalovirus; cytomegalovirus infection; human; Human immunodeficiency virus infection; Indonesia; Aged; Antibodies, Viral; Cytomegalovirus; Cytomegalovirus Infections; HIV Infections; Humans; Indonesia |
BioMed Central Ltd |
17426405 |
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34763708 |
Article |
Q1 |
1102 |
3778 |
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50 |
Sitorus R.S., Pambudy I.M., Rohsiswatmo R., Barliana J.D., Yulia D.E., Widyahening I.S. |
57221587271;57327482000;55533574600;57200964187;57225947931;54893154400; |
Retinal abnormalities in universal eye screening of healthy, full-term newborn infants in Jakarta. The incidence and its risk factors: a pilot study |
2021 |
International Journal of Retina and Vitreous |
7 |
1 |
67 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118713835&doi=10.1186%2fs40942-021-00337-1&partnerID=40&md5=e2db9f11d6ce04fd383ce64dbf98b9fa |
Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia; Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Sitorus, R.S., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia; Pambudy, I.M., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia; Rohsiswatmo, R., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Barliana, J.D., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia; Yulia, D.E., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia; Widyahening, I.S., Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Aim: To screen for ocular abnormalities in healthy full-term newborn infants using wide-field digital imaging and to analyze factors associated with the findings. Methods: A total of 1208 full-term newborn infants at a tertiary eye hospital (Cipto Mangunkusumo National Referral Hospital) and a district hospital in Jakarta (Koja Hospital) were enrolled to the study. All eligible newborns underwent fundus examination within 48 h after birth using the RetCam shuttle (Natus Medical Incorporated, USA). Retinal findings were documented and analyzed according to obstetric and neonatal risk factors. Results: Of the 1208 newborn infants enrolled, ocular abnormalities were found in 150 infants (12.4%). Retinal hemorrhage (RH) was the most common finding (88%) in which 2.67% involved the macula, followed by chorioretinitis (4.67%). Univariate analysis showed caesarean section (C-section) (OR 0.27, 95% CI 0.18–0.41, p < 0.001) was a protective factor against RH, while prolonged labor increased the risk of developing RH (OR 1.84, 95% CI 1.24–2.72, p = 0.002). Further multivariate analysis showed similar protective association between C-section and risk of RH (OR 0.29, 95% CI 0.19–0.44, p < 0.001), while other risk factors were not. Conclusions: Our study showed that universal eye screening in healthy neonates is beneficial in the early diagnosis, monitoring and treatment of ocular abnormalities such as retinal hemorrhage, chorioretinitis and retinoblastoma. Retinal hemorrhage is the most common ocular abnormality and is associated with the delivery method and the duration of labor. Universal eye screening is visual-saving and life-saving for neonates with chorioretinitis, retinoblastoma as well as other abnormalities and should be mandatory in newborn screening. © 2021, The Author(s). |
Delivery; Healthy newborn; Hemorrhage; Universal eye screening |
antibiotic agent; local anesthetic agent; phenylephrine; tropicamide; Article; cesarean section; chorioretinitis; coloboma; controlled study; cross-sectional study; digital imaging; early diagnosis; eye examination; female; human; incidence; intraocular tumor; macular degeneration; major clinical study; male; newborn; newborn screening; optic nerve disease; patient referral; pediatric patient; pilot study; retina disease; retina hemorrhage; retina macula hemorrhage; retina macula lutea; retina maculopathy; retinoblastoma; risk factor; vitreous hemorrhage |
BioMed Central Ltd |
20569920 |
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Article |
Q1 |
1617 |
1984 |
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53 |
Goenarjo R., Dupuy O., Fraser S., Berryman N., Perrochon A., Bosquet L. |
57192916469;55250097700;56214500000;35602918000;55628941600;6602849323; |
Cardiorespiratory fitness and prefrontal cortex oxygenation during Stroop task in older males |
2021 |
Physiology and Behavior |
242 |
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113621 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117564635&doi=10.1016%2fj.physbeh.2021.113621&partnerID=40&md5=ac7c0401817c51ece69279b94bfe1755 |
Laboratoire MOVE (EA 6314), Faculté des Sciences du Sport, Université de Poitiers, Poitiers, France; Department of Medical Physiology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa (Ontario), Canada; Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Canada; Laboratoire HAVAE (EA 6310), Université de Limoges, Limoges, France; Ecole de Kinésiologie et des Sciences de l'Activité Physique (EKSAP), Faculté de Médecine, Université de Montreal, Montreal, Canada; Département des Sciences de l'activité physique, Université du Québec à Montréal (UQAM), Montréal, Canada |
Goenarjo, R., Laboratoire MOVE (EA 6314), Faculté des Sciences du Sport, Université de Poitiers, Poitiers, France, Department of Medical Physiology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Dupuy, O., Laboratoire MOVE (EA 6314), Faculté des Sciences du Sport, Université de Poitiers, Poitiers, France, Ecole de Kinésiologie et des Sciences de l'Activité Physique (EKSAP), Faculté de Médecine, Université de Montreal, Montreal, Canada; Fraser, S., Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa (Ontario), Canada; Berryman, N., Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Canada, Département des Sciences de l'activité physique, Université du Québec à Montréal (UQAM), Montréal, Canada; Perrochon, A., Laboratoire HAVAE (EA 6310), Université de Limoges, Limoges, France; Bosquet, L., Laboratoire MOVE (EA 6314), Faculté des Sciences du Sport, Université de Poitiers, Poitiers, France, Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Canada, Ecole de Kinésiologie et des Sciences de l'Activité Physique (EKSAP), Faculté de Médecine, Université de Montreal, Montreal, Canada |
Aim: The aim of the current study was to assess whether executive function and prefrontal oxygenation are dependent on fitness level and age in older adults. Methods: Twenty-four healthy males aged between 55 and 69 years old were recruited for this study. They were stratified by age, leading to the creation of two groups: 55–60 years old and 61–69 years old. A median split based on CRF created higher- and lower-fit categories of participants. Cerebral oxygenation was assessed using functional near-infrared spectroscopy (fNIRS) during a computerized Stroop task. Accuracy (% of correct responses) and reaction times (ms) were used as behavioural indicators of cognitive performances. Changes in oxygenated (∆[HbO2]) and deoxygenated (∆[HHb]) hemoglobin were measured to capture neural changes. Repeated measures ANOVAs (CRF × Age × Stroop conditions) were performed to test the null hypothesis of an absence of interaction between CRF, Age and executive performance. Results: We also found an interaction between CRF and age on reaction times (p = .001), in which higher fitness levels were related to faster reaction times in the 61–69 year olds but not in the 55–60 year olds. Regarding ΔHHb, the ANOVA revealed a main effect of CRF in the right PFC (p = .04), in which higher-fit participants had a greater Δ[HHb] than the lower-fit (d = 1.5). We also found fitness by age interaction for Δ[HHb] in the right PFC (p = .04). Conclusion: Our results support the positive association of CRF on cerebral oxygenation and Stroop performance in healthy older males. They indicated that high-fit individuals performed better in the 61–69 year olds group, but not in the 55–60 years old group. We also observed a greater PFC oxygenation change (as measured by Δ[HHb]) in the high-fit individuals. © 2021 |
Cardiorespiratory fitness; Cerebral oxygenation; Older adults; Prefrontal cortex; Stroop |
hemoglobin; oxyhemoglobin; adult; age; aged; Article; blood oxygenation; brain oxygen consumption; brain radiography; cardiorespiratory fitness; controlled study; deoxygenation; executive function; functional near-infrared spectroscopy; hemoglobin blood level; human; human experiment; male; measurement accuracy; normal human; peak oxygen uptake; prefrontal cortex; reaction time; Stroop test; executive function; metabolism; middle aged; prefrontal cortex; Stroop test; Aged; Cardiorespiratory Fitness; Executive Function; Humans; Male; Middle Aged; Oxyhemoglobins; Prefrontal Cortex; Stroop Test |
Elsevier Inc. |
00319384 |
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34648819 |
Article |
Q1 |
960 |
4644 |
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55 |
Mansyur M., Sagitasari R., Wangge G., Sulistomo A.B., Kekalih A. |
37085506800;57290722900;36497482500;57024018500;55633562200; |
Long working hours, poor sleep quality, and work-family conflict: determinant factors of fatigue among Indonesian tugboat crewmembers |
2021 |
BMC Public Health |
21 |
1 |
1832 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116761265&doi=10.1186%2fs12889-021-11883-6&partnerID=40&md5=4563534bbfe5b850aae54955a11550c5 |
Occupational Medicine Division, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; South East Asian Ministers Education Organization, Regional Center for Food and Nutrition/SEAMEO-RECFON, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Occupational Medicine Post Graduate Study Program, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Mansyur, M., Occupational Medicine Division, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, South East Asian Ministers Education Organization, Regional Center for Food and Nutrition/SEAMEO-RECFON, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Sagitasari, R., Occupational Medicine Post Graduate Study Program, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wangge, G., South East Asian Ministers Education Organization, Regional Center for Food and Nutrition/SEAMEO-RECFON, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Sulistomo, A.B., Occupational Medicine Division, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kekalih, A., Occupational Medicine Division, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Tugboat crewmembers are susceptible to fatigue during their 24-h work shifts, despite the availability of rest time. The fatigue experienced by seafarers contributes to marine accidents and metabolic and cardiovascular diseases, which have long-term effects. This study aimed to analyse the association between working hours and fatigue and other possibly related factors in tugboat crewmembers. Method: This comparative cross-sectional study included 127 tugboat crew members from 15 randomly chosen tugboats in Samarinda Harbor, Indonesia. Their fatigue levels while at work were measured using a reaction timer and standardised questionnaire. Personal and occupational data of crewmembers, including age, marital status, rating (job ranking), duration on board, length of seafaring experience, watch system, smoking status, coffee and alcohol consumption, and working hours, were collected. Moreover, sleep quality and stress levels related to work-family conflict were measured and analysed using the Pittsburgh Sleep Quality Index (PSQI) and Work-Family Conflict Scale (WCFS), respectively. Results: The study found that 40.2% of the subjects were classified as having fatigue. The determinant factors were long working hours (> 72 h/week), poor sleep quality, and work-family conflict [adj. OR = 13.32; 95%-CI (4.78–31.23)] and p < 0.001, [adj. OR = 4.49 (1.39–14.52)] and p = 0.012, [adj. OR = 2.87 (1.12–7.33)] and p = 0.028, respectively. However, personal and occupational factors, including age, marital status, duration on board, length of seafaring experience, smoking status, and coffee and alcohol consumption, were not significantly associated with crewmember fatigue. Conclusion: The incidence of fatigue among Indonesian tugboat crewmembers operating on the Mahakam River was considerably high. Working hours, sleep quality, and work-family conflict were strongly associated with fatigue in tugboat crewmembers; therefore, the working hours of tugboat crewmembers need to be improved. Crewmember lifestyle variables need to be studied further. © 2021, The Author(s). |
Fatigue; Seafarer; Sleep quality; Tugboat crewmembers; Work-family conflict; Working hours |
cross-sectional study; family conflict; fatigue; human; Indonesia; sleep; work schedule; Cross-Sectional Studies; Family Conflict; Fatigue; Humans; Indonesia; Sleep; Work Schedule Tolerance |
BioMed Central Ltd |
14712458 |
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34627227 |
Article |
Q1 |
1230 |
3166 |
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56 |
Gunardi E.R., Surya R., Syafitri I., Pasidri Y. |
57192910998;56986345100;57195381844;57226151144; |
Impact of one-rod levonorgestrel implant on the blood chemistry profile |
2021 |
Scientific Reports |
11 |
1 |
20141 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116742568&doi=10.1038%2fs41598-021-99801-z&partnerID=40&md5=604f40cda19708636ac9b97fd82f17a7 |
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Gunardi, E.R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Surya, R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Syafitri, I., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pasidri, Y., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
The aim of this study was to investigate the effect of a one-rod levonorgestrel implant on the blood chemistry profile, including random blood glucose (RBG), haemoglobin (Hb), alanine transferase (ALT), aspartate transferase (AST), and the lipid profile, including total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides. This prospective cohort study was conducted at Raden Saleh Clinic, Jakarta, from 2010 to 2012. The implants were inserted subdermally in 30 patients. The subjects were evaluated every 6 month up to 2 years. Bivariate analysis using t-test or Wilcoxon signed rank test was performed for all variables. p < 0.05 was considered a significant value. The Hb, RBG, AST, and lipid profile levels were significantly different before and 6 months after one-rod implant insertion (p < 0.05). However, for 24 months, all of the parameters were still within normal limits and did not differ clinically. One-rod levonorgestrel implant insertion has a minimal effect on all blood chemistry profiles. © 2021, The Author(s). |
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cholesterol; contraceptive agent; high density lipoprotein cholesterol; levonorgestrel; lipid; low density lipoprotein cholesterol; triacylglycerol; adult; blood; blood analysis; drug implant; female; human; phase 2 clinical trial (topic); procedures; prospective study; young adult; Adult; Blood Chemical Analysis; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials, Phase II as Topic; Contraceptive Agents, Female; Drug Implants; Female; Humans; Levonorgestrel; Lipids; Prospective Studies; Triglycerides; Young Adult |
Nature Research |
20452322 |
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34635768 |
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Q1 |
1240 |
3130 |
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57 |
Diptyanusa A., Sari I.P. |
57205340891;57197543698; |
Treatment of human intestinal cryptosporidiosis: A review of published clinical trials |
2021 |
International Journal for Parasitology: Drugs and Drug Resistance |
17 |
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128 |
138 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115755098&doi=10.1016%2fj.ijpddr.2021.09.001&partnerID=40&md5=e7d5494025a277d99586bf5f73027625 |
Department of Parasitology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia; Study Program of Medical Specialist in Clinical Parasitology, Faculty of Medicine, University of Indonesia, Indonesia; Department of Parasitology, Faculty of Medicine, University of Indonesia, Indonesia |
Diptyanusa, A., Department of Parasitology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia, Study Program of Medical Specialist in Clinical Parasitology, Faculty of Medicine, University of Indonesia, Indonesia; Sari, I.P., Department of Parasitology, Faculty of Medicine, University of Indonesia, Indonesia |
The global burden of diarrhea caused by Cryptosporidium parasite is underestimated. In immunocompromised hosts, chronic and severe presentation of intestinal cryptosporidiosis can result in long-term morbidity and high illness costs. The evidence of effective treatments for cryptosporidiosis has been lacking. We reviewed the published clinical trials to bring forward the feasible therapeutic options of human cryptosporidiosis in various populations and settings according to clinical improvement and parasite clearance rates. A total of 42 studies consisting of the use of nitazoxanide, paromomycin, macrolides, somatostatin analogues, letrazuril, albendazole, rifaximin, miltefosine, clofazimine, and colostrum were included in the review. The trials were mostly conducted in small number of individuals infected with human immunodeficiency virus (HIV), and there is inadequate data of controlled trials to suggest the use of these treatment modalities. Nitazoxanide was reported to be highly efficacious only in immunocompetent hosts and was found to be superior to paromomycin in the same group of patients. Macrolides showed no effective results in both clinical and parasitological improvement. Human bovine colostrum should possibly be administered as one of complementary therapeutic modalities along with other antimicrobials to reach optimal parasite eradication. Other trials of therapeutic modalities were terminated due to futility. Currently, available data is intended to aid the development of strategies for improving access to treatments in different clinical settings, as well as to help guide further studies on treatments of human intestinal cryptosporidiosis. © 2021 |
Clearance; Clinical trial; Cryptosporidiosis; Cryptosporidium; Drug; Treatment |
acetylspiramycin; albendazole; alkaline phosphatase; antiparasitic agent; azithromycin; clofazimine; erythromycin; garlicin; immunoglobulin; letrazuril; macrolide; miltefosine; nitazoxanide; octreotide; paromomycin; placebo; probiotic agent; rifaximin; roxithromycin; somatostatin derivative; spiramycin; unclassified drug; vapreotide; antiprotozoal agent; paromomycin; abdominal pain; adolescent; adult; aged; alkaline phosphatase level; alternative medicine; anorexia; antiparasitic therapy; child; cholecystitis; clinical trial (topic); colostrum; constipation; cryptosporidiosis; diarrhea; dizziness; drowsiness; drug efficacy; fatigue; fever; headache; health care access; human; Human immunodeficiency virus infection; hypertransaminasemia; infant; injection site pain; intestine obstruction; k |
Elsevier Ltd |
22113207 |
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34562754 |
Review |
Q1 |
1071 |
3953 |
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62 |
Prasetyo M., Mongan A.E., Chozie N.A., Prihartono J., Setiawan S.I. |
57192905252;57226385960;57194329830;6602605635;57195939543; |
Hemosiderin deposition evaluation in hemophilic ankle joints: association between US finding and gradient-recalled echo MR imaging sequence |
2021 |
Insights into Imaging |
12 |
1 |
107 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111352122&doi=10.1186%2fs13244-021-01050-1&partnerID=40&md5=7acc2e0c4841079a7e9e49379be1ff9e |
Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jl. Diponegoro No.71, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Department of Pediatric, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Departement of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Prasetyo, M., Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jl. Diponegoro No.71, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Mongan, A.E., Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jl. Diponegoro No.71, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Chozie, N.A., Department of Pediatric, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Prihartono, J., Departement of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiawan, S.I., Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jl. Diponegoro No.71, Jakarta Pusat, DKI Jakarta 10430, Indonesia |
Background: Repeated bleeding in hemophilic arthropathy (HA) may result in severe degenerative changes and joint destruction. The gradient-recalled echo (GRE) sequence MR is proved to be the best method to detect hemosiderin deposition. However, MR is not widely available in developing countries, including Indonesia. Some studies have proposed ultrasonography (US) as an alternative tool in evaluating hemophilic joint. However, there is still some disagreement on the ability of US to detect hemosiderin deposition. Objective: To evaluate the association between US and GRE-sequence MR imaging in detecting hemosiderin deposition in hemophilic ankle joint. Material and methods: A total of 102 sites from 17 ankle joints of 11 boys with severe hemophilia A underwent US examination using a high-frequency linear array transducer. GRE-sequence MR examination was performed in sagittal view consistent with the sites scanned by US. Both examinations were performed on the same day, but MR interpretation was performed blindly at different times. The association between US and GRE-sequences in detecting hemosiderin deposition was analyzed using McNemar’s test. Results: Statistical analysis showed a significant association (p value < 0.001) between US and GRE MR in detecting hemosiderin deposition, but the association is weak (R = 0.26). Sensitivity and specificity of US for detecting hemosiderin deposition were 46.84% (95%CI: 35.51–58.40) and 95.65% (95%CI: 78.05–99.89), respectively, with positive predictive value 97.37% (95%CI: 84.29–99.61), negative predictive value 34.38% (95%CI: 29.50–39.60) and accuracy 57.84% (95%CI: 47.66–67.56). Conclusion: There was a weak association between US and GRE-sequences in detecting hemosiderin deposition of hemophilic ankle joint. ​​ © 2021, The Author(s). |
GRE MR imaging; Hemophilic arthropathy; Hemosiderin deposition; US |
gadolinium; hemosiderin; accuracy; adolescent; anisotropy; Article; child; clinical article; cross-sectional study; echography; gradient recalled echo; gray matter; hemophilic arthropathy; histopathology; human; image analysis; male; medial malleolus; nuclear magnetic resonance imaging; predictive value; sensitivity and specificity; synovectomy |
Springer Science and Business Media Deutschland GmbH |
18694101 |
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Article |
Q1 |
1405 |
2531 |
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63 |
Irwinda R., Hiksas R., Siregar A.A., Saroyo Y.B., Wibowo N. |
57190855256;57226152029;57226157581;57164888400;15049026900; |
Long-chain polyunsaturated fatty acid (LC-PUFA) status in severe preeclampsia and preterm birth: a cross sectional study |
2021 |
Scientific Reports |
11 |
1 |
14701 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110662198&doi=10.1038%2fs41598-021-93846-w&partnerID=40&md5=f379da0f3a9e78e16af9cc0ca6bb9968 |
Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia |
Irwinda, R., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Hiksas, R., Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Siregar, A.A., Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Saroyo, Y.B., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Wibowo, N., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia |
Long-Chain Polyunsaturated Fatty Acid (LCPUFA) is essential throughout pregnancy, since deficiency of LPUFA may linked to obstetrical complications. This study aimed to investigate LCPUFA status in severe preeclampsia and preterm birth. A cross sectional study was conducted in 104 pregnant women, which divided into normal pregnancy, severe preeclampsia and preterm birth groups. Serum percentage and concentration of total LCPUFA, omega-3, alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), omega-6, linoleic acid (LA), and arachidonic acid (AA) were measured using gas chromatography/mass spectrometry. Receiver operating characteristic (ROC), bivariate and multivariate analysis were performed. Severe preeclampsia showed the highest concentration of total PUFA and the lowest DHA percentage, with significantly higher Omega-6/Omega-3 ratio (p = 0.004) and lower omega-3 index (p < 0.002) compared to control. Preterm birth showed the least omega-3 concentrations, with significantly low omega-6 derivates (LA (p = 0.014) and AA (p = 0.025)) compared to control. LCPUFA parameters have shown to increase the risk in both conditions, particularly ALA ≤ 53 µmol/L in preeclampsia with OR 5.44, 95%CI 1.16–25.42 and preterm birth with OR 4.68, 95%CI 1.52–14.38. These findings suggest that severe preeclampsia and preterm birth have an imbalance in LCPUFA status. © 2021, The Author(s). |
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unsaturated fatty acid; adult; blood; case control study; cross-sectional study; female; human; Indonesia; male; newborn; nutritional status; pathology; preeclampsia; pregnancy; prematurity; severity of illness index; young adult; Adult; Case-Control Studies; Cross-Sectional Studies; Fatty Acids, Unsaturated; Female; Humans; Indonesia; Infant, Newborn; Male; Nutritional Status; Pre-Eclampsia; Pregnancy; Premature Birth; Severity of Illness Index; Young Adult |
Nature Research |
20452322 |
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34282168 |
Article |
Q1 |
1240 |
3130 |
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65 |
Setiawan E.A., Rianda D., Kadim M., Meilianawati, Susanto F., Kok F.J., Shankar A.H., Agustina R. |
57214103232;57214119630;26644177600;57224214324;57224212671;56506613800;7005442634;57214141404; |
Tenth year reenrollment randomized trial investigating the effects of childhood probiotics and calcium supplementation on height and weight at adolescence |
2021 |
Scientific Reports |
11 |
1 |
11860 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107265110&doi=10.1038%2fs41598-021-88819-y&partnerID=40&md5=ffa4a369e5635d1edafff9d5559b7d3c |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Human Nutrition and Health, Wageningen University, Wageningen, Netherlands; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Setiawan, E.A., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Rianda, D., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kadim, M., Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Meilianawati, Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Susanto, F., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Kok, F.J., Division of Human Nutrition and Health, Wageningen University, Wageningen, Netherlands; Shankar, A.H., Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Microbiota and its modification with specific probiotics in early life could provide long term health benefits. Probiotics and calcium strengthen intestinal integrity and may support linear growth. This study investigated the long-term effects of childhood probiotics and calcium supplementation on growth in adolescence. We re-enrolled 238 adolescents aged 11–18 years from 494 children 10-years after 6-months of supplementation with either low-lactose milk fortified with low levels of calcium (LC, ∼50 mg/day, n = 53/124), with regular levels of calcium (RC, ∼440 mg/day, n = 70/126), or with regular calcium + 5 x 108 CFU/day Lactobacillus reuteri DSM 17938 (Reuteri, n = 55/124), or regular calcium + 5 x 108 CFU/day L. casei CRL 431 (Casei, n = 60/120). Changes in height-for-age z-score (HAZ) and body mass index-for-age z-score (BMIZ) were determined from the end of intervention to re-enrollment. General linear models were used to assess the effects on HAZ and BMIZ of group, gender, living area, maternal education, family income, physical activity, diet quality, nutritional status, and gut integrity as determined by urinary lactulose/mannitol ratio (L:M). Adolescent mean age was 15.3 years, mean HAZ was − 1.11, mean BMIZ was − 0.2 and median L:M (n = 155) was 0.23. Changes in HAZ and BMIZ were not significantly different between Casei, Reuteri, LC compared to RC. However, a significant decrease in BMIZ was observed among female adolescents in the Casei compared to RC group (− 0.5 SD, 95% CI − 0.8 to − 0.003, p = 0.048). Childhood probiotic and calcium supplementation may therefore selectively affect female adolescents. Clinical trial registration: This follow-up study has been registered at www.clinicaltrials.gov, Registry name: Rina Agustina, Registration number: NCT04046289, First Registration Date 06/08/19. web link: https://www.clinicaltrials.gov/ct2/show/NCT04046289. © 2021, The Author(s). |
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lactulose; mannitol; probiotic agent; administration and dosage; adolescent; body height; body mass; body weight; calcium intake; controlled study; diet therapy; dietary supplement; double blind procedure; epidemiology; female; follow up; fortified food; health auxiliary; human; Indonesia; Lactobacillus casei; Lactobacillus reuteri; male; nutritional status; randomized controlled trial; risk factor; statistical model; Adolescent; Body Height; Body Mass Index; Body Weight; Calcium, Dietary; Community Health Workers; Dietary Supplements; Double-Blind Method; Female; Follow-Up Studies; Food, Fortified; Humans; Indonesia; Lactobacillus casei; Lactobacillus reuteri; Lactulose; Linear Models; Male; Mannitol; Nutrition Therapy; Nutritional Status; Probiotics; Risk Factors |
Nature Research |
20452322 |
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34088920 |
Article |
Q1 |
1240 |
3130 |
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67 |
Liem J.F., Mansyur M., Soemarko D.S., Kekalih A., Subekti I., Suyatna F.D., Suryandari D.A., Malik S.G., Pangaribuan B. |
57224169741;37085506800;57192889490;55633562200;24336854300;56039633100;6505763338;7402973374;54785015100; |
Cumulative exposure characteristics of vegetable farmers exposed to Chlorpyrifos in Central Java – Indonesia; a cross-sectional study |
2021 |
BMC Public Health |
21 |
1 |
1066 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107125504&doi=10.1186%2fs12889-021-11161-5&partnerID=40&md5=9fb7a1aa16134c6ee9e3e23e6280115f |
Doctoral Program, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Occupational Health and Safety, Faculty of Medicine and Health Science Universitas Kristen Krida Wacana, Jakarta, 11510, Indonesia; Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Biology, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Jalan Diponegoro No. 69, Kota Jakarta Pusat, Jakarta, Indonesia; Prodia Occupational Health Institute International, Jakarta, 10430, Indonesia |
Liem, J.F., Doctoral Program, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Occupational Health and Safety, Faculty of Medicine and Health Science Universitas Kristen Krida Wacana, Jakarta, 11510, Indonesia; Mansyur, M., Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Soemarko, D.S., Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Kekalih, A., Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Subekti, I., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Suyatna, F.D., Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Suryandari, D.A., Department of Biology, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Malik, S.G., Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Jalan Diponegoro No. 69, Kota Jakarta Pusat, Jakarta, Indonesia; Pangaribuan, B., Prodia Occupational Health Institute International, Jakarta, 10430, Indonesia |
Background: Agriculture is a major economic sector in Indonesia. Chemical pesticides are widely being used in agriculture for controlling pest. There is a growing concern that pesticide exposure, particularly chlorpyrifos (CPF) exposure, combined with other occupational characteristics that determine the level of exposure, can lead to further health impacts for farmers. Our objective was to evaluate the cumulative exposure characteristics among farmers exposed to CPF by using a validated algorithm. Methods: We conducted a cross-sectional study of 152 vegetable farmers aged 18–65 who actively used CPF for at least 1 year in Central Java, Indonesia. Subject characteristics were obtained using a structured interviewer-administered questionnaire, addressed for sociodemographic and work-related characteristics. The cumulative exposure level (CEL) was estimated as a function of the intensity level of pesticide exposure (IL), lifetime years of pesticide use and the number of days spraying per year. CEL was subsequently classified into two groups, high and low exposure groups. The difference in characteristics of the study population was measured using Chi-square, independent-t or Mann-Whitney test. Association between CEL and its characteristics variables were performed by multiple linear regression. Results: Seventy-one subjects (46.7%) were classified as the high exposure group. The use of multiple pesticide mixtures was common among our study population, with 94% of them using 2 or more pesticides. 73% reported direct contact with concentrated pesticides product, and over 80% reported being splashed or spilt during preparation or spraying activity. However, we found that the proportion of proper personal protective equipment (PPE) use in our subjects was low. Higher volume of mixture applied (p < 0.001) and broader acres of land (p = 0.001) were associated with higher cumulative exposure level, while using long-sleeved clothes and long pants (p < 0.05) during pesticide spraying were associated with lower cumulative exposure after adjusted for age and gender. Conclusions: These findings indicate an inadequate knowledge of using pesticides properly. Thus, we recommend comprehensive training on pesticide usage and encourage proper PPE to reduce the exposure level. © 2021, The Author(s). |
Exposure assessment; Exposure reduction; Occupational characteristics; Pesticide cumulative exposure; Work practices |
chlorpyrifos; pesticide; adverse event; agricultural worker; agriculture; cross-sectional study; epidemiology; human; Indonesia; occupational exposure; vegetable; Agriculture; Chlorpyrifos; Cross-Sectional Studies; Farmers; Humans; Indonesia; Occupational Exposure; Pesticides; Vegetables |
BioMed Central Ltd |
14712458 |
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34090393 |
Article |
Q1 |
1230 |
3166 |
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