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No records
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203 |
Sasmono R.T., Johar E., Yohan B., Ma’Roef C.N., Soebandrio A., Myint K.S.A., Pronyk P., Hadinegoro S.R., Soepardi E.J., Bouckenooghe A., Hawley W., Rosenberg R., Powers A.M. |
57245712300;57204001174;55843037500;6507740388;8602893200;7003758970;6602466584;57226218772;57191174412;18233281300;7004280510;35578810900;7005770718; |
In Response: Stability of zika virus antibodies in specimens from a retrospective serological study |
2021 |
American Journal of Tropical Medicine and Hygiene |
105 |
3 |
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853 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115293744&doi=10.4269%2fajtmh.21-0564b&partnerID=40&md5=4b5e07961e6006f21355f4fdf73c7fa8 |
Eijkman Institute for Molecular Biology, Jakarta, Indonesia; UNICEF Indonesia, Jakarta, Indonesia; Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Ministry of Health of the Republic of Indonesia, Jakarta, Indonesia; Sanofi Pasteur Lyon, Rhone-Alpes, France; Centers for Disease Control and Prevention, Atlanta, GA, United States; Centers for Disease Control and Prevention Fort, Collins, CO, United States |
Sasmono, R.T., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Johar, E., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Yohan, B., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Ma’Roef, C.N., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Soebandrio, A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Myint, K.S.A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Pronyk, P., UNICEF Indonesia, Jakarta, Indonesia; Hadinegoro, S.R., Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Soepardi, E.J., Ministry of Health of the Republic of Indonesia, Jakarta, Indonesia; Bouckenooghe, A., Sanofi Pasteur Lyon, Rhone-Alpes, France; Hawley, W., Centers for Disease Control and Prevention, Atlanta, GA, United States; Rosenberg, R., Centers for Disease Control and Prevention Fort, Collins, CO, United States; Powers, A.M., Centers for Disease Control and Prevention Fort, Collins, CO, United States |
[No abstract available] |
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immunoglobulin G antibody; virus antibody; enzyme linked immunosorbent assay; freezing; Letter; plaque reduction neutralization test; serology; storage; Zika virus; human; retrospective study; serodiagnosis; Zika fever; Humans; Neutralization Tests; Retrospective Studies; Zika Virus; Zika Virus Infection |
American Society of Tropical Medicine and Hygiene |
00029637 |
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34314374 |
Letter |
Q1 |
1015 |
4298 |
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361 |
Sasmono R.T., Johar E., Yohan B., Ma'Roef C.N., Pronyk P., Hadinegoro S.R., Soepardi E.J., Bouckenooghe A., Hawley W.A., Rosenberg R., Powers A.M., Soebandrio A., Myint K.S.A. |
6506482032;57204001174;55843037500;6507740388;6602466584;57226218772;57191174412;18233281300;7004280510;35578810900;7005770718;8602893200;7003758970; |
Spatiotemporal heterogeneity of zika virus transmission in indonesia: Serosurveillance data from a pediatric population |
2021 |
American Journal of Tropical Medicine and Hygiene |
104 |
6 |
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2220 |
2223 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107590950&doi=10.4269%2fajtmh.21-0010&partnerID=40&md5=31e9b723a56e45315c1b9d58055ee86b |
Eijkman Institute for Molecular Biology, Jakarta, Indonesia; UNICEF Indonesia, Jakarta, Indonesia; Faculty of Medicine and Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Ministry of Health of the Republic of Indonesia, Jakarta, Indonesia; Sanofi Pasteur, Lyon, Rhône-Alpes, France; Centers for Disease Control and Prevention, Atlanta, GA, United States; Centers for DiseaseControl and Prevention, Fort Collins, CO, United States |
Sasmono, R.T., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Johar, E., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Yohan, B., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Ma'Roef, C.N., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Pronyk, P., UNICEF Indonesia, Jakarta, Indonesia; Hadinegoro, S.R., Faculty of Medicine and Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Soepardi, E.J., Ministry of Health of the Republic of Indonesia, Jakarta, Indonesia; Bouckenooghe, A., Sanofi Pasteur, Lyon, Rhône-Alpes, France; Hawley, W.A., Centers for Disease Control and Prevention, Atlanta, GA, United States; Rosenberg, R., Centers for DiseaseControl and Prevention, Fort Collins, CO, United States; Powers, A.M., Centers for DiseaseControl and Prevention, Fort Collins, CO, United States; Soebandrio, A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Myint, K.S.A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
The presence of Zika virus (ZIKV) in Indonesia has been recognized since the 1970s, but its transmission dynamics there have been poorly understood. To understand more fully the geographic distribution and burden of ZIKV infection, we performed retrospective serological tests on specimens collected from asymptomatic children age 5 to 9 years old living at 30 sites in 14 provinces. Of 870 serum samples tested, 9.2% were found to be positive for anti-ZIKV antibodies, as confirmed by plaque reduction neutralization assays. This was the same overall prevalence reported previously for 1- to 4-year-old children collected at the same sites at the same time. Together with geographic differences in seroprevalence between the age groups, these data suggest that, although ZIKV might be endemic in Indonesia, its occurrence has been focal and episodic. © 2021 by The American Society of Tropical Medicine and Hygiene. |
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Article; asymptomatic disease; blood sampling; disease burden; geographic distribution; human; Indonesia; nonhuman; plaque reduction neutralization test; serological surveillance; serology; seroprevalence; virus transmission; Zika fever; Zika virus; blood; child; epidemiological monitoring; immunology; preschool child; retrospective study; seroepidemiology; spatiotemporal analysis; Zika fever; Zika virus; immunoglobulin M; virus antibody; Antibodies, Viral; Child; Child, Preschool; Epidemiological Monitoring; Humans; Immunoglobulin M; Indonesia; Retrospective Studies; Seroepidemiologic Studies; Spatio-Temporal Analysis; Zika Virus; Zika Virus Infection |
American Society of Tropical Medicine and Hygiene |
00029637 |
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33939632 |
Article |
Q1 |
1015 |
4298 |
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575 |
Fuady A., Houweling T.A.J., Richardus J.H. |
37085331400;10639726000;7003977198; |
Perspective piece COVID-19 and tuberculosis-related catastrophic costs |
2021 |
American Journal of Tropical Medicine and Hygiene |
104 |
2 |
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436 |
440 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101400221&doi=10.4269%2fajtmh.20-1125&partnerID=40&md5=a3c370677fb6cad8407b4d92b3768798 |
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Fuady, A., Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Houweling, T.A.J., Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Richardus, J.H., Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands |
The COVID-19 pandemic has created an unprecedented health crisis and a substantial socioeconomic impact. It also affects tuberculosis (TB) control severely worldwide. Interruptions of many TB control programs because of the COVID-19 pandemic could result in significant setbacks. One of the targets that can be affected is the WHO's End TB Strategy goal to eliminate catastrophic costs of TB-affected households by 2030. Disruptions to TB programs and healthcare services due to COVID-19 could potentially prolong diagnostic delays and worsen TB treatment adherence and outcomes. The economic recession caused by the pandemic could significantly impact household financial capacity because of the reduction of income and the rise in unemployment rates. All of these factors increase the risk of TB incidence and the gravity of economic impact on TB-affected households, and hamper efforts to eliminate catastrophic costs and control TB. Therefore, efforts to eliminate the incidence of TB-affected households facing catastrophic costs will be very challenging. Because financial constraint plays a significant role in TB control, the improvement of health and social protection systems is critical. Even before the pandemic, many TB-high-burden countries (HBCs) lacked robust health and social protection systems. These challenges highlight the substantial need for a more robust engagement of patients and civil society organizations and international support in addressing the consequences of COVID-19 on the control of TB. © 2021 by The American Society of Tropical Medicine and Hygiene. |
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tuberculostatic agent; clinical outcome; coronavirus disease 2019; delayed diagnosis; disaster; disease burden; disease control; economic recession; financial management; health care cost; health program; health service; household; human; incidence; income; infection control; infection risk; organization; pandemic; patient compliance; Review; social aspect; social protection system; socioeconomics; tuberculosis; unemployment; World Health Organization; economics; family size; health care cost; tuberculosis; COVID-19; Family Characteristics; Health Care Costs; Humans; Incidence; Income; SARS-CoV-2; Tuberculosis |
American Society of Tropical Medicine and Hygiene |
00029637 |
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33269683 |
Review |
Q1 |
1015 |
4298 |
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No records
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19 |
Tantri A.R., Sukmono R.B., Atmadja L.S. |
57188933853;57204643526;57422197300; |
Comparison of recovery time with target controlled infusion of propofol with sevoflurane anesthesia using bispectral index monitoring in vitrectomy surgery |
2021 |
Anaesthesia, Pain and Intensive Care |
25 |
6 |
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707 |
712 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123272271&doi=10.35975%2fapic.v25i6.1689&partnerID=40&md5=a8e07d9abeb4fd0d01a1bb03c52954f1 |
Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Pangeran Diponegoro Street No. 71, Kenari, Senen, DKI Jakarta, Central Jakarta, 10430, Indonesia |
Tantri, A.R., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Pangeran Diponegoro Street No. 71, Kenari, Senen, DKI Jakarta, Central Jakarta, 10430, Indonesia; Sukmono, R.B., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Pangeran Diponegoro Street No. 71, Kenari, Senen, DKI Jakarta, Central Jakarta, 10430, Indonesia; Atmadja, L.S., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Pangeran Diponegoro Street No. 71, Kenari, Senen, DKI Jakarta, Central Jakarta, 10430, Indonesia |
Background: Rapid recovery after anesthesia is critical and is associated with the anesthetic agents used. The bispectral index (BIS) monitoring to guide anesthetic agents' doses may play a significant role in the recovery time. This study compared recovery time after Target Controlled Infusion (TCI) of propofol with sevoflurane anesthesia by using BIS monitoring during vitrectomy surgery. Methodology: This was a prospective observational, randomized study on 40 patients aged 18-65 y, physical status ASA I-II, body mass index (BMI) 18-30 kg/m2, who underwent vitrectomy surgery. Subjects were randomly assigned into two groups, Group P - the TCI propofol group, and Group S - the sevoflurane group. Subjects in the Group P received TCI propofol (Schnider), and subjects in the Group S received sevoflurane for anesthesia maintenance, with a targeted BIS score of 40-60. Inj. fentanyl 1 μg/kg was administered if there was an increase in blood pressure, heart rate and/or BIS that could not be overcome by increasing the dose of TCI propofol or sevoflurane. Recovery time was calculated from when the maintenance regimen was stopped until the patient was able to obey simple commands. Recovery time, fentanyl consumption, postoperative agitation, nausea and vomiting incidence were noted and analyzed with SPSS v21.0 for Windows. T-Test or Mann-Whitney U test was performed to analyze the data. Result: Recovery time in the Group P [11.5 (5-25) min)] was not significantly different from the Group S [9 (4-18) min, p = 0.139]. Total fentanyl consumption was higher in the Group P than in the Group S (1.765 vs. 1.428 μg/kg). The frequency of agitation during recovery was higher in the Group S than in the Group P (30% vs. 20%) Conclusion: There was no significant difference in recovery time between TCI propofol and sevoflurane anesthesia using BIS monitoring in vitrectomy. Total fentanyl consumption was higher in the propofol group than in the sevoflurane group. The impact of these anesthetic regimens on postoperative agitation needs further investigation. © 2021 Faculty of Anaesthesia, Pain and Intensive Care, AFMS. All rights reserved. |
BIS; Bispectral index monitoring; Intravenous anesthesia; Propofol; Sevoflurane; Target Controlled Infusion; TCI; Vitrectomy |
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Faculty of Anaesthesia, Pain and Intensive Care, AFMS |
16078322 |
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Article |
Q3 |
170 |
21404 |
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430 |
Mariati N.M.A.S., Sugiarto A., Endriani E., Lestari R., Anindita K. |
57223228784;57189612291;57222314378;57223220725;57192903786; |
High flow nasal cannula to prevent intubation in obese patient with COVID-19 induced ARDS: a case report |
2021 |
Anaesthesia, Pain and Intensive Care |
25 |
2 |
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212 |
216 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105281913&doi=10.35975%2fAPIC.V25I2.1473&partnerID=40&md5=2108db369e86e24a12b1ed89d9a0970b |
Department of Anesthesiology & Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anesthesiology & Intensive Care, Faculty of Medicine, University of Mataram-West Nusa Tenggara General Hospital, Lombok, Indonesia; Pulmonology Department, Faculty of Medicine, University of Mataram-West Nusa Tenggara General Hospital, Lombok, Indonesia; Department of Internal Medicine, Siloam Hospitals Mataram, Jl. Majapahit, Pagesangan, Kec. Mataram, Kota Mataram, Nusa Tenggara Bar, 83115, Indonesia |
Mariati, N.M.A.S., Department of Anesthesiology & Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sugiarto, A., Department of Anesthesiology & Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Endriani, E., Department of Anesthesiology & Intensive Care, Faculty of Medicine, University of Mataram-West Nusa Tenggara General Hospital, Lombok, Indonesia; Lestari, R., Pulmonology Department, Faculty of Medicine, University of Mataram-West Nusa Tenggara General Hospital, Lombok, Indonesia; Anindita, K., Department of Internal Medicine, Siloam Hospitals Mataram, Jl. Majapahit, Pagesangan, Kec. Mataram, Kota Mataram, Nusa Tenggara Bar, 83115, Indonesia |
Obese patients have been identified to have a poor prognosis and a higher risk of death from coronavirus disease-2019 (COVID-19). We present reports of two obese patients infected with COVID-19 with acute respiratory distress syndrome (ARDS) who showed improvement with high flow nasal cannula (HFNC). HFNC is a noninvasive oxygen delivery device which is capable of delivering a high concentration of oxygen that can reduce the requirement for tracheal intubation. HFNC is convenient to use, can reduce dyspnea without effecting the length of stay in ICU in these cases; and has a high merit to be used in selected patients requiring oxygen before attempting intubation and mechanical ventilation. © the authors. |
ARDS; COVID-19; HFNC; High flow nasal cannula; Obese |
alanine aminotransferase; antiarrhythmic agent; ascorbic acid; aspartate aminotransferase; azithromycin; C reactive protein; chloroquine; dexamethasone; famotidine; heparin; hypertensive factor; levofloxacin; low molecular weight heparin; methylprednisolone; micafungin; oseltamivir; remdesivir; SARS-CoV-2 convalescent plasma; vancomycin; adult; adult respiratory distress syndrome; ageusia; alanine aminotransferase blood level; anosmia; Article; artificial ventilation; aspartate aminotransferase blood level; case report; clinical article; coronavirus disease 2019; coughing; COVID-19 testing; crackle; diarrhea; drug withdrawal; dyspnea; endotracheal intubation; fever; heart arrhythmia; high flow nasal cannula therapy; hospital admission; human; hypotension; hypoxemia; intensive care unit; le |
Faculty of Anaesthesia, Pain and Intensive Care, AFMS |
16078322 |
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Article |
Q3 |
170 |
21404 |
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No records
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683 |
Puspitasari H.A., Indriasti N., Hidayati E.L. |
57214119502;57310728900;57200542624; |
Antihypertensive management in children: A two-years experience of indonesia's national referral hospital |
2021 |
Anatolian Journal of Family Medicine |
4 |
1 |
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7 |
12 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117862602&doi=10.5505%2fanatoljfm.2020.18209&partnerID=40&md5=bb62f06ed1d11c2f9f176e26ae094521 |
Department of Child Health, Division of Pediatric Nephrology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Puspitasari, H.A., Department of Child Health, Division of Pediatric Nephrology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Indriasti, N., Department of Child Health, Division of Pediatric Nephrology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hidayati, E.L., Department of Child Health, Division of Pediatric Nephrology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objectives: The prevalence of hypertension (HT) in children has increased overtime. However, data related to antihypertensive options and outcomes are still limited in children, especially in Indonesia. This study aimed to describe pediatric HT cases and antihypertensive management in Cipto Mangunkusumo General Hospital (CMGH). Methods: A retrospective cross-sectional study was conducted in CMGH from January 2016 to December 2017. Inclusion criteria were children age <18 years with primary and secondary HT visiting pediatric nephrology clinic. Patients were excluded if no blood pressure records were found. Clinical and antihypertensive treatments data were recorded from medical records. Diagnosis was based on the Fourth Report classification. Results: This study included 176 children with HT. Secondary HT was found in 159 (90.3%) patients, and 82 (51.6%) of them had isolated kidney-urinary tract disease. Dual antihypertensive therapy was prescribed for 53 (30.1%) patients, whereas 55 (31.3%) patients was monotherapy. The most common antihypertensive used in monotherapy was angiotensin converting enzyme inhibitors (ACEI), received by 31 (56.3%) patients. The median duration of therapy until achievement of target blood pressure was 28.0 (1.0-365.0) days. Conclusion: Pediatric HT is an often overlooked growing medical issue. Secondary HT was found more in children compare to primary HT. Secondary etiology was suspected if HT was found in children with kidney disease. The first-line antihypertensive drug used was ACEI, as single or combination therapy. The therapeutic effect of antihypertensive drugs was expected within 28 days of treatment. © 2020 by Anatolian Journal of Family Medicine. |
Antihypertensive agents; Children; Essential hypertension; Hypertension |
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Kare Publishing |
26305593 |
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Article |
#N/A |
#N/A |
#N/A |
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No records
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351 |
Wijaya A.N., Margiana R., Kusumaningtyas S., Furqonita D. |
57225105688;56685900600;57193925307;57191057597; |
Comparison of decomposition rate of hind limbs of preserved mice with ethanol-glycerin and formaldehyde of advanced fixative solution |
2021 |
Anatomy and Cell Biology |
54 |
2 |
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225 |
231 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109181614&doi=10.5115%2facb.20.314&partnerID=40&md5=b084cc2abbf0ad3096da22401b79fe9b |
Undergraduate Program of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Wijaya, A.N., Undergraduate Program of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kusumaningtyas, S., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Furqonita, D., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Learning anatomy in medical school is still closely based on the use of cadavers. The burial of preserved cadaver poses a problem, specifically, it contaminates the soil with formalin. Many studies have been conducted to find an alternative fixative to update or modify formalin usage. One of them is ethanol-glycerin (EG), which suggests promising results. Despite that fact, there has yet to be any research comparing the decomposition rate between EG and formalin. This study is conducted to compare the rate of decomposition between the two fixative solutions, EG and 4% formalin on the hind limb of mice. The mice were first preserved using a standard primary fixative solution which is 10% formalin, following that procedure is preservation using advanced fixative solution, EG or 4% formalin. Upon completing the preservation steps, the mice were buried for 6 weeks and observed weekly. The stages of decomposition were assessed semi-quantitatively depending on its appearance. The hind limbs of mice that were fixed with EG solution managed to reach the last stage of decomposition, dry & remains, while the 4% formalin group of mice still remained in the previous stage, advanced decay. It is concluded that the mice hind limbs that have been previously preserved with EG advanced fixative solution has a faster decomposition rate compared to 4% formalin. Copyright © 2021. Anatomy & Cell Biology |
Burial; Glycerol; Mice; Preservation |
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Korean Association of Anatomists |
20933665 |
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Article |
Q2 |
366 |
12934 |
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No records
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774 |
Atmakusuma T.D., Girson R., Koesnoe S. |
57216961785;14324834100;26028015000; |
Correlations between Iron Load and CD4 in Adult Transfusion-Dependent Beta Thalassemia |
2021 |
Anemia |
2021 |
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5549503 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108909049&doi=10.1155%2f2021%2f5549503&partnerID=40&md5=86934d2b70e3a64770f20d2512ea4dfb |
Division of Hematology-Medical Oncology, Department of Internal Medicine Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia; Division of Allergy-Immunology, Department of Internal Medicine. Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia; Girson, R., Division of Hematology-Medical Oncology, Department of Internal Medicine Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia; Koesnoe, S., Division of Allergy-Immunology, Department of Internal Medicine. Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia |
Background. Thalassemia is a hereditary disease, and severe anemia is the main phenotype of major thalassemia. Furthermore, the most important method in the management of this disease is red blood cell transfusion. Regular transfusions administered 1 or 2 times every month improve prognosis and survival. However, there is higher risk of infections and iron overload, especially in transfusion-dependent thalassemia (TDT). Infections are the second leading cause of death in adult TDT, after heart failure. Higher risk of infection is also influenced by multiple blood transfusions which causes alteration in immune response due to alloimmunization, transfusion-related infections, and iron overload. Meanwhile, iron overload in TDT alters both innate and specific immune responses. Furthermore, previous studies have shown the correlation between ferritin with CD4, but this has not been carried out in Indonesia. Therefore, this study aims to determine the correlations between iron overload (serum ferritin and transferrin saturation) and specific immune cells (CD4). Methods. This is a cross-sectional study, and a total number of 64 subjects were examined consecutively. Chest X-ray and blood sera were obtained. The total number of subjects was 64. The seromarkers HBsAg, anti-HCV, and anti-HIV were tested using the ELISA method. Serum ferritin and transferrin saturation was tested using ECLIA, and lymphocyte subsets were analyzed using flowcytometry. Meanwhile, the correlation between variables was determined using Spearman's test. Results. The results showed that 4.9% subjects were HBsAg positive, 10.7% were anti-HCV positive, and none were anti-HIV positive. There were 4 subjects with lung tuberculosis based on the 41 chest X-ray. Meanwhile, there was a weak negative and insignificant correlation between serum ferritin with CD4 (p=0.75; r = -0.04) and a weak positive and insignificant correlation between transferrin saturation with CD4 (p=0.133; r = 0.19). Conclusion. There were no correlations between iron overload (ferritin) and cellular immunity (CD4) in adult transfusion-dependent thalassemia. © 2021 Tubagus Djumhana Atmakusuma et al. |
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C reactive protein; ferritin; hemoglobin; hepatitis B surface antigen; hepatitis C antibody; Human immunodeficiency virus antibody; iron chelating agent; transferrin; tuberculostatic agent; adult; antibiotic therapy; antibody detection; antigen detection; Article; beta thalassemia; blood sampling; blood transfusion; CD4 lymphocyte count; cellular immunity; chronic hepatitis; coinfection; cross-sectional study; disease association; electrochemiluminescence immunoassay; enzyme linked immunosorbent assay; facies; female; ferritin blood level; flow cytometry; hemoglobin blood level; hemoglobin E-beta thalassemia; hepatitis B; hepatitis C; human; human cell; Human immunodeficiency virus infection; iron overload; leukocyte count; lung tuberculosis; lymphocyte subpopulation; major clinical study; |
Hindawi Limited |
20901267 |
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Article |
Q2 |
921 |
4948 |
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No records
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137 |
Aditianingsih D., Hidayat J., Ginting V.M. |
56312263600;57221444286;57377973500; |
Comparison of bioimpedance versus pulse contour analysis for intraoperative cardiac index monitoring in patients undergoing kidney transplantation |
2021 |
Anesthesiology and Pain Medicine |
11 |
5 |
e117918 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121465922&doi=10.5812%2fAAPM.117918&partnerID=40&md5=cc44c95f4c7c6f8cc3dd0d4b279457ff |
Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Aditianingsih, D., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Hidayat, J., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Ginting, V.M., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Background: Cardiac index (CI; cardiac output indexed to body surface area) is routinely measured during kidney transplant surgery. Bioimpedance cardiometry is a transthoracic impedance as the non-invasive alternative for hemodynamic monitoring, using semi-invasive uncalibrated pulse wave or contour (UPC) analysis. Objectives: We performed a cross-sectional observational study on 50 kidney transplant patients to compare the CI measurement agreement, concordance rate, and trending ability between bioimpedance and UPC analysis. Methods: For each patient, CI was measured by bioimpedance analysis (ICON™) and UPC analysis (EV1000™) devices at three time points: after induction, during incision, and at reperfusion. The device measurement accuracy was assessed by the bias value, limit of agreement (LoA), and percentage error (PE) using Bland-Altman analyses. Trending ability was assessed by angular bias and polar concordance through four-quadrant and polar plot analyses. Results: From each time point and pooled measurement, the correlation coefficients were 0.267, 0.327, 0.321, and 0.348. BlandAltman analyses showed mean bias values of 1.18, 1.06, 1.48, and 1.30, LoA of-1.35 to 3.72,-1.39 to 3.51,-1.07 to 4.04, and-1.17 to 3.78, and PE of 82.21, 78.50, 68.74, and 74.58%, respectively. Polar plot analyses revealed angular bias values of-10.37º,-15.01º,-18.68º, and-12.62º, with radial LoA of 89.79º, 85.86º, 83.38º, and 87.82º, respectively. The four-quadrant plot concordance rates were 70.77, 67.35, 65.90, and 69.79%. These analyses showed poor agreement, weak concordance, and low trending ability of bioimpedance cardiometry to UPC analysis. Conclusions: Bioimpedance and UPC analysis for CI measurements were not interchangeable in patients undergoing kidney transplant surgery. Cardiac index monitoring using bioimpedance cardiometry during kidney transplantation should be interpreted cautiously because it showed poor reliability due to low accuracy, precision, and trending ability for CI measurement. © 2021, Author(s). |
Cardiac Output; Intraoperative Monitoring; Kidney Transplantation; Pulse Wave Analysis; Transthoracic Impedance |
atracurium besilate; dobutamine; fentanyl; noradrenalin; propofol; sevoflurane; adult; aged; agitation; anesthesia induction; arterial pressure; Article; body mass; bradycardia; cardiac index; cardiopulmonary bypass; central venous pressure; chronic kidney failure; correlation coefficient; cross-sectional study; female; heart arrhythmia; heart output; heart rate; heart stroke volume; hemodynamic monitoring; human; hypertension; intraoperative monitoring; kidney transplantation; major clinical study; male; mean arterial pressure; measurement accuracy; nausea and vomiting; observational study; outcome assessment; pleura effusion; prospective cost; prospective study; pulse oximetry; pulse wave; systolic blood pressure; tachycardia; transesophageal echocardiography; uncalibrated pulse contour |
Kowsar Medical Institute |
22287523 |
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Article |
Q2 |
438 |
11251 |
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No records
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453 |
Yani A., Dorothy D., Amaliah R. |
57215433374;57224003330;57224001785; |
Influence of Intestinal Strangulation Release on Ischemiareperfusion Injury in Sprague Dawley Rats |
2021 |
Annals of African Surgery |
18 |
2 |
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90 |
95 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106736281&doi=10.4314%2fAAS.V18I2.6&partnerID=40&md5=611bcf09b29bda5c9a4b2e09279bdd15 |
Department of Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Yani, A., Department of Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Dorothy, D., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Amaliah, R., Department of Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Background: In intestinal ischemia, reperfusion towards the injured intestine can cause further injury to the intestine itself and to remote organs. This research aimed to evaluate the influence of intestinal strangulation release (SR) before resection on the intestine outside margin of the strangulated intestine compared with subjects without intestinal strangulation release (WSR). Methods: Fourteen male Sprague Dawley rats were subjected to strangulation of one loop of the distal ileum for 4 h. In the SR group, the strangulated intestine was released for 5 min and then resected for necrotic parts. In the WSR group, the strangulated intestine was immediately resected WSR. The control group received a sham laparotomy. Four hours after the second laparotomy, the animals were sacrificed, and intestinal samples were taken for histomorphological analysis and measurement of intestinal malondialdehyde (MDA) level. Results: The injury on the histomorphological intestinal mucosa and intestinal MDA level were insignificantly higher in the SR group than in the WSR group (p>0.05). Conclusion: Intestinal SR before resection causes more tissue injury and oxidative stress on the intestine outside the strangulation section, but the difference is not statistically significant. © 2021 Surgical Society of Kenya. All rights reserved. |
Intestinal ischemia; Intestinal strangulation release; Intestine injury; Ischemia-reperfusion injury; Malondialdehyde |
ketamine; malonaldehyde; xylazine; animal experiment; animal model; animal tissue; Article; controlled study; histopathology; ileum; intestinal strangulation; intestine injury; intestine ischemia; intestine necrosis; laparotomy; male; nonhuman; oxidative stress; rat; reperfusion injury; sham procedure; small intestine obstruction; small intestine resection; Sprague Dawley rat |
Surgical Society of Kenya |
19999674 |
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Article |
Q4 |
114 |
27851 |
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