237 |
Suhaeri M., Kim Y.-M., Yunarti R.T., Song S.-C. |
56183087500;57294592700;56086215900;7403350156; |
Thermoresponsive and suspension forming cyclotriphosphazene conjugate for delivery vehicle of antitumor drug camptothecin |
2021 |
Journal of Drug Delivery Science and Technology |
64 |
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102049 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116958285&doi=10.1016%2fj.jddst.2020.102049&partnerID=40&md5=e52dca3896e5c2ec2892116e880dc19c |
Unit of Education, Research and Training, Universitas Indonesia Hospital, Universitas Indonesia, Depok, 16424, Indonesia; Medical Technology Research Cluster, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, 10430, Indonesia; Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, 10430, Indonesia; Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science & Technology, Seoul, 02792, South Korea; Inorganic Chemistry Research Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus UI Baru, Depok, Jawa Barat 16424, Indonesia; Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, South Korea |
Suhaeri, M., Unit of Education, Research and Training, Universitas Indonesia Hospital, Universitas Indonesia, Depok, 16424, Indonesia, Medical Technology Research Cluster, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, 10430, Indonesia, Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, 10430, Indonesia; Kim, Y.-M., Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science & Technology, Seoul, 02792, South Korea, Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, South Korea; Yunarti, R.T., Inorganic Chemistry Research Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus UI Baru, Depok, Jawa Barat 16424, Indonesia; Song, S.-C., Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science & Technology, Seoul, 02792, South Korea, Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, South Korea |
Camptothecin (CPT) has been used as antitumor drug against a wide range of cancer cells. However, its clinical application is greatly hindered by insolubility and instability issues under physiological condition. Therefore, an appropriate CPT administration technique directed for living system is greatly anticipated. In this study, a delivery method for CPT in the form of thermoresponsive system was prescribed. A conjugate of cyclotriphosphazene and CPT was synthesized by substituting hexachlorocyclotriphosphazene with sodium salt of methoxy-poly (ethylene glycol) (Mw = 350), 20-O-trifluoroglycinylCPT, and isoleucine ethyl ester, respectively. The resulting cyclotriphosphazene-CPT was characterized via multinuclear (1H and 31P) NMR as well as FT-IR. The current conjugate showed temperature induced phase transition (solution to suspension) with a lower critical solution temperature at 31 °C. Our result indicated that the stability issue related to the use of CPT in aqueous solution could be handled by acylation at 20-OH moiety. Additionally, antitumor activity of cyclotriphosphazene-CPT, to some extent, was found to be more profound than that of CPT alone as evaluated against human colorectal cancer cell HCT-116. Altogether, the current cyclotriphosphazene-CPT conjugate might offer a facile method in delivering CPT as a minimally invasive system for treating cancer. © 2020 Elsevier B.V. |
Antitumor; Camptothecin; Conjugate; Cyclotriphosphazene; Drug delivery; Thermoresponsive |
camptothecin; hexachlorocyclotriphosphazene; isoleucine; macrogol; polymer; sodium; unclassified drug; antineoplastic activity; Article; critical solution temperature; drug conjugation; drug delivery system; drug structure; drug synthesis; Fourier transform infrared spectroscopy; HCT 116 cell line; human; human cell; phase transition; phosphorus nuclear magnetic resonance; proton nuclear magnetic resonance; temperature |
Editions de Sante |
17732247 |
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Article |
Q2 |
663 |
7562 |
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