|
No records
|
|
495 |
Nadhif M.H., Assyarify H., Irsyad M., Pramesti A.R., Suhaeri M. |
57189057498;57220927630;57220935587;57222624921;56183087500; |
Recent advances in 3D printed wound dressings |
2021 |
AIP Conference Proceedings |
2344 |
|
020021 |
|
|
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103522380&doi=10.1063%2f5.0047183&partnerID=40&md5=494f3e384ff38d4974127c234d704499 |
Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Unit of Education, Research, and Training, Universitas Indonesia Hospital, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia |
Nadhif, M.H., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Assyarify, H., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Irsyad, M., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Pramesti, A.R., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Suhaeri, M., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Unit of Education, Research, and Training, Universitas Indonesia Hospital, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia |
Chronic and acute wounds interfere with personal aesthetics and appearance. Regarding the problematics, researchers enhance the functionalities of wound dressings. One of the enhancement approaches is using 3D printing technology. The use of 3D printing has enabled many types of wound dressings, including biodegradable multi-material, cell-laden, and drug-eluting wound dressings. The use of 3D printing even allows for a wound dressing with a 3D construct, facilitating the wound dressing placement at the wound bed. Unfortunately, the 3D printed wound dressing technology has never been reviewed, to the extent of our knowledge. In this report, we aim to reflect on the recent advances in 3D printed wound dressings. Reports regarding the 3D printed wound dressing were collected from the Google Scholar database. The search was limited from 2015 to 2020 with a logic search: "3D printed"AND "wound dressing,"which words can be found in the entire article. Irrelevant reports were excluded manually, thereby resulting in the 24 selected articles. The selected articles were subsequently reviewed in terms of the materials-efficacy analysis and 3D printing mechanism. The extracted information from all articles concluded that alginate is the most used material for 3D printed wound dressing, while the most used 3D printing mechanism is the pneumatic FDM. In terms of efficacy, wound dressings presented an antimicrobial performance against Gram-positive and Gram-negative bacteria, as well as biocompatibility to epidermis and dermis cells. © 2021 Author(s). |
|
|
American Institute of Physics Inc. |
0094243X |
9780735440869 |
|
Conference Paper |
- |
177 |
20880 |
|
|
|
496 |
Utomo M.S., Asmaria T., Malau D.P., Triwardono J., Kartika I., Dilogo I.H., Rahyussalim A.J. |
56180933900;57212340647;57208306899;57214135764;57218158170;56161962800;55212166100; |
Design criteria for cementless total hip arthroplasty: A retrospective study from cadaver implantation |
2021 |
AIP Conference Proceedings |
2344 |
|
020019 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103521074&doi=10.1063%2f5.0047288&partnerID=40&md5=d88d2b334a37cee012b14dd1543e1689 |
Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Department of Orthopedics and Traumatology, RSUPN Cipto Mangunkusumo, Jl. Diponegoro No. 71, Salemba, Jakarta, 10430, Indonesia |
Utomo, M.S., Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Asmaria, T., Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Malau, D.P., Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Triwardono, J., Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Kartika, I., Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Dilogo, I.H., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Department of Orthopedics and Traumatology, RSUPN Cipto Mangunkusumo, Jl. Diponegoro No. 71, Salemba, Jakarta, 10430, Indonesia; Rahyussalim, A.J., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Department of Orthopedics and Traumatology, RSUPN Cipto Mangunkusumo, Jl. Diponegoro No. 71, Salemba, Jakarta, 10430, Indonesia |
Total hip arthroplasty (THA) is the most frequent arthroplasty procedure performed worldwide including in Indonesia. To support Indonesian government initiative to establish a generic domestic THA implant, Research Center for Metallurgy and Materials - Indonesian Institute of Sciences in cooperation with Universitas Indonesia has designed and realized set of cementless titanium-based THA implant. Here we reported the result of first cadaver implantation for cementless titanium-based THA implant in Indonesia. There are three sets of cementless titanium-based THA implants implanted into the left leg of three cadavers. Implantation was performed simultaneously by three groups of orthopedic surgeons. There are three major aspects as evaluation from the cadaver implantation: design, material, and instrumentation. The current cementless titanium-based THA implant was designed based on the same template, material specification, process, and implanted using standard commercial instrumentation. As further directives, it is required to develop the cementless titanium-based THA implants with various shape and sizing in regard of Indonesia domestic requirement, appropriate coating for cementless implantation, refined material properties to facilitate the fabrication process, and customized instrumentation as a whole set of development within the development of the cementless titanium-based THA implant. © 2021 Author(s). |
|
|
American Institute of Physics Inc. |
0094243X |
9780735440869 |
|
Conference Paper |
- |
177 |
20880 |
|
|
|
497 |
Utomo M.S., Nadhif M.H., Bayani G.F.E., Whulanza Y. |
56180933900;57189057498;57222627409;36807053500; |
A low cost, off-the-shelf bioreactor as enabling technology for physiological modeling |
2021 |
AIP Conference Proceedings |
2344 |
|
050017 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103516555&doi=10.1063%2f5.0047233&partnerID=40&md5=321c75b01f581669d0c6f955fe9b2966 |
Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Department of Physiology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia |
Utomo, M.S., Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Nadhif, M.H., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Bayani, G.F.E., Department of Physiology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Whulanza, Y., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia |
Nowadays, tissue engineering has become a primary option for clinical treatment involving tissue damage or organ failure. One important enabling technological aspect for tissue engineering to produce successful outcomes is bioreactor where cells could be grown under certain conditions mimicking real physiological conditions and be prepared for in vivo integration before implantation to the patients. Physical stimulation by mechanical and electrical means could improve the development of engineered tissue to mimic the actual tissue. Mechanical stimulation could improve cellular function by improving the integrity and organization of the engineered tissue while electrical stimulation can improve the conductivity and contractility of tissue construction. The electric field would stimulate cellular calcium activity which could stimulate cell integration and gap junction formation. Thus, it is necessary to develop a bioreactor that is capable to provide a well-controlled environment and proper combination of mechanical and electrical stimulation to optimize the process of tissue engineering. Here we build a bioreactor that is capable to stimulate the engineered tissue mechanically and electrically to improve the tissue's contractile performance and functional maturity through an isovolumic contraction. The mechanical stimulation is generated by harmonic inflation and deflation of a balloon while the electrical stimulation is generated from a pair of carbon electrodes. The mechanical and electrical stimulations could function independently to each other. The bioreactor was successfully constructed and passed the functional test and ready for actual application for tissue engineering. © 2021 Author(s). |
|
|
American Institute of Physics Inc. |
0094243X |
9780735440869 |
|
Conference Paper |
- |
177 |
20880 |
|
|
|
498 |
Supriadi S., Rachman P., Saragih A.S., Whulanza Y., Rahyussalim A.J., Triwidodo A. |
16040272500;57222619791;24339579800;36807053500;55212166100;57222626174; |
Design, development, and finite element study on the novel biomimetic lumbosacroiliac prosthesis |
2021 |
AIP Conference Proceedings |
2344 |
|
050021 |
|
|
|
5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103512681&doi=10.1063%2f5.0047182&partnerID=40&md5=ceda670f69efa9020569efb213e95b5e |
Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10320, Indonesia |
Supriadi, S., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Rachman, P., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Saragih, A.S., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Whulanza, Y., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Rahyussalim, A.J., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10320, Indonesia; Triwidodo, A., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10320, Indonesia |
This study focused on the design of specific prostheses in the case of patients affected by Chordoma of the lumbar 4, lumbar 5, sacrum, and coccyx. A chordoma is a group of malignant and rare cancers, commonly found in the spine or skull bones. As a treatment method, if cancer has not spread beyond the bone, the infected bone's removal procedure is replaced with an artificial bone (prosthesis). The design method is carried out using a CT Scan of patient data, which is processed into a 3D model with Materialise Mimics software, 3D model engineering is done using Solidworks software and finite element analysis with ANSYS. The design process is carried out with several kinds of design variations, including the bone-implant model with a solid and shell model which is divided into several components, the use of iliac screw lateral connector, modification of iliac screw locking head, and modification of iliac screw locking head with cross connector. From the results of the calculation analysis and simulation, the best concept chosen based on the lowest dominant Peak von Mises Stress value in the iliac screw section is designs using the Iliac Screw Locking Head with Shell Model Lattice Structure. © 2021 Author(s). |
3d bone modeling; Chordoma; lumbar; pedicle screw; prosthesis; pull out; sacrum; simulation |
|
American Institute of Physics Inc. |
0094243X |
9780735440869 |
|
Conference Paper |
- |
177 |
20880 |
|
|
|
499 |
Pangjaya L.F., Khaerunnisa S., Mazfufah N.F., Budiman R.L., Antarianto R.D. |
57222624829;57221948155;57215595521;57222627263;57190862806; |
Investigating different type of ovary cancer cell line for NK cell in vitro co-culture cytotoxic assay |
2021 |
AIP Conference Proceedings |
2344 |
|
040010 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103511346&doi=10.1063%2f5.0049155&partnerID=40&md5=34e5a053702d387eeb6890faa2868915 |
Biology Undergraduate Program, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia |
Pangjaya, L.F., Biology Undergraduate Program, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Khaerunnisa, S., Biology Undergraduate Program, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Mazfufah, N.F., Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Budiman, R.L., Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Antarianto, R.D., Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia, Department of Histology, Faculty of Medicine, Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia |
Ovarian cancer is one of the gynecologic cancers with a high mortality rate and increased incidence. Surgery and therapies are used to treat ovarian cancer patients. Therapies such as chemotherapy and radiotherapy can cause resistance therefore immunotherapy using natural killer (NK) cells can be an alternative therapy. NK cells have shown an important role in anticancer activity because it is able to kill target cells without prior sensitization and can acquire immunology memory. However, NK cells as immunotherapy have low capacity and efficacy on infiltrating ovarian cancer's tumor microenvironment. To overcome these NK cells need to be induced with certain antigen resulting in enhanced NK cells. Enhanced NK cells display a higher cytotoxic activity that can be seen by co-culturing enhanced NK cells with ovarian cancer cell lines. In this mini-review, the selection of ovarian cancer cell lines was displayed to offer reliable consideration to obtain the expected research endpoint. © 2021 Author(s). |
co-culture; cytotoxic assay; NK cells; ovarian cancer; ovarian cancer cell lines |
|
American Institute of Physics Inc. |
0094243X |
9780735440869 |
|
Conference Paper |
- |
177 |
20880 |
|
|
|
500 |
Hartanto J., Purwaningsih E.H., Krisnamurti D.G.B. |
57222620672;57186723500;55934951600; |
Administration of Centella asiatica ethanolic extract reduces tumor necrosis factor-alpha in hearts of aged sprague-dawley rats but not kidneys |
2021 |
AIP Conference Proceedings |
2344 |
|
040012 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103510292&doi=10.1063%2f5.0048269&partnerID=40&md5=5a0382b6ee463f35130ebe47cde75fd1 |
Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Jakarta, 10430, Indonesia; Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Jakarta, 10430, Indonesia; Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Jakarta, 10430, Indonesia |
Hartanto, J., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Jakarta, 10430, Indonesia; Purwaningsih, E.H., Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Jakarta, 10430, Indonesia, Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Jakarta, 10430, Indonesia; Krisnamurti, D.G.B., Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Jakarta, 10430, Indonesia, Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Jakarta, 10430, Indonesia |
Aging is a time-related process leading to progressive deterioration of physiological bodily functions and increased vulnerability to degenerative disorders. The current trend of rapid growth in the global aging population poses a challenge for healthcare due to the increasing incidence of chronic diseases. In spite of this, preventive anti-aging agents such as vitamin supplements are not adequately available in many countries. Centella asiatica (CA), a traditional herb native to Southeast Asia, has been widely studied and demonstrated potent anti-inflammatory, antioxidant, neuroprotective, wound healing, and vasculoprotective effects in clinical studies. This study investigates the effect of CA treatment on aged Sprague-Dawley (SD) rats. Twenty-four rats were divided into four groups: positive control (vitamin E 6 IU), negative control (placebo), treatment group (CA 300 mg/kgBW), and comparison group (young SD rats with placebo). After 28 days of treatment, SD rats were terminated. TNF-a concentration in heart and kidney tissues were determined using enzyme-linked immunosorbent assay. We found that CA showed a significant decrease in heart TNF-alpha (p = 0.021) yet yields no statistically significant decrease in kidney TNF-alpha levels (p = 0.617). However, it was possible to identify a trend toward decreasing kidney TNF-a concentration in groups treated with CA as it was lower than the positive and negative control group. Our finding suggests different aging pathophysiology in different body organs and CA's potential as an anti-aging agent, corresponding to previous studies showing potent anti-inflammatory effects of CA in multiple organs. All in all, further research and exploration need to be made on aging pathophysiology and CA with variations of a more significant dose and longer time of administration. © 2021 Author(s). |
aging; Centella asiatica; oxidative stress; tumor necrosis factor-alpha |
|
American Institute of Physics Inc. |
0094243X |
9780735440869 |
|
Conference Paper |
- |
177 |
20880 |
|
|
|
501 |
Sutanto R.L., Purwaningsih E.H., Krisnamurti D.G.B. |
57222060277;57186723500;55934951600; |
Antiaging effects of Acalypha indica L. extract administration on tumor necrosis factor-a (TNF-a) protein level in major organs of aged Sprague-Dawley rats |
2021 |
AIP Conference Proceedings |
2344 |
|
040011 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103498448&doi=10.1063%2f5.0048267&partnerID=40&md5=0c80797e53b938c80ec492fb2905bba1 |
Undergraduate Student, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia |
Sutanto, R.L., Undergraduate Student, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Purwaningsih, E.H., Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia, Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Krisnamurti, D.G.B., Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia, Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia |
Non-communicable diseases, such as cardiovascular diseases or kidney dysfunctions, tend to have expensive and unavailable treatments. This fact, coupled with the rising trend of such diseases, means that priority should be given towards preventive measures. One such measure is the administration of antioxidants to counter the increasing inflammatory markers, such as TNF-a, in the pathogenesis of chronic non-communicable diseases. However, the usage of synthetic antioxidants chronically may incur side effects and expensive. Indonesia is home to diverse sorts of vegetations as an agricultural power, such as Acalypha indica L. (AI). AI has been used empirically by cultures across the globe and is found to have antioxidant properties. This study was conducted on aged Sprague-Dawley rats. Rats were divided into four groups, the negative control (placebo), positive control using 6 IU vitamin E, treatment group using 250 mg/kg of body weight (mg/kg BW) AI extract, and control using young rats. The rats were then terminated after 28 days, and the major organs, kidneys, and hearts were examined using ELISA to look for TNF-a concentration. Data collected were analyzed using Saphiro-Wilk test and one-way ANOVA. AI administration yielded a decrease of TNF-a in both the kidneys (0.95 ± 0.76 pg/mg in the treatment group vs. 1.37 ± 0.41 pg/mg in the negative control) and hearts (15.43 pg/mg ± 2.33 in the treatment group vs. 16.50 ± 1.33 pg/mg in the negative control), of aged SD rats, albeit insignificantly. A relatively short time of treatment in this study could be attributed to the insignificant decrease in kidney and cardiac tissue. Nevertheless, this finding of decreased TNF-a suggests a potential anti-inflammatory and antiaging effect of AI. Further research suggestions on the investigation of AI are using longer time of treatment and other test subjects. © 2021 Author(s). |
Acalypha indica; Aging; heart; kidney; TNF-a |
|
American Institute of Physics Inc. |
0094243X |
9780735440869 |
|
Conference Paper |
- |
177 |
20880 |
|
|
|
502 |
Zakaria H., Setiawan R., Mayza A. |
24465810100;57210969274;57211585788; |
Analysis of quantitative EEG (QEEG) parameters on post-stroke patients undergoing static bicycle and mirror combination therapy |
2021 |
AIP Conference Proceedings |
2344 |
|
050006 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103495833&doi=10.1063%2f5.0047217&partnerID=40&md5=194ec9233261b2f6297da53ee96182d2 |
School of Electrical Engineering and Informatics, Bandung Institute of Technology (ITB), Ganesa 10, Bandung, West Java, 40119, Indonesia; Neurology Department and Cluster of Medical Technology IMERI, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Central Jakarta, 10430, Indonesia |
Zakaria, H., School of Electrical Engineering and Informatics, Bandung Institute of Technology (ITB), Ganesa 10, Bandung, West Java, 40119, Indonesia; Setiawan, R., School of Electrical Engineering and Informatics, Bandung Institute of Technology (ITB), Ganesa 10, Bandung, West Java, 40119, Indonesia; Mayza, A., School of Electrical Engineering and Informatics, Bandung Institute of Technology (ITB), Ganesa 10, Bandung, West Java, 40119, Indonesia, Neurology Department and Cluster of Medical Technology IMERI, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Central Jakarta, 10430, Indonesia |
Stroke causes neurological disorders such as reduced muscle motor skills, as well as cognitive, visual, and coordination functions, significantly. The reduced level of independence and mobility of a person can affect their quality of life. Previous research used static bicycles or mirrors for stroke therapy. This work combined both static bicycle and mirror therapy for post-stroke patients. This study aimed to find quantitative EEG parameters that can be used to characterize neurological change. The expected decrease in the average relative power of delta and theta then increased alpha and beta. Twelve post-stroke patients and twelve healthy subjects were given 2 tasks: imaginary (motor imagery) and action (motor execution). The electrodes were placed on 8 points with 10-20 localization principle rules. Data were analyzed and tested using linear regression and paired t. The result showed that static bicycle and mirror combination therapy affects a subject group of right stroke patients than a subject group of left stroke patients. When given imaginary session (motor imagery), in relative power of delta-band frequency of right stroke patients decreased by -18.65 ± 4.9% (p = 0.0001) and action session (motor execution) by -11.23 ± 6.1% (p = 0.0035), while average relative power of theta frequency band only decreased significantly by -6.03 ± 6.4% (p = 0.0429) an imaginary session. Then, this therapy also succeeded in enhancement relative power of alpha frequency band when given imaginary session, i.e 5.45 ± 4.2% (p = 0.0161) and action session, i.e 6.92 ± 4.6% (p = 0.0024). Furthermore, the relative power of the beta frequency band also increased when given an imaginary session by 19.23 ± 9.1% (p = 0.0026) and action session by 7.29 ± 7.5% (p = 0.0194). In conclusion, relative power, amplitude, and time (latency) of P300 and C3 to C4 ratio indicated improved health data, especially for right stroke patient subjects during therapy. © 2021 Author(s). |
Combination Therapy; Mirror; Post-Stroke Patients; QEEG; Static Bicycle |
|
American Institute of Physics Inc. |
0094243X |
9780735440869 |
|
Conference Paper |
- |
177 |
20880 |
|
|
|
503 |
Putri N.M., Kreshanti P., Tunjung N., Indania A., Basuki A., Sukasah C.L. |
57192904294;36192866200;57208446370;57195935195;57201667022;57218391534; |
Efficacy of honey dressing versus hydrogel dressing for wound healing |
2021 |
AIP Conference Proceedings |
2344 |
|
020022 |
|
|
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103495468&doi=10.1063%2f5.0047363&partnerID=40&md5=961e15f5dfacb7b7506f8a12294a1104 |
Plastic and Reconstructive Division, Department of Surgery, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus Baru UI, Depok, West-Java, 16424, Indonesia; Plastic and Reconstructive Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia |
Putri, N.M., Plastic and Reconstructive Division, Department of Surgery, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kreshanti, P., Plastic and Reconstructive Division, Department of Surgery, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus Baru UI, Depok, West-Java, 16424, Indonesia; Tunjung, N., Plastic and Reconstructive Division, Department of Surgery, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Indania, A., Plastic and Reconstructive Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Basuki, A., Plastic and Reconstructive Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Sukasah, C.L., Plastic and Reconstructive Division, Department of Surgery, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: The field of plastic surgery involves wounds, such as acute and chronic or non-healing wounds. The mortality and morbidity inflicted by wounds may be substantial. To enhance wound healing and decrease morbidity and mortality, wound dressing selection is critical. Hydrogel dressing is a modern dressing that is versatile for various clinical situations. Nevertheless, a hydrogel may be expensive and not always readily available. Since the Egyptian period, honey has been used as a dressing, which was suggested to have an antimicrobial, anti-inflammatory, and immunomodulatory effect. Aim: To compare hydrogel and honey as dressing for all types of wounds in terms of wound healing time and slough production. Method: We conducted literature searching in multiple online databases using the keywords "wound", "honey"or "honey dressing", "hydrogel"or "hydrogel dressing", "healing time", and "slough"or "necrotic tissue". Key terms were combined using Boolean operators and also searched using Medical Subheading (MeSH terms). Literature searches were conducted in the following databases; ProQuest, MEDLINE, Ebsco, EMBASE, Cochrane, Scopus, and Science Direct for randomized-controlled trial studies. Results: Literature searching yielded two randomized-controlled trials. Critical appraisal revealed that both studies were deemed valid. Honey dressing were similar to hydrogel dressing in terms of healing time 30.3 ± 6.7 (7-58) days vs. 33.2 ± 5.4 (14-61) days; 16.08 (12.3-19.9) days vs 17.12 (11.7-22.5) days; 17.13 (13.1-21.1) days vs 16.53 (12.3-20.8) days, respectively. However, Honey group has a slightly higher risk of slough production with an absolute risk increase of 4% for the non-HIV group and 3% for the combined group (HIV and non-HIV). Conclusion: The efficacy of honey as a wound dressing is equivalent to hydrogel for treating wounds in terms of wound healing duration. Nevertheless, the risk of slough production is slightly higher in the honey group. © 2021 Author(s). |
Acute wound; chronic wound; healing time; honey dressing; hydrogel dressing |
|
American Institute of Physics Inc. |
0094243X |
9780735440869 |
|
Conference Paper |
- |
177 |
20880 |
|
|
|
504 |
Adawiyah R., Alhaq A.H., Mandala D.K., Sahlan M., Pratami D.K., Farida S. |
57208658742;57222626933;57216338830;57189182661;57200370046;57193707159; |
The effectivity of Indonesian propolis from Tetragonula biroi bee as an antifungal agent for Candida sp. And Cryptococcus neoformans |
2021 |
AIP Conference Proceedings |
2344 |
|
040013 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103494652&doi=10.1063%2f5.0047205&partnerID=40&md5=38e06697e888ef36f79129d52eb047f1 |
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Study Program of Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, West Java, 16424, Indonesia; Undergraduate Programm, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, West Java, 16424, Indonesia; Lab of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Pancasila University, Jakarta, 12640, Indonesia; Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Adawiyah, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Study Program of Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, West Java, 16424, Indonesia; Alhaq, A.H., Undergraduate Programm, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Mandala, D.K., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, West Java, 16424, Indonesia; Sahlan, M., Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, West Java, 16424, Indonesia, Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, West Java, 16424, Indonesia; Pratami, D.K., Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, West Java, 16424, Indonesia, Lab of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Pancasila University, Jakarta, 12640, Indonesia; Farida, S., Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, West Java, 16424, Indonesia, Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
In recent years, there has been an increase in the incidence of fungal infections accompanied by a decrease in susceptibility to fluconazole as one of the drug choices for fungal infections. So that it needs to be considered the existence of an alternative drug that is effective and also expected to have a minimal side effect, one of which is Propolis. This research was done to determine the effectivity of Indonesian Propolis from Tetragonula biroi bee on the growth of Candida sp. and Cryptococcus neoformans. An experimental study to test the susceptibility of Propolis using disc diffusion technique performed on six types of fungi, e.g. Candida albicans, Candida glabrata, Candida parapsilosis, Candida krusei, Candida tropicalis, dan Cryptococcus neoformans. The samples tested were Indonesian propolis emulsion from Tetragonula biroi bee with a concentration of 10 mg/ml, 50 mg/ml, and 70 mg/ml. The sample selection based on the result of "Exploration of Antifungal Potential of Indonesian Propolis from Tetragonula biroi Bee"from the Faculty of Engineering, University of Indonesia. Indonesian Propolis emulsion from Tetragonula biroi bee can inhibit the growth of Candida sp., especially Candida glabrata and Candida krusei, and also Cryptococcus neoformans with an optimum concentration of 10 mg/ml. The lower concentration than 10 mg/ml of Indonesian Propolis emulsion from Tetragonula biroi bee could be considered to provide more optimal results. © 2021 Author(s). |
fungal infection; Indonesian; Propolis; susceptibility test |
|
American Institute of Physics Inc. |
0094243X |
9780735440869 |
|
Conference Paper |
- |
177 |
20880 |
|
|
