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901 |
Kadosh K.C., Muhardi L., Parikh P., Basso M., Mohamed H.J.J., Prawitasari T., Samuel F., Ma G., Geurts J.M.W. |
12243251700;57216729101;35269493300;57221482131;41861368100;57190686255;14421774000;57199673360;57197926057; |
Nutritional support of neurodevelopment and cognitive function in infants and young children—an update and novel insights |
2021 |
Nutrients |
13 |
1 |
199 |
1 |
26 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099415887&doi=10.3390%2fnu13010199&partnerID=40&md5=9754b1ffd94e454fc9ae27ba058537af |
School of Psychology, University of Surrey, Guildford, GU2 7XH, United Kingdom; FrieslandCampina AMEA, Singapore, 039190, Singapore; Department of General Psychology, University of Padova, Padova, 35131, Italy; Nutrition and Dietetics Programme, School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Malaysia; Nutrition and Metabolic Diseases Working Group, Indonesian Pediatric Society, Jakarta, 10310, Indonesia; Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusomo National Referral Hospital Jakarta, Jakarta, 10430, Indonesia; Department of Human Nutrition, University of Ibadan, Ibadan, 200284, Nigeria; Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 10019, China; Laboratory of Toxicological Research and Risk assessment for Food Safety, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191, China; FrieslandCampina, Amersfoort, 3818 LE, Netherlands |
Kadosh, K.C., School of Psychology, University of Surrey, Guildford, GU2 7XH, United Kingdom; Muhardi, L., FrieslandCampina AMEA, Singapore, 039190, Singapore; Parikh, P., FrieslandCampina AMEA, Singapore, 039190, Singapore; Basso, M., School of Psychology, University of Surrey, Guildford, GU2 7XH, United Kingdom, Department of General Psychology, University of Padova, Padova, 35131, Italy; Mohamed, H.J.J., Nutrition and Dietetics Programme, School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Malaysia; Prawitasari, T., Nutrition and Metabolic Diseases Working Group, Indonesian Pediatric Society, Jakarta, 10310, Indonesia, Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusomo National Referral Hospital Jakarta, Jakarta, 10430, Indonesia; Samuel, F., Department of Human Nutrition, University of Ibadan, Ibadan, 200284, Nigeria; Ma, G., Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 10019, China, Laboratory of Toxicological Research and Risk assessment for Food Safety, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191, China; Geurts, J.M.W., FrieslandCampina, Amersfoort, 3818 LE, Netherlands |
Proper nutrition is crucial for normal brain and neurocognitive development. Failure to optimize neurodevelopment early in life can have profound long-term implications for both mental health and quality of life. Although the first 1000 days of life represent the most critical period of neurodevelopment, the central and peripheral nervous systems continue to develop and change throughout life. All this time, development and functioning depend on many factors, including adequate nutrition. In this review, we outline the role of nutrients in cognitive, emotional, and neural development in infants and young children with special attention to the emerging roles of polar lipids and high quality (available) protein. Furthermore, we discuss the dynamic nature of the gut-brain axis and the importance of microbial diversity in relation to a variety of outcomes, including brain maturation/function and behavior are discussed. Finally, the promising therapeutic potential of psychobiotics to modify gut microbial ecology in order to improve mental well-being is presented. Here, we show that the individual contribution of nutrients, their interaction with other micro-and macronutrients and the way in which they are organized in the food matrix are of crucial importance for normal neurocognitive development. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Brain; Childhood; Gut-brain axis; Kynurenine; Minerals; Neurodevelopment; Polar lipids; Polyunsaturated fatty acids; Prebiotics; Probiotics; Protein quality; Tryptophan; Tyrosine; Vitamins |
amino acid; branched chain amino acid; cyanocobalamin; iodine; iron; lipid; long chain fatty acid; mammalian target of rapamycin complex 1; phenylalanine; polar lipid; polyunsaturated fatty acid; prebiotic agent; probiotic agent; retinol; trace element; tryptophan; tyrosine; unclassified drug; vitamin D; zinc; fatty acid; kynurenine; mineral; brain development; child; cognition; emotion; human; infant; infant nutrition; intestine flora; macronutrient; nerve cell differentiation; nonhuman; nutritional support; protein intake; protein quality; Review; brain; cognitive aging; food; growth, development and aging; preschool child; quality of life; Brain; Child, Preschool; Cognition; Cognitive Aging; Emotions; Fatty Acids; Food; Gastrointestinal Microbiome; Humans; Infant; Kynurenine; Minerals; |
MDPI AG |
20726643 |
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33435231 |
Review |
Q1 |
1418 |
2497 |
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902 |
Bahtiar A., Miranda A.J., Arsianti A. |
35365874400;57221531432;36124567000; |
The effect of artocarpus altilis (parkinson) fosberg extract supplementation on kidney ischemia-reperfusion injury rat |
2021 |
Pharmacognosy Journal |
13 |
1 |
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150 |
154 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099365078&doi=10.5530%2fpj.2021.13.21&partnerID=40&md5=13b866767b1597a22566e8ac646a0b9f |
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Kampus UI Salemba, Jakarta, Indonesia |
Bahtiar, A., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Miranda, A.J., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Arsianti, A., Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Kampus UI Salemba, Jakarta, Indonesia |
Background: Acute kidney injury (AKI) is a kidney disease resulting in high morbidity and mortality levels in humans. One of the disorders classified as AKI is ischemia-reperfusion injury (IRI), characterized by two phases. The first phase is Ischemia in the kidneys due to obstruction of the renal arteries or veins, followed by the second phase, which is the occurrence of reperfusion with blood flowing back in the renal arteries veins. The aim of this current research is to analyze the efficacy of Artocarpus altilis on Kidney ischemia-reperfusion model rats. Methods: To this end, first, we established Ischaemia-reperfusion kidney injury rat. We then evaluated the Artocarpus altilis extract on IRI model rats. A total of 36 rats have grouped into six groups. Group I is the Sham group, Group II is the negative control group, Group III is the positive control group (vitamin C 100 mg/kg BW), Group IV is Dose I of Artocarpus altilis extract 50 mg/kg BW), Group V is Dose II Artocarpus altilis extract 100 mg/kg BW), Group VI is Dose III Artocarpus altilis extract 200 mg/kg BW). The vitamin C and Artocarpus altilis extract administered 14 days before and after Ischemia-reperfusion treatment. At day 0, Ischemia was made by bilateral renal pedicle clamping method for 30 minutes, sacrificed 14 days after reperfusion. The blood and histology samples were collected on day 0, a day after reperfusion, at 24 hrs after reperfusion, at 48 hrs after reperfusion, and 14 days after treatment. Results: The clamping duration of 30 minutes leads to achieving the most representative clinical IRI conditions. It shows the most significant recovery of injury conditions within the 14-day reperfusion period in IRI animal models, making it ideal for IRI operations for the preliminary test. The administration of 100 mg/kg BW of Artocarpus altilis extract could reduce the malondialdehyde plasma compared with the sham group. The SOD and Catalase activity showed improvement after reperfusion. Conclusion: Artocarpus altilis extracts showed antioxidant activity to prevent the kidney from ischemia-reperfusion injury by modulated SOD and Catalase. © 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
Acute kidney disease; Artocarpus altilis (Parkinson) Fosberg; Free radicals; Reperfusion injury; Sukun |
antiinflammatory agent; antioxidant; Artocarpus altilis extract; ascorbic acid; catalase; creatinine; malonaldehyde; nitrogen; plant extract; protective agent; superoxide dismutase; unclassified drug; urea; animal experiment; animal model; animal tissue; antiinflammatory activity; antioxidant activity; Article; blood sampling; controlled study; creatinine blood level; dose response; drug efficacy; enzyme activity; enzyme blood level; glomerulus filtration rate; histopathology; male; nonhuman; rat; renal ischemia reperfusion injury; renal protection; supplementation; treatment duration; urea nitrogen blood level |
EManuscript Technologies |
09753575 |
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Article |
Q3 |
268 |
15961 |
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903 |
Kusmardi K., Wiyarta E., Estuningtyas A., Sahar N., Midoen Y.H., Tedjo A. |
56966625300;57221521342;55650360200;57212464367;57197805109;57189320451; |
Potential of phaleria macrocarpa leaves ethanol extract to upregulate the expression of caspase-3 in mouse distal colon after dextran sodium sulphate induction |
2021 |
Pharmacognosy Journal |
13 |
1 |
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23 |
29 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099343021&doi=10.5530%2fpj.2021.13.4&partnerID=40&md5=8dd1b8ac126d5a96f41668c2f3066c1f |
Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Department Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia |
Kusmardi, K., Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Estuningtyas, A., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Sahar, N., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Midoen, Y.H., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Tedjo, A., Department Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia |
Ulcerative colitis (UC) is a part of incurable chronic inflammatory disease that has gained importance over the past few decades. A lot of research has been done to find effective treatments for UC, one of which is herbal medicine. Phaleria macrocarpa (PM), an Indonesian native plant, is thought to be an alternative therapy for UC because of its anti-inflammatory properties. Therefore, in this research, Phaleria macrocarpa Leaves Ethanol Extract (PMLEE) is used to assess its effect on UC by using Caspase-3 as apoptosis marker. PMLEE was made from dried material of PM that undergo maceration. Animals were separated into six groups: normal, negative control, positive control, and PMLEE groups (100, 200, 300 mg/kgBW). PMLEE was then injected to BALB/c mice that have been induced by dextran sodium sulphate (DSS) for 7 consecutive days. DSS is used to model UC in mice colon tissue. All animals were sacrificed and their colons were collected then stained with anti-Caspase-3. The stained sections were subsequently examined with ImageJ based on color intensity which generated H-Score as the results. Based on H-Score of each group, PMLEE 300mg has significantly upregulate the expression of Caspase-3 compare to the negative control (p=0.015). PMLEE also has a tendency to be dose dependent based on the significant difference between PMLEE doses. Therefore, it concludes that PMLEE is able to upregulate the expression of Caspase-3 in colon cells as in this study it was directly proportional. © 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
Apoptosis; Inflammation; Mahkota Dewa; Ulcerative colitis |
acetylsalicylic acid; alcohol; antiinflammatory agent; apoptotic protease activating factor 1; caspase 3; cytochrome c; dextran sulfate; Phaleria macrocarpa extract; plant extract; unclassified drug; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; apoptosis; Article; cell death; cell proliferation; colon tissue; controlled study; descending colon; dysplasia; medicinal plant; mitochondrion; mouse; nonhuman; Phaleria macrocarpa; plant leaf; protein expression; ulcerative colitis; upregulation |
EManuscript Technologies |
09753575 |
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Article |
Q3 |
268 |
15961 |
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904 |
Widaty S., Soebono H., Sunarto, Emilia O. |
57208261546;6508242918;57221528270;6504322013; |
Development of a new instrument to assess clinical performance of residents in dermatology-Venereology department |
2021 |
Asia Pacific Scholar |
6 |
1 |
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70 |
82 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099335332&doi=10.29060%2fTAPS.2021-6-1%2fOA2241&partnerID=40&md5=7ccb3f67cc4a32f511df79fd292001b5 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Indonesia; Department of Dermatology and Venereology Faculty of Medicine, Universitas Gadjah Mada, Indonesia; Pediatric Department, Faculty of Medicine, Universitas Gadjah Mada Indonesia, Indonesia; Medical Education Department, Faculty of Medicine, Universitas Gadjah Mada, Indonesia |
Widaty, S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Indonesia; Soebono, H., Department of Dermatology and Venereology Faculty of Medicine, Universitas Gadjah Mada, Indonesia; Sunarto, Pediatric Department, Faculty of Medicine, Universitas Gadjah Mada Indonesia, Indonesia; Emilia, O., Medical Education Department, Faculty of Medicine, Universitas Gadjah Mada, Indonesia |
Introduction: Performance assessment of residents should be achieved with evaluation procedures, informed by measured and current educational standards. The present study aimed to develop, test, and evaluate a psychometric instrument for evaluating clinical practice performance among Dermatology and Venereology (DV) residents. Methods: This is a qualitative and quantitative study conducted from 2014 to 2016. A pilot instrument was developed by 10 expert examiners from five universities to rate four video-recorded clinical performance, previously evaluated as good and bad performance. The next step was the application of the instrument to evaluate the residents which was carried out by the faculty of DV at two Universities. Results: The instrument comprised 11 components. There was a statistically significant difference (p < 0.001) between good and bad performance. Cronbach’s alpha documented high overall reliability (α = 0.96) and good internal consistency (α = 0.90) for each component. The new instrument correctly evaluated 95.0% of poor performance. The implementation study showed that inter-rater reliability between evaluators range from low to high (correlation coefficient α =0.79, p < 0.001). Conclusion: The instrument is a reliable and valid instrument for assessing clinical practice performance of DV residents. More studies are required to evaluate the instrument in different situation. © 2021 TAPS. All rights reserved. |
Clinical Assessment; Dermatology-Venereology; Instrument; Performance; Resident; Workplace-Based Assessment |
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National University of Singapore, Faculty of Law |
24249335 |
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Article |
#N/A |
#N/A |
#N/A |
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905 |
Aniwidyaningsih W., Elhidsi M., Sari A., Burhan E. |
25421525900;57203157152;57221412037;36058554600; |
Characteristics and outcomes of endobronchial tuberculosis therapy |
2021 |
Lung India |
38 |
1 |
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101 |
103 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099112158&doi=10.4103%2flungindia.lungindia-132-20&partnerID=40&md5=5591017e20ced501e613a0e37ddc0328 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Aniwidyaningsih, W., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Elhidsi, M., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Sari, A., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Burhan, E., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
[No abstract available] |
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ethambutol; isoniazid; pyrazinamide; rifampicin; steroid; adult; airway obstruction; balloon dilatation; bronchoscopy; clinical article; computer assisted tomography; endobronchial tuberculosis; female; human; Letter; lung tuberculosis; main bronchus; male; retrospective study; thorax radiography; treatment response |
Wolters Kluwer Medknow Publications |
09702113 |
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Letter |
Q3 |
457 |
10877 |
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906 |
Utami T.W., Putri H.M.A.R., Hellyanti T. |
57195720528;57221287879;57217993236; |
High Frequency of Malignant Transformations on Ovarian Mature Teratomas at a Single University Hospital, Jakarta, Indonesia (2015–2018) |
2021 |
Journal of Obstetrics and Gynecology of India |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098720629&doi=10.1007%2fs13224-020-01392-8&partnerID=40&md5=007db828cc36d3a44c192cdca5656bab |
Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Indonesia Army Hospital, Jakarta, Indonesia; Department of Pathological Anatomy, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Utami, T.W., Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Putri, H.M.A.R., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Indonesia Army Hospital, Jakarta, Indonesia; Hellyanti, T., Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Department of Pathological Anatomy, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
[No abstract available] |
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Springer |
09719202 |
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Article |
Q3 |
313 |
14416 |
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907 |
Rif’Ati L., Halim A., Lestari Y.D., Moeloek N.F., Limburg H. |
18233777300;57221267910;55695844500;6507038307;7003274856; |
Blindness and Visual Impairment Situation in Indonesia Based on Rapid Assessment of Avoidable Blindness Surveys in 15 Provinces |
2021 |
Ophthalmic Epidemiology |
28 |
5 |
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408 |
419 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098633293&doi=10.1080%2f09286586.2020.1853178&partnerID=40&md5=1271e1805bf327f6c5bde79d43fc953e |
National Institute for Health Research and Development (NIHRD, Ministry of Health Republic of Indonesia, Jakarta, Indonesia; Research Department, The Indonesian Eye Center, Cicendo Eye Hospital, Bandung, Indonesia; Ophthalmology Department, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Health Information Services, Grootebroek, Netherlands |
Rif’Ati, L., National Institute for Health Research and Development (NIHRD, Ministry of Health Republic of Indonesia, Jakarta, Indonesia; Halim, A., Research Department, The Indonesian Eye Center, Cicendo Eye Hospital, Bandung, Indonesia; Lestari, Y.D., Ophthalmology Department, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Moeloek, N.F., Ophthalmology Department, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Limburg, H., Health Information Services, Grootebroek, Netherlands |
Purpose: To report the latest data on blindness and visual impairment (VI) in Indonesia. Methods: Rapid Assessment of Avoidable Blindness (RAAB) surveys were done in 15 provinces in Indonesia between 2013 and 2017. The population of the study was people aged 50 +. In each province, the required number of clusters was selected with a probability proportionately to size. A weighted average analysis for prevalence, causes of visual impairment, and cataract surgical coverage (CSC) estimated the values of the country. Results: The prevalence of blindness in East Java was the highest at 4.4% (95% CI: 3.1–5.6%), followed by Nusa Tenggara Barat (NTB) at 4.0% (95% CI: 3.0–5.1%) and South Sumatra at 3.4% (95% CI: 2.4–4.4%). In number, blindness among people aged 50+ in East Java was the highest at 371,599, followed by West Java at 180,666 and Central Java at 176,977. Untreated cataract was the commonest cause of blindness in all provinces (range: 71.7% to 95.5%). CSCperson<3/60 and CSCperson<6/60 in Bali were the highest at 81.3% and 72.4%, respectively. Indonesia countrywide prevalence of blindness was 3.0%. The total number of people with VI (PVA less than 6/18 in the better eye) in Indonesia was 8,019,427, consisting of 1,654,595 of blindness and 6,364,832 of moderate and severe VI. Conclusion: The burden of blindness in Indonesia is high, and untreated cataract contributes the most. There is an urgent need to increase cataract surgical coverage by providing better access to cataract surgery services for all people in need. © 2020 Taylor & Francis Group, LLC. |
avoidable blindness; cataract; Indonesia; Prevalence; RAAB |
adult; Article; blindness; cataract; female; glaucoma; health care survey; human; Indonesian; Irian Jaya; major clinical study; male; middle aged; prevalence; probability; pterygium; refraction error; visual impairment; blindness; cataract; cataract extraction; cross-sectional study; Indonesia; low vision; prevalence; visual disorder; Blindness; Cataract; Cataract Extraction; Cross-Sectional Studies; Humans; Indonesia; Prevalence; Vision Disorders; Vision, Low |
Taylor and Francis Ltd. |
09286586 |
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33380229 |
Article |
Q2 |
728 |
6800 |
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908 |
Lazarus G., Audrey J., Wangsaputra V.K., Tamara A., Tahapary D.L. |
57214599425;57217634074;57215576000;57205305387;55944492500; |
High admission blood glucose independently predicts poor prognosis in COVID-19 patients: A systematic review and dose-response meta-analysis |
2021 |
Diabetes Research and Clinical Practice |
171 |
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108561 |
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20 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098602441&doi=10.1016%2fj.diabres.2020.108561&partnerID=40&md5=16a5cb07b3f5de39c14a9eb1370dcd17 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Lazarus, G., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Audrey, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wangsaputra, V.K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tamara, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tahapary, D.L., Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Aims: To investigate the prognostic value of admission blood glucose (BG) in predicting COVID-19 outcomes, including poor composite outcomes (mortality/severity), mortality, and severity. Methods: Eligible studies evaluating the association between admission fasting BG (FBG) and random BG (RBG) levels with COVID-19 outcomes were included and assessed for risk of bias with the Quality in Prognosis Studies tool. Random-effects dose-response meta-analysis was conducted to investigate potential linear or non-linear exposure-response gradient. Results: The search yielded 35 studies involving a total of 14,502 patients. We discovered independent association between admission FBG and poor COVID-19 prognosis. Furthermore, we demonstrated non-linear relationship between admission FBG and severity (Pnon-linearity < 0.001), where each 1 mmol/L increase augmented the risk of severity by 33% (risk ratio 1.33 [95% CI: 1.26–1.40]). Albeit exhibiting similar trends, study scarcity limited the evidence strength on the independent prognostic value of admission RBG. GRADE assessment yielded high-quality evidence for the association between admission FBG and COVID-19 severity, and moderate-quality evidence for its association with mortality and poor outcomes. Conclusion: High admission FBG level independently predicted poor COVID-19 prognosis. Further research to confirm the prognostic value of admission RBG and to ascertain the estimated dose-response risk between admission FBG and COVID-19 severity are required. © 2020 Elsevier B.V. |
Blood glucose; COVID-19; Fasting; Patient admission; Prognosis |
glucose; Article; coronavirus disease 2019; diabetes mellitus; disease association; disease severity; evidence based medicine; glucose blood level; high risk population; hospital admission; human; hyperglycemia; intensive care unit; meta analysis; mortality; outcome assessment; prognosis; risk assessment; systematic review; complication; diabetes mellitus; hyperglycemia; isolation and purification; metabolism; mortality; pathophysiology; prognosis; risk factor; survival rate; virology; Blood Glucose; COVID-19; Diabetes Mellitus; Humans; Hyperglycemia; Prognosis; Risk Factors; SARS-CoV-2; Survival Rate |
Elsevier Ireland Ltd |
01688227 |
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33310127 |
Article |
Q1 |
1605 |
2008 |
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909 |
Sugianto J.A., Hadipranata T., Lazarus G., Amrullah A.H. |
57221192052;57221199976;57214599425;57221196528; |
Proximal fibular osteotomy for the management of medial compartment knee osteoarthritis: A systematic review and meta-analysis |
2021 |
Knee |
28 |
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169 |
185 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098481652&doi=10.1016%2fj.knee.2020.11.020&partnerID=40&md5=3036d47b70bc39dabc84ff7ada033e00 |
Ngimbang General Hospital, LamonganEast Java, Indonesia; Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Orthopaedic and Traumatology Surgeon, Ngimbang General HospitalEast Java, Indonesia |
Sugianto, J.A., Ngimbang General Hospital, LamonganEast Java, Indonesia; Hadipranata, T., Ngimbang General Hospital, LamonganEast Java, Indonesia; Lazarus, G., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Amrullah, A.H., Orthopaedic and Traumatology Surgeon, Ngimbang General HospitalEast Java, Indonesia |
Background: The promising prospects of proximal fibular osteotomy (PFO) as an alternative treatment of knee osteoarthritis (KOA), which has gained popularity in recent years, has yet to be systematically evaluated. Hence, this meta-analysis aims to critically assess the clinical and radiological outcome of PFO in the management of medial compartment KOA. Methods: Literature searches through PubMed, Scopus, CENTRAL, CINAHL, Google Scholar, and ProQuest databases were conducted, searching for eligible studies published from inception up to April 2020. Risk of bias assessments of randomized trials were performed via Cochrane RoB 2, while those of non-randomized studies with ROBINS-I tool. Random-effects model was utilized to estimate effect sizes. Results: A total of 907 patients and 1012 knees were included in this meta-analysis. PFO successfully ameliorated patients’ knee function (Hedges’ g 1.90; 95% confidence interval (CI) 1.62–2.18; I2 = 67%) and pain (visual analog scale: mean difference (MD) −4.13; 95% CI: −5.29 to −2.97), and also resulted in minimal complication rates, with peroneal nerve paresthesia being the most prevalent adverse event (5.93%; 95% CI: 2.15–11.25%), followed by peroneal nerve palsy (2.25%; 95% CI: 0.14–6.14%), fracture (0.56%; 95% CI: 0–1.74%), and recurrent deformity (0.54%; 95% CI: 0–1.74%). Furthermore, PFO was also associated with improved medial/lateral joint space ratio (MD 0.17; 95% CI: 0.15–0.19). Conclusion: PFO yielded promising prospects in the management of medial compartment KOA, as shown by substantial improvements in clinical and radiological outcomes. However, considering the low quality of evidence, further studies with more diverse populations and higher quality of body evidence are required to confirm these findings. © 2020 Elsevier B.V. |
High fibular osteotomy; Knee osteoarthritis; Osteotomy; Proximal fibular osteotomy; Upper partial fibulectomy |
anthropometric parameters; bone malformation; fracture; human; joint cavity; knee function; knee osteoarthritis; knee pain; lateral joint space; medial joint space; meta analysis; osteotomy; peroneus nerve paralysis; postoperative complication; prevalence; priority journal; proximal fibular osteotomy; radiological procedures; randomized controlled trial (topic); recurrent disease; Review; systematic review; treatment outcome; visual analog scale; adverse event; fibula; knee osteoarthritis; osteotomy; postoperative complication; procedures; Fibula; Humans; Osteoarthritis, Knee; Osteotomy; Postoperative Complications; Visual Analog Scale |
Elsevier B.V. |
09680160 |
|
33387808 |
Review |
Q1 |
1012 |
4317 |
|
|
|
910 |
Novriansyah R., Prabowo I., Laras S. |
57221099996;57221098612;57221107761; |
Non-microsurgical bipedicled reverse sural fasciocutaneous flap with preservation of medial and lateral sural cutaneous nerve: Current surgical management of skin defect after traumatic Achilles tendon rupture – A case report |
2021 |
International Journal of Surgery Case Reports |
78 |
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259 |
264 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098153477&doi=10.1016%2fj.ijscr.2020.12.027&partnerID=40&md5=dfcacbe40a7720f01ffdc937f2618e67 |
Department of Orthopaedics and Traumatology, Kariadi Hospital – Faculty of Medicine Universitas Diponegoro, Semarang, Indonesia; Department of Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital – Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Novriansyah, R., Department of Orthopaedics and Traumatology, Kariadi Hospital – Faculty of Medicine Universitas Diponegoro, Semarang, Indonesia; Prabowo, I., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital – Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Laras, S., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital – Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: The challenging issue that still remains for reverse sural flap is the withstand of the flap against time, the width of coverage area, and the donor site morbidity such as pain after the medial or lateral sural cutaneous nerve harvested. Presentation of case: A 55 years old male was suffered from traumatic Achilles tendon rupture for 3 months and was repaired with Krakow's technique in a medical center in Pemalang, Indonesia. After the surgery, the defect was revealed as another surgery was planned to cover the skin defect. The author had chosen the bipedicled reverse sural fasciocutaneous flap in regular basis which addressed the superiority and viability of the flap, thus the donor site morbidity was also concerned as the preservation of medial and lateral sural cutaneous nerve, which leading to good quality of life as the patient still could feel and sensate his medial and lateral leg. Discussion: The bipedicled reverse sural fasciocutaneous flap was successfully covered the skin defect on post traumatic Achilles tendon reconstruction, with retained medial sural nerve on its place, and the remaining harvested skin area was leave opened without skin graft which healed spontaneously. Conclusion: Bipedicled reverse sural fasciocutaneous flap with retained medial sural nerve offer a good clinical outcome either the viability of the flap and the maintained sensation along the medial and lateral sural cutaneous nerve distribution. © 2020 |
Bipedicled reverse sural fasciocutaneous flap; Medial sural nerve; Traumatic Achilles tendon rupture |
achilles tendon rupture; adult; Article; case report; clinical article; fasciocutaneous flap; human; male; middle aged; pedicled skin flap; priority journal; skin defect; skin nerve; sural nerve; surgical technique; treatment outcome |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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