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Id	Authors	Author S Id	Title	Year	Source Title	Volume	Issue	Art No	Page Start	Page End	Cited By	Link	Affiliations	Authors With Affiliations	Abstract	Author Keywords	Index Keywords	Publisher	Issn	Pubmed Id	Document Type	Sjr Best Quartile	Sjr	Sjr Rank
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480	Sukmawan R., Hoetama E., Suridanda Danny S., Giantini A., Listiyaningsih E., Gilang Rejeki V., Aziz Alkatiri A., Firdaus I.	8651025300;57214138849;57222312102;12776781400;57224237184;57222313503;57222311692;55796864700;	Increase in the risk of clopidogrel resistance and consequent TIMI flow impairment by DNA hypomethylation of CYP2C19 gene in STEMI patients undergoing primary percutaneous coronary intervention (PPCI)	2021	Pharmacology Research and Perspectives	9	2	e00738			2	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102225470&doi=10.1002%2fprp2.738&partnerID=40&md5=444f8c3e75e75ed786eedbe412614a0b	Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Clinical Pathology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Public Hospital, Jakarta, Indonesia; Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia	Sukmawan, R., Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Hoetama, E., Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Suridanda Danny, S., Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Giantini, A., Clinical Pathology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Public Hospital, Jakarta, Indonesia; Listiyaningsih, E., Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Gilang Rejeki, V., Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Aziz Alkatiri, A., Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Firdaus, I., Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia	Clopidogrel resistance is an important risk factor of ischemic event recurrence after optimal antiplatelet therapy. This study aims to investigate the role of CYP2C19 gene DNA methylation as one of the epigenetic factors for the risk of clopidogrel resistance in STEMI patients undergoing PPCI. ST-segment elevation myocardial infarction (STEMI) patients undergoing PPCI were pretreated with clopidogrel, and their platelet function was measured using VerifyNow™ assay. The criteria for high on-treatment platelet reactivity (HPR) were defined according to the expert consensus criteria (PRU >208). DNA methylation of the CYP2C19 gene was performed using bisulfite genomic sequencing technology. Furthermore, clinical, laboratory, and angiographic data including TIMI flow were collected. Among 122 patients, clopidogrel resistance was found in 22%. DNA methylation level percentage was lower in the clopidogrel resistance group (76.7 vs. 88.8, p-value.038). But, the <50% methylation group was associated with increased risk of clopidogrel resistance (OR =4.5, 95%CI =2.1–9.3, p-value =.018). This group was also found to have suboptimal post-PCI TIMI flow (OR =3.4 95%CI =1.3–8.7, p-value =.045). The lower DNA methylation level of the CYP2C19 gene increases the risk of clopidogrel resistance and subsequent poorer clinical outcome. © 2021 The Authors. Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd.	acute coronary syndrome; clopidogrel resistance; CYP2C19; DNA methylation	acetylsalicylic acid; clopidogrel; cytochrome P450 2C19; clopidogrel; CYP2C19 protein, human; cytochrome P450 2C19; aged; angiography; blood clotting parameters; Cytochrome P450 2C19 gene; diabetes mellitus; DNA methylation; echocardiography; female; human; loading drug dose; major clinical study; male; percutaneous coronary intervention; Review; ST segment elevation myocardial infarction; adult; complication; drug effect; drug resistance; fibrinolytic therapy; genetics; metabolism; middle aged; percutaneous coronary intervention; procedures; recurrent disease; secondary prevention; ST segment elevation myocardial infarction; thrombocyte aggregation; Adult; Clopidogrel; Cytochrome P-450 CYP2C19; DNA Methylation; Drug Resistance; Female; Humans; Male; Middle Aged; Percutaneous Coronary Inte	John Wiley and Sons Inc	20521707	33641235	Review	Q1	975	4541	View
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402	van Crevel R., Avila-Pacheco J., Thuong N.T.T., Ganiem A.R., Imran D., Hamers R.L., Alisjahbana B., Dian S., Estiasari R., Tram T.T.B., Vinh D.N., Hai H.T., Donovan J., Ardiansyah E., Koeken V., Kumar V., Netea M.G., van Laarhoven A., Clish C., Thwaites G., The ULTIMATE consortium	6603956378;57194750113;16551464800;35145741500;57203976849;23034345900;6506944516;55418398700;55240204000;56426109200;56562746100;57197774138;57203943392;57205617822;57194441324;57222877712;35378641700;55625910500;35460787900;57220045286;	Improving host-directed therapy for tuberculous meningitis by linking clinical and multi-omics data	2021	Tuberculosis	128		102085			1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106295161&doi=10.1016%2fj.tube.2021.102085&partnerID=40&md5=4ce0f74084aad8c1c23b99ba0823c3f8	Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Eijkman Oxford Clinical Research Unit, Jakarta, Indonesia	van Crevel, R., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Avila-Pacheco, J., The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Thuong, N.T.T., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Ganiem, A.R., TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Imran, D., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hamers, R.L., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Eijkman Oxford Clinical Research Unit, Jakarta, Indonesia; Alisjahbana, B., TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Dian, S., TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Estiasari, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tram, T.T.B., Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Vinh, D.N., Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Hai, H.T., Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Donovan, J., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Ardiansyah, E., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Koeken, V., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Kumar, V., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Netea, M.G., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; van Laarhoven, A., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Clish, C., The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Thwaites, G., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; The ULTIMATE consortium	There is a clear need to improve host-directed therapy for tuberculous meningitis (TBM), the most severe and deadly manifestation of tuberculosis. Corticosteroids represent the only host-directed therapy of proven benefit in TBM, yet their effect is modest, the mechanism by which they reduce mortality is unknown, and there is evidence for heterogeneity in their effect. Novel therapeutic approaches are therefore urgently needed. Cellular metabolism is critical for the function of immune cells; through unbiased metabolomics we recently found that high concentrations of cerebrospinal fluid (CSF) tryptophan are associated with increased mortality in Indonesian TBM patients, and that CSF tryptophan concentrations are under strong genetic regulation. Many questions remain. How exactly is tryptophan metabolism altered during TBM? How does it correlate with inflammation, immunopathology, and response to corticosteroids? How is tryptophan metabolism genetically regulated? What is the effect of HIV co-infection on tryptophan metabolism before and during TBM treatment? The ULTIMATE project addresses these questions by integrating data and specimens from large patient studies and clinical trials evaluating the effects of corticosteroids in Vietnam and Indonesia. Through its powerful and unbiased approach, ULTIMATE aims to identify which TBM patients benefit from corticosteroids and if novel therapeutic targets, such as the tryptophan pathway, could be targeted. © 2021	Cerebrospinal fluid; Genetics; Host-directed therapy; Meningitis; Metabolomics; Tryptophan; Tuberculosis	corticosteroid; tryptophan; corticosteroid; tryptophan; tuberculostatic agent; Article; cerebrospinal fluid level; clinical trial (topic); coinfection; corticosteroid therapy; genetic regulation; host-directed therapy; human; Human immunodeficiency virus infection; multiomics; nonhuman; pathogenesis; priority journal; treatment response; tryptophan metabolism; tuberculous meningitis; cerebrospinal fluid; metabolomics; mortality; tuberculous meningitis; Adrenal Cortex Hormones; Antitubercular Agents; Humans; Metabolomics; Tryptophan; Tuberculosis, Meningeal	Churchill Livingstone	14729792	34022506	Article	Q2	977	4524	View
579	Lee C.-C., Kwa A.L.H., Apisarnthanarak A., Feng J.-Y., Gluck E.H., Ito A., Karuniawati A., Periyasamy P., Pratumvinit B., Sharma J., Solante R., Swaminathan S., Tyagi N., Vu D.M., Zirpe K., Schuetz P.	57216571107;57277379200;6603905554;24168534700;7003341685;37007598100;54886816200;57218573063;35722893000;12545686500;8728553100;56354453600;56471440500;57214066572;56521747700;35235208800;	Erratum: Procalcitonin (PCT)guided antibiotic stewardship in Asia-Pacific countries: Adaptation based on an expert consensus meeting. (Clin Chem Lab Med (2020) 58:12 (1983–91) Doi:10.1515/cclm-2019-1122)	2021	Clinical Chemistry and Laboratory Medicine	59	3		631	632		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100458517&doi=10.1515%2fcclm-2020-1724&partnerID=40&md5=b517d7656483da02741274bbd916bf57	Singapore General Hospital, Singapore, Singapore; Emerging Infectious Diseases Program, Duke-National University of Singapore Medical School, Singapore, Singapore; Division of Infectious Diseases, Thammasart University Hospital, Bangkok, Thailand; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Critical Care Services, Swedish Covenant Hospital, Chicago, IL, United States; Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital, Okayama, Japan; Department of Microbiology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Infectious Disease Unit, PPUKM (HCTM), Hospital Canselor Tuanku Muhriz UKM (HCTM), Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, Malaysia; Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Artemis Hospital Critical Care Medicine, Gurgaon, India; Adult Infectious Diseases and Tropical Medicine, San Lazaro Hospital, Manila, Philippines; Infectious Diseases, Gleneagles Global Hospitals, Chennai and Bengaluru, India; Institute of Critical Care and Emergency Medicine, Sir Ganga Ram Hospital, Delhi, India; Critical Care Department, National Hospital of Tropical Diseases, Hanoi, Viet Nam; Department of Neuro Critical Care, Ruby Hall Clinic, Grant Medical Foundation, Pune, India; Department of Internal Medicine, Kantonsspital Aarau, Aarau, Switzerland; University of Basel, Basel, Switzerland	Lee, C.-C., Singapore General Hospital, Singapore, Singapore; Kwa, A.L.H., Emerging Infectious Diseases Program, Duke-National University of Singapore Medical School, Singapore, Singapore, Division of Infectious Diseases, Thammasart University Hospital, Bangkok, Thailand; Apisarnthanarak, A., Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Feng, J.-Y., Critical Care Services, Swedish Covenant Hospital, Chicago, IL, United States; Gluck, E.H., Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital, Okayama, Japan; Ito, A., Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital, Okayama, Japan; Karuniawati, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Periyasamy, P., Infectious Disease Unit, PPUKM (HCTM), Hospital Canselor Tuanku Muhriz UKM (HCTM), Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, Malaysia; Pratumvinit, B., Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Sharma, J., Artemis Hospital Critical Care Medicine, Gurgaon, India; Solante, R., Adult Infectious Diseases and Tropical Medicine, San Lazaro Hospital, Manila, Philippines; Swaminathan, S., Infectious Diseases, Gleneagles Global Hospitals, Chennai and Bengaluru, India; Tyagi, N., Institute of Critical Care and Emergency Medicine, Sir Ganga Ram Hospital, Delhi, India; Vu, D.M., Critical Care Department, National Hospital of Tropical Diseases, Hanoi, Viet Nam; Zirpe, K., Department of Neuro Critical Care, Ruby Hall Clinic, Grant Medical Foundation, Pune, India; Schuetz, P., Department of Internal Medicine, Kantonsspital Aarau, Aarau, Switzerland, University of Basel, Basel, Switzerland	There is typo in Figure 1 and Figure 2 of this article. Instead of “… repeated testing or monitoring for discontinuation …” it should read “… repeated testing for monitoring and discontinuation …” (see corrected Figures). © 2021 De Gruyter. All rights reserved.		erratum	De Gruyter Open Ltd	14346621	33554531	Erratum	Q1	977	4522	View
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548	Pranata R., Henrina J., Lim M.A., Lawrensia S., Yonas E., Vania R., Huang I., Lukito A.A., Suastika K., Kuswardhani R.A.T., Setiati S.	57201973901;57218482646;57216039756;57219781613;57201987097;57208328436;57208576645;57213835420;8736266500;36863900500;14325991900;	Clinical frailty scale and mortality in COVID-19: A systematic review and dose-response meta-analysis: Clinical Frailty Scale in COVID-19	2021	Archives of Gerontology and Geriatrics	93		104324			53	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098467342&doi=10.1016%2fj.archger.2020.104324&partnerID=40&md5=f9eef93f03ae5cb88ddf255820cbd190	Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Siloam Heart Institute, Jakarta, Indonesia; Ken Saras General Hospital, Semarang, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Division of Plastic, Reconstructive and Aesthetic, Department of Surgery, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia; Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University Denpasar, Bali, Indonesia; Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Udayana University, Sanglah Teaching Hospital, Denpasar - Bali, Indonesia; Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo General Hospital, Jakarta, Indonesia	Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Henrina, J., Siloam Heart Institute, Jakarta, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Lawrensia, S., Ken Saras General Hospital, Semarang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Vania, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Division of Plastic, Reconstructive and Aesthetic, Department of Surgery, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, Indonesia; Huang, I., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia; Lukito, A.A., Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Suastika, K., Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University Denpasar, Bali, Indonesia; Kuswardhani, R.A.T., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Udayana University, Sanglah Teaching Hospital, Denpasar - Bali, Indonesia; Setiati, S., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo General Hospital, Jakarta, Indonesia	Introduction: National Institute for Health and Care Excellence (NICE) endorsed clinical frailty scale (CFS) to help with decision-making. However, this recommendation lacks an evidence basis and is controversial. This meta-analysis aims to quantify the dose-response relationship between CFS and mortality in COVID-19 patients, with a goal of supplementing the evidence of its use. Methods: We performed a systematic literature search from several electronic databases up until 8 September 2020. We searched for studies investigating COVID-19 patients and reported both (1) CFS and its distribution (2) CFS and its association with mortality. The outcome of interest was mortality, defined as clinically validated death or non-survivor. The odds ratio (ORs) will be reported per 1% increase in CFS. The potential for a non-linear relationship based on ORs of each quantitative CFS was examined using restricted cubic splines with a three-knots model. Results: There were a total of 3817 patients from seven studies. Mean age was 80.3 (SD 8.2), and 53% (48–58%) were males. The pooled prevalence for CFS 1–3 was 34% (32–36%), CFS 4–6 was 42% (40–45%), and CFS 7–9 was 23% (21–25%). Each 1-point increase in CFS was associated with 12% increase in mortality (OR 1.12 (1.04, 1.20), p = 0.003; I2: 77.3%). The dose-response relationship was linear (Pnon-linearity=0.116). The funnel-plot analysis was asymmetrical; Trim-and-fill analysis by the imputation of two studies on the left side resulted in OR of 1.10 [1.03, 1.19]. Conclusion: This meta-analysis showed that increase in CFS was associated with increase in mortality in a linear fashion. © 2020 Elsevier B.V.	Age; Coronavirus; COVID-19; Frailty; Prognosis; Risk stratification	Article; Clinical Frailty Scale; coronavirus disease 2019; data analysis; functional status assessment; human; medical research; mortality; odds ratio; outcome assessment; prevalence; priority journal; quantitative analysis; systematic error; systematic review; frailty; male; meta analysis; very elderly; Aged, 80 and over; COVID-19; Frailty; Humans; Male; Prevalence; SARS-CoV-2	Elsevier Ireland Ltd	01674943	33352430	Article	Q1	985	4466	View
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26	Soemantri D., Greviana N., Findyartini A., Azzahra T.B., Suryoadji K.A., Mustika R., Felaza E.	36640659100;57197709749;56543777300;57223601523;57223633894;57220273147;57217487889;	"To obey or not to obey" - Medical students' response towards professional dilemmas in a hierarchical and collectivist culture	2021	PLoS ONE	16	12 December	e0261828			1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122028276&doi=10.1371%2fjournal.pone.0261828&partnerID=40&md5=379871263550acde1f1182540ba60243	Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Undergraduate Medical Program, Universitas Indonesia, Jakarta, Indonesia	Soemantri, D., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Greviana, N., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Findyartini, A., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Azzahra, T.B., Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Undergraduate Medical Program, Universitas Indonesia, Jakarta, Indonesia; Suryoadji, K.A., Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Undergraduate Medical Program, Universitas Indonesia, Jakarta, Indonesia; Mustika, R., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Felaza, E., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia	Background Clinical clerkship programme in medical schools were developed to provide students with direct interactions with patients and observe clinical teachers in practice. However, professional dilemmas are prone to occur due to the nature of experiential learning. Several studies across different cultures showed that medical students responded differently towards professional dilemma. Aims This study aims to explore how medical students respond to professional dilemmas occurred during their clinical clerkships and to what extent culture influences the responses. Method A qualitative descriptive approach was used in this study. We conducted four focus group discussions with final year medical students who were selected using maximum variety sampling method. Thematic analysis was conducted following the transcription of the focus groups. Results We identified the impact of dilemmas on students' emotions and concerns, students' responses towards professional dilemmas, and factors affecting responses to dilemmas in clinical clerkship, which confirmed that cultures played roles in how students responded towards professional dilemmas. Conclusion This study has identified that culture, to some extent, influenced the way students responded to professional dilemmas. Therefore, it is paramount to develop a conducive and culturally sensitive educational environment and students' ability to learn from professional dilemma experienced in the workplace for developing their professional identity. © 2021 Soemantri et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.		article; clinical education; emotion; genetic transcription; human; human experiment; medical student; thematic analysis; workplace; clinical trial; emotion; female; male; medical school; problem based learning; Emotions; Female; Humans; Male; Problem-Based Learning; Schools, Medical; Students, Medical	Public Library of Science	19326203	34941959	Article	Q1	990	4434	View
27	Koesnoe S., Masjkuri N., Adisasmita A., Djauzi S., Kartasasmita C., Sundoro J., Nadjib M., Korib M., Muthia A.N., Muzellina V.N., Habibah U., Nursyirwan S.A., Djaya K.H., Bachtiar N.S., Sari R.M.	26028015000;57189271669;22978283200;23495847800;57206248946;49762130000;24401623600;57391576000;57391576100;57223968527;57391443900;57249143800;57392218600;54879388400;57191341371;	A randomized controlled trial to evaluate the effect of influenza vaccination and probiotic supplementation on immune response and incidence of influenza-like illness in an elderly population in Indonesia	2021	PLoS ONE	16	12 December	e0250234				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122024701&doi=10.1371%2fjournal.pone.0250234&partnerID=40&md5=6918933f17507c8ed64013b241adb3c2	Division of Allergy and Immunology, Department of Internal Medicine, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine, Padjadjaran University, Hasan Sadikin General Hospital, Bandung, Indonesia; Indonesian Technical Advisory Group on Immunization, Jakarta, Indonesia; Department of Health Policy and Administration, Faculty of Public Health University of Indonesia, Jakarta, Indonesia; Indonesian Society of Internal Medicine, Jakarta, Indonesia; Division of Gastroenterology, Depertment of Internal Medicine, dr. Cipto Mangunkusomo Hospital, Jakarta, Indonesia; Division of Gastroenterology, Depertment of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; PT. Bio Farma, Bandung, Indonesia	Koesnoe, S., Division of Allergy and Immunology, Department of Internal Medicine, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Masjkuri, N., Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Adisasmita, A., Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Djauzi, S., Division of Allergy and Immunology, Department of Internal Medicine, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Kartasasmita, C., Department of Child Health, Faculty of Medicine, Padjadjaran University, Hasan Sadikin General Hospital, Bandung, Indonesia; Sundoro, J., Indonesian Technical Advisory Group on Immunization, Jakarta, Indonesia; Nadjib, M., Department of Health Policy and Administration, Faculty of Public Health University of Indonesia, Jakarta, Indonesia; Korib, M., Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Muthia, A.N., Indonesian Society of Internal Medicine, Jakarta, Indonesia; Muzellina, V.N., Division of Gastroenterology, Depertment of Internal Medicine, dr. Cipto Mangunkusomo Hospital, Jakarta, Indonesia, Division of Gastroenterology, Depertment of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Habibah, U., Indonesian Society of Internal Medicine, Jakarta, Indonesia; Nursyirwan, S.A., Division of Gastroenterology, Depertment of Internal Medicine, dr. Cipto Mangunkusomo Hospital, Jakarta, Indonesia, Division of Gastroenterology, Depertment of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Djaya, K.H., Indonesian Society of Internal Medicine, Jakarta, Indonesia; Bachtiar, N.S., PT. Bio Farma, Bandung, Indonesia; Sari, R.M., PT. Bio Farma, Bandung, Indonesia	Aim To investigate the effect of influenza vaccination with or without probiotic supplementation on the immune response and incidence of influenza-like illness (ILI) in the elderly. Methods A randomized double-blind, placebo-controlled trial with a modified factorial design was conducted in 554 healthy elderly subjects aged 67 ± 5.6 (ranging from 60–90) years old in the Primary Health Care Center (Puskesmas area) of the Pulo Gadung District East Jakarta. Subjects received either a trivalent influenza vaccine or placebo at the start of the study, and a probiotic supplement (Lactobacillus helveticus R0052 and Lactobacillus rhamnosus R0011) or a placebo for 6 months. Subjects were randomly assigned into four intervention groups: influenza vaccine and probiotics (n = 141), influenza vaccine and placebo (n = 136), placebo and probiotics (n = 140), and both placebo (n = 137). The primary outcome was ILI incidence within 6 months. The secondary outcomes were seroprotection and seroconversion rates at 1, 4, and 6 months after administering the interventions. Results This study showed that the trivalent influenza vaccine increased seroprotection (RR 3.6 [95%CI 2.92–4.47]; p<0.010) and seroconversion (RR 29.8 [95%CI 11.1–79.5]; p<0.010) rates 1 month after vaccination in elderly people while the probiotic supplement did not alter influenza antibody titers (p = 1.000 and p = 0.210). The relative ILI incidence risk was similar between vaccinated and non-vaccinated groups, as well as in the probiotic group compared to the non-probiotic group. Conclusion The tested trivalent influenza vaccine significantly induced seroprotection and seroconversion in the vaccinated subjects, while probiotics administration did not influence these parameters. Vaccinated individuals displayed a similarly low ILI incidence as those in the Control Group. However, the observed trend towards a reduction of ILI incidence with probiotics supplementation warrants further assessments in a larger, at-risk population. © 2021 Koesnoe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.		flubio; influenza vaccine; placebo; influenza vaccine; probiotic agent; adult; aged; antibody titer; Article; controlled study; diet supplementation; double blind procedure; drug effect; female; human; immune response; incidence; Indonesia; influenza; major clinical study; male; middle aged; population risk; population structure; primary health care; randomized controlled trial; sample size; seroconversion; treatment duration; treatment outcome; vaccination; very elderly; incidence; influenza; Lactobacillus helveticus; Lactobacillus rhamnosus; Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Incidence; Indonesia; Influenza Vaccines; Influenza, Human; Lactobacillus helveticus; Lactobacillus rhamnosus; Male; Middle Aged; Probiotics	Public Library of Science	19326203	34914726	Article	Q1	990	4434	View
37	Tamin S., Adham M., Noer A., Supriana N., Bardosono S.	57195719598;14024202100;57370851100;8438653200;21933841000;	Upright epiglottis prevents aspiration in patients with nasopharyngeal carcinoma post-chemoradiation	2021	PLoS ONE	16	12 December	e0261110				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121054797&doi=10.1371%2fjournal.pone.0261110&partnerID=40&md5=c09f68482b8e097a20b06089e0d5849e	Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radio Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Nutrition Science, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia	Tamin, S., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Adham, M., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Noer, A., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Supriana, N., Department of Radio Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bardosono, S., Department of Nutrition Science, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia	NPC is the most widely found malignant tumor in the head and neck region in Indonesia. Chemoradiation therapy for NPC can induce swallowing disorders (dysphagia) that adversely affects a patients quality of life. This study aimed to assess the swallowing process by flexible endoscopic evaluation of swallowing in patients with nasopharyngeal carcinoma after chemoradiation. Thirty-nine patients with NPC who had chemoradiation therapy more than one month previously underwent flexible endoscopic evaluation of swallowing and were assessed for oral transport time, sensation, standing-secretion, pre-swallowing leakage, residue, penetration, aspiration, and silent aspiration. The most common structural abnormalities were an upright and swollen epiglottis (89.4%), poor oral hygiene, and velopharyngeal closure defects (56.4%). This examination also revealed a mild degree of standing secretion (38.5%) and aspiration (10.3%). No penetration was observed in 64.1% of the patients, and no silent aspiration was observed in any of the patients. A severe degree of residue (45.7%) was observed when administering oatmeal, while the residue was mild to moderate when administering gastric rice, crackers, and milk. The residue changed to a mild degree (32.3%-51.4%) in all food administrations after the watering maneuver. The highest penetration was noted after oatmeal administration (42.8%), and the highest aspiration was found after milk administration (8.6%). Standing secretion in almost all patients was caused by hyposensitivity of the hypopharynx. Persistent residue and hyposensitivity of the hypopharynx led to aspiration. The low percentage of aspiration and silent aspiration might have been caused by the upright and swollen epiglottis that prevented aspiration. Poor oral hygiene and a dry mouth led to prolonged oral transport. Therefore, most patients had hypopharyngeal abnormalities in the form of a swollen and upright epiglottis. Secretion and food residue were also detected. Drinking helps to expedite the swallowing process by facilitating oral phase transport and reducing residues. © 2021 Tamin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.		acid aspiration; adult; adverse event; chemoradiotherapy; digestive tract endoscopy; dysphagia; female; human; male; middle aged; nasopharynx carcinoma; nasopharynx tumor; pathology; pathophysiology; procedures; Adult; Chemoradiotherapy; Deglutition Disorders; Endoscopy, Digestive System; Female; Humans; Male; Middle Aged; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Respiratory Aspiration	Public Library of Science	19326203	34882745	Article	Q1	990	4434	View
80	Paramita R.I., Nelwan E.J., Fadilah F., Renesteen E., Puspandari N., Erlina L.	54882436900;14527452900;56966708600;57216633036;56786591900;57190181680;	Genome-based characterization of Escherichia coli causing bloodstream infection through next-generation sequencing	2021	PLoS ONE	15	12 December	e0244358			5	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099074536&doi=10.1371%2fjournal.pone.0244358&partnerID=40&md5=4997d32055c7a3e5834f747ae4be685e	Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Bioinformatics Core Facilities-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Infectious Disease and Immunology Research Center-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, DKI Jakarta, Indonesia	Paramita, R.I., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Bioinformatics Core Facilities-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Nelwan, E.J., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Infectious Disease and Immunology Research Center-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Fadilah, F., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Bioinformatics Core Facilities-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Renesteen, E., Infectious Disease and Immunology Research Center-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Puspandari, N., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, DKI Jakarta, Indonesia; Erlina, L., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Bioinformatics Core Facilities-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia	Escherichia coli are one of the commonest bacteria causing bloodstream infection (BSI). The aim of the research was to identify the serotypes, MLST (Multi Locus Sequence Type), virulence genes, and antimicrobial resistance of E. coli isolated from bloodstream infection hospitalized patients in Cipto Mangunkusumo National Hospital Jakarta. We used whole genome sequencing methods rather than the conventional one, to characterized the serotypes, MLST (Multi Locus Sequence Type), virulence genes, and antimicrobial resistance (AMR) of E. coli. The composition of E. coli sequence types (ST) was as follows: ST131 (n=5), ST38 (n=3), ST405 (n=3), ST69 (n=3), and other STs (ST1057, ST127, ST167, ST3033, ST349, ST40, ST58, ST6630). Enteroaggregative E. coli (EAEC) and Extra-intestinal pathogenic E. coli (ExPEC) groups were found dominant in our samples. Twenty isolates carried virulence genes for host cells adherence and 15 for genes that encourage E. coli immune evasion by enhancing survival in serum. ESBL-genes were present in 17 E. coli isolates. Other AMR genes also encoded resistance against aminoglycosides, quinolones, chloramphenicol, macrolides and trimethoprim. The phylogeny analysis showed that phylogroup D is dominated and followed by phylogroup B2. The E. coli isolated from 22 patients in Cipto Mangunkusumo National Hospital Jakarta showed high diversity in serotypes, sequence types, virulence genes, and AMR genes. Based on this finding, routinely screening all bacterial isolates in health care facilities can improve clinical significance. By using Whole Genome Sequencing for laboratory-based surveillance can be a valuable early warning system for emerging pathogens and resistance mechanisms. © 2020 Paramita et al.		aminoglycoside antibiotic agent; beta lactam antibiotic; chloramphenicol; macrolide; quinoline derived antiinfective agent; trimethoprim; virulence factor; antibiotic resistance; Article; bacterial gene; bacterial genome; bacterial virulence; bacterium isolate; bloodstream infection; cell adhesion; clinical article; DNA isolation; enteroaggregative Escherichia coli; Escherichia coli; extraintestinal pathogenic Escherichia coli; gene isolation; gene sequence; genetic code; high throughput sequencing; hospital patient; host cell; human; Indonesia; multilocus sequence typing; nonhuman; nuclear magnetic resonance; phylogeny; serotype; virulence gene; whole genome sequencing; bacteremia; bacterial genome; classification; Escherichia coli; Escherichia coli infection; genetics; high throughput se	Public Library of Science	19326203	33362261	Article	Q1	990	4434	View
144	Susiloretni K.A., Smith E.R., Suparmi, Marsum, Agustina R., Shankar A.H.	55920057100;55479658700;57201388096;57203690495;57214141404;7005442634;	The psychological distress of parents is associated with reduced linear growth of children: Evidence from a nationwide population survey	2021	PLoS ONE	16	10 October	e0246725				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118229642&doi=10.1371%2fjournal.pone.0246725&partnerID=40&md5=e63e172d790e5a4d43ab7ba273dd42d6	Semarang Health Polytechnic Ministry of Health - Poltekkes Kemenkes Semarang, Central Java, Semarang, Indonesia; Department of Global Health, George Washington University, Washington, D.C., United States; National Health Institute Research and Development, Jakarta, Indonesia; Faculty of Medicine, Department of Nutrition, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Medicine, Human Nutrition Research Center, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Nuffield Department of Medicine, The Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom	Susiloretni, K.A., Semarang Health Polytechnic Ministry of Health - Poltekkes Kemenkes Semarang, Central Java, Semarang, Indonesia; Smith, E.R., Department of Global Health, George Washington University, Washington, D.C., United States; Suparmi, National Health Institute Research and Development, Jakarta, Indonesia; Marsum, Semarang Health Polytechnic Ministry of Health - Poltekkes Kemenkes Semarang, Central Java, Semarang, Indonesia; Agustina, R., Faculty of Medicine, Department of Nutrition, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Faculty of Medicine, Human Nutrition Research Center, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Shankar, A.H., Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia, Nuffield Department of Medicine, The Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom	Background Stunting, an indicator of restricted linear growth, has become a primary measure of childhood undernutrition due to its persistent high prevalence globally, and importance for health and development. Although the etiology is recognized as complex, most analyses have focused on social and biomedical determinants, with limited attention on psychological factors affecting care and nurturing in the home. We assessed whether the psychological distress of parents is related to child linear growth and stunting, and documented the associated risk factors, and examined the relationship between parental distress and behavioral and other risk factors for stunting. Methods We used data from the Indonesia National Health Survey 2013, including 46,315 children 6–59 months of age. Multivariate linear, logistic, and multilevel multinomial logistic regression, using survey weights, were used to assess the relationship between parental distress, as assessed by the WHO Self Reporting Questionnaire (SRQ20), with height-for-age z score (HAZ), stunting, and behavioral and other risk factors for stunting. Results Maternal, paternal and parental distress (i.e. both maternal and paternal distress) were associated with reduced linear growth of the children by 0.086 (95% CI -0.17, -0.00), 0.11 (95% CI -0.24, -0.02) and 0.19 (95% CI -0.37, -0.00) HAZ-scores, respectively. Maternal and paternal distress increased the risk of mild stunting (HAZ <-1) by 33% (95% CI 1.17,1.50) and 37% (95% CI 1.18,1.60), and the risk of moderate stunting (HAZ <-2) by 25% (95% CI 1.10,1.43) and 28% (95% CI 1.08,1.51]), respectively. Parental stress increased the risk of moderate stunting by 40% (95% CI 1.06,1.85). Amongst specific groups of risk factors, the proportion of HAZ-score lost was associated with socioeconomic factors (30.3%) including, low wealth, low maternal occupational status, low maternal education, rural residence, and low paternal occupational status; physiological factors (15.5%) including low maternal height, low maternal mid-upper arm circumference, being male, low paternal height; behavioral factors (8.9%) including open garbage disposal, paternal smoking, not using iodized salt; and experiencing at least one infectious diseases episode (1.1%). Conclusions Maternal, paternal and parental stress were associated with reduced linear growth of children. These findings highlight the complex etiology of stunting and suggest nutritional and other biomedical interventions are insufficient, and that promotion of mental and behavioral health programs for parents must be pursued as part of a comprehensive strategy to enhance child growth and development, i.e. improved caretaker capacity, integrated community development, improved parenting skills, as well as reduced gender discrimination, and domestic violence. © 2021 Susiloretni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.		sodium chloride; adult; anthropometric parameters; arm circumference; Article; body height; child; child development; child growth; child parent relation; distress syndrome; domestic violence; education; female; health behavior; health program; health survey; height for age z score; human; Indonesia; infant; infection; male; maternal stress; multivariate logistic regression analysis; occupation; parental stress; paternal smoking; paternal stress; physiology; population; risk factor; rural area; Self Reporting Questionnaire 20; sex ratio; sexism; socioeconomics; stunting; waste disposal; wealth distribution; cross-sectional study; distress syndrome; educational status; growth disorder; nutritional status; physiology; preschool child; prevalence; psychology; rural population; Body Height; Ch	Public Library of Science	19326203	34699530	Article	Q1	990	4434	View
206	Findyartini A., Greviana N., Hanum C., Husin J.M., Sudarsono N.C., Krisnamurti D.G.B., Rahadiani P.	56543777300;57197709749;57257072300;57221607411;57201862518;55934951600;55524183700;	Supporting newly graduated medical doctors in managing COVID-19: An evaluation of a Massive Open Online Course in a limitedresource setting	2021	PLoS ONE	16	9 September	e0257039			2	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114841740&doi=10.1371%2fjournal.pone.0257039&partnerID=40&md5=d823d8aaf9a69d130347230f477800d5	Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sports and Exercise Study, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Center for E-learning, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia	Findyartini, A., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Greviana, N., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hanum, C., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Husin, J.M., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sudarsono, N.C., Sports and Exercise Study, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Krisnamurti, D.G.B., Center for E-learning, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Pharmacy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rahadiani, P., Center for E-learning, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia	Introduction Newly graduated medical doctors in their internships are positioned to strengthen the front line in combating COVID-19. We developed a Massive Open Online Course (MOOC) to equip them with adequate knowledge for COVID-19 management. This paper aims to analyze the MOOC and evaluate participant satisfaction and increase in knowledge after completing the course. Methods An observational study was conducted. Quantitative data were obtained from questionnaires and pre-and post-Tests. Responses to open-ended questions of the questionnaires were collected. Analysis using the Quality Reference Framework was also completed. Results The MOOC consisted of fundamental knowledge of COVID-19 (Part A) and further enrichment (Part B), and the content was written in the Indonesian language. A total of 3,424 and 2,462 participants completed the course in August and November 2020, respectively. Most participants agreed that the platform was easy to navigate, the design was interesting, and the content was aligned with their needs. Pre-and post-Test scores in Part A s subjects increased significantly. Factors contributing to and inhibiting usability and areas for improvement were further highlighted. Discussion The use of a specific quality framework facilitated a comprehensive evaluation of the MOOC s strengths, weaknesses, and areas for future improvements. The participants satisfaction and pre-and post-Test results showed that the current MOOC holds great potential benefit for continuing education for medical interns joining the frontliners during the pandemic. Future implementation should consider increasing the quality of learning resources, scaling up the platform and its technical supports, and enhancing organizational supports. © 2021 Public Library of Science. All rights reserved.		education; epidemiology; human; Indonesia; medical education; procedures; program evaluation; questionnaire; COVID-19; Education, Distance; Education, Medical, Graduate; Educational Measurement; Humans; Indonesia; Program Evaluation; Surveys and Questionnaires	Public Library of Science	19326203	34506524	Article	Q1	990	4434	View

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