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Hasan A.A.A.F., Supriadi S., Kreshanti P., Umas R.A., Whulanza Y. |
57222257599;16040272500;36192866200;57222252781;36807053500; |
Concept design and stress evaluation on modular mini plate for complex fracture maxillofacial trauma |
2021 |
AIP Conference Proceedings |
2344 |
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050016 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103490764&doi=10.1063%2f5.0047179&partnerID=40&md5=dc080d2db923ed2607a759c04729c8ef |
Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Cleft and Craniofacial Center Cipto Mangunkusumo Hospital, Plastic and Reconstructive Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia |
Hasan, A.A.A.F., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Supriadi, S., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Kreshanti, P., Cleft and Craniofacial Center Cipto Mangunkusumo Hospital, Plastic and Reconstructive Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Umas, R.A., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Whulanza, Y., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia |
Complex fracture facial trauma is a condition when some part of the skull shattered into multiple pieces. Intricate fractured skull often deforms the suspect's face, which damaging the aesthetic and the functionality of some part of the skull, or even the whole skull. The procedure to fix this condition uses mini plates in large parts of the procedure. Unfortunately, there is some condition when the existing mini plates can not handle the condition due to the fracture position and another obstacle like teeth root. The lack of mini plates that can adapt according to the obstacles makes the fixation is difficult. This study aims to develop modular mini plates that can adapt the fracture lines and the obstacles that exist in the patients. The method of this study is assembling the modular mini plates to determine the possible angle configuration using CAD software and determining the maximum load of each angle configuration using finite element analysis simulation software. The CAD software result concludes that the possible angle configuration using modular mini plates with 18 holes and pins varies from 40° to 320° with 20° interval (15 configurations). 0°, 20°, and 340° deemed not suitable because the model will collide with each other if using the angle as mentioned earlier configuration. The Von- Mises Stress of each configuration varies, with the maximum value is 535,03 MPa in 240° configuration and the minimum value is 461,26 MPa in 320° configuration with 10 N load configuration. This study concludes that the modular concept is applicable in some angle configuration. © 2021 Author(s). |
Complex fracture; Facial trauma; Implant; Mini plate; Modular |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
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177 |
20880 |
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506 |
Guntara A., Rahyussalim A.J. |
56369500300;55212166100; |
The uses of lower limb exoskeleton, functional electrical stimulation, and future improvements for leg paralysis management - A systematic review |
2021 |
AIP Conference Proceedings |
2344 |
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050015 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103489541&doi=10.1063%2f5.0047952&partnerID=40&md5=69696a97ac769e4c62286b54212c6cf8 |
Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Kampus UI Salemba, DKI Jakarta, 10430, Indonesia |
Guntara, A., Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Rahyussalim, A.J., Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Kampus UI Salemba, DKI Jakarta, 10430, Indonesia |
Introduction: Ambulatory disability is one of the causes of depression and decreased quality of life. The common treatments used by patients are wheelchair, walker, forearm crutches, or immobilization in their house. Other orthoses such as knee ankle foot orthosis (KAFO) is very useful in certain conditions. Replacement therapy with a lower limb exoskeleton may increase the quality of life. The current review aims to evaluate the lower limb exoskeleton with or without functional electrical stimulation (FES) in assisting mobility in paraplegic patients. Methods: A search was performed to identify studies that compared lower limb exoskeleton to KAFO or hybrid exoskeleton with FES in paraplegic patients. Three publications were identified, with subjects ranging from 1 to 3 presenting with spinal injuries between T6 to T10. The measured parameters were locomotion ability, exoskeleton motor power, and torque. Results: The single-use of lower limb exoskeleton in paraplegia patients resulted in 15 sec faster (96s) Timed Up Go (TUG) test, 38 seconds faster (58s) 10-meter walked test (10MWT), and a 27 m farther 6-minute walked test (6MWT) compared to KAFO. The combination of exoskeleton with functional electrical stimulation (FES) reduces muscle fatigue and prevents muscle atrophy by providing stimulus to the muscle that imitates physiological stimulation by nerves. Discussion: Exoskeleton may assist disabled individuals in performing daily routine activity by improving gait, lessening exertion, and thus increasing the quality of life. Further improvement to exoskeleton devices includes integration with FES. Exoskeleton fit on the user also needs to be adjusted to user age and leg dimension to optimize movement and quality of life. © 2021 Author(s). |
functional electrical stimulus; lower limb exoskeleton; paraplegia; spinal cord injuries |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
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177 |
20880 |
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507 |
Khaerunnisa S., Pangjaya L.F., Mazfufah N.F., Budiman R.L., Antarianto R.D. |
57221948155;57222624829;57215595521;57222627263;57190862806; |
Nidogen-1 (NID1) as specific ligand in natural killer (NK) cells stimulated from advanced ovarian cancer: Immunotherapy review |
2021 |
AIP Conference Proceedings |
2344 |
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040009 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103487578&doi=10.1063%2f5.0049157&partnerID=40&md5=c45066e93f8193a8972229dcd9d4bfb0 |
Biology Undergraduate Program, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia |
Khaerunnisa, S., Biology Undergraduate Program, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Pangjaya, L.F., Biology Undergraduate Program, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Mazfufah, N.F., Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Budiman, R.L., Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Antarianto, R.D., Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia, Department of Histology, Faculty of Medicine, Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia |
The pathway for the introduction of NK cell into abnormal cells is mediated by the receptor-ligand interaction on the cell surface. Among all the activation receptors, NKP44 has become a unique activation receptor because it has an ITIMs signaling pathway and actively plays an important role in several functions of stimulated NK cells. A potential ligand that can specifically regulate the activity of NKP44 receptors is NID1. NID1 is a novel ligand that can initiate two different regulations on NK cells activity. In addition, NID1 also provides predictions that are compatible with the electrophoretic glycoprotein mobility that has been detected by NKp44 through SDS-PAGE and ELISA tests compared to all proteins in the microenvironment of ovarian cancer. Curently, NID1 has been proven to be able to increase the cytotoxic reaction of non-cancerous NK cells. Further research is needed for the development of ovarian cancer immunotherapy based on the receptor-ligand interactions. © 2021 Author(s). |
immunotherapy; NID1; NK cell; NKP44; ovary cancer |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
- |
177 |
20880 |
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508 |
Nadhif M.H., Utomo M.S., Ferian M.F., Taufikulhakim F.H., Soerojo N.H.P., Nain M.D., Yusuf P.A., Susanto A.P., Prasetyono T.O.H. |
57189057498;56180933900;57222626931;57222619312;57222624010;57222621216;57192156597;57221504275;26646993900; |
Cost-efficacy of skin grafting techniques using negative pressure wound therapy and tissue-engineered skin for burns |
2021 |
AIP Conference Proceedings |
2344 |
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050008 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103487191&doi=10.1063%2f5.0047187&partnerID=40&md5=166e12d943897b27d5a5f4ebaaf1ddef |
Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Medical Technology Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Building 470, South Tangerang, Banten, 15314, Indonesia; Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Division of Plastic Surgery, Department of Surgery, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Indonesian Clinical Training and Education Centre (ICTEC), Cipto Mangunkusumo Central Hospital, Jl. Pangeran Diponegoro No. 71, Senen, Central Jakarta, DKI Jakarta, 10430, Indonesia |
Nadhif, M.H., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia, Medical Technology Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Utomo, M.S., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia, Medical Technology Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia, Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Building 470, South Tangerang, Banten, 15314, Indonesia; Ferian, M.F., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Taufikulhakim, F.H., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Soerojo, N.H.P., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Nain, M.D., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Yusuf, P.A., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia, Medical Technology Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Susanto, A.P., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia, Medical Technology Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Prasetyono, T.O.H., Medical Technology Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia, Division of Plastic Surgery, Department of Surgery, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia, Indonesian Clinical Training and Education Centre (ICTEC), Cipto Mangunkusumo Central Hospital, Jl. Pangeran Diponegoro No. 71, Senen, Central Jakarta, DKI Jakarta, 10430, Indonesia |
Burns, which generate hypertrophic scar formation, may decrease functional and aesthetical aspects of patients' quality of life. To date, grafting treatments were not only proceeded solitarily. The technological development of burn treatments emerged with approaches, such as negative pressure wound therapy (NPWT) and tissue-engineered skin (TES). By incorporating negative pressure on the wound bed, NPWT was able to remove debris, remove exudates, maintain humidity, and improve epithelization. A latter development of wound management, TES, also showed prominent results of wound healing. Benefitting from tissue engineering approaches, TES provided the wound bed with extracellular matrix (ECM) and 3D structure to support wound healing. In some reports, NPWT was combined with TES to promote better efficacy. Unfortunately, the efficacies of NPWT, TES, or NPWT-TES hybrid as assisting approaches for skin drafting techniques are not reviewed yet, as well as the cost comparison of the three treatments. In this report, the comparison of skin grafting techniques assisted with the three treatments (NPWT, TES, or NPWT-TES hybrid) was investigated in terms of efficacy and cost. The review starts with brief technical aspects of the three treatments. Subsequently, the efficacy and cost analyses were discussed. © 2021 Author(s). |
cost; efficacy; grafting; NPWT; TES |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
- |
177 |
20880 |
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509 |
Yusuf P.A., Susanto A.P., Amelia A.Z., Supandi D.P., Septhendy, Nadhif M.H., Utomo M.S., Hamid A.R.A.H. |
57192156597;57221504275;57222626360;57222624055;57222622640;57189057498;56180933900;57202054669; |
Recent updates in artificial kidney technology: Potential parsing for universal coverage burden of chronic kidney disease in Indonesia |
2021 |
AIP Conference Proceedings |
2344 |
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050020 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103484551&doi=10.1063%2f5.0047542&partnerID=40&md5=4e38248c7fa9c1f7c684e7eff9de9e5a |
Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10340, Indonesia; Medical Technology Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10340, Indonesia; Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10340, Indonesia; Research Center for Metallurgy and Material, Indonesia Institute of Science (LIPI), Banten, 15310, Indonesia; Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10340, Indonesia |
Yusuf, P.A., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10340, Indonesia, Medical Technology Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10340, Indonesia; Susanto, A.P., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10340, Indonesia, Medical Technology Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10340, Indonesia; Amelia, A.Z., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10340, Indonesia; Supandi, D.P., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10340, Indonesia; Septhendy, Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10340, Indonesia; Nadhif, M.H., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10340, Indonesia, Medical Technology Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10340, Indonesia; Utomo, M.S., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10340, Indonesia, Medical Technology Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10340, Indonesia, Research Center for Metallurgy and Material, Indonesia Institute of Science (LIPI), Banten, 15310, Indonesia; Hamid, A.R.A.H., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10340, Indonesia |
Chronic Kidney Disease has high mortality and financial burden. It was the third most catastrophic and expensive disease protected by universal coverage. The growth of medical technology gives hope to solve this hardship potentially. This paper aims to review current and future developments of artificial kidney technologies from different aspects. The scoops are popularity, cost-effectiveness, liters of dialysate needed, portability, safety issues, adverse effect reports, quality of life, the availability, and the number of professional medical workers needed to operate the device. The currently available treatments such as hemodialysis, peritoneal dialysis, and kidney transplantation have its benefits and challenges. Peritoneal dialysis gives a better quality of life and more cost-effective, however, it has the highest dropout ratio. The future artificial kidneys, such as the wearable artificial kidney, automated wearable artificial kidney, and implantable artificial kidney, offer solutions to overcome the existing challenges. Although the new technologies have not yet reached the Indonesian market, the potential benefits are high in helping chronic kidney disease patients - by offering simplicity, accessibility, reachability, and affordability of the treatment. © 2021 Author(s). |
Artificial kidney; Chronic kidney disease; Medical technology |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
- |
177 |
20880 |
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510 |
Rahyussalim A.J., Marsetio A.F., Kurniawati T. |
55212166100;57192180884;55213290600; |
Rod and screw corrective manipulation technique, an alternative technique for rigid and severe scoliosis correction management |
2021 |
AIP Conference Proceedings |
2344 |
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050022 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103484021&doi=10.1063%2f5.0047983&partnerID=40&md5=a08a9b1f3ede725651914e30e3021176 |
Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10320, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia |
Rahyussalim, A.J., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10320, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Marsetio, A.F., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10320, Indonesia; Kurniawati, T., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia |
The terms correction and manipulation in the surgical management of scoliosis define a harmonization of several measures performed individually or simultaneously to realign a deformed spine into its normal state on sagittal or coronal views. Scoliosis surgical procedures are modified due to the fact that they are complex procedures with frequent complications and unsatisfactory surgical outcomes. This technique combines rod and screws corrective manipulations applied to each vertebral segment according to the pathobiomechanic state of the deformity to simplify the manipulation process and achieve a good surgical outcome. A preliminary experimental study was done on modifications to the screw application technique, rod application for vertebral segment maneuver techniques during manipulation, and connecting rod use. Surgical outcomes were compared between the rod and screw corrective manipulation (RSCM) and conventional techniques in patients who underwent corrective surgery for scoliosis. Twelve scoliosis patients who underwent the RSCM technique had better complication rates, operative time, estimated blood loss, length of hospital stay, and sagittal alignment correction outcome compared with the 15 scoliosis patients who underwent surgery via the conventional technique. The RSCM technique was not complex, and it was easy to apply and provided better corrective outcomes. Hence, this is a promising treatment of choice for the surgical management of scoliosis patients. © 2021 Author(s). |
connecting rod; corrective manipulation; extreme scoliosis; scoliosis correction |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
- |
177 |
20880 |
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511 |
Zakaria H., Valentine O., Mayza A. |
24465810100;57210969043;57211585788; |
Analysis of quantitative EEG (QEEG) parameters on the effect of transcranial direct current stimulation (TDCS) on post-stroke patients |
2021 |
AIP Conference Proceedings |
2344 |
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050001 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103483309&doi=10.1063%2f5.0047216&partnerID=40&md5=c64c2b06ed2088913d8d35589059c49a |
School of Electrical Engineering and Informatics, Bandung Institute of Technology (ITB), Jl. Ganesha No. 10, Bandung, 40132, Indonesia; Neurology Department and Cluster of Medical Technology IMERI, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Senen, Central Jakarta, 10430, Indonesia |
Zakaria, H., School of Electrical Engineering and Informatics, Bandung Institute of Technology (ITB), Jl. Ganesha No. 10, Bandung, 40132, Indonesia; Valentine, O., School of Electrical Engineering and Informatics, Bandung Institute of Technology (ITB), Jl. Ganesha No. 10, Bandung, 40132, Indonesia; Mayza, A., Neurology Department and Cluster of Medical Technology IMERI, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Senen, Central Jakarta, 10430, Indonesia |
Cerebrovascular accident (CVA) or stroke is a condition where the blood flow to the brain is impaired, which can be caused by a blockage (ischemic stroke) or rupture of blood vessels (hemorrhagic stroke), resulting in cell death in some brain areas. Stroke can cause significant impairment in motoric, cognitive, and coordination skills of limbs and muscles. One of the non-invasive stimuli that can be applied in post-stroke patient rehabilitation is Transcranial Direct Current Stimulation (TDCS), aiming to improve the frequency spectrum towards normal. This study aimed to find the Quantitative Electroenchepalograph (QEEG) parameters that characterize the improvement of post-stroke patients' brain signals after the administration of TDCS. QEEG parameters included absolute power, relative power, ratio power Delta Theta Alpha Beta (DTAB), Delta Alpha (DA), and the percentage of each frequency wave band in the brain. EEG signals were recorded for 5 minutes before and after TDCS administration from 23 subjects, consisted of 12 post-stroke patients and 11 healthy subjects as a control. The result showed that there were significant differences in QEEG parameters before and after TDCS administration to both post-stroke patients and healthy subjects. The alpha frequency was dominant for healthy subjects, with the average of 25.67% before stimulus then increased by 1.91% after the stimulus. For post-stroke patients, delta frequency before the stimulus was dominant, with an average percentage of 43.03% then decreased by 10.44% after the stimulus. These results show that with TDCS, there is a change in the EEG wave pattern in post-stroke patients, which followed the profile pattern of healthy subjects. © 2021 Author(s). |
Quantitative EEG (QEEG); Stroke; Transcranial Direct Current Stimulation (TDCS) |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
- |
177 |
20880 |
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512 |
Inayati R., Suhaeri M., Fahdia N., Remelia M., Antarianto R.D. |
57222623427;56183087500;57222625988;57209653885;57190862806; |
Optimization of hybrid PVA/hFDM scaffold preparation |
2021 |
AIP Conference Proceedings |
2344 |
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020012 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103481516&doi=10.1063%2f5.0049156&partnerID=40&md5=d049606831bf9a961d70f9a9c49ec7bf |
Master Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Rumah Sakit Universitas Indonesia, Kampus Universitas Indonesia, Depok, West Java, 16424, Indonesia; Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Doctoral Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Department of Basic Biomedicine, Faculty of Medicine, Universitas Kristen Indonesia, Jl Mayjen Sutoyo No 2, DKI Jakarta, 13630, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia |
Inayati, R., Master Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Suhaeri, M., Rumah Sakit Universitas Indonesia, Kampus Universitas Indonesia, Depok, West Java, 16424, Indonesia; Fahdia, N., Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Remelia, M., Doctoral Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia, Department of Basic Biomedicine, Faculty of Medicine, Universitas Kristen Indonesia, Jl Mayjen Sutoyo No 2, DKI Jakarta, 13630, Indonesia; Antarianto, R.D., Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia, Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia |
Osteogenic differentiation from Mesenchymal Stem Cell (MSC) to osteoblast has a clinical significance which is very important for treating bone injuries, in the form of femoral fractures with the most cases in Indonesia. Various studies have been conducted to find the best scaffold that can improve osteogenic differentiation, one of which is the development of a hybrid scaffold made from natural biomaterials in the form of the extracellular matrix, and from synthetic biomaterials. The discovery of the best scaffold is not only focused on the source of the scaffold but also requires optimization of the method in making the scaffold. Therefore, the aim of this study is to find out the optimum method for making hybrid scaffolds that support osteogenic differentiation from MSC. Materials and methods: human Fibroblast-derived Matrix (hFDM) as a hybrid scaffold material collected from decellularized fibroblasts cultures from post-cleft-surgery reconstruction palatal skin. Fibroblast cell cultures were divided into two groups of cultures, cultures without Platelet Rich Plasma (PRP), and cultures with the addition of PRP. For decellularization, we performed optimization at the preparation stage of the decellularization solution, and the time of culture for decellularization. In the preparation of the decellularization solution, we divided it into two groups, NH4OH as material from the decellularization solution was diluted with PBS before mixing with 0.25% Triton X-100, and NH4OH was diluted directly in 0.25% Triton X-100. In optimizing the culture time for decellularization, we divided it into three groups, decellularization on the day when cell growth reached 100% confluent, decellularization on the 3rd day after 100% confluent (H + 3) cells, and decellularization on the 4th day after 100% confluent (H + 4) cells. Next, the hFDM matrix is collected and added Polyvinyl Alcohol (PVA) solutions to form a hybrid PVA / hFDM scaffold in the form of a hydrogel. Observations on hybrid PVA / hFDM scaffolds were made using an inversion microscope. Results and discussion: Optimization of methods for culture techniques found that the addition of PRP to fibroblast culture medium increased the rate of fibroblast proliferation. For the decellularization technique, it is known that the preparation of the decellular solution by diluting NH4OH directly in 0.25% Triton X-100 to obtain a final concentration of 50mM NH4OH is known to be effectively used in decellularizing fibroblasts. The optimum culture time is also known that a thicker hFDM matrix can be obtained on day 4 after 100% confluent (H + 4) cells. Conclusion: Making a good hFDM hybrid PVA scaffold requires method optimization, ranging from fibroblast culture techniques and decellularization techniques. Proper optimization can produce a hybrid PVA / hFDM scaffold which is suitable for bone tissue engineering applications. © 2021 Author(s). |
decellularization; fibroblast culture; hybrid PVA/hFDM scaffold |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
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177 |
20880 |
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513 |
Rizal, Syaidah R., Aqsha Z.M., Josephin A., Pakpahan V.M. |
57222623832;55418885900;57222626455;57222619624;57222621602; |
Characterization, differentiation, and population doubling time of Wharton's jelly mesenchymal stem cells (WJ-MSCs) in passage 5 and 8 |
2021 |
AIP Conference Proceedings |
2344 |
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040002 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103479666&doi=10.1063%2f5.0047340&partnerID=40&md5=346f0fd284692390adaef1a8feae20b2 |
Biomedical Engineering Program, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Undergraduate Program in Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia |
Rizal, Biomedical Engineering Program, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Syaidah, R., Department of Histology, Faculty of Medicine, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Aqsha, Z.M., Undergraduate Program in Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Josephin, A., Undergraduate Program in Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Pakpahan, V.M., Undergraduate Program in Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia |
Wharton's jelly mesenchymal stem cells (WJ-MSCs) is proposed to be the best source of mesenchymal stem cells (MSCs). It has better self-renewal and differentiation capacity compare to adult stem cells such as bone marrow- derived stem cells (BM-MSCs). However, their characteristics in different passages do not yet well described. This research aims to isolate and characterize WJ-MSCs with regard to their proliferation capacity, immunophenotypes, and differentiation capacity. The WJ-MSCs were isolated by the explant method. The cultured WJ-MSCs at P5 and P8 were then characterized using flow cytometric analysis with regard to its surface marker, which are CD44, CD90, CD105, CD73, and negative lineages. The proliferation capacity of WJ-MSCs was analyzed with the population doubling time method and the characterized cells were differentiated into three different lineages. The result revealed that the isolated cells highly express MSCs surface marker with >98% for all surface markers and 0.00% for negative lineages. Isolated WJ-MSCs also exhibited a high proliferation capacity with a range of 1.06 to 1.59 days. Both passages revealed excellent differentiation capacity into chondrocytes, adipocytes, and osteocytes. © 2021 Author(s). |
characterization; differentiation; Mesenchymal stem cells; proliferation; Wharton's jelly |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
|
Conference Paper |
- |
177 |
20880 |
|
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