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No records
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225 |
Tandaju J.R., Ii W., Barati-Boldaji R., Raeisi-Dehkordi H. |
57222662533;57226738113;57204935735;57195065694; |
Meta-analysis of statin and outcomes of coronavirus disease 2019 (COVID-19): Reconsideration is needed |
2021 |
Nutrition, Metabolism and Cardiovascular Diseases |
31 |
9 |
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2737 |
2739 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112531675&doi=10.1016%2fj.numecd.2021.06.009&partnerID=40&md5=51cf1abe5238935b3bcbca2d4b7a9969 |
Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia; The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Nutrition Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran |
Tandaju, J.R., Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia; Ii, W., The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Barati-Boldaji, R., Nutrition Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Raeisi-Dehkordi, H., Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran |
[No abstract available] |
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hydroxymethylglutaryl coenzyme A reductase inhibitor; human; COVID-19; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; SARS-CoV-2 |
Elsevier B.V. |
09394753 |
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34366177 |
Letter |
Q1 |
1127 |
3665 |
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702 |
Deviandri R., van der Veen H.C., Lubis A.M.T., Postma M.J., van den Akker-Scheek I. |
57222171014;57265936900;15122639800;7006296502;55936129400; |
Translation, Cross-Cultural Adaptation, Validity, and Reliability of the Indonesian Version of the IKDC Subjective Knee Form |
2021 |
Orthopaedic Journal of Sports Medicine |
9 |
9 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116266022&doi=10.1177%2f23259671211038372&partnerID=40&md5=ce2114ff8fec736ec8dc0057566bccd5 |
Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; Department of Physiology--Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia; Division of Orthopaedics--Sports Injury, Arifin Achmad Hospital, Pekanbaru, Indonesia; Department of Orthopaedics--Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Health Sciences, University of Groningen, University Medical Center Groningen, Netherlands; Department of Economics, Econometrics and Finance, University of Groningen, Faculty of Economics Business, Groningen, Netherlands; Department of Pharmacology and Therapy, Universitas Airlangga, Surabaya, Indonesia; Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, Indonesia |
Deviandri, R., Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, Department of Physiology--Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia, Division of Orthopaedics--Sports Injury, Arifin Achmad Hospital, Pekanbaru, Indonesia; van der Veen, H.C., Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; Lubis, A.M.T., Department of Orthopaedics--Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Postma, M.J., Department of Health Sciences, University of Groningen, University Medical Center Groningen, Netherlands, Department of Economics, Econometrics and Finance, University of Groningen, Faculty of Economics Business, Groningen, Netherlands, Department of Pharmacology and Therapy, Universitas Airlangga, Surabaya, Indonesia, Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, Indonesia; van den Akker-Scheek, I., Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands |
Background: No questionnaire is currently available for use in patients with anterior cruciate ligament (ACL) injuries in an Indonesian population. The most-used questionnaire in clinical research for these patients is the International Knee Documentation Committee (IKDC) Subjective Knee Form, as its psychometric properties are considered to be excellent. Purpose: To translate the IKDC into Indonesian and assess its validity for use in Indonesian-speaking patients with ACL injuries. Study Design: Cohort study (diagnosis); Level of evidence, 2. Methods: After a forward-and-backward translation procedure and cross-cultural adaptation, the validity and reliability of the questionnaire were investigated. The responses of ACL injury patients on 3 questionnaires, the Indonesian-IKDC (I-IKDC), 36-Item Short Form Health Survey, and Kujala Anterior Knee Pain Scale, were compared. Following consensus-based standards for the selection of health measurement instruments guidelines, construct validity, test-retest reliability, internal consistency, floor and ceiling effects, and measurement error were determined. The Bland-Altman method was used to explore absolute agreement. Results: Of 253 ACL injury patients, 106 (42%) responded to the invitation. Construct validity was considered good, as all predefined hypotheses on correlations between the I-IKDC and other scores were confirmed. Reliability proved excellent, with a high test-retest correlation (intraclass correlation coefficient = 0.99). Bland-Altman analyses showed no systematic bias between test and retest. Internal consistency was good (Cronbach α =.90). There were no floor or ceiling effects. Standard error of measurement was 2.1, and the minimal detectable change was 5.8 at the individual level and 0.7 at the group level. Conclusion: The I-IKDC, as developed, appeared to be a good evaluation instrument for Indonesian patients with ACL injuries. © The Author(s) 2021. |
anterior cruciate ligament; IKDC; Indonesian version; reliability; validity |
adult; Article; controlled study; female; human; human experiment; human tissue; major clinical study; male; retrospective study |
SAGE Publications Ltd |
23259671 |
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Article |
Q1 |
1329 |
2772 |
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No records
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206 |
Findyartini A., Greviana N., Hanum C., Husin J.M., Sudarsono N.C., Krisnamurti D.G.B., Rahadiani P. |
56543777300;57197709749;57257072300;57221607411;57201862518;55934951600;55524183700; |
Supporting newly graduated medical doctors in managing COVID-19: An evaluation of a Massive Open Online Course in a limitedresource setting |
2021 |
PLoS ONE |
16 |
9 September |
e0257039 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114841740&doi=10.1371%2fjournal.pone.0257039&partnerID=40&md5=d823d8aaf9a69d130347230f477800d5 |
Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sports and Exercise Study, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Center for E-learning, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Findyartini, A., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Greviana, N., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hanum, C., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Husin, J.M., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sudarsono, N.C., Sports and Exercise Study, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Krisnamurti, D.G.B., Center for E-learning, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Pharmacy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rahadiani, P., Center for E-learning, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction Newly graduated medical doctors in their internships are positioned to strengthen the front line in combating COVID-19. We developed a Massive Open Online Course (MOOC) to equip them with adequate knowledge for COVID-19 management. This paper aims to analyze the MOOC and evaluate participant satisfaction and increase in knowledge after completing the course. Methods An observational study was conducted. Quantitative data were obtained from questionnaires and pre-and post-Tests. Responses to open-ended questions of the questionnaires were collected. Analysis using the Quality Reference Framework was also completed. Results The MOOC consisted of fundamental knowledge of COVID-19 (Part A) and further enrichment (Part B), and the content was written in the Indonesian language. A total of 3,424 and 2,462 participants completed the course in August and November 2020, respectively. Most participants agreed that the platform was easy to navigate, the design was interesting, and the content was aligned with their needs. Pre-and post-Test scores in Part A s subjects increased significantly. Factors contributing to and inhibiting usability and areas for improvement were further highlighted. Discussion The use of a specific quality framework facilitated a comprehensive evaluation of the MOOC s strengths, weaknesses, and areas for future improvements. The participants satisfaction and pre-and post-Test results showed that the current MOOC holds great potential benefit for continuing education for medical interns joining the frontliners during the pandemic. Future implementation should consider increasing the quality of learning resources, scaling up the platform and its technical supports, and enhancing organizational supports. © 2021 Public Library of Science. All rights reserved. |
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education; epidemiology; human; Indonesia; medical education; procedures; program evaluation; questionnaire; COVID-19; Education, Distance; Education, Medical, Graduate; Educational Measurement; Humans; Indonesia; Program Evaluation; Surveys and Questionnaires |
Public Library of Science |
19326203 |
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34506524 |
Article |
Q1 |
990 |
4434 |
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208 |
Widodo D.W., Mars R., Suwento R., Alviandi W., Oriza I.I.D., Bardosono S. |
56644646600;57248384300;55743638800;57189731254;57205092885;21933841000; |
Satisfaction and health-related quality of life of patients with microtia following reconstructive surgery using the Nagata technique |
2021 |
PLoS ONE |
16 |
9 September |
e0256652 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114383156&doi=10.1371%2fjournal.pone.0256652&partnerID=40&md5=3f7c84ef725b34720da5ae494a0fc02a |
Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Faculty of Psychology, Universitas Indonesia, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Widodo, D.W., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Mars, R., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Suwento, R., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Alviandi, W., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Oriza, I.I.D., Faculty of Psychology, Universitas Indonesia, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Objective This study aimed to investigate the functional outcomes, satisfaction, and quality of life of patients with microtia following reconstructive surgery. Methods This cross-sectional study was conducted using retrospective data of patients with microtia following reconstructive surgery using the Nagata technique. Data were obtained from the medical records of patients who underwent reconstructive surgery at the Division of Facial Plastic and Reconstructive Surgery, Department of Otorhinolaryngology, Head and Neck Surgery, Dr. Cipto Mangunkusumo Hospital between 2014 and 2018. All eligible patients were referred to participate in this study between November 2018 and March 2019. The hearing function was assessed by a professional audiologist after surgery. Patient satisfaction was evaluated by interview using a previously developed questionnaire, while quality of life was assessed using the EuroQol-5D-Young questionnaire. Results Thirty-one eligible subjects were included in the study. Pain and discomfort were the most commonly reported factors related to the quality of life following surgery. Approximately 67.7% of the patients were satisfied; 19.4% were very satisfied, and 12.9% reported acceptance of their surgical outcomes. The most common complication was infection (n = 8). Most patients did not experience any problems in their lives after microtia surgery. Conclusions The highest rate of satisfactory outcomes was observed for the lobule subunit, which was assumed to be associated with the use of the Z-plasty technique. The most common complication was infection, as environmental hygiene was the most important factor. Thus, further concern for maintaining good hygiene is necessary to improve the quality of reconstructive surgery. The level of satisfaction with microtia reconstructive surgery was adequate. Most patients had a good health-related quality of life without experiencing any problems. © 2021 Widodo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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adolescent; Article; audiologist; child; clinical article; cross-sectional study; ear infection; European Quality of Life 5 Dimensions questionnaire; female; hearing; human; interview; male; medical record; microtia; otalgia; patient referral; patient satisfaction; quality of life; questionnaire; reconstructive surgery; retrospective study; external ear; microtia; patient satisfaction; procedures; psychology; reconstructive surgery; treatment outcome; Adolescent; Child; Congenital Microtia; Cross-Sectional Studies; Ear, External; Female; Humans; Male; Patient Satisfaction; Quality of Life; Reconstructive Surgical Procedures; Retrospective Studies; Treatment Outcome |
Public Library of Science |
19326203 |
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34469475 |
Article |
Q1 |
990 |
4434 |
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No records
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652 |
Indarti J., Ria S., Maulina F., Andardi B., Octavianti J., Santawi V.P.A. |
39161587400;57366269400;57365981600;57219905485;57365684400;57192917419; |
Maternal and Perinatal outcomes in pregnancies affected by maternal cardiovascular disease |
2021 |
Journal of Reproductive Medicine |
66 |
9-10 |
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298 |
302 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120797893&partnerID=40&md5=15870fc71073943a029b179358e65364 |
Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Indarti, J., Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Ria, S., Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Maulina, F., Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Andardi, B., Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Octavianti, J., Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Santawi, V.P.A., Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
OBJECTIVE: To investigate the incidence, profile, and maternal and perinatal outcomes in pregnancies affected by maternal cardiovascular disease. STUDY DESIGN: We performed a retrospective data collection from the database of pregnancies in which the mother had cardiovascular disease. Maternal age, parity, gestational age at delivery, type of cardiovascular disease, subsequent contraceptive method, mode of delivery, intensive care unit (ICU) admission, maternal death, APGAR scores, presence of acidosis, neonatal ICU (NICU) admission, and perinatal death were investigated. Medical records with incomplete variables were excluded. We obtained 70 cases of pregnant women with cardiovascular disease from 2014 to 2018 who were admitted to Cipto Mangunkusumo National Hospital. RESULTS: Out of 70 cases, 60% were acquired heart disease, while 40% were congenital heart disease. It was found that 74.3% of the pregnancies had preterm birth, and the cesarean section rate was 72.9%. While the ICU admission rate was 52.9%, the maternal mortality rate remained at 7.1%. We found that 11.4% of neonates suffered asphyxia, with a 5.0% rate of NICU admissions. CONCLUSION: This study shows that preterm delivery might be indicated in pregnancies affected by maternal cardiovascular disease to prevent maternal mortality at the expense of neonatal outcomes. © Journal of Reproductive Medicine Inc. |
Cardiovascular disease; Heart disease; Maternal and neonatal outcome; Maternal outcomes; Pregnancy; Pregnancy complications |
acidosis; adult; Apgar score; Article; asphyxia; cardiovascular disease; cesarean section; congenital heart disease; contraception; cross-sectional study; female; fetus; fetus death; gestational age; heart rate; hospital admission; hospital discharge; human; hypertension; intensive care unit; major clinical study; maternal age; maternal death; maternal hypertension; maternal mortality; maternal outcome; multicenter study; neonatal intensive care unit; newborn; parity; perinatal death; perinatal outcome; pregnancy complication; pregnancy outcome; pregnant woman; premature fetus membrane rupture; premature labor; prematurity; puerperium; retrospective study; vaginal delivery |
Journal of Reproductive Medicine, Inc. |
00247758 |
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Article |
#N/A |
#N/A |
#N/A |
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No records
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619 |
Makkiyah F., Sadewo W., Nurrizka R.H. |
57210232162;55014544900;57210747260; |
Comparative dose of intracarotid autologous bone marrow mononuclear therapy in chronic ischemic stroke in rats |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
A |
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233 |
243 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107180848&doi=10.3889%2foamjms.2021.5675&partnerID=40&md5=a05eb1c39d7b38d60e04285fce893c7d |
Department of Neurosurgery, Faculty of Medicine, UPN Veteran Jakarta, Depok, Indonesia; Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Central Jakarta, Indonesia; Department of Public Health, Universitas Islam Negeri Syarif Hidayatullah Jakarta, South Tangerang, Indonesia |
Makkiyah, F., Department of Neurosurgery, Faculty of Medicine, UPN Veteran Jakarta, Depok, Indonesia; Sadewo, W., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Central Jakarta, Indonesia; Nurrizka, R.H., Department of Public Health, Universitas Islam Negeri Syarif Hidayatullah Jakarta, South Tangerang, Indonesia |
BACKGROUND: Research on chronic ischemic stroke is limited. One of the more promising approaches showing positive effects in the acute stage is mononuclear bone marrow cell therapy. This research may be the first which presents data about the optimum dose of bone marrow mononuclear cells (BM-MNCs) for chronic ischemic stroke in rats and discusses factors influencing recovery in the chronic stage. AIM: To elucidate the optimum dose of BM-MNCs for chronic ischemic stroke and to demonstrate factors influencing recovery in chronic stage of stroke ischemia. METHODS: Thirty-two male Sprague-Dawley rats sourced from the Kalbe Farma Institution (Bandung, Indonesia), aged 6–10 aged months, weighing 350–450 g were used in this study. We performed temporary middle cerebral artery occlusion (MCAO) procedures on the rats which were then randomly assigned to one of two experimental groups in which they were given either low or high doses of autologous BM-MNCs (5 million or 10 million cells per kg body weight intracarotid), after 4 week of MCAO. At 8th or 12 week, rats were necropsied and rat brains were fixed for HE, cluster of differentiation (CD) 31, and doublecortin staining for analysis of the effects. Rat behavior was assessed weekly using the cylinder test and a modified neurological severity score (NSS) test. Cylinder test scores and NSS scores were analyzed by one-way ANOVA repeated measures and post hoc Bonferroni. The size of the infarct zone, the CD 31 vessels, and the DCX-neuroblast were analyzed using one-way ANOVA and a post hoc Bonferroni test. To investigate the degree of correlation between time and dose, two-way ANOVA and simple mass effect analyses were conducted. A linear regression test was used to evaluate the correlation between CD34 and other variables. RESULTS: In the 4 weeks before administration of BM-MNC, cylinder test scores improved to near normal, and NSS test scores improved moderately. The infarct zone decreased significantly (p < 0.01), there was an improvement in angiogenesis (p = 0.1590) and a significant improvement in neurogenesis (p < 0.01). Reduction of the infarct zone was associated with a higher dose whereas both higher and lower doses were found to have a similar effect on improving angiogenesis, and neurogenesis. Recovery was superior after 12 weeks compared with the recovery assessment at 8 weeks. CONCLUSION: A dose of 10 million cells was more effective than a dose of 5 million cells per kg body weight for reducing the infarct zone and ameliorating neurogenesis. There was an improvement of histopathological parameters associated with the longer infarct period. © 2021 Feda Makkiyah, Wismaji Sadewo, Rahmah Hida Nurrizka. |
Bone marrow mononuclear cells; Chronic infarct; Dose; Intracarotid; Rats brain |
CD34 antigen; platelet endothelial cell adhesion molecule 1; adipose derived stem cell; analysis of variance; angiogenesis; animal cell; animal experiment; animal model; animal tissue; arteriotomy; Article; autopsy; body weight; bone marrow derived mononuclear cell; breathing rate; chronic ischemic stroke; controlled study; cylinder test; drug megadose; endothelial progenitor cell; gap junction; histopathology; immunohistochemistry; infarction; interphalangeal joint; intracarotid drug administration; linear regression analysis; low drug dose; micro-computed tomography; middle cerebral artery occlusion; National Institutes of Health Stroke Scale; neuroblast; neurological severity score; nonhuman; rat; Sprague Dawley rat |
Open Access Macedonian Journal of Medical Sciences |
18579655 |
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Article |
Q3 |
288 |
15252 |
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No records
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644 |
Immanuel S., Ginanjar E., Nurtyas F.I.P., Sukartini N., Yusra Y., Pasaribu M.M.B.R. |
12777341300;23472616600;57391656300;6505680329;57220998367;57391787700; |
The role of neutrophil lymphocyte ratio as a major adverse cardiac events predictor and its correlation with coronary severity in acute coronary syndrome patients with chronic kidney disease: A case control and cross-sectional study |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
B |
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1758 |
1763 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122018503&doi=10.3889%2foamjms.2021.7488&partnerID=40&md5=f88a00ee4d9113e8e49425b6276d9400 |
Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Immanuel, S., Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ginanjar, E., Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nurtyas, F.I.P., Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sukartini, N., Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yusra, Y., Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pasaribu, M.M.B.R., Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND: Acute coronary syndrome (ACS) patients with chronic kidney disease (CKD) are known to have a higher risk of mortality compared to ACS patients without CKD. In ACS patients with CKD, chronic inflammation plays an important role in morphological and functional changes in endothelial cells, resulting in atherosclerosis acceleration associated with coronary severity that leads to an increase in major adverse cardiac events (MACE). AIM: Therefore, this study aims to determine the role of neutrophil lymphocyte ratio (NLR) as a predictor of MACE and its correlation with coronary severity in ACS patients with CKD. METHODS: The study was conducted at National General Hospital Cipto Mangunkusumo Jakarta, Indonesia in October to November 2019. We used quota sampling with two designs study. First, a nested case control study was conducted with a total of 59 ACS patients with CKD: 31 subjects who had experienced MACE as a case group and 28 subjects who had not experienced MACE as a control group. Second, a correlative study with a cross-sectional approach was undertaken. RESULTS: There was no significant difference or relationship between NLR and MACE (p > 0.05; OR = 2.16 [95% CI = 0.63–7.51]), also no correlation between NLR and coronary severity degree assessed using the Gensini score (r = 0.10; p = 0.474). CONCLUSION: NLR can not predict MACE in ACS patients with CKD nor be employed interchangeably with the Gensini score in assessing coronary severity in ACS patients with CKD. © 2021 Suzanna Immanuel, Eka Ginanjar, Fahrani Imanina Putri Nurtyas, Ninik Sukartini, Yusra Yusra, Merci Monica B. R. Pasaribu. |
Acute coronary syndrome; Chronic kidney disease; Major adverse cardiac events predictor; Neutrophil lymphocyte ratio |
beta 2 microglobulin; hemoglobin; acute coronary syndrome; adult; Article; basophil count; case control study; chronic kidney failure; controlled study; coronary angiography; cross-sectional study; diabetes mellitus; disease severity; dyslipidemia; eosinophil count; female; Gensini score; human; hypertension; leukocyte count; leukocyte differential count; lymphocyte count; major adverse cardiac event; major clinical study; male; middle aged; monocyte count; neutrophil count; neutrophil lymphocyte ratio; non ST segment elevation myocardial infarction; platelet count; prediction; ST segment elevation myocardial infarction |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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738 |
Ardinata D., Zain-Hamid R., Roesyanto-Mahadi I.D., Mihardja H. |
57201518818;8059724800;57222900126;57195721818; |
Interleukin-31 serum and pruritus dimension after acupuncture treatment in hemodialysis patients: A randomized clinical trial |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
B |
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196 |
201 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112120177&doi=10.3889%2foamjms.2021.5599&partnerID=40&md5=a48058e1ca315a987857bbabd6864b39 |
Department of Physiology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Ardinata, D., Department of Physiology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Zain-Hamid, R., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Roesyanto-Mahadi, I.D., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Mihardja, H., Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Interleukin (IL)-31 serum levels were significantly higher in hemodialysis patients with pruritus, whereas acupuncture in LI11 was shown to improve symptoms of pruritus. However, there is limited information that IL-31 serum levels that correlate with decreased dimensions of the pruritus after acupuncture in LI11 in a hemodialysis patient. AIM: The aim of the study was to demonstrate the impact of acupuncture in LI11 and IL-31 serum level and its correlation with dimensions of the pruritus in hemodialysis patients. METHODS: A randomized clinical trial has been carried out from August 2019 to December 2019 at H. Adam Malik General Hospital, Medan, Indonesia. Sixty patients underwent hemodialysis who were randomly allocated to two groups, one group got acupuncture in Quchi LI11 (intervention group), and the other group got a placebo (control group). IL-31 serum levels and pruritus were measured before and after 6 weeks of acupuncture in both groups. RESULTS: Acupuncture did not significantly reduce IL-31 (p = 0.931) and decreased dimensions: Degree, duration, disability, and distribution of the pruritus between the intervention group and the control group after 6 weeks of acupuncture in LI11. It can be shown that there is no significant correlation between IL-31 serum levels and dimensions of the pruritus. CONCLUSION: This study demonstrates the effect of acupuncture on reducing dimensions of the pruritus not related to IL-31 serum levels. Identifying the action mechanism of acupuncture to minimize pruritus considerably enhances knowledge of the impacts of acupuncture on reducing pruritus in hemodialysis patients. © 2021 Dedi Ardinata, Rozaimah Zain-Hamid, Irma. D. Roesyanto-Mahadi, Hasan Mihardja. |
Acupuncture; Hemodialysis; Interleukin 31; LI11 Quchi; Pruritus |
bicarbonate; C reactive protein; chemical compound; hemoglobin; interleukin 31; naltrexone; polysulphane; tumor necrosis factor; unclassified drug; acupuncture; adult; Article; atopic dermatitis; body mass; controlled study; data analysis; diabetic nephropathy; disability; disease severity; enzyme linked immunosorbent assay; female; hemodialysis; hemodialysis patient; histamine release; human; hypertension; iontophoresis; kidney disease; major clinical study; male; middle aged; percutaneous coronary intervention; protein blood level; pruritus; psoriasis; quchi acupoint; questionnaire; randomized controlled trial; scoring system; urticaria; visual analog scale |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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793 |
Sitohang I.B.S., Nelson B., Marissa M., Indriatmi W., Wisnu W. |
56734569200;57222619613;57210795916;57189888041;57200425452; |
Evaluation of modified melasma area and severity index in hyperthyroid patients receiving anti-thyroid drugs |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
B |
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344 |
349 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107477787&doi=10.3889%2foamjms.2021.6082&partnerID=40&md5=ecf1548d04f6591bb645bfc03792883e |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Metabolic Endocrine Division, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nelson, B., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Marissa, M., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Indriatmi, W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wisnu, W., Department of Internal Medicine, Metabolic Endocrine Division, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND: Melasma is a common hyperpigmentation disorder, which causes brownish discoloration of the face. Despite unclear mechanisms, thyroid hormones were thought to play a role in melasma. AIM: This study aims to determine and compare the clinical improvement of melasma in hyperthyroid patients receiving anti-thyroid drugs. METHODS: An interventional study with a quasi-experimental design (pre-post-intervention study) was conducted at the Internal Medicine Outpatient Clinic and Dermatology and Venereology Outpatient Clinic, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, from July 2019 to March 2020. A comparative analysis was done to compare the modified melasma area and severity index (mMASI) in hyperthyroid patients before and after 12 weeks of anti-thyroid drugs. All subjects did not receive any additional topical therapies for their melasma. The clinical features were evaluated objectively at baseline and 12th-week visit, by mMASI score on different areas of the face (forehead, left-right malar, and chin) and Wood’s lamp examination. RESULTS: All areas showed a decline in mMASI score components (e.g., involvement areas and darkness degree) after 12 weeks of treatment. However, only the malar area showed a significant decline (p < 0.05). Wood’s lamp examination at baseline revealed dermal type melasma on 17 subjects, mixed type on six subjects, and epidermal type on one subject. All types remained unchanged after 12 weeks of treatment. CONCLUSIONS: Our study demonstrated that mMASI score in malar area improved significantly, this might be because malar area included this study were comprised of epidermal, dermal, and mixed type. On the other hand, based on Wood’s lamp examination, all types of melasma remained unchanged after 12 weeks of treatment. © 2021 Irma Bernadette S. Sitohang, Benny Nelson, Melani Marissa, Wresti Indriatmi, Wismandari Wisnu. |
Hyperthyroid; Melasma; Modified melasma area and severity index; Wood’s lamp |
amiodarone; antithyroid agent; octreotide; thiamazole; thyroid hormone; adult; Article; chloasma; clinical article; clinical assessment; clinical feature; dermatology; experimental design; female; follow up; forehead; human; hyperpigmentation; hyperthyroidism; intervention study; male; observational study; outpatient department; prospective study; thyroid disease; thyroid function test; topical treatment; visual analog scale |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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890 |
Elliyanti A., Rustam R., Tofrizal T., Yenita Y., Susanto Y.D.B. |
57217097313;57210705603;57219663511;57221789235;57197866044; |
Evaluating the natrium iodide symporter expressions in thyroid tumors |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
B |
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18 |
23 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100161267&doi=10.3889%2foamjms.2021.5534&partnerID=40&md5=f5dd69104ea66dab03a6a98ac2928162 |
Department of Medical Physics, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Division of Nuclear Medicine, Department of Radiology, Dr. M.Djamil Hospital, Padang, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Elliyanti, A., Department of Medical Physics, Faculty of Medicine, Universitas Andalas, Padang, Indonesia, Division of Nuclear Medicine, Department of Radiology, Dr. M.Djamil Hospital, Padang, Indonesia; Rustam, R., Department of Surgery, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Tofrizal, T., Department of Pathology Anatomy, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Yenita, Y., Department of Pathology Anatomy, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Susanto, Y.D.B., Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Decreased Natrium iodide symporter (NIS) expression levels or diminished NIS targeting thyroid cancer cells’ plasma membrane leads to radioiodine-refractory disease. AIM: The aim of this study was to analyze the NIS expression in thyroid tumors. MATERIALS AND METHODS: The samples were thyroid tissues of patients who underwent surgery for a thyroid tumor. The tissues were processed for NIS protein expressions by immunohistochemistry (IHC) and Western blot (WB). Graves’ disease samples were used as positive controls. The samples were incubated without the primary antibody, and they were used as negative controls for IHC examination. Na+/K+ ATPase was a plasma membrane protein marker in the WB procedure. RESULTS: Twenty-nine samples were assessed for NIS protein. All of them showed the expression in the cytoplasm with intensity 1+ to 3+ with Allred score 3-8. Fourteen out of 29 cases (48.2%) showed NIS cytoplasm staining intensity ≥2+ consist of 10 papillary thyroid cancer (PTC), three follicular thyroid cancer, and one adenoma. Membrane staining was found in 2 samples of PTC (6.9%). Six samples (adenoma 1 sample, PTC 5 samples) showed NIS expression at membrane very weak (1+); they were considered as negative. NIS protein has several bands of ~ 80 kDa, ~ 62 kDa, and ~ 49 kDa. CONCLUSION: NIS expression in thyroid cancer mostly expresses in the cytoplasm instead of the membrane. NIS will play a functional role in the membrane to bring iodine across the membrane against the concentration. It can be the main reason for the lack of response of radioiodine in some differentiated thyroid cancers. © 2021 Aisyah Elliyanti, Rony Rustam, Tofrizal Tofrizal, Yenita Yenita, Susanto YDB. |
Follicular thyroid cancer; Immunohistochemistry; Membrane staining; Papillary thyroid cancer; Western blot |
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Open Access Macedonian Journal of Medical Sciences |
18579655 |
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Article |
Q3 |
288 |
15252 |
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