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Id	Authors	Author S Id	Title	Year	Source Title	Volume	Issue	Art No	Page Start	Page End	Cited By	Link	Affiliations	Authors With Affiliations	Abstract	Author Keywords	Index Keywords	Publisher	Issn	Document Type	Sjr Best Quartile	Sjr	Sjr Rank
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Ukrainian Biochemical Journal(1)
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854	Kirana A.N., Prafiantini E., Hardiany N.S.	57222361321;57193088368;57192910605;	Protein intake and loss of proteostasis in the eldery	2021	Ukrainian Biochemical Journal	93	1		30	39		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102434761&doi=10.15407%2fubj93.01.030&partnerID=40&md5=e09be01091937944ac8ad3197ad54b2c	Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Indonesia; Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine, Universitas Indonesia, Indonesia	Kirana, A.N., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Prafiantini, E., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hardiany, N.S., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine, Universitas Indonesia, Indonesia	Ageing is a process of declining bodily function and a major risk factor of chronic diseases. The declining bodily function in ageing can cause loss of proteostasis (protein homeostasis), which is a balance between protein synthesis, folding, modification and degradation. For the elderly, adequate protein intake is necessary to prevent sarcopenia, frailty, fracture and osteoporosis as well as reduced resistance to infection. However, increasing the protein intake can enhance the risk of oxidized protein formation, loss of proteostasis and degenerative disorder occurrence. On the other hand, several studies show that protein restriction would increase longevity. The aim of this review was to explain the importance of determining the right amount and composition of protein intake for the elderly. Oxidative stress and molecular mechanism of proteostasis loss in ageing cells as well as its suppression pathway by protein restriction are discussed in this review. © 2021 Kirana A. N. et al.	Ageing; Dietary proteins; MTOR; Oxidative stress; Proteostasis loss		Palladin Institute of Biochemistry of the NASU	24094943	Article	Q4	173	21241	View
Urogynaecologia International Journal(1)
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347	Moegni F., Ocsilia Wengkang I.F.	55450456100;57226112377;	Correlation of levator ani muscle strength measurement between Modified Oxford Grading Scale and perineometer on pelvic organ prolapse patient	2021	Urogynaecologia International Journal	33	1	268				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110513972&doi=10.4081%2fUIJ.2021.268&partnerID=40&md5=f4aa2afc9d600b8716b8e0217ad613a6	Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Moegni, F., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ocsilia Wengkang, I.F., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Pelvic Organ Prolapse (POP) is a debilitating condition affecting about half of all women aged of more than 60 years globally. Reduced levator ani muscle strength in POP is associated with worse symptoms and prognosis. Measurement of levator ani muscle strength can be done with several tools such as perineometer and digital palpation. However, there is currently no study regarding conformity between tests. The aim of this study is to determine the correlation between tests in POP patients. An analytic observational study using cross sectional design was done to determine conformity between perineometer and digital examination using Modified Oxford Grading Scale (MOS) in Dr Cipto Mangunkusumo National General Hospital, Indonesia during the period of July, 2018 to June, 2020. Correlation between tests was determined using Spearman test. Cut-off of perineometer reading for each MOS score was also determined. A total of 110 subjects examined with both perineometer and digital palpation were recruited to the study. Positive correlation was observed between perineometer reading and Modified Oxford Grading Scale (r = 0.790, p < 0.001). According to the result, values between 0.01 – 9.64 cmH2O correspond to very weak pressure (MOS 1); 9.65 – 22.49 cmH2O represent weak pressure (MOS 2); 22.5 – 35.24 cmH2O represent moderate pressure (MOS 3); ≥ 35.25 cmH2O represent good pressure (MOS 4). There was a strong correlation between MOS and perineometer result for measuring levator ani strength in POP patients. Non ©Copyright: the Author(s), 2021 Licensee PAGEPress, Italy	Levator ani muscle strength; Modified Oxford Grading Scale, pelvic organ prolapse; Perineometer		Page Press Publications	20388314	Article	Q4	103	30394	View
Urology Case Reports(5)
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113	Tirtayasa P.M.W., Samuel A.G., Lisnawati, Retnowulan A.	56245176500;57226642220;24449072000;57226640316;	Parameatal glans cyst: A case report	2021	Urology Case Reports	39		101802				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112167978&doi=10.1016%2fj.eucr.2021.101802&partnerID=40&md5=a508fda307bc2bbe4ba2dcbc8048eb84	Department of Urology, Faculty of Medicine Universitas Udayana, Bali, Indonesia; Urology Consultant, Pelni General Hospital, Jakarta, Indonesia; Pathology Consultant, Pelni General Hospital, Jakarta, Indonesia; Department of Pathological Anatomy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia	Tirtayasa, P.M.W., Department of Urology, Faculty of Medicine Universitas Udayana, Bali, Indonesia; Samuel, A.G., Urology Consultant, Pelni General Hospital, Jakarta, Indonesia; Lisnawati, Pathology Consultant, Pelni General Hospital, Jakarta, Indonesia, Department of Pathological Anatomy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Retnowulan, A., Pathology Consultant, Pelni General Hospital, Jakarta, Indonesia, Department of Pathological Anatomy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia	Parameatal glans cyst is unusual and only a few cases reported until currently. We presented a four-year-old boy with dysuria and inappropriate appearance of parameatal glans cyst. The cystic mass was slow-growing and was present since birth. Complete surgical excision was performed to prevent recurrencies and to achieve good cosmesis. © 2021 The Authors	Glans cyst; Parameatal cyst; Urethral cyst	Article; case report; child; clinical article; cuboidal epithelium; cyst; dysuria; epithelium; esthetic surgery; excision; follow up; general anesthesia; globular cystic swelling; histopathology; human; human tissue; male; parameatal glans cyst; penis glans; physical examination; preschool child; squamous epithelium; swelling; urethra; urethral meatus; urinalysis	Elsevier Inc.	22144420	Article	Q3	245	16962	View
115	Meutia A.P., Yonathan K., Widia F.	57203368133;57226144513;26028200800;	Giant urethral caruncle resembling urethral prolapse causing outflow obstruction	2021	Urology Case Reports	39		101783				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110776549&doi=10.1016%2fj.eucr.2021.101783&partnerID=40&md5=01ebfd6f9c1caac70e9244d1c3ffe391	Division of Urogynecology and Reconstruction Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Urogynecology Clinic, Bunda General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia	Meutia, A.P., Division of Urogynecology and Reconstruction Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Urogynecology Clinic, Bunda General Hospital, Jakarta, Indonesia; Yonathan, K., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Widia, F., Department of Urology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia	Urethral caruncle is a rare condition primarily affecting elderly. Sometimes, it resembles urethral prolapse or malignancies. It can even cause outflow obstruction or urinary retention. A case of 83-years-old woman with urinary retention since a week prior was presented. Physical examination revealed a bulging mass originating from posterior lip of external urethral meatus. Due to the size, it caused outflow obstruction. The whole mass was excised. Histology examination reported the mass as urethral caruncle. Urethral caruncle is a common problem in elderly which rarely cause outflow obstruction. A thorough examination is required to distinguish it from malignancies and other disorders. © 2021	Pelvic organ prolapse; Urethral caruncle; Urethral disease	aged; Article; blood cell count; case report; clinical article; female; general anesthesia; histology; histopathology; human; human tissue; pelvic examination; physical examination; postmenopause; urethra disease; urethra obstruction; urethral caruncle; urethral prolapse; urine retention; uroflowmetry; urothelium; vital sign	Elsevier Inc.	22144420	Article	Q3	245	16962	View
550	Patandung R., Prapiska F.F., Kadar D.D.	57200945097;57208879216;57217832474;	Open pyelolithotomy in an ectopic kidney: A case report	2021	Urology Case Reports	35		101528			1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097735075&doi=10.1016%2fj.eucr.2020.101528&partnerID=40&md5=95fd95b0363fa0eb89c9009f10649d8d	Department of Urology, Faculty of Medicine Universitas Indonesia, Haji Adam Malik Hospital, Medan, Indonesia; Division of Urology, Department of Surgery, Faculty of Medicine Universitas Sumatera Utara, Haji Adam Malik Hospital, Medan, Indonesia	Patandung, R., Department of Urology, Faculty of Medicine Universitas Indonesia, Haji Adam Malik Hospital, Medan, Indonesia; Prapiska, F.F., Division of Urology, Department of Surgery, Faculty of Medicine Universitas Sumatera Utara, Haji Adam Malik Hospital, Medan, Indonesia; Kadar, D.D., Division of Urology, Department of Surgery, Faculty of Medicine Universitas Sumatera Utara, Haji Adam Malik Hospital, Medan, Indonesia	Renal ectopia with stone is a rare case with no specific reported incidence rate. The treatment of kidney stone in ectopic kidneys poses a challenge to urologists. A 48-year-old male presenting with colicky pain on the right flank since one year ago. CT urography revealed an right-crossed renal ectopia and hyperdense lesions (25 × 20 mm and 10 × 10 mm) in the ureteropelvic junction of the right kidney. Under general anesthesia, we performed open pyelolithotomy for the patient and removed two stones completely. Open surgery could be the choice for patients with complex stone burden and associated renal anomalies such as ectopic kidney. © 2020	Ectopic kidney; Open pyelolithotomy; Renal stones	polyglactin; abdominal drainage; abdominal mass; abdominal radiography; adult; Article; case report; clinical article; computer assisted tomography; ectopic kidney; gerota fascia; human; kidney function test; kidney pelvis; male; middle aged; nephrolithiasis; open surgery; physical examination; pyelolithotomy; retroperitoneum; ureteropelvic junction; urinalysis; urography; urologist	Elsevier Inc.	22144420	Article	Q3	245	16962	View
914	Andika R., Birowo P., Rasyid N., Atmoko W.	57200945045;6504153311;56245069300;57193125664;	Supine PCNL in patient with staghorn renal stone and severe degree kyphosis: A case report	2021	Urology Case Reports	34		101509				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097421344&doi=10.1016%2fj.eucr.2020.101509&partnerID=40&md5=0f9040a4a723f7b0d51e13ce3bd1fb6e	Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia	Andika, R., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Birowo, P., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rasyid, N., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Atmoko, W., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia	Spinal deformity concomitantly with large renal stone has become a challenges for urologist since it needs different approach in performing percutaneous procedures. This case report highlight our success experience in treating a 53-years old female patients with severe degree of kyphosis and staghorn stone using supine PCNL. She underwent right PCNL and right Double-J stent insertion anterograde after stone were released. The duration of surgery was 2 hours and 45 minutes with no intra and post-operative complication reported. Supine position can be safely chosen if prone cannot be placed in complex situation such as staghorn stone in severe kyphosis patients. © 2020 The Authors	Kyphosis; PCNL; Spinal deformity; Staghorn renal stone	creatinine; hemoglobin; urea; adult; anemia; Article; backache; bleeding; case report; chronic kidney failure; clinical article; computer assisted tomography; female; flank pain; human; kyphosis; middle aged; percutaneous nephrolithotomy; postoperative complication; priority journal; staghorn stone; urinalysis; urography; urology; visual analog scale	Elsevier Inc.	22144420	Article	Q3	245	16962	View
920	Hakim R.L., Wahyudi I., Irdham G.A., Situmorang G.R., Rodjani A.	57219532152;36341995300;57194729795;57190001213;6504653529;	Kidney transplantation with vesicostomy in small-bladder capacity neurogenic bladder dysfunction patient: A case report	2021	Urology Case Reports	34		101464			1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85093653802&doi=10.1016%2fj.eucr.2020.101464&partnerID=40&md5=0f09bb4561e856acd141c2350b8c7bec	Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Hakim, R.L., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wahyudi, I., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Irdham, G.A., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Situmorang, G.R., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rodjani, A., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Spinal cord injury often results in neurogenic bladder condition and eventually lead to an end-stage renal disease requiring kidney transplantation. However, transplantation in abnormal bladder carries special considerations. We report a case of an adult male with end-stage chronic kidney disease and small bladder capacity after having spinal cord injury. The evaluation of videourodynamic showed reduced compliance and detrusor overactivity during filling phase. Kidney transplantation and vesicostomy was performed. Eighteen months follow-up after surgery showed that kidney function could be maintained. The prevention of increasing bladder pressure and UTI should be monitored to prevent the damage of the graft kidney. © 2020 The Author(s)	Kidney transplantation; Neurogenic bladder; Spinal cord injury; Vesicostomy	antibiotic agent; creatinine; hemoglobin; urea; accident; adult; allograft; anuria; Article; bladder capacity; bladder dysfunction; case report; catheter removal; clinical article; cystostomy; end stage renal disease; estimated glomerular filtration rate; falling; hemodialysis; human; kidney function; kidney transplantation; male; nuclear magnetic resonance imaging; overactive bladder; spine fracture; urinary tract disease	Elsevier Inc.	22144420	Article	Q3	245	16962	View
Vaccines(2)
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34	Gustiananda M., Sulistyo B.P., Agustriawan D., Andarini S.	6507570171;57215020738;55382929300;8716259500;	Immunoinformatics analysis of sars-cov-2 orf1ab polyproteins to identify promiscuous and highly conserved t-cell epitopes to formulate vaccine for indonesia and the world population	2021	Vaccines	9	12	1459			1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121528747&doi=10.3390%2fvaccines9121459&partnerID=40&md5=e6eaaf1e02bbe5e81bf5d0e390d38566	Department of Biomedicine, School of Life Sciences, Indonesia International Institute for Life Sciences, Jl. Pulomas Barat Kav 88, Jakarta, 13210, Indonesia; Department of Bioinformatics, School of Life Sciences, Indonesia International Institute for Life Sciences, Jl. Pulomas Barat Kav 88, Jakarta, 13210, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia, Persahabatan Hospital, Jl Persahabatan Raya 1, Jakarta, 13230, Indonesia	Gustiananda, M., Department of Biomedicine, School of Life Sciences, Indonesia International Institute for Life Sciences, Jl. Pulomas Barat Kav 88, Jakarta, 13210, Indonesia; Sulistyo, B.P., Department of Biomedicine, School of Life Sciences, Indonesia International Institute for Life Sciences, Jl. Pulomas Barat Kav 88, Jakarta, 13210, Indonesia; Agustriawan, D., Department of Bioinformatics, School of Life Sciences, Indonesia International Institute for Life Sciences, Jl. Pulomas Barat Kav 88, Jakarta, 13210, Indonesia; Andarini, S., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia, Persahabatan Hospital, Jl Persahabatan Raya 1, Jakarta, 13230, Indonesia	SARS-CoV-2 and its variants caused the COVID-19 pandemic. Vaccines that target conserved regions of SARS-CoV-2 and stimulate protective T-cell responses are important for reducing symptoms and limiting the infection. Seven cytotoxic (CTL) and five helper T-cells (HTL) epitopes from ORF1ab were identified using NetCTLpan and NetMHCIIpan algorithms, respectively. These epitopes were generated from ORF1ab regions that are evolutionary stable as reflected by zero Shannon’s entropy and are presented by 56 human leukocyte antigen (HLA) Class I and 22 HLA Class II, ensuring good coverage for the Indonesian and world population. Having fulfilled other criteria such as immunogenicity, IFNγ inducing ability, and non-homology to human and microbiome peptides, the epitopes were assembled into a vaccine construct (VC) together with β-defensin as adjuvant and appropriate linkers. The VC was shown to have good physicochemical characteristics and capability of inducing CTL as well as HTL responses, which stem from the engagement of the vaccine with toll-like receptor 4 (TLR4) as revealed by docking simulations. The most promiscuous peptide899WSMATYYLF907 was shown via docking simulation to interact well with HLA-A*24:07, the most predominant allele in Indonesia. The data presented here will contribute to the in vitro study of T-cell epitope mapping and vaccine design in Indonesia. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.	Cytotoxic T-cells; Helper T-cells; HLA-A*24:07; Human leukocyte antigen; Immunoinformatics; Multi-epitope peptide-based vaccine; SARS-CoV-2; T-cell epitopes	epitope; gamma interferon; HLA A antigen; HLA antibody; T lymphocyte receptor; toll like receptor 4; allele; allergenicity; amino acid sequence; antigenicity; Article; binding affinity; CD8+ T lymphocyte; controlled study; cytotoxic T lymphocyte; endoplasmic reticulum; entropy; epitope mapping; gene frequency; gene structure; HLA typing; human; human cell; hydrophilicity; immune response; immunogenicity; immunoinformatics; Indonesia; microbiome; molecular docking; open reading frame; peptide synthesis; protein interaction; protein secondary structure; protein structure; sequence alignment; sequence analysis; sequence homology; Severe acute respiratory syndrome coronavirus 2; vaccination	MDPI	2076393X	Article	Q1	1296	2913	View
403	Fuady A., Nuraini N., Sukandar K.K., Lestari B.W.	37085331400;24605696400;57216947725;56589945500;	Targeted vaccine allocation could increase the covid-19 vaccine benefits amidst its lack of availability: A mathematical modeling study in indonesia	2021	Vaccines	9	5	462			9	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105974918&doi=10.3390%2fvaccines9050462&partnerID=40&md5=4a9375c9281f8f4834500172552d5373	Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10310, Indonesia; Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3015 GD, Netherlands; Department of Mathematics, Institut Teknologi Bandung, Bandung, 40132, Indonesia; Epidemiology Group of COVID-19 Task Force for West Java, Bandung, 40171, Indonesia; Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, Indonesia; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, 6525 GA, Netherlands	Fuady, A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10310, Indonesia, Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3015 GD, Netherlands; Nuraini, N., Department of Mathematics, Institut Teknologi Bandung, Bandung, 40132, Indonesia, Epidemiology Group of COVID-19 Task Force for West Java, Bandung, 40171, Indonesia; Sukandar, K.K., Department of Mathematics, Institut Teknologi Bandung, Bandung, 40132, Indonesia; Lestari, B.W., Epidemiology Group of COVID-19 Task Force for West Java, Bandung, 40171, Indonesia, Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, Indonesia, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, 6525 GA, Netherlands	With a limited number of vaccines and healthcare capacity shortages, particularly in low-and middle-income countries, vaccination programs should seek the most efficient strategy to reduce the negative impact of the COVID-19 pandemics. This study aims at assessing several scenarios of delivering the vaccine to people in Indonesia. We develop a model for several scenarios of delivering vaccines: without vaccination, fair distribution, and targeted distribution to five and eight districts with the highest COVID-19 incidence in West Java, one of the most COVID-19-affected regions in Indonesia. We calculate the needs of vaccines and healthcare staff for the program, then simulate the model for the initial 4-month and one-year scenarios. A one-year vaccination program would require 232,000 inoculations per day by 4833 vaccinators. Targeted vaccine allocation based on the burden of COVID-19 cases could benefit the COVID-19 vaccination program by lowering at least 5000 active cases. The benefits would increase by improving the number of vaccines and healthcare staff. Amidst lacking available vaccines, targeted vaccine allocation based on the burden of COVID-19 cases could increase the benefit of the COVID-19 vaccination program but still requires progressive efforts to improve healthcare capacity and vaccine availability for optimal protection for people. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.	COVID-19; Low-and middle-income countries; Modeling; Strategy; Vaccine	SARS-CoV-2 vaccine; Article; coronavirus disease 2019; disease model; disease predisposition; disease transmission; drug bioavailability; drug efficacy; health care need; health care personnel; human; Indonesia; infection rate; mathematical model; mortality; quarantine; reinfection; resource allocation; SIQRD model; vaccination	MDPI AG	2076393X	Article	Q1	1296	2913	View
Veterinary World(1)
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94	Subahar R., Susanto L., Aidilla R., Aulia A.P., Yulhasri Y., Winita R., Lubis N.S., Sari I.P.	6508197883;6507704130;57365800900;57366528800;57225180520;57220782528;57222661567;57197543698;	In vitro experiments of Pediculus humanus capitis (Phthiraptera: Pediculidae) resistance to permethrin and 6-paradol in East Jakarta: Detoxification enzyme activity and electron microscopic changes in lice	2021	Veterinary World	14	11		3065	3075		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120814548&doi=10.14202%2fvetworld.2021.3065-3075&partnerID=40&md5=1d1646983a8b7f7da98a7d4f5896e795	Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jln. Salemba Raya 4, Jakarta, 10430, Indonesia	Subahar, R., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Susanto, L., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Aidilla, R., Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Aulia, A.P., Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Yulhasri, Y., Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jln. Salemba Raya 4, Jakarta, 10430, Indonesia; Winita, R., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Lubis, N.S., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Sari, I.P., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia	Background and Aim: Pediculus humanus capitis, the human head louse, remains a global health problem. This study evaluated the resistance of head lice to permethrin and 6-paradol mediated by in vitro detoxification enzyme activity experiments and to describe physical changes in the lice using scanning electron microscopy (SEM). Materials and Methods: The adult stages of P. h. capitis were collected from patients exposed to 1% permethrin and three different concentrations of 6-paradol (0.00005%, 0.0001%, and 0.00015%) using a filter paper diffusion bioassay. Healthy P. h. capitis adults served as the control. The in vitro bioassays were conducted after 10, 20, 30, and 60 min of exposure. The activities of acetylcholinesterase (AChE), glutathione S-transferase (GST), and oxidase were analyzed. Physical changes in the lice were analyzed using SEM. Results: Permethrin and 6-paradol exhibited low toxicity against the lice. At 60 min, 1% permethrin had killed 36.7% of the lice present, while 6-paradol had killed 66.7-86.7%. Permethrin induced significantly elevated AChE, GST, and oxidase activity; 6-paradol also caused significantly elevated AChE, GST, and oxidase activity. Permethrin did not cause any ultrastructural morphological changes on the lice, while 6-paradol severely damaged the head, thorax, respiratory spiracles, and abdomen of the dead lice. Conclusion: This in vitro experimental of P. h. capitis is the first study to report P. h. capitis in East Jakarta shows complete resistance to permethrin and 6-paradol, and to describe the associated increase in AChE, GST, and oxidase activity. It was observed that 6-paradol severely damaged the head, thorax, respiratory spiracles, and abdomen of the dead lice. © 2021 Veterinary World. All rights reserved.	6-paradol; Detoxifying enzyme; Electron microscopy; Pediculus humanus capitis; Permethrin; Resistance	6 paradol; acetylcholinesterase; chitin; glutathione transferase; oxidoreductase; permethrin; phenol derivative; unclassified drug; Article; bioassay; controlled study; detoxification; diffusion; enzyme activity; enzyme linked immunosorbent assay; hair loss; LT50; LT90; nonhuman; Pediculus humanus capitis; scanning electron microscopy; ultrastructure	Veterinary World	09728988	Article	Q2	550	9187	View

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