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911 |
Kurniawan A., Kodrat E., Gani Y.I. |
57204398223;57191430080;57195936648; |
Effectiveness of granulocyte colony stimulating factor to enhance healing on delayed union fracture model Sprague-Dawley rat |
2021 |
Annals of Medicine and Surgery |
61 |
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54 |
60 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098139356&doi=10.1016%2fj.amsu.2020.12.005&partnerID=40&md5=55751366daec87d69d3f9b7fe9113d43 |
Paediatric Orthopaedic Division, Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Musculoskletal Pathology Division, Departement of Anatomic Phatology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Kurniawan, A., Paediatric Orthopaedic Division, Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kodrat, E., Musculoskletal Pathology Division, Departement of Anatomic Phatology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gani, Y.I., Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Delayed union is a problem that can occur after fracture healing. Many studies were conducted based on the diamond concept approach to solve the problem of delayed union. Granulocyte-colony stimulating factor (G-CSF) is one of the various substances known to have a positive role in healing skeletal tissue or adjuvant regeneration. This study was conducted to see the effect of G-CSF in affecting delayed union fracture healing. Materials and method: The experimental study was conducted by randomized posttest only control group design on 24 experimental animals Sprague-Dawley white rats that had experienced delayed union models. The study compared the treatment group injected with subcutaneous G-CSF with a control group and was divided into four groups (n = 6). Harvest and follow-up histomorphometry and immunohistochemistry were performed in the second week and in the fourth week the histomorphometry analysis consisted of the percentage of immature bone area, cartilage, and fibrous area. The semiquantitative evaluation of immunohistochemistry with the expression of BMP-2 through the immunoreactive score (IRS). Result: In the evaluation of histomorphometry and immunohistochemical parameters, there were significantly more woven bone area (p = 0,015), less fibrosis area (p = 0,002) and higher BMP 2 expression (p = 0,004) in treatment group week four compared to control. . Conclusion: G-CSF was shown to increase the speed of healing in Sprague-Dawley rats on delayed union models evaluated from histomorphometry and immunohistochemical aspects. © 2020 The Author(s) |
BMP-2; Delayed union; Fracture healing; Granulocyte-colony stimulating factor; Histomorphometry; Immunohistochemistry |
bone morphogenetic protein 2; CD146 antigen; granulocyte colony stimulating factor; phenobarbital; animal experiment; animal model; animal tissue; Article; cartilage; comparative study; controlled study; fibrosis; follow up; fracture healing; histopathology; immunohistochemistry; immunoreactivity; male; morphometry; nonhuman; osteoblast; osteocyte; osteotomy; outcome assessment; protein expression; quantitative analysis; rat; surgical wound |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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912 |
Sperber A.D., Bangdiwala S.I., Drossman D.A., Ghoshal U.C., Simren M., Tack J., Whitehead W.E., Dumitrascu D.L., Fang X., Fukudo S., Kellow J., Okeke E., Quigley E.M.M., Schmulson M., Whorwell P., Archampong T., Adibi P., Andresen V., Benninga M.A., Bonaz B., Bor S., Fernandez L.B., Choi S.C., Corazziari E.S., Francisconi C., Hani A., Lazebnik L., Lee Y.Y., Mulak A., Rahman M.M., Santos J., Setshedi M., Syam A.F., Vanner S., Wong R.K., Lopez-Colombo A., Costa V., Dickman R., Kanazawa M., Keshteli A.H., Khatun R., Maleki I., Poitras P., Pratap N., Stefanyuk O., Thomson S., Zeevenhooven J., Palsson O.S. |
55222586700;57224646613;57189767321;7005966711;57202571330;7102745366;16154954100;7005124531;57220861049;57219719431;57204305024;6701372042;7103105068;55993764500;35243963700;56401993900;56229001100;13805283000;7003532912;7004197628;7004013649;6701734343;7408119608;7006168774;6603069136;57204159889;7005446863;56191149300;6603579531;57216556340;7402389020;36469259800;8443384400;7005049888;55499852700;6504805230;56435522900;35965540900;7202046963;15765371700;57212081425;18935849300;35944673000;35249230500;56657486600;7202276913;57191854958;6603768529; |
Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study |
2021 |
Gastroenterology |
160 |
1 |
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99 |
114.e3 |
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233 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097793980&doi=10.1053%2fj.gastro.2020.04.014&partnerID=40&md5=db0ef85211fc480b0dc645b05ce86665 |
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Population Health Research Institute, McMaster University, Hamilton, ON, Canada; Center for Functional GI & Motility Disorders, University of North Carolina, Center for Education and Practice of Biopsychosocial Care, and Drossman Gastroenterology, Chapel Hill, NC, United States; Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGI), Lucknow, India; Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven, Belgium; Center for Functional GI & Motility Disorders, University of North Carolina-Chapel Hill, Chapel Hill, NC, United States; Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; Discipline of Medicine, Northern Clinical School, University of Sydney, Sydney, Australia; Department of Medicine, University of Jos, Jos University Teaching Hospital, Jos, Nigeria; Lynda K. and David M. Underwood Center for Digestive Disorder, Gastroenterology and Hepatology, Houston Methodist Hospital and Weill Cornell Medical College, Houston, TX, United States; Laboratory of Liver, Pancreas and Motility (HIPAM), Unit of Research in Experimental Medicine, Faculty of Medicine, Universidad Nacional Autónoma de Mexico (UNAM). Hospital General de México, Mexico City, Mexico; Neurogastroenterology Unit, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, United Kingdom; Department of Medicine, University of Ghana School of Medicine and Dentistry, Accra, Ghana; Integrative Functional Gastroenterology Research Center, Department of Internal Medicine, School of Medicine, Isfahan University of Medical SciencesIsfahan, Iran; Department of Medicine, Israelitic Hospital, Hamburg, Germany; Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Pediatric Gastroenterology, Amsterdam, The Netherlands, Netherlands; Service d'Hépato-Gastroentérologie, CHU Grenoble Alpes, Grenoble, France; Ege University School of Medicine, Division of Gastroenterology, Bornova Izmir, Turkey; “Centro Medico Dr. Bustos Fernandez”, Buenos Aires, Argentina; Department of Gastroenterology, School of Medicine, Wonkwang University, Iksan, South Korea; Department of Gastroenterology, Istituto Clinico Humanitas, Rozzano, Italy; Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Gastroenterology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil; Gastroenterology Unit, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogotá, Colombia; Department of Outpatient Medicine, Faculty of Internal Medicine, Moscow State University of Medicine and Dentistry, Moscow, Russian Federation; School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia; Department of Gastroenterology and Hepatology, Wroclaw Medical University, Wroclaw, Poland; Dhaka Medical College & Hospital, Dhaka, Bangladesh; Department of Gastroenterology, University Hospital Vall d'Hebron, Autonomous University of Barcelona & Neuro-Inmuno-Gastroenterology Lab, Vall d'Hebron Research Institute, Barcelona, Spain; Department of Medicine, Division of Gastroenterology, University of Cape Town, Cape Town, South Africa; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gastrointestinal Diseases Research Unit, Kingston Health Science Centre, Queen's University, Kingston, ON, Canada; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore; UMAE Hospital de Especialidades C.M.N. Manuel Avila Camacho, Puebla Pue, Mexico; Division of Gastroenterology, Rabin Medical Center, Sackler School of Medicine, Tel-Aviv, Israel; CEGIIR-Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada; Gut and Liver Research Center, Department of Internal Medicine, Mazandaran University of Medical Sciences, Sari, Iran; CHUM, Université de Montréal, Montréal, QC, Canada; KIMS Hospitals, Secunderabad, India; Department of Biochemical Markers of Chronic Non-Communicable Diseases Research National Medical Research Centre for Preventive Medicine, Moscow, Russian Federation |
Sperber, A.D., Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Bangdiwala, S.I., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada, Population Health Research Institute, McMaster University, Hamilton, ON, Canada; Drossman, D.A., Center for Functional GI & Motility Disorders, University of North Carolina, Center for Education and Practice of Biopsychosocial Care, and Drossman Gastroenterology, Chapel Hill, NC, United States; Ghoshal, U.C., Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGI), Lucknow, India; Simren, M., Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Tack, J., Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven, Belgium; Whitehead, W.E., Center for Functional GI & Motility Disorders, University of North Carolina-Chapel Hill, Chapel Hill, NC, United States; Dumitrascu, D.L., Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Fang, X., Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Fukudo, S., Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; Kellow, J., Discipline of Medicine, Northern Clinical School, University of Sydney, Sydney, Australia; Okeke, E., Department of Medicine, University of Jos, Jos University Teaching Hospital, Jos, Nigeria; Quigley, E.M.M., Lynda K. and David M. Underwood Center for Digestive Disorder, Gastroenterology and Hepatology, Houston Methodist Hospital and Weill Cornell Medical College, Houston, TX, United States; Schmulson, M., Laboratory of Liver, Pancreas and Motility (HIPAM), Unit of Research in Experimental Medicine, Faculty of Medicine, Universidad Nacional Autónoma de Mexico (UNAM). Hospital General de México, Mexico City, Mexico; Whorwell, P., Neurogastroenterology Unit, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, United Kingdom; Archampong, T., Department of Medicine, University of Ghana School of Medicine and Dentistry, Accra, Ghana; Adibi, P., Integrative Functional Gastroenterology Research Center, Department of Internal Medicine, School of Medicine, Isfahan University of Medical SciencesIsfahan, Iran; Andresen, V., Department of Medicine, Israelitic Hospital, Hamburg, Germany; Benninga, M.A., Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Pediatric Gastroenterology, Amsterdam, The Netherlands, Netherlands; Bonaz, B., Service d'Hépato-Gastroentérologie, CHU Grenoble Alpes, Grenoble, France; Bor, S., Ege University School of Medicine, Division of Gastroenterology, Bornova Izmir, Turkey; Fernandez, L.B., “Centro Medico Dr. Bustos Fernandez”, Buenos Aires, Argentina; Choi, S.C., Department of Gastroenterology, School of Medicine, Wonkwang University, Iksan, South Korea; Corazziari, E.S., Department of Gastroenterology, Istituto Clinico Humanitas, Rozzano, Italy; Francisconi, C., Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Gastroenterology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil; Hani, A., Gastroenterology Unit, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogotá, Colombia; Lazebnik, L., Department of Outpatient Medicine, Faculty of Internal Medicine, Moscow State University of Medicine and Dentistry, Moscow, Russian Federation; Lee, Y.Y., School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia; Mulak, A., Department of Gastroenterology and Hepatology, Wroclaw Medical University, Wroclaw, Poland; Rahman, M.M., Dhaka Medical College & Hospital, Dhaka, Bangladesh; Santos, J., Department of Gastroenterology, University Hospital Vall d'Hebron, Autonomous University of Barcelona & Neuro-Inmuno-Gastroenterology Lab, Vall d'Hebron Research Institute, Barcelona, Spain; Setshedi, M., Department of Medicine, Division of Gastroenterology, University of Cape Town, Cape Town, South Africa; Syam, A.F., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Vanner, S., Gastrointestinal Diseases Research Unit, Kingston Health Science Centre, Queen's University, Kingston, ON, Canada; Wong, R.K., Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore; Lopez-Colombo, A., UMAE Hospital de Especialidades C.M.N. Manuel Avila Camacho, Puebla Pue, Mexico; Costa, V., Gastroenterology Unit, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogotá, Colombia; Dickman, R., Division of Gastroenterology, Rabin Medical Center, Sackler School of Medicine, Tel-Aviv, Israel; Kanazawa, M., Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; Keshteli, A.H., CEGIIR-Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada; Khatun, R., Population Health Research Institute, McMaster University, Hamilton, ON, Canada; Maleki, I., Gut and Liver Research Center, Department of Internal Medicine, Mazandaran University of Medical Sciences, Sari, Iran; Poitras, P., CHUM, Université de Montréal, Montréal, QC, Canada; Pratap, N., KIMS Hospitals, Secunderabad, India; Stefanyuk, O., Department of Biochemical Markers of Chronic Non-Communicable Diseases Research National Medical Research Centre for Preventive Medicine, Moscow, Russian Federation; Thomson, S., Department of Medicine, Division of Gastroenterology, University of Cape Town, Cape Town, South Africa; Zeevenhooven, J., Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Pediatric Gastroenterology, Amsterdam, The Netherlands, Netherlands; Palsson, O.S., Center for Functional GI & Motility Disorders, University of North Carolina-Chapel Hill, Chapel Hill, NC, United States |
Background & Aims: Although functional gastrointestinal disorders (FGIDs), now called disorders of gut-brain interaction, have major economic effects on health care systems and adversely affect quality of life, little is known about their global prevalence and distribution. We investigated the prevalence of and factors associated with 22 FGIDs, in 33 countries on 6 continents. Methods: Data were collected via the Internet in 24 countries, personal interviews in 7 countries, and both in 2 countries, using the Rome IV diagnostic questionnaire, Rome III irritable bowel syndrome questions, and 80 items to identify variables associated with FGIDs. Data collection methods differed for Internet and household groups, so data analyses were conducted and reported separately. Results: Among the 73,076 adult respondents (49.5% women), diagnostic criteria were met for at least 1 FGID by 40.3% persons who completed the Internet surveys (95% confidence interval [CI], 39.9–40.7) and 20.7% of persons who completed the household surveys (95% CI, 20.2–21.3). FGIDs were more prevalent among women than men, based on responses to the Internet survey (odds ratio, 1.7; 95% CI, 1.6–1.7) and household survey (odds ratio, 1.3; 95% CI, 1.3–1.4). FGIDs were associated with lower quality of life and more frequent doctor visits. Proportions of subjects with irritable bowel syndrome were lower when the Rome IV criteria were used, compared with the Rome III criteria, in the Internet survey (4.1% vs 10.1%) and household survey (1.5% vs 3.5%). Conclusions: In a large-scale multinational study, we found that more than 40% of persons worldwide have FGIDs, which affect quality of life and health care use. Although the absolute prevalence was higher among Internet respondents, similar trends and relative distributions were found in people who completed Internet vs personal interviews. © 2021 The Authors |
DGBI; epidemiology; IBS |
abdominal pain; adult; anorectal disease; Article; biliary tract pain; comparative study; confidence interval; data analysis; descriptive research; digestive system function disorder; disease burden; duodenum disease; esophagus disease; female; gastrointestinal disease; human; information processing; Internet; irritable colon; Italy; major clinical study; male; prevalence; priority journal; quality of life; questionnaire; Research Diagnostic Criteria; adolescent; age distribution; aged; gastrointestinal disease; global health; middle aged; sex ratio; young adult; Adolescent; Adult; Age Distribution; Aged; Female; Gastrointestinal Diseases; Global Health; Humans; Male; Middle Aged; Prevalence; Sex Distribution; Surveys and Questionnaires; Young Adult |
W.B. Saunders |
00165085 |
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32294476 |
Article |
Q1 |
7828 |
131 |
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913 |
Kurniawan A., Sitorus I.P., Loho T., Hutami W.D. |
57204398223;57191052269;55624513300;57219938996; |
A rare case of septic arthritis of the knee caused by Salmonella typhi with preexisting typhoid fever in a healthy, immunocompetent child – A case report |
2021 |
International Journal of Surgery Case Reports |
78 |
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76 |
80 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097465725&doi=10.1016%2fj.ijscr.2020.12.003&partnerID=40&md5=c608b24d71212feafb989d8f6247e661 |
Pediatric Orthopaedic Surgeon, Department of Orthopaedic & Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta 10430, Indonesia; Department of Orthopaedic and Traumatology, Department of Orthopaedic & Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta 10430, Indonesia; Department of Clinical Pathology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta 10430, Indonesia |
Kurniawan, A., Pediatric Orthopaedic Surgeon, Department of Orthopaedic & Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta 10430, Indonesia; Sitorus, I.P., Department of Orthopaedic and Traumatology, Department of Orthopaedic & Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta 10430, Indonesia; Loho, T., Department of Clinical Pathology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta 10430, Indonesia; Hutami, W.D., Department of Orthopaedic and Traumatology, Department of Orthopaedic & Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta 10430, Indonesia |
Introduction: Septic arthritis is a rapid and progressive infection caused by invasion of bacteria into the synovial joint. Disease of the joint causedby Salmonella spp in healthy children is an unusual event, with an estimated incidence of 0.1 to 0.2% of septic arthritis cases among children. The incidence of knee septic arthritis caused by Salmonella typhi with preexisting typhoid fever is very rare. Method: We reported a case of 2-years old boy with a history of saddle-type fever 2 weeks prior to right knee pain. Typhoid fever was confirmed by immunoassay test. Knee septic arthritis was established from clinical findings, increased CRP level, ultrasonography, and joint aspiration. Culture of the aspirate subsequently grew Salmonella typhi. This case report had been reported in line with SCARE criteria. Result: Arthrotomy and debridement were immediately performed.Intravenous piperacillin tazobactam was given for 6 days and replaced by amoxicillin clavulanic acid after the culture and sensitivity test was available. Patient recovered completely 5 months post surgery and showed excellence result with normal range of knee joint motion. Conclusion: This case report suggests that any episode of joint swelling following preexisting typhoid fever should arise the physician's awareness toward the possibility of septic arthritis and warrant immediate as well as proper management. © 2020 The Authors |
Case report; Salmonella typhi; Septic arthritis; Typhoid fever |
amikacin; amoxicillin plus clavulanic acid; C reactive protein; cefotaxime; ceftazidime; ceftriaxone; chloramphenicol; cotrimoxazole; gentamicin; meropenem; piperacillin plus tazobactam; sultamicillin; tetracycline; antibiotic sensitivity; arthrotomy; Article; bacterial arthritis; bacterial growth; bacterium isolation; case report; child; clinical article; clinical feature; clinical outcome; debridement; fine needle aspiration biopsy; follow up; human; immunoassay; immunocompetence; joint aspiration; joint effusion; knee arthritis; knee pain; limp (gait); male; preschool child; prescription; priority journal; range of motion; Salmonella enterica serovar Typhi; treatment duration; typhoid fever |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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914 |
Andika R., Birowo P., Rasyid N., Atmoko W. |
57200945045;6504153311;56245069300;57193125664; |
Supine PCNL in patient with staghorn renal stone and severe degree kyphosis: A case report |
2021 |
Urology Case Reports |
34 |
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101509 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097421344&doi=10.1016%2fj.eucr.2020.101509&partnerID=40&md5=0f9040a4a723f7b0d51e13ce3bd1fb6e |
Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Andika, R., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Birowo, P., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rasyid, N., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Atmoko, W., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Spinal deformity concomitantly with large renal stone has become a challenges for urologist since it needs different approach in performing percutaneous procedures. This case report highlight our success experience in treating a 53-years old female patients with severe degree of kyphosis and staghorn stone using supine PCNL. She underwent right PCNL and right Double-J stent insertion anterograde after stone were released. The duration of surgery was 2 hours and 45 minutes with no intra and post-operative complication reported. Supine position can be safely chosen if prone cannot be placed in complex situation such as staghorn stone in severe kyphosis patients. © 2020 The Authors |
Kyphosis; PCNL; Spinal deformity; Staghorn renal stone |
creatinine; hemoglobin; urea; adult; anemia; Article; backache; bleeding; case report; chronic kidney failure; clinical article; computer assisted tomography; female; flank pain; human; kyphosis; middle aged; percutaneous nephrolithotomy; postoperative complication; priority journal; staghorn stone; urinalysis; urography; urology; visual analog scale |
Elsevier Inc. |
22144420 |
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Article |
Q3 |
245 |
16962 |
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915 |
Arozal W., Louisa M., Rahmat D., Chendrana P., Sandhiutami N.M.D. |
32067462200;41461551400;36673726800;57220117465;56692904000; |
Development, characterization and pharmacokinetic profile of chitosan-sodium tripolyphosphate nanoparticles based drug delivery systems for curcumin |
2021 |
Advanced Pharmaceutical Bulletin |
11 |
1 |
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77 |
85 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096977127&doi=10.34172%2fapb.2021.008&partnerID=40&md5=8dc05f691c7524d3d33c6f2b7b701019 |
Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Arozal, W., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmat, D., Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Chendrana, P., Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Sandhiutami, N.M.D., Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia, Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: This study aimed to provide the method of preparation, characterization of curcumin-loaded chitosan-sodium tripolyphosphate (NaTPP) nanoparticle, and evaluate its pharmacokinetic profiles. Methods: Curcumin-loaded chitosan-NaTPP nanoparticles were synthesized using ionic gelation methods. Curcumin was dissolved using surfactants and cosurfactants. Chitosan polymer was then mixed in the curcumin solution and dripped with NaTPP solution until nanoparticle formation. The mucoadhesive study was evaluated by measuring the fluorescence of curcumin within the prepared nanoparticles. The pharmacokinetic profiles of curcumin particles and nanoparticles were then assessed in rats by administering a single oral dose of 100 mg/kg BW. Blood samples were taken from nine predetermined time points, and curcumin plasma concentrations were then analyzed using UPLC-MS/MS. Results: The particle size of the curcumin nanoparticles obtained were 11.5 nm. Entrapment efficiency (EE) of curcumin nanoparticles were exceeding 99.97%, and drug loading capacity (DLC) was 11.34%. The mucoadhesive properties of the nanoparticles were superior to that of curcumin particles. Pharmacokinetic evaluation in rats revealed that curcumin nanoparticles resulted in an increase of area under the curve (AUC), maximum concentration (Cmax), earlier time to reach maximum concentration (Tmax), and lower clearance (CL). Conclusion: Curcumin-loaded chitosan-NaTPP nanoparticles is an effective formulation to improve curcumin plasma concentrations. Thus, enable its applications for the treatment of various diseases. © 2021 The Author(s). |
Chitosan; Curcumin; Mucoadhesive; Nanoparticles; Pharmacokinetics |
chitosan; cosurfactant; curcumin; nanoparticle; polymer; surfactant; tripolyphosphate; animal experiment; animal tissue; area under the curve; Article; blood sampling; controlled study; drug delivery system; female; fluorescence; gelation; human; maximum concentration; mucoadhesion; nonhuman; particle size; pharmacokinetic parameters; plasma concentration-time curve; rat; tandem mass spectrometry; ultra performance liquid chromatography; zeta potential |
Tabriz University of Medical Sciences |
22285881 |
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Article |
Q1 |
773 |
6281 |
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916 |
Coughlin C.R., II, Tseng L.A., Abdenur J.E., Ashmore C., Boemer F., Bok L.A., Boyer M., Buhas D., Clayton P.T., Das A., Dekker H., Evangeliou A., Feillet F., Footitt E.J., Gospe S.M., Jr., Hartmann H., Kara M., Kristensen E., Lee J., Lilje R., Longo N., Lunsing R.J., Mills P., Papadopoulou M.T., Pearl P.L., Piazzon F., Plecko B., Saini A.G., Santra S., Sjarif D.R., Stockler-Ipsiroglu S., Striano P., Van Hove J.L.K., Verhoeven-Duif N.M., Wijburg F.A., Zuberi S.M., van Karnebeek C.D.M. |
57203153211;57193113158;6602690660;55329181300;22133268100;18433647100;56442108100;54415352400;26643542700;7403597535;57072925500;6601972696;6701669931;24066333000;7004867097;19234327400;55964701800;57218823969;57219907275;6507651491;7004663930;7801612204;57202556029;57213632266;7003948257;54950108600;55990557800;37087697200;24172569400;6506242684;55930268500;6701766775;7005706056;35747586800;7003454408;7005936517;6506453512; |
Consensus guidelines for the diagnosis and management of pyridoxine-dependent epilepsy due to α-aminoadipic semialdehyde dehydrogenase deficiency |
2021 |
Journal of Inherited Metabolic Disease |
44 |
1 |
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178 |
192 |
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9 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096935873&doi=10.1002%2fjimd.12332&partnerID=40&md5=519c5479b1e22e3b77f1890b9b382e4d |
Section of Clinical Genetics and Metabolism, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States; Department of Pediatrics Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam, Netherlands; Division of Metabolic Disorders, CHOC Children's Hospital, Orange, CA, United States; Birmingham Women's and Children's NHS Foundation Trust, Birmingham, United Kingdom; Department of Human Genetics, Centre Hospitalier Universitaire Sart-Tilman, Liège, Belgium; Department of Pediatrics and Neonatology, Máxima Medical Center, Veldhoven, Netherlands; Division of Medical Genetics, Department of Specialized Medicine, Montreal Children's Hospital, McGill University Health Centre, Québec, Canada; Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom; Clinic for Paediatric Kidney, Liver, and Metabolic Diseases, Hannover Medical School, Hannover, Germany; VKS: Dutch Patient Organization for Metabolic Diseases, Zwolle, Netherlands; Division of Child Neurology and Inherited Metabolic Disorders, 4th Department of Pediatrics, Aristotle University of Thessaloniki, General Hospital Papageorgiou, Thessaloniki, Greece; Reference Center for Inborn Errors of Metabolism, Pediatric Unit, University Hospital of Nancy, Nancy, France; INSERM UMR S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, University of Lorraine, Nancy, France; Department of Metabolic Paediatrics, Great Ormond Street Hospital, London, United Kingdom; Division of Pediatric Neurology, Departments of Neurology and Pediatrics, University of Washington, Seattle, WA, United States; Department of Pediatrics, Duke University, Durham, NC, United States; Department of Pediatrics, University of Tripoli, Tripoli, Libyan Arab Jamahiriya; National Management of Newborn Screening and Advanced Laboratory Diagnostics in Inborn Errors of Metabolism, Department of Children and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Department of Metabolic Medicine, The Royal Children's Hospital, Melbourne, VIC, Australia; Department of Children and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Division of Medical Genetics, Department of Pediatrics, University of Utah, Salt Lake City, UT, United States; Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States; Neurometabolic Clinic, Children's Institute, University of Sao Paulo, Brazil; Division of General Pediatrics, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria; Pediatric Neurology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Biochemical Genetics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada; Pediatric Neurology and Muscular Diseases Unit, IRCCS “G. Gaslini” Institute, Genoa, Italy; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genoa, Italy; Department of Genetics, University Medical Center Utrecht, Utrecht, Netherlands; Paediatric Neurosciences Research Group, Royal Hospital for Children & School of Medicine, University of Glasgow, Glasgow, United Kingdom; Department of Pediatrics, Amalia Children's Hospital, Radboud Centre for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen, Netherlands |
Coughlin, C.R., II, Section of Clinical Genetics and Metabolism, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States; Tseng, L.A., Department of Pediatrics Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam, Netherlands; Abdenur, J.E., Division of Metabolic Disorders, CHOC Children's Hospital, Orange, CA, United States; Ashmore, C., Birmingham Women's and Children's NHS Foundation Trust, Birmingham, United Kingdom; Boemer, F., Department of Human Genetics, Centre Hospitalier Universitaire Sart-Tilman, Liège, Belgium; Bok, L.A., Department of Pediatrics and Neonatology, Máxima Medical Center, Veldhoven, Netherlands; Boyer, M., Division of Metabolic Disorders, CHOC Children's Hospital, Orange, CA, United States; Buhas, D., Division of Medical Genetics, Department of Specialized Medicine, Montreal Children's Hospital, McGill University Health Centre, Québec, Canada; Clayton, P.T., Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom; Das, A., Clinic for Paediatric Kidney, Liver, and Metabolic Diseases, Hannover Medical School, Hannover, Germany; Dekker, H., VKS: Dutch Patient Organization for Metabolic Diseases, Zwolle, Netherlands; Evangeliou, A., Division of Child Neurology and Inherited Metabolic Disorders, 4th Department of Pediatrics, Aristotle University of Thessaloniki, General Hospital Papageorgiou, Thessaloniki, Greece; Feillet, F., Reference Center for Inborn Errors of Metabolism, Pediatric Unit, University Hospital of Nancy, Nancy, France, INSERM UMR S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, University of Lorraine, Nancy, France; Footitt, E.J., Department of Metabolic Paediatrics, Great Ormond Street Hospital, London, United Kingdom; Gospe, S.M., Jr., Division of Pediatric Neurology, Departments of Neurology and Pediatrics, University of Washington, Seattle, WA, United States, Department of Pediatrics, Duke University, Durham, NC, United States; Hartmann, H., Clinic for Paediatric Kidney, Liver, and Metabolic Diseases, Hannover Medical School, Hannover, Germany; Kara, M., Department of Pediatrics, University of Tripoli, Tripoli, Libyan Arab Jamahiriya; Kristensen, E., National Management of Newborn Screening and Advanced Laboratory Diagnostics in Inborn Errors of Metabolism, Department of Children and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Lee, J., Department of Metabolic Medicine, The Royal Children's Hospital, Melbourne, VIC, Australia; Lilje, R., Department of Children and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Longo, N., Division of Medical Genetics, Department of Pediatrics, University of Utah, Salt Lake City, UT, United States; Lunsing, R.J., Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Mills, P., Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom; Papadopoulou, M.T., Division of Child Neurology and Inherited Metabolic Disorders, 4th Department of Pediatrics, Aristotle University of Thessaloniki, General Hospital Papageorgiou, Thessaloniki, Greece; Pearl, P.L., Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States; Piazzon, F., Neurometabolic Clinic, Children's Institute, University of Sao Paulo, Brazil; Plecko, B., Division of General Pediatrics, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria; Saini, A.G., Pediatric Neurology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Santra, S., Birmingham Women's and Children's NHS Foundation Trust, Birmingham, United Kingdom; Sjarif, D.R., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stockler-Ipsiroglu, S., Division of Biochemical Genetics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada; Striano, P., Pediatric Neurology and Muscular Diseases Unit, IRCCS “G. Gaslini” Institute, Genoa, Italy, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genoa, Italy; Van Hove, J.L.K., Section of Clinical Genetics and Metabolism, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States; Verhoeven-Duif, N.M., Department of Genetics, University Medical Center Utrecht, Utrecht, Netherlands; Wijburg, F.A., Department of Pediatrics Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam, Netherlands; Zuberi, S.M., Paediatric Neurosciences Research Group, Royal Hospital for Children & School of Medicine, University of Glasgow, Glasgow, United Kingdom; van Karnebeek, C.D.M., Department of Pediatrics Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam, Netherlands, Department of Pediatrics, Amalia Children's Hospital, Radboud Centre for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen, Netherlands |
Pyridoxine-dependent epilepsy (PDE-ALDH7A1) is an autosomal recessive condition due to a deficiency of α-aminoadipic semialdehyde dehydrogenase, which is a key enzyme in lysine oxidation. PDE-ALDH7A1 is a developmental and epileptic encephalopathy that was historically and empirically treated with pharmacologic doses of pyridoxine. Despite adequate seizure control, most patients with PDE-ALDH7A1 were reported to have developmental delay and intellectual disability. To improve outcome, a lysine-restricted diet and competitive inhibition of lysine transport through the use of pharmacologic doses of arginine have been recommended as an adjunct therapy. These lysine-reduction therapies have resulted in improved biochemical parameters and cognitive development in many but not all patients. The goal of these consensus guidelines is to re-evaluate and update the two previously published recommendations for diagnosis, treatment, and follow-up of patients with PDE-ALDH7A1. Members of the International PDE Consortium initiated evidence and consensus-based process to review previous recommendations, new research findings, and relevant clinical aspects of PDE-ALDH7A1. The guideline development group included pediatric neurologists, biochemical geneticists, clinical geneticists, laboratory scientists, and metabolic dieticians representing 29 institutions from 16 countries. Consensus guidelines for the diagnosis and management of patients with PDE-ALDH7A1 are provided. © 2020 SSIEM |
ALDH7A1; alpha aminoadipic semialdehyde; consensus guidelines; pyridoxine-dependent epilepsy; pyridoxine-responsive seizures |
aminoadipate semialdehyde dehydrogenase; arginine; pipecolic acid; pyridoxine; aldehyde dehydrogenase; arginine; lysine; pyridoxine; ALDH7A1 gene; apnea; Article; autosomal recessive disorder; coma; developmental delay; developmental screening; diet restriction; diet supplementation; epilepsy; gene; gene mutation; genetic screening; heterozygote detection; homocystinuria; human; hyperargininemia; incidence; infantile spasm; intellectual impairment; lumbar puncture; lysine restricted diet; MELAS syndrome; peripheral neuropathy; prenatal diagnosis; protein restriction; pyridoxine dependent epilepsy; recommended drug dose; sensory neuropathy; urea cycle disorder; consensus; dietary supplement; epilepsy; international cooperation; practice guideline; Aldehyde Dehydrogenase; Arginine; Consensus |
John Wiley and Sons Inc |
01418955 |
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33200442 |
Article |
Q1 |
1462 |
2367 |
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917 |
Aziza Y., Inatomi T., Sotozono C., Kinoshita S. |
57214455776;7003842530;7003976484;7402391671; |
Pterygium excision with modified bare sclera technique combined with mitomycin C |
2021 |
Japanese Journal of Ophthalmology |
65 |
1 |
|
89 |
96 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096149087&doi=10.1007%2fs10384-020-00786-5&partnerID=40&md5=184828afad7b83063fe2f20bcb75744d |
Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan; Department of Ophthalmology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Ophthalmology, National Center for Geriatrics and Gerontology, Aichi, Japan; Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan |
Aziza, Y., Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan, Department of Ophthalmology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Inatomi, T., Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan, Department of Ophthalmology, National Center for Geriatrics and Gerontology, Aichi, Japan; Sotozono, C., Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan; Kinoshita, S., Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan |
Purpose: Numerous surgical methods, with varying rates of recurrence, have been applied for the treatment of pterygium. Adjuvant mitomycin C (MMC) application has shown promising results in the prevention of recurrence. Here we propose and describe modified bare sclera technique combined with the intraoperative application of MMC for pterygium excision. Study design: Retrospective study. Methods: Primary pterygium patients who underwent pterygium excision via the bare sclera combined with 0.04% MMC technique from January 2014 to December 2016 were reviewed. In all patients, the subconjunctival pterygium strand was exposed and then sufficiently excised in combination with the safe use of MMC; i.e., the prevention of MMC dilution and diffusion to surrounding tissue. Surgical complications, recurrence rates, and recurrence onset were recorded. Results: This study involved 32 primary pterygium eyes (grade T1 = 22 eyes; 68.7%). The mean postoperative follow-up period was 26.4 ± 14.5 months (range: 12–60 months). MMC was applied for 1–3 min. The mean complete epithelialization was 12.6 ± 7.6 days and no surgical complications were observed. In 1 patient with double-head primary pterygium, recurrence occurred at 15-months postoperative. Conclusions: The modified bare sclera technique combined with MMC application was found to be safe, effective, and presents good cosmetic appearance for the treatment of primary pterygium when safety points are strictly applied. © 2020, Japanese Ophthalmological Society. |
Bare sclera with MMC; Recurrence rate; Safety profile |
betamethasone; levofloxacin; mitomycin; oxybuprocaine; mitomycin; adult; aged; Article; controlled study; diffusion; dilution; drug safety; epithelization; eye surgery; female; follow up; human; intraoperative period; Japan; major clinical study; male; medical record review; modified bare sclera technique; optical coherence tomography; patient; postoperative complication; postoperative period; priority journal; pterygium; recurrent disease; retrospective study; surgical technique; university hospital; conjunctiva; pterygium; sclera; treatment outcome; Conjunctiva; Follow-Up Studies; Humans; Mitomycin; Pterygium; Recurrence; Retrospective Studies; Sclera; Treatment Outcome |
Springer Japan |
00215155 |
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33205316 |
Article |
Q2 |
934 |
4846 |
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918 |
Ramani S., McKimm J., Findyartini A., Nadarajah V.D., Hays R., Chisolm M.S., Filipe H.P., Fornari A., Kachur E.K., Kusurkar R.A., Thampy H., Wilson K.W. |
56186462600;26433565200;56543777300;14048599600;7202509928;25957566100;36657108400;6701517660;6603938626;6603461994;55349958700;56926010000; |
Twelve tips for developing a global community of scholars in health professions education |
2021 |
Medical Teacher |
43 |
8 |
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966 |
971 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094560355&doi=10.1080%2f0142159X.2020.1839034&partnerID=40&md5=5cfe14caf9b8e1e02d7e63fd250a2375 |
Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States; Swansea University Medical School, United Kingdom; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; International Medical University, Kuala Lumpur, Malaysia; James Cook University, Townesville, QLD, Australia; Johns Hopkins University School of Medicine, Baltimore, MD, United States; University of Lisbon, Lisbon, Portugal; Donald and Barbara Zucker SOM at Hofstra/Northwell, Hempstead, NY, United States; Medical Education Development, Global Consulting, New York, NY, United States; Faculty of Medicine, Vrije Universiteit Amsterdam, Netherlands; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom; Dalhousie University, Halifax, NS, Canada |
Ramani, S., Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States; McKimm, J., Swansea University Medical School, United Kingdom; Findyartini, A., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Nadarajah, V.D., International Medical University, Kuala Lumpur, Malaysia; Hays, R., James Cook University, Townesville, QLD, Australia; Chisolm, M.S., Johns Hopkins University School of Medicine, Baltimore, MD, United States; Filipe, H.P., University of Lisbon, Lisbon, Portugal; Fornari, A., Donald and Barbara Zucker SOM at Hofstra/Northwell, Hempstead, NY, United States; Kachur, E.K., Medical Education Development, Global Consulting, New York, NY, United States; Kusurkar, R.A., Faculty of Medicine, Vrije Universiteit Amsterdam, Netherlands; Thampy, H., Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom; Wilson, K.W., Dalhousie University, Halifax, NS, Canada |
Scholarship in Health Professions Education is not just original research, it also includes study of educational processes, and application of new knowledge to practice. The pathways to successful scholarship are not always clear to novice educators. In this article, we describe strategies to establish a Community of Scholars (CoS), where more experienced and senior members guide junior members in scholarship to advance the field. Drawing on Lave and Wenger’s concepts of Communities of Practice (CoP), we describe twelve practical tips, which include generation of a shared vision, formation of a global community of scholars, engagement in scholarly initiatives, and development of a professional identity, categorised under three major steps: establish, grow, and sustain the community. The tips embrace inclusivity for diverse cultural contexts which further provide opportunities for Health Professions Educators, interested in forming communities of practice, to work on scholarly outputs and add value to the professional arena. © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
continuing; Leadership; mentoring; staff development |
article; drawing; human; human experiment; leadership; mentoring; occupation; personnel management; vision; medical education; medical profession; Fellowships and Scholarships; Health Occupations; Humans |
Taylor and Francis Ltd. |
0142159X |
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33108740 |
Article |
Q1 |
1355 |
2689 |
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919 |
Adham M., Aldino N., Zahra S., Rachmadi L., Bardosono S. |
14024202100;57219533691;57219536231;55062422000;21933841000; |
Feasibility of p16 surrogate biomarker as adjunct diagnosis of oral and oropharyngeal malignancy in a resource-constrained country |
2021 |
Acta Oto-Laryngologica |
141 |
1 |
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106 |
110 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85093677891&doi=10.1080%2f00016489.2020.1821915&partnerID=40&md5=eb216333808982b0694f8695f96c5a55 |
Head and Neck Oncology Division, Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Adham, M., Head and Neck Oncology Division, Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Aldino, N., Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Zahra, S., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rachmadi, L., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Cases of Human papillomavirus (HPV)-associated oral and oropharyngeal cancer are increasing. Proper diagnostic tools are required to detect HPV among patients, especially in areas where high technology is lacking. Aims: To provide mapping of HPV prevalence in Southeast Asia and to determine the effectivity of p16 as a surrogate biomarker for HPV infection in oral and oropharyngeal cancer. Methods: Medical records of 56 patients diagnosed with oral and oropharyngeal squamous cell carcinomas (SCC) were reviewed. HPV PCR DNA and p16 immunohistochemistry (IHC) examination were performed to detect HPV positivity. Results: HPV PCR prevalence in oropharyngeal SCC is 42.9% and 28.6% in oral SCC. P16 IHC has 67% sensitivity and 75% specificity in detecting HPV in oropharyngeal cancer, and 33% and 72% in oral cancer. Conclusion: We conclude that p16 IHC with a 5% cut-off can be used as a surrogate biomarker for oropharyngeal SCC, but not oral SCC, in areas where resources are restricted. However, further diagnostic tools may be needed. © 2020 Acta Oto-Laryngologica AB (Ltd). |
HPV; Oral cancer; oropharyngeal cancer; p16 |
protein p16; virus DNA; cyclin dependent kinase inhibitor 2A; tumor marker; adult; aged; Article; awareness; controlled study; diagnostic test accuracy study; female; human; human tissue; immunohistochemistry; Indonesian; major clinical study; male; medical record; mouth squamous cell carcinoma; oropharynx squamous cell carcinoma; papillomavirus infection; polymerase chain reaction; prevalence; priority journal; sensitivity and specificity; Southeast Asia; feasibility study; head and neck tumor; metabolism; middle aged; oropharynx tumor; Adult; Aged; Biomarkers, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Feasibility Studies; Female; Head and Neck Neoplasms; Humans; Immunohistochemistry; Male; Middle Aged; Oropharyngeal Neoplasms; Squamous Cell Carcinoma of Head and Neck |
Taylor and Francis Ltd. |
00016489 |
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33085553 |
Article |
Q2 |
609 |
8285 |
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920 |
Hakim R.L., Wahyudi I., Irdham G.A., Situmorang G.R., Rodjani A. |
57219532152;36341995300;57194729795;57190001213;6504653529; |
Kidney transplantation with vesicostomy in small-bladder capacity neurogenic bladder dysfunction patient: A case report |
2021 |
Urology Case Reports |
34 |
|
101464 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85093653802&doi=10.1016%2fj.eucr.2020.101464&partnerID=40&md5=0f09bb4561e856acd141c2350b8c7bec |
Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Hakim, R.L., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wahyudi, I., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Irdham, G.A., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Situmorang, G.R., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rodjani, A., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Spinal cord injury often results in neurogenic bladder condition and eventually lead to an end-stage renal disease requiring kidney transplantation. However, transplantation in abnormal bladder carries special considerations. We report a case of an adult male with end-stage chronic kidney disease and small bladder capacity after having spinal cord injury. The evaluation of videourodynamic showed reduced compliance and detrusor overactivity during filling phase. Kidney transplantation and vesicostomy was performed. Eighteen months follow-up after surgery showed that kidney function could be maintained. The prevention of increasing bladder pressure and UTI should be monitored to prevent the damage of the graft kidney. © 2020 The Author(s) |
Kidney transplantation; Neurogenic bladder; Spinal cord injury; Vesicostomy |
antibiotic agent; creatinine; hemoglobin; urea; accident; adult; allograft; anuria; Article; bladder capacity; bladder dysfunction; case report; catheter removal; clinical article; cystostomy; end stage renal disease; estimated glomerular filtration rate; falling; hemodialysis; human; kidney function; kidney transplantation; male; nuclear magnetic resonance imaging; overactive bladder; spine fracture; urinary tract disease |
Elsevier Inc. |
22144420 |
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Article |
Q3 |
245 |
16962 |
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