Naito Foundation; Astellas Foundation for Research on Metabolic Disorders; Sumitomo Foundation, SF; Takeda Science Foundation, TSF; Suntory Foundation for Life Sciences Bioorganic Research Institute; Kobayashi Foundation for Cancer Research, Foundation for Promotion of Cancer Research; Princess Takamatsu Cancer Research Fund; Japan Agency for Medical Research and Development, AMED, (JP23zf0127008, JP22zf0127008); Japan Agency for Medical Research and Development, AMED; National Cancer Center, NC