Funding text 1: The study's limitation falls short of adequately representing the entirety of S. pneumoniae isolates in Indonesia's population. This study was reviewed and approved by The Ethic Committee of the Faculty of Medicine University of Indonesia – Cipto Mangunkusumo Hospital (No: 955/UN2.F1/ETIK/PPM.00.02/2023) following The Code of Ethics of the World Medical Association (Declaration of