Japan Agency for Medical Research and Development, AMED; Ministry of Education, Culture, Sports, Science and Technology, MEXT; Japan Society for the Promotion of Science, JSPS, (23659618, 25253094, 25293405, 25670744, 24659815); Japan Society for the Promotion of Science, JSPS; Ministry of Health, Labor and Welfare for Research on Rare and Intractable Diseases, (H26–040)