Jordi Bozzo PhD, CMPP (Grifols) is acknowledged for assistance in the preparation of the manuscript. M Chris Runken from Grifols SSNA and Rashad Carlton from Xcenda LLC are acknowledged for their support in the original model development and interpretation. Royasia Ramadani is acknowledged for her support in the literature review and interpretation of results. Prof. Rino Alvani Gani MD, PhD, Prof.