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Publikasi Scopus 2024 per tanggal 30 Juni 2024 (499 artikel)
Publikasi Scopus 2024 per tanggal 30 Juni 2024 (499 artikel)
Kurniawan, Farid (57202309006); Subekti, Imam (24336854300); Yunir, Em (36520254800); Harbuwono, Dante Saksono (36056341600); Purnamasari, Dyah (36519537700); Tarigan, Tri Juli Edi (36057746500); Wisnu, Wismandari (57200425452); Tahapary, Dicky Levenus (55944492500); Wafa, Syahidatul (57208422885); Astrella, Cindy (57210793320); Christabel, Eunike Vania (57555549700); Lubis, Anna Mira (56702707800); Wijaya, Ika Prasetya (57193731572); Karim, Birry (57192910797); Azizi, Mohamad Syahrir (572095789
Autologous intraarterial pancreatic bone-marrow mononuclear cells infusion in T2D patients: Changes on beta-cells function, insulin resistance, and inflammatory marker
2024
Current Research in Translational Medicine
72
2
103437
0
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85182889391&doi=10.1016%2fj.retram.2023.103437&partnerID=40&md5=aa6bb400dcc2bb93965a9eaa2c1dad78
Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Metabolic Disorder, Cardiovascular, and Aging Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Cardiology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Prodia StemCell Indonesia, Jakarta, Indonesia
Background: Type 2 diabetes (T2D) is a progressive disease. Many drugs currently being used for the management of T2D have minimal effect on pancreatic beta cells regeneration. Cell-based therapies might provide potential benefits in this aspect. Methods: A pilot study in five T2D patients with 12 months follow-up was performed to evaluate the effect of autologous bone marrow mononuclear stem cells (BM-MNCs) infusion into pancreatic arteries on the insulin requirement, beta-cell function, insulin resistance, and systemic inflammatory marker (CRP). Results: The primary endpoint, a 50 % reduction of total insulin doses from baseline, was not achieved in this study. However, a trend of increasing fasting C-peptide (p = 0.07) and C-peptide 60′ (p = 0.07) and 90′ (p = 0.07) after a mixed-meal tolerance test was observed 12 months post-infusion compared to baseline levels. A similar result was observed for the homeostatic model assessment of beta cell function (HOMA1-B), an index for beta cell function. No improvement was observed for insulin resistance measured by homeostasis model assessment of insulin resistance (HOMA1-IR) and systemic inflammatory parameter. Conclusion: Intraarterial pancreatic autologous BM-MNCs infusion might potentially improve beta cell function in T2D patients, although further study is needed to confirm this finding. © 2023
Adult; Aged; Biomarkers; Bone Marrow Transplantation; C-Peptide; Diabetes Mellitus, Type 2; Female; Humans; Inflammation; Infusions, Intra-Arterial; Insulin; Insulin Resistance; Insulin-Secreting Cells; Leukocytes, Mononuclear; Male; Middle Aged; Pancreas; Pilot Projects; Transplantation, Autologous; C peptide; C reactive protein; glucose; hemoglobin A1c; insulin; biological marker; C peptide; insulin; adult; Article; autologous intraarterial pancreatic bone marrow mononuclear cell transplantation; bone marrow aspiration; cell transplantation; clinical article; controlled study; enzyme linked immunosorbent assay; female; follow up; glucose blood level; homeostasis model assessment; homeostatic model assessment of beta cell function; human; human cell; human tissue; insulin resistance; male
Universitas Indonesia, UI
This work was supported by the Prototype Design (PHD PRO) Grant 2020 from University of Indonesia .
Elsevier Masson s.r.l.
24523186
38244275
Article
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840
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