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Publikasi Scopus 2024 per tanggal 30 Juni 2024 (499 artikel)
Publikasi Scopus 2024 per tanggal 30 Juni 2024 (499 artikel)
Rahman, Siti Fauziyah (55440248200); Ghiffary, Muhammad Maulana (57927703300); Tampubolon, Joshua Yoshihiko (57894791800); Yulianti, Elly Septia (57222155918); Nadhif, Muhammad Hanif (57189057498); Katili, Puspita Anggraini (56608201800); Hanafiah, Siti (58996661000); Pangesty, Azizah Intan (57195717687); Maras, Muhammad Artha Jabatsudewa (57222618983)
Effect of graphite, graphene oxide, and multi-walled carbon nanotubes on the physicochemical characteristics and biocompatibility of chitosan/hyaluronic acid/hydroxyapatite scaffolds for tissue engineering applications
2024
Journal of Science: Advanced Materials and Devices
9
2
100719
1
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190975258&doi=10.1016%2fj.jsamd.2024.100719&partnerID=40&md5=f6a3d19f77acd631d93d2a48844b4f23
Division of Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Medical Physiology and Biophysics Department, Faculty of Medicine, Universitas Indonesia, Kampus UI Salemba, Jakarta, 10430, Indonesia; Medical Technology Cluster, Indonesian Medical Education and Research Institute, Kampus UI Salemba, Jakarta, 10430, Indonesia; Botnar Research Institute, Nuffield Department of Orthopaedics and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, United Kingdom; Department of Metallurgy and Material Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Biomedical Engineering, Institut Teknologi Sumatera, Lampung, 35365, Indonesia
Bone tissue engineering (BTE) is a promising alternative approach to the repair of damaged bone tissue. This study aims to fabricate and characterize scaffolds composed of chitosan (CS), hyaluronic acid (HA), hydroxyapatite (HAp), and a combination of graphite (Gr), graphene oxide (GO), and multi-walled carbon nanotubes (MWCNT) for BTE applications. The Gr and MWCNT were functionalized by acid oxidation, while the GO was synthesized using the improved Hummers' method. The scaffolds were prepared by lyophilization, and the physical, chemical, and biological properties were evaluated. Scanning electron microscopy (SEM), energy-dispersive x-ray spectroscopy (EDS), Fourier transform infrared (FTIR) spectroscopy, mechanical testing, water contact angle, degradation, and biocompatibility assays were used to characterize the scaffolds. The degradation rate was determined using the liquid displacement method. Pores of different sizes were present on the surface of and throughout the scaffold. According to the FTIR results, the scaffolds contained functional groups that promote cell differentiation and proliferation. These scaffolds have compressive strength, Young's modulus, and toughness similar to cancellous bone, with reasonable porosity and controllable degradation rates. Biocompatibility testing confirmed that the scaffolds support cell proliferation and differentiation. © 2024 Vietnam National University, Hanoi
UC-MSC
The CS/HA/HAp/GO scaffold contains GO, a material known for its scaffolding ability and bone-inducing properties. However, despite these favorable properties, the results indicated that proliferation in this scaffold was inferior to that in the CS/HA/HAp scaffold. This study showed that five of the eight materials demonstrated the ability to induce cell proliferation in culture with medium alone.
Elsevier B.V.
24682284
Article
Q1
1130
3425