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Publikasi Scopus 2024 per tanggal 30 Juni 2024 (499 artikel)
Publikasi Scopus 2024 per tanggal 30 Juni 2024 (499 artikel)
La Distia Nora, Rina (56001881000); Putera, Ikhwanuliman (56485949000); Schrijver, Benjamin (36345029700); Singh, Gurmeet (57209127647); Bakker, Marleen (7101722384); Riasanti, Mei (57565527600); Edwar, Lukman (55695047800); Susiyanti, Made (19640377300); Aziza, Yulia (57214455776); ten Berge, Josianne C.E.M. (56601233400); Rombach, Saskia M. (58860662800); van Hagen, P. Martin (57210765646); Sitompul, Ratna (8312163900); Dik, Willem A. (6603280038)
Ocular Tuberculosis Diagnosis Through Biomarkers: Clinical Relevance of Serum C1q and Whole Blood Interferon Gene Signature Score
2024
Ocular Immunology and Inflammation
0
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196720125&doi=10.1080%2f09273948.2024.2368670&partnerID=40&md5=90e9ebb4b8293b16143edf21e828102d
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Laboratory Medical Immunology, Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Internal Medicine Section Allergy & Clinical Immunology, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Internal Medicine, Respirology and Critical Illness Division, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pulmonary Diseases, Erasmus Medical Center, Rotterdam, Netherlands
Purpose: To assess the clinical relevance of pathophysiology-based biomarkers, specifically serum C1q and whole blood interferon gene signature score (IGSS), in ocular tuberculosis (OTB) diagnosis by conducting an integrative analysis of clinical presentations and treatment response. Methods: This retrospective cohort study analysed data from 70 patients with suspected OTB at a tertiary care uveitis practice in Indonesia. Serum C1q levels and whole blood IGSS were quantified. Patients were categorized into four quadrants based on their biomarker profiles: quadrant 1 (high C1q & low IGSS), quadrant 2 (high C1q & high IGSS), quadrant 3 (low C1q & high IGSS), and quadrant 4 (low C1q & low IGSS). Characteristics of clinical presentations, work-up results, and treatment outcomes were explored according to the predefined quadrants. Results: We identified that the majority of OTB patients diagnosed with concurrent active pulmonary TB were in quadrant 1, 2, or 3 (20/23, 87.0%). Twenty-seven patients (27/47, 57.4%) with clinically undifferentiated uveitis were in quadrant 4 (p < 0.001). Among patients in quadrants 1, 2, and 3, completion of a full course of antitubercular treatment (ATT) was associated with a lower number of patients showing persistence or recurrence of ocular inflammation compared to those who were not fully treated with ATT (14.3% vs 85.7%, p = 0.001). Conclusions: Based on the analysis of clinical features and treatment outcomes, patients with elevated levels of either or both serum C1q and whole blood IGSS may reflect active TB disease in the eye, necessitating full ATT management. © 2024 Taylor & Francis Group, LLC.
Taylor and Francis Ltd.
09273948
Article
Q1
805
5924