Publikasi Scopus 2024 per tanggal 30 Juni 2024 (499 artikel)

Hilmy F.; Dilogo I.H.; Reksodiputro M.H.; Antarianto R.D.; Al Mashur M.I.; Adhimulia K.J.
Hilmy, Fahresa (57925319600); Dilogo, Ismail Hadisoebroto (56161962800); Reksodiputro, Mirta Hediyati (35090488800); Antarianto, Radiana Dhewayani (57190862806); Al Mashur, Muslich Idris (57833530100); Adhimulia, Kevin Jonathan (57222107905)
57925319600; 56161962800; 35090488800; 57190862806; 57833530100; 57222107905
Evaluation of adipose-derived stem cells (ASCS) exosome implantation and platelet-rich fibrin (PRF) on critical long bone defects in Sprague-Dawley rats
2024
European Journal of Orthopaedic Surgery and Traumatology
0
Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Ear, Nose and Throat Clinic, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia
Hilmy F., Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Dilogo I.H., Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Reksodiputro M.H., Department of Ear, Nose and Throat Clinic, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Antarianto R.D., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Al Mashur M.I., Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Adhimulia K.J., Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia
Introduction: This study aimed to assess the efficacy of adipose-derived mesenchymal stem cell exosomes (ASCs exosome) and platelet-rich fibrin (PRF) in treating critical long bone defects in Sprague-Dawley rats. Critical long bone defects, defined as exceeding 2 cm or 50% of the bone diameter, often pose a healing challenge. While autologous bone grafts have been considered, they have shown unreliable results and donor-site complications, necessitating alternative treatments. Methods: The research followed a quasi-experimental post-test only control group design involving 30 male Sprague-Dawley rats. The rats were divided into five groups and subjected to femur bone defect creation, internally fixed with a 1.4 mm K-wire, and treated with various combinations of hydroxyapatite (HA), bone graft (BG), ASCs exosome, and PRF. Histomorphometry and BMP-2 gene expression analysis were performed to evaluate bone healing. Results and Discussion: The results indicated that the group treated with HA + BG + ASCs exosome (group IV) exhibited the highest BMP-2 gene expression, while group III (HA + BG + ASCs exosome + PRF) had the highest chordin level. Overall, groups receiving ASCs exosome or PRF intervention showed elevated BMP-2 expression compared to the control group. The use of ASCs exosome and PRF showed comparable outcomes compared to bone graft administration in terms of histomorphometry analysis. Conclusion: The administration of adipose tissue derived mesenchymal stem cells and PRF has a comparable outcome with the use of bone graft in terms of osseus area and expression of BMP-2 in critical bone defect. © The Author(s) 2024.
Adipose-derived stem cells (ASCs) exosome; Critical long bone defect; Platelet-rich fibrin (PRF); Sprague-Dawley
PUTI Q1 University of Indonesia; Fakultas Kedokteran, Universitas Indonesia, FKUI, (PENG-006/UN2.RST/PPM.00.00/2022); Fakultas Kedokteran, Universitas Indonesia, FKUI
Funding text 1: This research was funded by a grant from the PUTI Q1 University of Indonesia based on the Letter of Research Grant from UI for the year 2022 (Batch 2) with reference number PENG-006/UN2.RST/PPM.00.00/2022. ; Funding text 2: Funding was provided by Fakultas Kedokteran, Universitas Indonesia (Grant no. PENG-006/UN2.RST/PPM.00.00/2022).
Springer Nature
16338065
Article
Q1
720
6864