Publikasi Scopus 2024 per tanggal 30 Juni 2024 (499 artikel)

Dirjayanto V.J.; Martin-Ruiz C.; Pompei G.; Rubino F.; Kunadian V.
Dirjayanto, Valerie Josephine (57404619000); Martin-Ruiz, Carmen (6701718262); Pompei, Graziella (57242359600); Rubino, Francesca (57208753088); Kunadian, Vijay (55390915800)
57404619000; 6701718262; 57242359600; 57208753088; 55390915800
The association of inflammatory biomarkers and long-term clinical outcomes in older adults with non-ST elevation acute coronary syndrome
2024
International Journal of Cardiology
409
132177
0
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom; Faculty of Medicine, Universitas Indonesia, Indonesia; BioScreening Core Facility, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom; Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, FE, Cona, Italy; Division of Cardiology, Department of Medicine, University of Verona, Verona, Italy; Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
Dirjayanto V.J., Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom, Faculty of Medicine, Universitas Indonesia, Indonesia; Martin-Ruiz C., BioScreening Core Facility, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom; Pompei G., Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom, Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, FE, Cona, Italy; Rubino F., Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom, Division of Cardiology, Department of Medicine, University of Verona, Verona, Italy; Kunadian V., Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom, Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
Background: The prognostic significance of inflammatory markers on the long-term risk of major adverse cardiovascular and cerebrovascular events (MACCE) in older NSTEACS patients remains unclear. Methods: NSTEACS patients aged 75 and older were recruited to the multicentre cohort study Improve Cardiovascular Outcomes in High-Risk PatieNts with Acute Coronary Syndrome (ICON1). Inflammatory markers including interleukin-6 (IL-6), myeloperoxidase (MPO), high-sensitivity C-reactive protein (hsCRP), fibrinogen and tumor necrosis factor-alpha (TNF-α) were collected at baseline. Primary outcome was MACCE consisting of all-cause mortality, reinfarction, stroke/transient ischaemic attack, urgent revascularization, and significant bleeding at 5-year follow-up. Results: There were 230 patients with baseline IL-6 (median age 80.9 [interquartile range (IQR):78.2–83.9] years). High IL-6 was not associated with MACCE, but it was independently associated with all-cause mortality (adjusted hazard ratio [aHR]: 2.26 [95% Confidence Interval (CI):1.34–3.82]; P = 0.002). For patients with hsCRP (n = 260, median age 80.9 [IQR:77.9–84.1] years), higher levels were significantly associated with increased risk of MACCE (aHR:1.77 [95% CI:1.26–2.49], P = 0.001). In the cohort with MPO (230 patients, median age 80.9 [IQR:78.2–83.9] years), lower MPO was independently associated with the risk of MACCE (aHR: 0.67 [95%CI:0.46–0.96]; P = 0.029). There was no prognostic significance with fibrinogen and TNF-α. Conclusion: Among older NSTEACS patients, elevated IL-6 and hsCRP were associated with increased risk of all-cause mortality and MACCE, respectively. Low MPO levels were associated with higher MACCE. Further studies are required to determine how these biomarkers should influence treatment strategy in this understudied subset. Clinical Trial Registration: NCT01933581 © 2024 Elsevier B.V.
Inflammatory biomarkers; Major adverse cardiovascular events; Non-ST elevation acute coronary syndrome; Older adults
Acute Coronary Syndrome; Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; Cohort Studies; Female; Follow-Up Studies; Humans; Inflammation; Interleukin-6; Male; Peroxidase; Prognosis; Time Factors; Treatment Outcome; biological marker; C reactive protein; fibrinogen; interleukin 6; myeloperoxidase; troponin; tumor necrosis factor; C reactive protein; interleukin 6; peroxidase; acute coronary syndrome; adult; all cause mortality; angiography; Article; atrial fibrillation; blood pressure; cardiogenic shock; cardiomyopathy; cardiovascular disease; cerebrovascular accident; chi square test; clinical outcome; confidence interval; coronary artery bypass graft; demographics; electrocardiography; enzyme linked immunosorbent assay; follow up; hazard ratio; heart arrhythmia; heart reinfarctio
NIHR Newcastle Biomedical Research Centre; National Institute for Health and Care Research, NIHR; Newcastle cardiovascular research team; Newcastle University; Newcastle upon Tyne Hospitals NHS Foundation Trust; British Heart Foundation, BHF, (CS/15/7/31679); British Heart Foundation, BHF
We are grateful to the Newcastle cardiovascular research team for their support with the long-term follow-up. This research is supported by the National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre based at Newcastle-upon-Tyne Hospitals NHS Foundation Trust and Newcastle University. VK has received research funding from the British Heart Foundation (CS/15/7/31679).
Elsevier Ireland Ltd
01675273
38761976
Article
Q1
1122
3475