Publikasi Scopus 2024 per tanggal 30 Juni 2024 (499 artikel)

Rachman A.; Rahmaniyah R.; Khomeini A.; Iriani A.
Rachman, Andhika (15056701600); Rahmaniyah, Rizky (57195516171); Khomeini, Andi (58019738400); Iriani, Anggraini (57192888893)
15056701600; 57195516171; 58019738400; 57192888893
The association between vitamin D deficiency and the clinical outcomes of hospitalized COVID-19 patients
2024
F1000Research
12
394
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Division of Hematology and Oncology, Department of Internal Medicine, Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Centra Jakarta, DKI Jakarta, Dr, 10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Central Jakarta, 10430, Indonesia; Department of Internal Medicine, Wisma Atlet COVID-19 Emergency Hospital, DKI Jakarta, North Jakarta, 14360, Indonesia; Department of Clinical Pathology, Yarsi University, DKI Jakarta, Central Jakarta, 10510, Indonesia
Rachman A., Division of Hematology and Oncology, Department of Internal Medicine, Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Centra Jakarta, DKI Jakarta, Dr, 10430, Indonesia; Rahmaniyah R., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Central Jakarta, 10430, Indonesia; Khomeini A., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Central Jakarta, 10430, Indonesia, Department of Internal Medicine, Wisma Atlet COVID-19 Emergency Hospital, DKI Jakarta, North Jakarta, 14360, Indonesia; Iriani A., Department of Clinical Pathology, Yarsi University, DKI Jakarta, Central Jakarta, 10510, Indonesia
Background: Vitamin D deficiency is an emerging public health problem that affects more than one billion people worldwide. Vitamin D has been shown to be effective in preventing and reducing the severity of viral respiratory diseases, including influenza. However, the role of vitamin D in COVID-19 infection remains controversial. This study aimed to analyze the association of vitamin D deficiency on the clinical outcome of hospitalized COVID-19 patients. Methods: A prospective cohort study was conducted among hospitalized COVID-19 patients at two COVID-19 referral hospitals in Indonesia from October 2021 until February 2022. Results: The median serum 25(OH)D level in 191 hospitalized COVID-19 patients was 13.6 [IQR=10.98] ng/mL. The serum 25(OH)D levels were significantly lower among COVID-19 patients with vitamin D deficiency who had cardiovascular disease (p-value=0.04), the use of a ventilator (p-value=0.004), more severe COVID-19 cases (p-value=0.047), and mortality (p-value=0.002). Furthermore, serum 25(OH)D levels were significantly different between patients with mild and severe COVID-19 cases (p-value=0.019). Serum 25(OH)D levels in moderate and severe COVID-19 cases were significantly different (p-value=0.031). Lower serum 25(OH)D levels were significantly associated with an increased number of comorbidities (p-value=0.03), the severity of COVID-19 (p-value=0.002), and the use of mechanical ventilation (p-value=0.032). Mortality was found in 7.3% of patients with deficient vitamin D levels. However, patients with either sufficient or insufficient vitamin D levels did not develop mortality. Conclusions: COVID-19 patients with vitamin D deficiency were significantly associated with having cardiovascular disease, mortality, more severe COVID-19 cases, and the used of mechanical ventilation. Lower serum 25(OH)D levels were associated with an increased number of comorbidities, COVID-19 severity, and the use of mechanical-ventilation. Thus, we suggest hospitalized COVID-19 patients to reach a sufficient vitamin D status to improve the clinical outcome of the disease. Copyright: © 2024 Rachman A et al.
25(OH)D; clinical outcome; COVID-19; Vitamin D
25 hydroxyvitamin D; SARS-CoV-2 vaccine; adult; Article; artificial ventilation; cardiovascular disease; clinical outcome; cohort analysis; comorbidity; controlled study; coronavirus disease 2019; cross-sectional study; disease severity; female; high flow nasal cannula therapy; hospital patient; human; Indonesia; major clinical study; male; mortality; people by vaccination status; prospective study; vitamin blood level; vitamin D deficiency
Direktorat Riset and Pengembangan, Universitas Indonesia, DRPM UI, (ND-5463/UN2.F1.D1.4/PPM.00.00/2022)
This research was funded by Directorate of Research and Development, Universitas Indonesia’s grant program “Hibah PUTI 2022” (grant number: ND-5463/UN2.F1.D1.4/PPM.00.00/2022).
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