Publikasi Scopus FKUI 2021 per tanggal 30 Juni 2021 (428 artikel)

Kamal A.F., Abubakar I., Salamah T.
56648996700;57204179162;57195380322;
Alkaline phosphatase, lactic dehidrogenase, inflammatory variables and apparent diffusion coefficients from MRI for prediction of chemotherapy response in osteosarcoma. A cross sectional study
2021
Annals of Medicine and Surgery
64
102228
Department of Orthopaedic and Traumatology Faculty of Medicine Universitas Indonesia/ Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Orthopaedic and Traumatology-Department of Surgery Faculty of Medicine Universitas Syiah Kuala/ Zainoel Abidin General Hospital, Banda Aceh, Indonesia; Department of Radiology Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo, General Hospital, Jakarta, Indonesia
Kamal, A.F., Department of Orthopaedic and Traumatology Faculty of Medicine Universitas Indonesia/ Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Abubakar, I., Department of Orthopaedic and Traumatology Faculty of Medicine Universitas Indonesia/ Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Division of Orthopaedic and Traumatology-Department of Surgery Faculty of Medicine Universitas Syiah Kuala/ Zainoel Abidin General Hospital, Banda Aceh, Indonesia; Salamah, T., Department of Radiology Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo, General Hospital, Jakarta, Indonesia
Background: This present study aimed to assess if clinical, laboratory and MRI were an accurate benchmark in assessing the effectiveness of neoadjuvant chemotherapy in osteosarcoma patients. Methods: This was an observational analytic study with a cross-sectional design. We correlated among clinical, laboratory and magnetic resonance imaging (MRI) data before and after neoadjuvant chemotherapy; and percentage of tumor necroses from osteosarcoma patients during the period between January 2017–July 2019. Results: Of the 58 patients included in this study, 38 were male and 20 were female aged 5 - 67 years (mean: 16-year-old. 37(63.8%) patients underwent neoadjuvant chemotherapy with CAI regimens and 13 (36.2%) with CA regiments. The tumors were classified as stage IIB in 43 (74.1%) patients and stage III in 15 (25.9%) patients. Wilcoxon test showed significant differences between alkaline phosphatase (ALP), erythrocyte sedimentation rate (ESR), and neutrophil to lymphocyte ratio (NLR) before and after neoadjuvant chemotherapy in the poor-response group. We found no significant difference between lactic dehydrogenase (LDH) and lymphocyte-to-monocyte ratio (LMR) before and after neoadjuvant chemotherapy in the good-response group. MRI revealed decreased tumor volume in patients in the good-response to chemotherapy. Conclusion: We demonstrated that ALP level was statistically significant in the poor-response group. We also found that LDH value before neoadjuvant chemotherapy had a strong correlation with degree of necrosis and could be used as a predictive indicator. MRI plays an important role in evaluating tumor volumes and preoperative radiological changes to predict histological necrosis. © 2021
Alkaline phospkatase; Chemotherapy; LDH; MRI Apparent diffusion coefficients; NLR,LMR; Osteosarcoma
alanine aminotransferase; alkaline phosphatase; C reactive protein; cisplatin; doxorubicin; fluorodeoxyglucose f 18; ifosfamide; lactate dehydrogenase; adjuvant therapy; adolescent; adult; aged; analytical research; apparent diffusion coefficient; Article; cancer chemotherapy; cancer size; cancer staging; child; comparative effectiveness; computer assisted tomography; cross-sectional study; erythrocyte sedimentation rate; female; histology; human; human tissue; hypertransaminasemia; lymphocyte monocyte ratio; major clinical study; male; MSTS score; neoadjuvant chemotherapy; neutrophil lymphocyte ratio; nuclear magnetic resonance imaging; observational study; osteosarcoma; platelet lymphocyte ratio; receiver operating characteristic; retrospective study; scoring system; treatment response;
Elsevier Ltd
20490801
Article
Q3
410
11547

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