Publikasi Scopus FKUI 2021 per tanggal 31 Maret 2021 (187 artikel)

Yusuf P.A., Hubka P., Tillein J., Vinck M., Kral A.
57192156597;6506008977;6602884109;35338597200;55668482500;
Deafness Weakens Interareal Couplings in the Auditory Cortex
2021
Frontiers in Neuroscience
14
625721
Department of Medical Physics/Medical Technology Core Cluster IMERI, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Institute of AudioNeuroTechnology, Hannover Medical School, Hanover, Germany; Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hanover, Germany; Department of Otorhinolaryngology, Goethe University, Frankfurt am Main, Germany; MedEL Company, Innsbruck, Austria; Ernst Strüngmann Institut for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany; Donders Centre for Neuroscience, Radboud University, Department of Neuroinformatics, Nijmegen, Netherlands; Department of Biomedical Sciences, School of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia
Yusuf, P.A., Department of Medical Physics/Medical Technology Core Cluster IMERI, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Institute of AudioNeuroTechnology, Hannover Medical School, Hanover, Germany, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hanover, Germany; Hubka, P., Institute of AudioNeuroTechnology, Hannover Medical School, Hanover, Germany, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hanover, Germany; Tillein, J., Institute of AudioNeuroTechnology, Hannover Medical School, Hanover, Germany, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hanover, Germany, Department of Otorhinolaryngology, Goethe University, Frankfurt am Main, Germany, MedEL Company, Innsbruck, Austria; Vinck, M., Ernst Strüngmann Institut for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany, Donders Centre for Neuroscience, Radboud University, Department of Neuroinformatics, Nijmegen, Netherlands; Kral, A., Institute of AudioNeuroTechnology, Hannover Medical School, Hanover, Germany, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hanover, Germany, Department of Biomedical Sciences, School of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia
The function of the cerebral cortex essentially depends on the ability to form functional assemblies across different cortical areas serving different functions. Here we investigated how developmental hearing experience affects functional and effective interareal connectivity in the auditory cortex in an animal model with years-long and complete auditory deprivation (deafness) from birth, the congenitally deaf cat (CDC). Using intracortical multielectrode arrays, neuronal activity of adult hearing controls and CDCs was registered in the primary auditory cortex and the secondary posterior auditory field (PAF). Ongoing activity as well as responses to acoustic stimulation (in adult hearing controls) and electric stimulation applied via cochlear implants (in adult hearing controls and CDCs) were analyzed. As functional connectivity measures pairwise phase consistency and Granger causality were used. While the number of coupled sites was nearly identical between controls and CDCs, a reduced coupling strength between the primary and the higher order field was found in CDCs under auditory stimulation. Such stimulus-related decoupling was particularly pronounced in the alpha band and in top–down direction. Ongoing connectivity did not show such a decoupling. These findings suggest that developmental experience is essential for functional interareal interactions during sensory processing. The outcomes demonstrate that corticocortical couplings, particularly top-down connectivity, are compromised following congenital sensory deprivation. © Copyright © 2021 Yusuf, Hubka, Tillein, Vinck and Kral.
bottom-up; cochlear implant; congenital deafness; predictive coding; synchronization; top–down
Frontiers Media S.A.
16624548
Article
Q1
1554
2089