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Publikasi Scopus FKUI 2021 per tanggal 31 Mei 2021 (358 artikel)
Publikasi Scopus FKUI 2021 per tanggal 31 Mei 2021 (358 artikel)
Understanding the effects of CMV on γδ T-cell populations in HIV patients starting antiretroviral therapy
2021
Clinical Immunology
226
108696
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103343868&doi=10.1016%2fj.clim.2021.108696&partnerID=40&md5=537b6ce49573252250340726edc3d07d
Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Virology and Cancer Pathobiology Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Microbiology, Pathwest Laboratory Medicine, Perth, Australia; School of Pharmacy & Biomedical Science, Curtin University, Perth, Australia; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia
Cytomegalovirus (CMV) affects γδ T-cell profiles in healthy individuals and transplant recipients, but the effects of HIV and CMV have not been distinguished in HIV patients. CMV-seropositive Indonesian HIV patients (n = 40) were studied before ART and after six months, alongside healthy controls (n = 20). 50% of patients started ART with detectable CMV DNA. Proportions of Vδ2− γδ T-cells were high in patients and declined on ART, whilst proportions of Vδ2+ γδ T-cells were uniformly low, and correlated inversely with levels of CMV DNA and CMV-reactive antibody. Residual Vδ2+ cells were enriched for markers of terminal differentiation, but this did not associate with CMV metrics. Patients with CMV DNA at baseline showed a direct correlation between CMV reactive-antibody and CD8+ γδ T-cells. Our data are consistent with a role for CMV in the depletion of Vδ2+ γδ T-cells in HIV patients beginning ART, with no consistent evidence of a role for CMV in γδ T-cell activation or differentiation. © 2021
adult; antiretroviral therapy; article; cell population; clinical article; controlled study; Cytomegalovirus; female; gamma delta T lymphocyte; human; human cell; Human immunodeficiency virus infected patient; male; nonhuman; T lymphocyte activation
Academic Press Inc.
15216616
33621667
Article
Q2
1217
3173