Publikasi Scopus FKUI 2021 per tanggal 31 Mei 2021 (358 artikel)

Publikasi Scopus FKUI 2021 per tanggal 31 Mei 2021 (358 artikel)

van Crevel R., Avila-Pacheco J., Thuong N.T.T., Ganiem A.R., Imran D., Hamers R.L., Alisjahbana B., Dian S., Estiasari R., Tram T.T.B., Vinh D.N., Hai H.T., Donovan J., Ardiansyah E., Koeken V., Kumar V., Netea M.G., van Laarhoven A., Clish C., Thwaites G., The ULTIMATE consortium
6603956378;57194750113;16551464800;35145741500;57203976849;23034345900;6506944516;55418398700;55240204000;56426109200;56562746100;57197774138;57203943392;57205617822;57194441324;57218972843;35378641700;55625910500;35460787900;6603796838;
Improving host-directed therapy for tuberculous meningitis by linking clinical and multi-omics data
2021
Tuberculosis
128
102085
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106295161&doi=10.1016%2fj.tube.2021.102085&partnerID=40&md5=4ce0f74084aad8c1c23b99ba0823c3f8
Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Eijkman Oxford Clinical Research Unit, Jakarta, Indonesia
van Crevel, R., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Avila-Pacheco, J., The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Thuong, N.T.T., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Ganiem, A.R., TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Imran, D., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hamers, R.L., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Eijkman Oxford Clinical Research Unit, Jakarta, Indonesia; Alisjahbana, B., TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Dian, S., TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Estiasari, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tram, T.T.B., Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Vinh, D.N., Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Hai, H.T., Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Donovan, J., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Ardiansyah, E., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Koeken, V., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Kumar, V., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Netea, M.G., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; van Laarhoven, A., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Clish, C., The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Thwaites, G., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; The ULTIMATE consortium
There is a clear need to improve host-directed therapy for tuberculous meningitis (TBM), the most severe and deadly manifestation of tuberculosis. Corticosteroids represent the only host-directed therapy of proven benefit in TBM, yet their effect is modest, the mechanism by which they reduce mortality is unknown, and there is evidence for heterogeneity in their effect. Novel therapeutic approaches are therefore urgently needed. Cellular metabolism is critical for the function of immune cells; through unbiased metabolomics we recently found that high concentrations of cerebrospinal fluid (CSF) tryptophan are associated with increased mortality in Indonesian TBM patients, and that CSF tryptophan concentrations are under strong genetic regulation. Many questions remain. How exactly is tryptophan metabolism altered during TBM? How does it correlate with inflammation, immunopathology, and response to corticosteroids? How is tryptophan metabolism genetically regulated? What is the effect of HIV co-infection on tryptophan metabolism before and during TBM treatment? The ULTIMATE project addresses these questions by integrating data and specimens from large patient studies and clinical trials evaluating the effects of corticosteroids in Vietnam and Indonesia. Through its powerful and unbiased approach, ULTIMATE aims to identify which TBM patients benefit from corticosteroids and if novel therapeutic targets, such as the tryptophan pathway, could be targeted. © 2021
Cerebrospinal fluid; Genetics; Host-directed therapy; Meningitis; Metabolomics; Tryptophan; Tuberculosis
Churchill Livingstone
14729792
Article
Q2
1026
4170

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