Publikasi Scopus FKUI 2021 per tanggal 31 Mei 2021 (358 artikel)

Publikasi Scopus FKUI 2021 per tanggal 31 Mei 2021 (358 artikel)

Aitken R.J., Curry B.J., Shokri S., Pujianto D.A., Gavriliouk D., Gibb Z., Whiting S., Connaughton H.S., Nixon B., Salamonsen L.A., Baker M.A.
7201959888;56908506100;57222061734;8745734300;56926729700;36650800200;55363694400;55488741500;34571659200;7005800278;57201355280;
Evidence that extrapancreatic insulin production is involved in the mediation of sperm survival
2021
Molecular and Cellular Endocrinology
526
111193
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101239641&doi=10.1016%2fj.mce.2021.111193&partnerID=40&md5=dd3268ec7434c8487b5f42a0d81d0e4a
Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia; Department of Anatomical Sciences, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Family Fertility Centre, Ashford Specialist CentreSA 5035, Australia; Hudson Institute of Medical Research, Centre for Reproductive Health, Monash UniversityVIC 3168, Australia
Aitken, R.J., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia, Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia; Curry, B.J., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Shokri, S., Department of Anatomical Sciences, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; Pujianto, D.A., Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Gavriliouk, D., Family Fertility Centre, Ashford Specialist CentreSA 5035, Australia; Gibb, Z., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Whiting, S., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Connaughton, H.S., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Nixon, B., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia, Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia; Salamonsen, L.A., Hudson Institute of Medical Research, Centre for Reproductive Health, Monash UniversityVIC 3168, Australia; Baker, M.A., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia, Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia
Evidence is presented for expression of the insulin receptor on the surface of mammalian spermatozoa as well as transcripts for the receptor substrate adaptor proteins (IRS1-4) needed to mediate insulin action. Exposure to this hormone resulted in insulin receptor phosphorylation (pTyr972), activation of AKT (pSer473) and the stimulation of sperm motility. Intriguingly, the male germ line is also shown to be capable of generating insulin, possessing the relevant mRNA transcript and expressing strong immunocytochemical signals for both insulin and C-peptide. Insulin could be released from the spermatozoa by sonication in a concentration-dependent manner but was not secreted in response to glucose, fructose or stimulation with progesterone. However, insulin release could be induced by factors present in human uterine lavages. Furthermore, the endometrium was also shown to possess the machinery for insulin production and action (mRNA, insulin, C-peptide, proprotein convertase and insulin receptor), releasing insulin into the uterine lumen prior to ovulation. These studies emphasize the fundamental importance of extra-pancreatic insulin in regulating the reproductive process, particularly in the support of spermatozoa on their perilous voyage to the site of fertilization. © 2021 Elsevier B.V.
AKT-1; Apoptosis; Insulin; Motility; Spermatozoa
Elsevier Ireland Ltd
03037207
33610643
Article
Q1
1305
2852

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