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Publikasi Scopus FKUI 2021 per tanggal 31 Mei 2021 (358 artikel)
Publikasi Scopus FKUI 2021 per tanggal 31 Mei 2021 (358 artikel)
Association of body mass index with immune recovery, virological failure and cardiovascular disease risk among people living with HIV
2021
HIV medicine
22
4
294
306
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102909777&doi=10.1111%2fhiv.13017&partnerID=40&md5=f5a9331ca3fb9c08afd9d5ae25f327ba
Kirby Institute, UNSW, NSW, Sydney, Australia; HIV-NAT, Thai Red Cross AIDS Research CentreBangkok, Thailand; Faculty of Medicine, Universitas Indonesia - Dr Cipto Mangunkusumo General HospitalJakarta, Indonesia; Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of MedicineSeoul, South Korea; Research Institute for Tropical Medicine, Philippines; Research Institute for Health SciencesChiang Mai, Thailand; National Center for HIV/AIDS, Dermatology & STDsPhnom Penh, Cambodia; Chiangrai Prachanukroh HospitalChiang Rai, Thailand; Faculty of Medicine, Udayana University & Sanglah HospitalBali, Indonesia; Bach Mai HospitalHanoi, Viet Nam; University Malaya Medical CentreKuala Lumpur, Malaysia; Queen Elizabeth Hospital, Hong Kong SAR, India; National Hospital for Tropical DiseasesHanoi, Viet Nam; Taipei Veterans General HospitalTaipei, Taiwan; Faculty of Medicine Ramathibodi Hospital, Mahidol UniversityBangkok, Thailand; Tan Tock Seng Hospital, Singapore; National Center for Global Health and MedicineTokyo, Japan; Institute of Infectious Diseases, Pune, India; Beijing Ditan Hospital, Capital Medical UniversityBeijing, China; Hospital Sungai Buloh, Sungai Buloh, Malaysia; BJ Government Medical College and Sassoon General Hospital, Pune, India; TREAT Asia, amfAR - The Foundation for AIDS ResearchBangkok, Thailand; Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India
OBJECTIVES: We conducted a longitudinal cohort analysis to evaluate the association of pre-treatment body mass index (BMI) with CD4 recovery, virological failure (VF) and cardiovascular risk disease (CVD) markers among people living with HIV (PLHIV). METHODS: Participants who were enrolled between January 2003 and March 2019 in a regional Asia HIV cohort with weight and height measurements prior to antiretroviral therapy (ART) initiation were included. Factors associated with mean CD4 increase were analysed using repeated-measures linear regression. Time to first VF after 6 months on ART and time to first development of CVD risk markers were analysed using Cox regression models. Sensitivity analyses were done adjusting for Asian BMI thresholds. RESULTS: Of 4993 PLHIV (66% male), 62% had pre-treatment BMI in the normal range (18.5-25.0 kg/m2 ), while 26%, 10% and 2% were underweight (< 18.5 kg/m2 ), overweight (25-30 kg/m2) and obese (> 30 kg/m2 ), respectively. Both higher baseline and time-updated BMI were associated with larger CD4 gains compared with normal BMI. After adjusting for Asian BMI thresholds, higher baseline BMIs of 23-27.5 and > 27.5 kg/m2 were associated with larger CD4 increases of 15.6 cells/µL [95% confidence interval (CI): 2.9-28.3] and 28.8 cells/µL (95% CI: 6.6-50.9), respectively, compared with normal BMI (18.5-23 kg/m2 ). PLHIV with BMIs of 25-30 and > 30 kg/m2 were 1.27 times (95% CI: 1.10-1.47) and 1.61 times (95% CI: 1.13-2.24) more likely to develop CVD risk factors. No relationship between pre-treatment BMI and VF was observed. CONCLUSIONS: High pre-treatment BMI was associated with better immune reconstitution and CVD risk factor development in an Asian PLHIV cohort. © 2020 British HIV Association.
NLM (Medline)
14681293
33200864
Article
Q1
1494
2240