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Publikasi Scopus FKUI 2021 per tanggal 31 Oktober 2021 (739 artikel)
Publikasi Scopus FKUI 2021 per tanggal 31 Oktober 2021 (739 artikel)
Development of rat metabolic syndrome models: A review
2021
Veterinary World
14
7
1774
1783
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111179239&doi=10.14202%2fvetworld.2021.1774-1783&partnerID=40&md5=609e64dbfe9d6c9660d991f611abbd71
Department of Pharmacology, Faculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia; Doctoral Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Metabolic syndrome (MetS) has become a global problem. With the increasing prevalence of MetS worldwide, understanding its pathogenesis and treatment modalities are essential. Animal models should allow an appropriate representation of the clinical manifestations of human conditions. Rats are the most commonly used experimental animals for the study. The development of a proper MetS model using rats will contribute to the successful application of research findings to the clinical setting. Various intervention methods are used to induce MetS through diet induction with various compositions, chemicals, or a combination of both. This review will provide a comprehensive overview of several studies on the development of rat MetS models, along with the characteristics of the clinical manifestations resulting from each study. ? 2021 Veterinary World. All rights reserved.
cholesterol; diacylglycerol; glucose; high density lipoprotein cholesterol; leptin receptor; low density lipoprotein cholesterol; triacylglycerol; abdominal circumference; abdominal obesity; animal model; bipolar disorder; body weight; bone metabolism; caloric intake; carbohydrate intake; cardiovascular disease; diastolic blood pressure; dyslipidemia; exercise; fat mass; food intake; gene; glucose blood level; glucose tolerance; high-fructose diet; human; hyperglycemia; insulin resistance; insulin sensitivity; insulin tolerance test; lipid diet; lipid metabolism; lipid storage; lipogenesis; major depression; male; mental disease; metabolic syndrome X; nonalcoholic fatty liver; nonhuman; osmotic stress; oxidative stress; pathogenesis; physical activity; prevalence; rat; Review; risk factor;
Veterinary World
9728988
Review
Q2
550
9187