Publikasi Scopus FKUI 2021 per tanggal 31 Oktober 2021 (739 artikel)

Ngadimin K.D., Stokes A., Gentile P., Ferreira A.M.
57224568038;57224586577;24478479500;16068361700;
Biomimetic hydrogels designed for cartilage tissue engineering
2021
Biomaterials Science
9
12
4246
4259
8
Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom; Faculty of Medicine, Universitas Indonesia, Indonesia; Faculty of Science, Agriculture and Engineering, Newcastle University, Newcastle upon Tyne, United Kingdom
Ngadimin, K.D., Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom, Faculty of Medicine, Universitas Indonesia, Indonesia; Stokes, A., Faculty of Science, Agriculture and Engineering, Newcastle University, Newcastle upon Tyne, United Kingdom; Gentile, P., Faculty of Science, Agriculture and Engineering, Newcastle University, Newcastle upon Tyne, United Kingdom; Ferreira, A.M., Faculty of Science, Agriculture and Engineering, Newcastle University, Newcastle upon Tyne, United Kingdom
Cartilage regeneration and repair remain a clinical challenge due to the limited capability of cartilage to self-regenerate. Worldwide, the costs associated with cartilage regeneration per patient are estimated on average ?30?000 for producing and supplying cells. Regenerative approaches may include the use of cell therapies and tissue engineering by combining relevant cells, scaffolds and instructive biomolecules to stimulate or modulate cartilage repair. Hydrogels have been of great interest within these fields to be used as 3D substrates to cultivate and grow cartilage cells. Currently, biomimetic hydrogels with adequate biological and physicochemical properties, such as mechanical properties, capable of supporting load-bearing capability, are yet to succeed. In this review, biomaterials' advantages and disadvantages for the manufacturing of biomimetic hydrogels for cartilage regeneration are presented. Different studies on the formulation of cartilage-like hydrogels based on materials such as gelatin, chondroitin sulfate, hyaluronic acid and polyethylene glycol are summarised and contrasted in terms of their mechanical properties (e.g. elastic modulus) and ability to enhance cell function such as cell viability and GAG content. Current limitations and challenges of biomimetic hydrogels for cartilage regeneration are also presented. ? 2021 The Royal Society of Chemistry.
Biomechanics; Biomimetics; Cartilage; Cells; Cytology; Hyaluronic acid; Hydrogels; Mechanical properties; Molecular biology; Physicochemical properties; Scaffolds (biology); Sulfur compounds; Tissue; Biomimetic hydrogels; Cartilage cells; Cartilage regeneration; Cartilage repair; Cartilage tissue engineering; Chondroitin sulfates; Current limitation; Load bearing capabilities; Cell engineering; biomaterial; biomimetic material; chondroitin sulfate; gelatin; hyaluronic acid; hydrogel; macrogol; biological activity; biomimetics; cartilage; cell therapy; cell viability; chemical composition; computer model; cross linking; human; in vitro study; nonhuman; Review; tissue engineering; tissue regeneration; Young modulus; articular cartilage; biomimetics; cartilage; hydrogel; regeneration; tissue
Royal Society of Chemistry
20474830
33710205
Review
Q1
1422
2479