Publikasi Scopus FKUI 2021 per tanggal 31 Oktober 2021 (739 artikel)

Susantiningsih T., Makkiyah F.A., Thadeus M.S., Yulianti R., Hadi S.
57192907038;57210232162;57226238484;57201696813;26534077400;
Progressive acute liver damage induced by repeated 2-nitropropane: Focused on obese mice
2021
Biomedical and Pharmacology Journal
14
2
695
700
Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Chemistry, Universitas Lampung, Bandar Lampung, 35145, Indonesia
Susantiningsih, T., Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Makkiyah, F.A., Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Thadeus, M.S., Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Yulianti, R., Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Hadi, S., Department of Chemistry, Universitas Lampung, Bandar Lampung, 35145, Indonesia
Obesity is linked to more deaths worldwide. In obesity, there will be a dysregulation of growth signals such as tumorigenesis. Despite the fact that obesity is tend to progress to acute liver damage, not many study using 2-nitropropane (2NP) as a hepatoxicity agent are undertaken especially in obese mice. This study aimed to determine the regime of 2NP that causes acute liver damage. This is an experimental research using a post-test control design group only, with 3 groups of mice ie O1 (obesity), O2+2-NP 1x (induced by 2NP 100 mg/kg BW once), and O2+2-NP 2x (induced by 2NP 100 mg/kg BW twice). At 10 weeks, rats were sacrificed and 100 mg liver tissue were collected for MDA, GSH, MnSOD and CAT enzymes analysis. Analysis statistics were performed by SPSS by one-way Anova and post hoc Tukey. MDA levels of mice were found to be increased in 2NP group than control (3.768 ? 0.407 nmol/ mg) (p < 0,01). Liver GSH, MnSOD and CAT levels of both single injection 2-NP and repeated injection 2-NP groups decreased compared to those of controls (p<0,01). Repeated injection of 2-NP worsen the acute liver damage in obese mice. ? 2021 Oriental Scientific Publishing Company. All rights reserved.
2-NP; CAT; GSH; MDA; MnSOD; Obesity
2 nitropropane; catalase; glutathione peroxidase; ketamine; manganese superoxide dismutase; oxygen; reactive oxygen metabolite; superoxide dismutase; triacylglycerol; xylazine; analysis of variance; animal model; animal tissue; Article; body weight; carcinogenesis; centrifugation; controlled study; data analysis software; DNA damage; enzyme activity; liver injury; liver tissue; male; mouse; nonhuman; obesity; oxidative stress; post hoc analysis; protein content; repeated drug dose
Oriental Scientific Publishing Company
9746242
Article
Q4
191
19920