Publikasi Scopus FKUI 2021 per tanggal 31 Oktober 2021 (739 artikel)

Riset dan Pengabdian Masyarakat Do Research Sosial Service and Innovation

Publikasi Scopus FKUI 2021 per tanggal 31 Oktober 2021 (739 artikel)

242

Authors_(Last_Name)

Mori Y., Sato H., Kumazawa T., Mayang Permata T.B., Yoshimoto Y., Murata K., Noda S.-E., Kaminuma T., Ando K., Oike T., Okonogi N., Okada K., Kakoti S., Suzuki K., Ikota H., Yokoo H., Nakano T., Ohno T., Shibata A.

Author S Id

57210846989;55697961900;57210432294;57215844296;36453407100;36103294900;14621772700;23994005700;55641963900;36453136000;36453127400;57222984111;57197814645;55550919200;57214213081;55588986400;35353843800;35395665700;8323572900;

Title

Analysis of radiotherapy-induced alteration of CD8+ T cells and PD-L1 expression in patients with uterine cervical squamous cell carcinoma

Year

2021

Source Title

Oncology Letters

Volume

Issue

Art No

446

Page Start

Page End

Page Count

Cited By

Link

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104336493&doi=10.3892%2fol.2021.12707&partnerID=40&md5=a047e0e92118f6cb0de5b48cfc613e96

Affiliations

Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Department of Radiotherapy, Saitama Cancer Center, Ina, Saitama, 362-0806, Japan; Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Department of Radiation Oncology, Fukushima Medical University, Fukushima, 960-1247, Japan; Department of Radiation Oncology, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, Hidaka, Saitama, 350-1298, Japan; National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan; Signal Transduction Program, Gunma University Initiative for Advanced Research, Gunma University, Maebashi, Gunma, 371-8511, Japan; Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan; Clinical Department of Pathology, Gunma University Hospital, Maebashi, Gunma, 371-8511, Japan; Department of Human Pathology, Gunma University, Graduate School of Medicine, Maebashi, Gunma, 371-8511, Japan

Authors With Affiliations

Mori, Y., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan, Department of Radiotherapy, Saitama Cancer Center, Ina, Saitama, 362-0806, Japan; Sato, H., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Kumazawa, T., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Mayang Permata, T.B., Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Yoshimoto, Y., Department of Radiation Oncology, Fukushima Medical University, Fukushima, 960-1247, Japan; Murata, K., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Noda, S.-E., Department of Radiation Oncology, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, Hidaka, Saitama, 350-1298, Japan; Kaminuma, T., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Ando, K., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Oike, T., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Okonogi, N., National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan; Okada, K., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Kakoti, S., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan, Signal Transduction Program, Gunma University Initiative for Advanced Research, Gunma University, Maebashi, Gunma, 371-8511, Japan; Suzuki, K., Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan; Ikota, H., Clinical Department of Pathology, Gunma University Hospital, Maebashi, Gunma, 371-8511, Japan; Yokoo, H., Department of Human Pathology, Gunma University, Graduate School of Medicine, Maebashi, Gunma, 371-8511, Japan; Nakano, T., National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan; Ohno, T., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Shibata, A., Signal Transduction Program, Gunma University Initiative for Advanced Research, Gunma University, Maebashi, Gunma, 371-8511, Japan

Abstract

Radiotherapy induces an immune response in the cancer microenvironment that may influence clinical outcome. The present study aimed to analyse the alteration of CD8+ T-cell infiltration and programmed death-ligand 1 (PD-L1) expression following radiotherapy in clinical samples from patients with uterine cervical squamous cell carcinoma. Additionally, the current study sought to analyse the associa- tion between these immune responses and clinical outcomes. A total of 75 patients who received either definitive chemoradio- therapy or radiotherapy were retrospectively analyzed. CD8+ T-cell infiltration and PD-L1 expression were determined by immunohistochemistry using biopsy specimens before radio- therapy (pre-RT) and after 10 Gy radiotherapy (post-10 Gy). The PD-L1+ rate was significantly increased from 5% (4/75) pre-RT to 52% (39/75) post-10 Gy (P<0.01). Despite this increase in the PD-L1+ rate post-10 Gy, there was no significant association between both pre-RT and post-10 Gy and overall survival (OS), locoregional control (LC) and progression-free survival (PFS). On the other hand, the CD8+ T-cell infiltration density was significantly decreased for all patients (median, 23.1% pre-RT vs. 16.9% post-10 Gy; P=0.038); however, this tended to increase in patients treated with radiotherapy alone (median, 17.7% pre-RT vs. 24.0% post-10 Gy; P=0.400). Notably, patients with high CD8+ T-cell infiltration either pre-RT or post-10 Gy exhibited positive associations with OS, LC and PFS. Thus, the present analysis suggested that CD8+ T-cell infiltration may be a prognostic biomarker for patients with cervical cancer receiving radiotherapy. Furthermore, immune checkpoint inhibitors may be effective in patients who have received radiotherapy, since radiotherapy upregu- lated PD-L1 expression in cervical cancer specimens. ? 2021 Spandidos Publications. All rights reserved.

Author Keywords

CD8+ T cell; Cervical cancer; Immune modulation; Programmed death-ligand 1; Radiotherapy; Tumor microenvironment

Index Keywords

alcohol; biological marker; biotin; cisplatin; citric acid; diaminobenzidine; edetic acid; formaldehyde; hydrogen peroxide; immune checkpoint inhibitor; paraffin; peroxidase; platinum; programmed death 1 ligand 1; streptavidin; adult; aged; antigen retrieval; Article; biopsy; brachytherapy; cancer radiotherapy; cancer staging; CD8+ T lymphocyte; cell density; cell infiltration; chemoradiotherapy; controlled study; diagnostic test accuracy study; down regulation; female; follow up; human; human tissue; immune response; immunohistochemistry; irradiation; lymph node metastasis; major clinical study; microscopy; overall survival; paraffin embedding; progression free survival; protein expression; receiver operating characteristic; retrospective study; room temperature; tumor associated leukocyt

Publisher

Spandidos Publications

Issn

17921074

Isbn

Pubmed Id

Document Type

Article

Sjr Best Quartile

Sjr

766

Sjr Rank

6367