Publikasi Scopus FKUI 2021 per tanggal 31 Oktober 2021 (739 artikel)

Introduction: The evidence on the association between obesity and atrial fibrillation (AF) recurrence was equivocal. We aimed to evaluate the dose-response relationship between body mass index (BMI) and AF recurrence and adverse events. Methods: A systematic literature search was conducted using PubMed, Europe PMC, EBSCO, ProQuest and Cochrane Library. Obesity was defined as BMI ?28?kg/m2. The primary outcome was AF recurrence, and the secondary outcome was adverse events. Adverse events were defined as procedure-related complications and cardio-cerebrovascular events. Results: There were a total of 52,771 patients from 20 studies. Obesity was associated with higher AF recurrence (Odds ratio [OR] 1.30 [95% confidence interval [CI] 1.16-1.47], P?<.001; I2: 72.7%) and similar rate of adverse events (OR 1.21 [95% CI 0.87-1.67], P?=.264; I2: 23.9%). Meta-regression showed that the association varies by age (coefficient: ?0.03, P?=.024). Meta-analysis of highest versus lowest BMI showed that the highest group had higher AF recurrence (OR 1.37 [95% CI 1.18-1.58], P?<.001; I2: 64.9%) and adverse events (OR 2.02 [95% CI 1.08-3.76], P?=.028; I2: 49.5%). The linear association analysis for AF recurrence was not significant (P?=.544). The dose-response relationship for BMI and AF recurrence was nonlinear (pnonlinearity?