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Publikasi Scopus FKUI 2021 per tanggal 31 Oktober 2021 (739 artikel)
Publikasi Scopus FKUI 2021 per tanggal 31 Oktober 2021 (739 artikel)
Aetiology, course and treatment of acute tubulointerstitial nephritis in paediatric patients: A cross-sectional web-based survey
2021
BMJ Open
11
5
e047059
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107244372&doi=10.1136%2fbmjopen-2020-047059&partnerID=40&md5=8b9d8549b7d6c5d3a71a823dffc235d5
Department of Pediatric Nephrology, MHH, Hannover, Germany; Department of Pediatric Nephrology, Veltischev Research and Clinical Institute for Pediatrics, The Pirogov Russian National Research Medical University, Moskva, Russian Federation; Department of Pediatric Nephrology, Temple Street Children's University Hospital, Dublin, Ireland; Department of Pediatric Nephrology, Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Central Jakarta, Indonesia; Department of Pediatric Nephrology, Meyer Children's Hospital, Florence, Italy; Department of Pediatric Nephrology, Bambino Ges? Children's Hospital, Roma, Italy; Department of Pediatric Nephrology, Montpellier University, Arnaud de Villeneuve Hospital, Montpellier, France; Department of Pediatric Nephrology, Dona Estef?nia Hospital, Lisboa, Portugal; Department of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkey; Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey; KfH Centre of Pediatric Nephrology, Clementine Kinderhospital, Frankfurt am Main, Germany; Department of Pediatric Nephrology and Transplantation, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland; Department of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, OH, United States; Department of Pediatric Nephrology, Aarhus University Hospital, Aarhus, Denmark; Department of Pediatric Nephrology, Connecticut Children's Medical Center, Hartford, CT, United States; Department of Pediatric Nephrology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pediatric Nephrology, Azienda Ospedaliero-Universitaria di Bologna, Ospedale S. Orsola-Malpighi, Bologna, Italy; Department of Pediatric Nephrology, Karolinska University Hospital, Stockholm, Sweden; Department of Pediatric Nephrology, University Children's Hospital, Ljubljana, Slovenia; Department of Pediatric Nephrology, Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey; Department of Pediatric Nephrology, Dr Behcet Uz Children Hospital, Izmir, Turkey; Department of Pediatric Nephrology, Faculty of Medicine, Ege University, Izmir, Turkey; Department of Pediatric Nephrology, University Hospital of Padova, Padova, Italy; Department of Pediatric Nephrology, Stony Brook Children's Hospital, Stony Brook, NY, United States; Department of Pediatric Nephrology, Faculty of Medicine, Erciyes University, Kayseri, Turkey; Department of Pediatric Nephrology, 2nf Faculty of Medicine, University Hospital Motol, Charles University, Praha, Czech Republic; Department of Pediatrics II, University Hospital Essen, Essen, Germany; H?pital Necker-Enfants malades, MARHEA, Institut Imagine, Universit? de Paris, Paris, France; Pediatric Department, University Hospital Carl Gustav Carus, Technical University, Dresden, Germany; Ege University Faculty of Medicine, Izmir, Turkey; Radboud University Medical Center, Nijmegen, Netherlands; Hospital Universitario 12 de Octubre, Madrid, Spain; Ali-Asghar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran; Asklepios Medical School, Hamburg, Germany; CHC Li?ge, Belgium; Pediatric Nephrology, Hospital Universitario Central de Asturias, University of Oviedo, Spain; Universit?tsklinikum Kinderklinik Augsburg, Germany
Background Acute tubulointerstitial nephritis (TIN) is a significant cause of acute renal failure in paediatric and adult patients. There are no large paediatric series focusing on the aetiology, treatment and courses of acute TIN. Patients, design and setting We collected retrospective clinical data from paediatric patients with acute biopsy-proven TIN by means of an online survey. Members of four professional societies were invited to participate. Results Thirty-nine physicians from 18 countries responded. 171 patients with acute TIN were included (54% female, median age 12 years). The most frequent causes were tubulointerstitial nephritis and uveitis syndrome in 31% and drug-induced TIN in 30% (the majority of these caused by non-steroidal anti-inflammatory drugs). In 28% of patients, no initiating noxae were identified (idiopathic TIN). Median estimated glomerular filtration rate (eGFR) rose significantly from 31 at time of renal biopsy to 86 mL/ min/1.73 m2 3-6 months later (p<0.001). After 3-6 months, eGFR normalised in 41% of patients (eGFR ?90 mL/ min/1.73 m2), with only 3% having severe or end-stage impairment of renal function (<30 mL/min/1.73 m2). 80% of patients received corticosteroid therapy. Median eGFR after 3-6 months did not differ between steroid-treated and steroid-untreated patients. Other immunosuppressants were used in 18% (n=31) of patients, 21 of whom received mycophenolate mofetil. Conclusions Despite different aetiologies, acute paediatric TIN had a favourable outcome overall with 88% of patients showing no or mild impairment of eGFR after 3-6 months. Prospective randomised controlled trials are needed to evaluate the efficacy of glucocorticoid treatment in paediatric patients with acute TIN. ? Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
aciclovir; amoxicillin plus clavulanic acid; antiinfective agent; bee venom; chlorpheniramine maleate; corticosteroid; cotrimoxazole; flurbiprofen; herbaceous agent; hydrochlorothiazide; ibuprofen; immunosuppressive agent; ketoprofen; levetiracetam; mesalazine; methylprednisolone; midecamycin; morniflumate; mycophenolate mofetil; nonsteroid antiinflammatory agent; oxcarbazepine; paracetamol; penicillin G potassium; prednisolone; prednisone; toxic substance; anuria; arthralgia; Article; child; clinical feature; cohort analysis; controlled study; corticosteroid therapy; cross-sectional study; disease course; end stage renal disease; enuresis; estimated glomerular filtration rate; eye disease; fatigue; female; fever; flank pain; glucosuria; headache; health care survey; hematuria; human; huma
BMJ Publishing Group
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