Publikasi Scopus FKUI 2021 per tanggal 31 Oktober 2021 (739 artikel)

Kartinah N.T., Komara N., Noviati N.D., Dewi S., Yolanda S., Radhina A., Heriyanto H., Sianipar I.R.
57192914846;57305640200;57306573600;57192904541;57190854113;57306103600;57210426527;55486707100;
Potential of Hibiscus sabdariffa Linn. in managing FGF21 resistance in diet-induced-obesity rats via miR-34a regulation
2021
Veterinary Medicine and Science
Department of Medical Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Physiology, Faculty of Medicine, UKRIDA, Jakarta, Indonesia
Kartinah, N.T., Department of Medical Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Komara, N., Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Noviati, N.D., Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dewi, S., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yolanda, S., Department of Medical Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Radhina, A., Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Heriyanto, H., Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Physiology, Faculty of Medicine, UKRIDA, Jakarta, Indonesia; Sianipar, I.R., Department of Medical Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Background: Obesity is a cause of FGF21 resistance, which affects the browning and thermogenesis process of the adipose tissue. Decreased receptor expression is influenced by miR-34a, whose expression is increased in obesity. While FGF21-based therapies have been widely investigated, the potential activity of Hibiscus sabdariffa Linn. extract (HSE) against FGF21 resistance is unknown. Objective: This study aims to determine the effects of HSE on the expression of miR-34a and FGF21 receptors in white adipose tissue. Methods: This experimental study used 24 male Sprague-Dawley rats and divided into four groups: Control (N); diet-induced-obesity rats (DIO); DIO rats with HSE 200?mg/kgBW/day and DIO rats with HSE 400?mg/kgBW/day. Rats were fed a high-fat diet for 17?weeks. HSE was administered daily for 5 weeks. The administration of HSE 400?mg/kgBW/day resulted in the equivalent expression of miR-34a to that of the control (p?>?0.05). Results: FGFR1 receptor expression was also similar to controls (p?>?0.05). Beta-klotho expression was significantly lower than that of control (p?
inflammation; metabolism; obesity; physiology
John Wiley and Sons Inc
20531095
Article
Q2
485
10348